Project name: 5f6cc4c5f2c3c4a

Chain sequence(s)	A: QAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLVPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLD
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.4489
• Maximal score value: 1.7554
• Average score: -0.8099
• Total score value: -371.749

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
68	Q	A	-1.0388
69	A	A	-0.1225
70	A	A	-0.1241
71	H	A	0.0000
72	L	A	-0.0472
73	S	A	-0.5254
74	F	A	0.0000
75	A	A	-1.1796
76	R	A	-2.2440
77	L	A	-1.3205
78	A	A	-1.6785
79	R	A	-3.0196
80	R	A	-2.4545
81	Y	A	-0.4885
82	G	A	-0.9999
83	D	A	-1.4475
84	V	A	0.1388
85	F	A	-0.0045
86	Q	A	-0.8165
87	I	A	-0.9861
88	R	A	-1.9908
89	L	A	-0.9151
90	G	A	-0.8432
91	S	A	-0.7660
92	C	A	-0.6821
93	P	A	-1.0502
94	I	A	0.0000
95	V	A	0.0000
96	V	A	0.0000
97	L	A	0.0000
98	N	A	0.0000
99	G	A	-1.4308
100	E	A	-2.3874
101	R	A	-2.5389
102	A	A	0.0000
103	I	A	0.0000
104	H	A	-1.3567
105	Q	A	-1.3835
106	A	A	0.0000
107	L	A	0.0000
108	V	A	0.0306
109	Q	A	-1.1537
110	Q	A	-0.7109
111	G	A	-0.5208
112	S	A	-0.4275
113	A	A	-0.9578
114	F	A	0.0000
115	A	A	0.0000
116	D	A	-0.8219
117	R	A	0.0000
118	P	A	0.0000
119	A	A	-0.5438
120	F	A	-0.1829
121	A	A	-0.4624
122	S	A	0.0000
123	F	A	0.0000
124	R	A	-2.0655
125	V	A	-1.3684
126	V	A	0.0000
127	S	A	0.0000
128	G	A	-1.6136
129	G	A	-1.5781
130	R	A	-1.7351
131	S	A	0.0000
132	M	A	0.0000
133	A	A	-0.2715
134	F	A	0.0000
135	G	A	-1.0146
136	H	A	-1.4492
137	Y	A	-1.1959
138	S	A	-1.6446
139	E	A	-2.6902
140	H	A	-2.2912
141	W	A	0.0000
142	K	A	-2.5466
143	V	A	-1.8381
144	Q	A	0.0000
145	R	A	-1.8508
146	R	A	-2.3114
147	A	A	0.0000
148	A	A	0.0000
149	H	A	-1.5914
150	S	A	-1.6277
151	M	A	0.0000
152	M	A	0.0000
153	R	A	-2.7891
154	N	A	-2.3721
155	F	A	-1.6512
156	F	A	0.0000
157	T	A	-2.7747
158	R	A	-3.4489
159	Q	A	-3.0434
160	P	A	-2.5084
161	R	A	-3.1230
162	S	A	-2.5687
163	R	A	-3.0007
164	Q	A	-1.9879
165	V	A	0.0337
166	L	A	0.0000
167	E	A	-0.5495
168	G	A	-0.1847
169	H	A	-0.1195
170	V	A	0.0000
171	L	A	-0.2433
172	S	A	-0.4773
173	E	A	0.0000
174	A	A	0.0000
175	R	A	-0.9264
176	E	A	-0.9524
177	L	A	0.0000
178	V	A	0.0000
179	A	A	-0.6214
180	L	A	-0.4482
181	L	A	0.0000
182	V	A	-0.3647
183	R	A	-1.7479
184	G	A	-0.9805
185	S	A	0.0000
186	A	A	-1.4143
187	D	A	-2.1720
188	G	A	-1.3707
189	A	A	-0.8698
190	F	A	-0.2154
191	L	A	-0.0852
192	V	A	-0.4123
193	P	A	0.0000
194	R	A	-1.1137
195	P	A	-0.5829
196	L	A	-0.2460
197	T	A	0.0000
198	V	A	0.0000
199	V	A	0.0000
200	A	A	0.0000
201	V	A	0.0000
202	A	A	0.0000
203	N	A	0.0000
204	V	A	0.0000
205	M	A	0.0000
206	S	A	0.0000
207	A	A	0.0000
208	V	A	0.0000
209	C	A	0.0000
210	F	A	0.0000
211	G	A	-0.7089
212	C	A	-0.2771
213	R	A	-0.8914
214	Y	A	-1.0315
215	S	A	-1.3886
216	H	A	-1.5649
217	D	A	-2.5551
218	D	A	-2.5199
219	P	A	-2.7446
220	E	A	-3.2070
221	F	A	0.0000
222	R	A	-3.0106
223	E	A	-3.2207
224	L	A	0.0000
225	L	A	0.0000
226	S	A	-1.6602
227	H	A	-1.3972
228	N	A	0.0000
229	E	A	-1.8120
230	E	A	-1.9809
231	F	A	-1.1126
232	G	A	0.0000
233	R	A	-1.8990
234	T	A	0.0000
235	V	A	0.0000
236	G	A	0.0000
237	A	A	-0.0566
238	G	A	-0.3516
239	S	A	-0.2115
240	L	A	0.2055
241	V	A	0.0000
242	D	A	0.0032
243	V	A	0.0000
244	M	A	0.2450
245	P	A	0.3309
246	W	A	1.2723
247	L	A	0.0000
248	Q	A	0.3651
249	Y	A	1.7554
250	F	A	1.5104
251	P	A	0.2470
252	N	A	-0.1223
253	P	A	-0.5050
254	V	A	-0.4931
255	R	A	-0.5101
256	T	A	-1.0272
257	V	A	0.0000
258	F	A	-1.7355
259	R	A	-2.8630
260	E	A	-2.5167
261	F	A	0.0000
262	E	A	-2.7478
263	Q	A	-3.1182
264	L	A	0.0000
265	N	A	0.0000
266	R	A	-3.1584
267	N	A	-2.3624
268	F	A	0.0000
269	S	A	0.0000
270	N	A	-1.9974
271	F	A	-1.0168
272	I	A	0.0000
273	L	A	-0.5239
274	D	A	-1.2748
275	K	A	-1.1241
276	F	A	0.0000
277	L	A	-0.4565
278	R	A	-2.1609
279	H	A	-1.7580
280	C	A	-1.3794
281	E	A	-2.5380
282	S	A	-1.9087
283	L	A	-1.9249
284	R	A	-2.3846
285	P	A	-1.3093
286	G	A	-1.0659
287	A	A	-1.0976
288	A	A	-0.8333
289	P	A	-1.2805
290	R	A	-2.0287
291	D	A	-1.1486
292	M	A	0.0000
293	M	A	0.0000
294	D	A	-0.8696
295	A	A	0.0000
296	F	A	0.0000
297	I	A	0.0000
298	L	A	-1.0494
299	S	A	-1.4211
300	A	A	0.0000
301	E	A	-2.8883
302	K	A	-3.4022
303	K	A	-2.9783
304	A	A	-1.9813
305	A	A	-1.9534
306	G	A	-2.0679
307	D	A	-2.8271
312	G	A	-1.0594
313	A	A	-1.1993
314	R	A	-1.5531
315	L	A	0.0000
316	D	A	-2.2605
317	L	A	-1.4199
318	E	A	-2.1172
319	N	A	-1.4947
320	V	A	0.0000
321	P	A	0.0000
322	A	A	0.0000
323	T	A	0.0000
324	I	A	0.0000
325	T	A	0.0000
326	D	A	-0.3015
327	I	A	0.0000
328	F	A	0.0000
329	G	A	-0.1442
330	A	A	-0.0392
331	S	A	-0.1043
332	Q	A	0.0000
333	D	A	0.0000
334	T	A	0.0264
335	L	A	0.0000
336	S	A	0.0000
337	T	A	0.0000
338	A	A	0.0000
339	L	A	0.0000
340	Q	A	0.0000
341	W	A	0.0000
342	L	A	0.0000
343	L	A	0.0000
344	L	A	0.0000
345	L	A	0.0000
346	F	A	0.0000
347	T	A	0.0000
348	R	A	-0.8702
349	Y	A	-0.8045
350	P	A	-1.5328
351	D	A	-2.2757
352	V	A	0.0000
353	Q	A	0.0000
354	T	A	-1.4736
355	R	A	-2.1023
356	V	A	0.0000
357	Q	A	0.0000
358	A	A	-1.2269
359	E	A	-1.3720
360	L	A	0.0000
361	D	A	-2.3271
362	Q	A	-1.8375
363	V	A	-0.9765
364	V	A	0.0000
365	G	A	-2.1043
366	R	A	-3.0076
367	D	A	-3.1199
368	R	A	-2.5176
369	L	A	-1.1925
370	P	A	0.0000
371	C	A	-0.1883
372	M	A	0.0000
373	G	A	-0.7817
374	D	A	-0.8695
375	Q	A	-0.9137
376	P	A	-0.9617
377	N	A	-1.4855
378	L	A	0.0000
379	P	A	-0.0925
380	Y	A	0.0000
381	V	A	0.0000
382	L	A	0.1419
383	A	A	0.0000
384	F	A	0.0000
385	L	A	0.0000
386	Y	A	-0.0753
387	E	A	0.0000
388	A	A	0.0000
389	M	A	0.0000
390	R	A	0.0000
391	F	A	-0.4244
392	S	A	0.0000
393	S	A	0.0000
394	F	A	0.0000
395	V	A	0.5073
396	P	A	0.0000
397	V	A	0.0000
398	T	A	0.0000
399	I	A	0.2565
400	P	A	0.0000
401	H	A	0.0000
402	A	A	0.0000
403	T	A	0.0000
404	T	A	-1.4872
405	A	A	-1.8768
406	N	A	-2.6353
407	T	A	-1.3223
408	S	A	-0.6296
409	V	A	0.0000
410	L	A	-0.1188
411	G	A	-0.0712
412	Y	A	0.2572
413	H	A	-1.1514
414	I	A	0.0000
415	P	A	-2.1651
416	K	A	-3.3169
417	D	A	-2.8991
418	T	A	-1.6221
419	V	A	0.0000
420	V	A	0.0000
421	F	A	0.0000
422	V	A	0.0000
423	N	A	0.0000
424	Q	A	0.0000
425	W	A	0.2617
426	S	A	-0.4173
427	V	A	0.0000
428	N	A	0.0000
429	H	A	0.0000
430	D	A	-0.6020
431	P	A	-0.3430
432	L	A	0.8019
433	K	A	-0.6090
434	W	A	0.0000
435	P	A	-1.0112
436	N	A	-1.8884
437	P	A	-1.7548
438	E	A	-2.7530
439	N	A	-2.5739
440	F	A	0.0000
441	D	A	-1.3166
442	P	A	0.0000
443	A	A	-0.4463
444	R	A	-0.8727
445	F	A	0.0000
446	L	A	-0.6605
447	D	A	-1.6267
448	K	A	-2.5689
449	D	A	-2.4594
450	G	A	-1.1253
451	L	A	-0.2778
452	I	A	-0.6571
453	N	A	-1.7690
454	K	A	-2.8886
455	D	A	-3.0813
456	L	A	-2.0524
457	T	A	0.0000
458	S	A	-2.1104
459	R	A	-2.6242
460	V	A	-1.1001
461	M	A	0.0000
462	I	A	0.0000
463	F	A	0.2169
464	S	A	0.0000
465	V	A	-0.0991
466	G	A	-0.6815
467	K	A	-1.2632
468	R	A	0.0000
469	R	A	-0.8437
470	C	A	-0.3078
471	I	A	-0.8641
472	G	A	-0.9446
473	E	A	-1.2816
474	E	A	-2.2308
475	L	A	0.0000
476	S	A	-0.7876
477	K	A	-1.0331
478	M	A	-0.8623
479	Q	A	0.0000
480	L	A	0.0000
481	F	A	0.0000
482	L	A	0.0000
483	F	A	0.0000
484	I	A	0.0000
485	S	A	0.0000
486	I	A	0.0000
487	L	A	0.0000
488	A	A	0.0000
489	H	A	0.0000
490	Q	A	0.0000
491	C	A	0.0000
492	D	A	-0.7630
493	F	A	0.0000
494	R	A	-1.3194
495	A	A	-1.3211
496	N	A	-1.7212
497	P	A	-1.8334
498	N	A	-2.3912
499	E	A	-3.1183
500	P	A	-1.9419
501	A	A	-1.6856
502	K	A	-2.3163
503	M	A	-1.9748
504	N	A	-1.9480
505	F	A	-0.8654
506	S	A	-0.6650
507	Y	A	0.2510
508	G	A	-0.4278
509	L	A	-0.0373
510	T	A	0.0000
511	I	A	0.0000
512	K	A	0.0000
513	P	A	0.0000
514	K	A	-2.0471
515	S	A	-1.4560
516	F	A	0.0000
517	K	A	-1.1809
518	V	A	0.0000
519	N	A	0.0000
520	V	A	0.0000
521	T	A	-1.0710
522	L	A	-1.0996
523	R	A	-2.4459
524	E	A	-2.8918
525	S	A	-1.5139
526	M	A	-1.2047
527	E	A	-2.3371
528	L	A	0.0000
529	L	A	-0.1614
530	D	A	-1.4703