Chain sequence(s) |
A: DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC C: PREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSIWKFPDEEGACQPCPIN B: EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP |
Distance of aggregation | 10 Å |
Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | D | A | -2.1881 | |
2 | I | A | -1.8331 | |
3 | Q | A | -2.0881 | |
4 | M | A | 0.0000 | |
5 | T | A | -1.3529 | |
6 | Q | A | 0.0000 | |
7 | S | A | -0.8555 | |
8 | P | A | -0.5678 | |
9 | S | A | -0.7710 | |
10 | S | A | -0.6556 | |
11 | L | A | -0.5720 | |
12 | S | A | -1.0667 | |
13 | A | A | -1.0714 | |
14 | S | A | -0.8978 | |
15 | V | A | 0.2493 | |
16 | G | A | -0.5508 | |
17 | D | A | -1.5891 | |
18 | R | A | -2.3077 | |
19 | V | A | 0.0000 | |
20 | T | A | -0.6412 | |
21 | I | A | 0.0000 | |
22 | T | A | -0.7423 | |
23 | C | A | 0.0000 | |
24 | R | A | -2.7602 | |
25 | A | A | 0.0000 | |
26 | S | A | -2.1796 | |
27 | Q | A | -2.8240 | |
28 | D | A | -2.6400 | |
29 | V | A | 0.0000 | |
30 | N | A | 0.0000 | |
31 | T | A | -0.4763 | |
32 | A | A | 0.0000 | |
33 | V | A | 0.0000 | |
34 | A | A | 0.0000 | |
35 | W | A | 0.0000 | |
36 | Y | A | 0.0000 | |
37 | Q | A | 0.0000 | |
38 | Q | A | 0.0000 | |
39 | K | A | -1.7290 | |
40 | P | A | -1.5169 | |
41 | G | A | -1.7502 | |
42 | K | A | -2.5818 | |
43 | A | A | -1.7015 | |
44 | P | A | 0.0000 | |
45 | K | A | -1.9050 | |
46 | L | A | 0.0000 | |
47 | L | A | 0.0000 | |
48 | I | A | 0.0000 | |
49 | Y | A | 0.5684 | |
50 | S | A | 0.1913 | |
51 | A | A | 0.0000 | |
52 | S | A | 0.0665 | |
53 | F | A | 0.7377 | |
54 | L | A | 0.8052 | |
55 | Y | A | 0.2236 | |
56 | S | A | -0.1776 | |
57 | G | A | -0.4715 | |
58 | V | A | 0.0000 | |
59 | P | A | -0.3624 | |
60 | S | A | -0.3875 | |
61 | R | A | -0.7347 | |
62 | F | A | 0.0000 | |
63 | S | A | -0.1329 | |
64 | G | A | -0.1838 | |
65 | S | A | -0.7582 | |
66 | R | A | -1.4235 | |
67 | S | A | -1.1631 | |
68 | G | A | -1.5620 | |
69 | T | A | -1.9323 | |
70 | D | A | -1.7169 | |
71 | F | A | 0.0000 | |
72 | T | A | -0.7239 | |
73 | L | A | 0.0000 | |
74 | T | A | -0.6347 | |
75 | I | A | 0.0000 | |
76 | S | A | -1.4445 | |
77 | S | A | -1.0936 | |
78 | L | A | 0.0000 | |
79 | Q | A | -0.9348 | |
80 | P | A | -1.5325 | |
81 | E | A | -1.5601 | |
82 | D | A | 0.0000 | |
83 | F | A | 0.0000 | |
84 | A | A | 0.0000 | |
85 | T | A | -0.7045 | |
86 | Y | A | 0.0000 | |
87 | Y | A | 0.0000 | |
88 | C | A | 0.0000 | |
89 | Q | A | 0.0000 | |
90 | Q | A | 0.0000 | |
91 | H | A | 0.0000 | |
92 | Y | A | -0.1577 | |
93 | T | A | -0.4102 | |
94 | T | A | -0.3365 | |
95 | P | A | -0.5556 | |
96 | P | A | 0.0000 | |
97 | T | A | -0.6551 | |
98 | F | A | -0.4738 | |
99 | G | A | 0.0000 | |
100 | Q | A | -1.7280 | |
101 | G | A | 0.0000 | |
102 | T | A | 0.0000 | |
103 | K | A | -1.1708 | |
104 | V | A | 0.0000 | |
105 | E | A | -1.5489 | |
106 | I | A | 0.0000 | |
107 | K | A | -1.6600 | |
108 | R | A | -1.2352 | |
109 | T | A | -0.2553 | |
110 | V | A | 0.3216 | |
111 | A | A | -0.0011 | |
112 | A | A | -0.0186 | |
113 | P | A | 0.0000 | |
114 | S | A | -0.1239 | |
115 | V | A | 0.0000 | |
116 | F | A | 0.0000 | |
117 | I | A | 0.0000 | |
118 | F | A | 0.0000 | |
119 | P | A | -0.6744 | |
120 | P | A | 0.0000 | |
121 | S | A | -1.5468 | |
122 | D | A | -2.9159 | |
123 | E | A | -2.8725 | |
124 | Q | A | 0.0000 | |
125 | L | A | -2.2436 | |
126 | K | A | -2.7720 | |
127 | S | A | -1.7675 | |
128 | G | A | -1.4982 | |
129 | T | A | -1.1464 | |
130 | A | A | 0.0000 | |
131 | S | A | 0.0000 | |
132 | V | A | 0.0000 | |
133 | V | A | 0.0000 | |
134 | C | A | 0.0000 | |
135 | L | A | 0.0000 | |
136 | L | A | 0.0000 | |
137 | N | A | 0.0000 | |
138 | N | A | -0.8979 | |
139 | F | A | 0.0000 | |
140 | Y | A | 0.0000 | |
141 | P | A | -1.7212 | |
142 | R | A | -2.7142 | |
143 | E | A | -3.1257 | |
144 | A | A | -2.3985 | |
145 | K | A | -2.6983 | |
146 | V | A | -1.6947 | |
147 | Q | A | -1.5005 | |
148 | W | A | 0.0000 | |
149 | K | A | -1.0398 | |
150 | V | A | 0.0000 | |
151 | D | A | -2.1468 | |
152 | N | A | -1.6545 | |
153 | A | A | -0.4033 | |
154 | L | A | 0.4442 | |
155 | Q | A | -0.4625 | |
156 | S | A | -0.7548 | |
157 | G | A | -1.1165 | |
158 | N | A | -1.2276 | |
159 | S | A | -1.4718 | |
160 | Q | A | -1.5787 | |
161 | E | A | -2.1520 | |
162 | S | A | -1.0826 | |
163 | V | A | -1.0531 | |
164 | T | A | -1.1760 | |
165 | E | A | -2.3353 | |
166 | Q | A | 0.0000 | |
167 | D | A | -2.1985 | |
168 | S | A | -2.2351 | |
169 | K | A | -2.7033 | |
170 | D | A | -2.2385 | |
171 | S | A | 0.0000 | |
172 | T | A | 0.0000 | |
173 | Y | A | -1.3928 | |
174 | S | A | 0.0000 | |
175 | L | A | 0.0000 | |
176 | S | A | 0.0000 | |
177 | S | A | 0.0000 | |
178 | T | A | -0.7178 | |
179 | L | A | 0.0000 | |
180 | T | A | -0.6483 | |
181 | L | A | -0.9795 | |
182 | S | A | -1.3747 | |
183 | K | A | -2.4985 | |
184 | A | A | -2.3731 | |
185 | D | A | -3.2274 | |
186 | Y | A | 0.0000 | |
187 | E | A | -3.8499 | |
188 | K | A | -3.9208 | |
189 | H | A | -3.2362 | |
190 | K | A | -2.8290 | |
191 | V | A | -1.2860 | |
192 | Y | A | 0.0000 | |
193 | A | A | 0.0000 | |
194 | C | A | 0.0000 | |
195 | E | A | -1.3612 | |
196 | V | A | 0.0000 | |
197 | T | A | -1.3521 | |
198 | H | A | 0.0000 | |
199 | Q | A | -1.7252 | |
200 | G | A | -0.3352 | |
201 | L | A | -0.1600 | |
202 | S | A | -0.4190 | |
203 | S | A | -0.4225 | |
204 | P | A | -0.6899 | |
205 | V | A | -0.1943 | |
206 | T | A | -0.7249 | |
207 | K | A | -1.0232 | |
208 | S | A | -0.9752 | |
209 | F | A | 0.0000 | |
210 | N | A | -1.9777 | |
211 | R | A | -2.4952 | |
212 | G | A | -2.0932 | |
213 | E | A | -2.2350 | |
214 | C | A | -0.6080 | |
1 | E | B | -2.0475 | |
2 | V | B | -1.3819 | |
3 | Q | B | -1.3786 | |
4 | L | B | 0.0000 | |
5 | V | B | 0.2728 | |
6 | E | B | 0.0000 | |
7 | S | B | -0.6208 | |
8 | G | B | -0.9441 | |
9 | G | B | -0.8031 | |
10 | G | B | -0.4454 | |
11 | L | B | -0.2204 | |
12 | V | B | 0.0000 | |
13 | Q | B | -1.7106 | |
14 | P | B | -1.5856 | |
15 | G | B | -1.4578 | |
16 | G | B | -1.2272 | |
17 | S | B | -1.4130 | |
18 | L | B | -1.2573 | |
19 | R | B | -2.1788 | |
20 | L | B | 0.0000 | |
21 | S | B | -0.5322 | |
22 | C | B | 0.0000 | |
23 | A | B | -0.3485 | |
24 | A | B | 0.0000 | |
25 | S | B | -1.1472 | |
26 | G | B | -1.3186 | |
27 | F | B | -1.5012 | |
28 | N | B | -2.4828 | |
29 | I | B | 0.0000 | |
30 | K | B | -2.7825 | |
31 | D | B | -3.0668 | |
32 | T | B | 0.0000 | |
33 | Y | B | -0.5725 | |
34 | I | B | 0.0000 | |
35 | H | B | 0.0000 | |
36 | W | B | 0.0000 | |
37 | V | B | 0.0000 | |
38 | R | B | 0.0000 | |
39 | Q | B | -0.8073 | |
40 | A | B | -1.1620 | |
41 | P | B | -0.9616 | |
42 | G | B | -1.4721 | |
43 | K | B | -2.3976 | |
44 | G | B | -1.6579 | |
45 | L | B | 0.0000 | |
46 | E | B | -1.0990 | |
47 | W | B | 0.0000 | |
48 | V | B | 0.0000 | |
49 | A | B | 0.0000 | |
50 | R | B | 0.0000 | |
51 | I | B | 0.0000 | |
52 | Y | B | -0.4898 | |
53 | P | B | 0.0000 | |
54 | T | B | -1.3767 | |
55 | N | B | -1.2015 | |
56 | G | B | -0.7736 | |
57 | Y | B | 0.0731 | |
58 | T | B | 0.0036 | |
59 | R | B | -0.5038 | |
60 | Y | B | -0.9952 | |
61 | A | B | -1.4847 | |
62 | D | B | -2.4538 | |
63 | S | B | -1.8111 | |
64 | V | B | 0.0000 | |
65 | K | B | -2.6424 | |
66 | G | B | -1.8203 | |
67 | R | B | -1.5131 | |
68 | F | B | 0.0000 | |
69 | T | B | -1.0067 | |
70 | I | B | 0.0000 | |
71 | S | B | -0.2356 | |
72 | A | B | -0.8950 | |
73 | D | B | -1.4962 | |
74 | T | B | -1.6450 | |
75 | S | B | -1.5896 | |
76 | K | B | -2.2568 | |
77 | N | B | -1.8492 | |
78 | T | B | 0.0000 | |
79 | A | B | 0.0000 | |
80 | Y | B | -0.5968 | |
81 | L | B | 0.0000 | |
82 | Q | B | -1.4268 | |
83 | M | B | 0.0000 | |
84 | N | B | -1.6011 | |
85 | S | B | -1.3904 | |
86 | L | B | 0.0000 | |
87 | R | B | -2.8407 | |
88 | A | B | -1.9591 | |
89 | E | B | -2.3961 | |
90 | D | B | 0.0000 | |
91 | T | B | -0.8162 | |
92 | A | B | 0.0000 | |
93 | V | B | 0.1466 | |
94 | Y | B | 0.0000 | |
95 | Y | B | 0.0000 | |
96 | C | B | 0.0000 | |
97 | S | B | 0.0000 | |
98 | R | B | -0.2418 | |
99 | W | B | 0.0000 | |
100 | G | B | 0.0000 | |
101 | G | B | -0.9924 | |
102 | D | B | -1.7856 | |
103 | G | B | 0.0000 | |
104 | F | B | 0.0091 | |
105 | Y | B | -0.1102 | |
106 | A | B | 0.0000 | |
107 | M | B | 0.0000 | |
108 | D | B | -0.3237 | |
109 | Y | B | -0.5972 | |
110 | W | B | -0.6520 | |
111 | G | B | 0.0000 | |
112 | Q | B | -1.5425 | |
113 | G | B | -0.7303 | |
114 | T | B | -0.1862 | |
115 | L | B | 0.0874 | |
116 | V | B | 0.0000 | |
117 | T | B | -0.5656 | |
118 | V | B | 0.0000 | |
119 | S | B | -0.9059 | |
120 | S | B | -0.7194 | |
121 | A | B | -0.4792 | |
122 | S | B | -0.5907 | |
123 | T | B | -0.6217 | |
124 | K | B | -1.0826 | |
125 | G | B | -1.3529 | |
126 | P | B | -0.6522 | |
127 | S | B | -0.4990 | |
128 | V | B | 0.0000 | |
129 | F | B | 0.0000 | |
130 | P | B | -1.0805 | |
131 | L | B | 0.0000 | |
132 | A | B | -0.8407 | |
133 | P | B | 0.0000 | |
134 | S | B | -0.7852 | |
135 | S | B | -0.9684 | |
136 | K | B | -1.6006 | |
137 | S | B | 0.0000 | |
138 | T | B | -0.8477 | |
139 | S | B | -0.7550 | |
140 | G | B | -0.8127 | |
141 | G | B | -0.8809 | |
142 | T | B | -0.6084 | |
143 | A | B | 0.0000 | |
144 | A | B | 0.0000 | |
145 | L | B | 0.0000 | |
146 | G | B | 0.0000 | |
147 | C | B | 0.0000 | |
148 | L | B | 0.0000 | |
149 | V | B | 0.0000 | |
150 | K | B | 0.0000 | |
151 | D | B | -0.6120 | |
152 | Y | B | 0.0000 | |
153 | F | B | 0.0000 | |
154 | P | B | 0.0000 | |
155 | E | B | -0.3955 | |
156 | P | B | -0.5929 | |
157 | V | B | -0.3893 | |
158 | T | B | -0.4933 | |
159 | V | B | -0.2613 | |
160 | S | B | -0.3272 | |
161 | W | B | 0.0000 | |
162 | N | B | -0.7551 | |
163 | S | B | -0.6413 | |
164 | G | B | -0.4995 | |
165 | A | B | -0.2274 | |
166 | L | B | 0.0044 | |
167 | T | B | -0.1570 | |
168 | S | B | -0.1584 | |
169 | G | B | -0.1785 | |
170 | V | B | 0.1919 | |
171 | H | B | -0.3378 | |
172 | T | B | -0.1561 | |
173 | F | B | 0.0000 | |
174 | P | B | -0.3952 | |
175 | A | B | 0.1894 | |
176 | V | B | 0.4208 | |
177 | L | B | 0.9858 | |
178 | Q | B | 0.1995 | |
179 | S | B | -0.0952 | |
180 | S | B | -0.2529 | |
181 | G | B | -0.0366 | |
182 | L | B | 0.0277 | |
183 | Y | B | 0.3826 | |
184 | S | B | 0.0000 | |
185 | L | B | 0.0000 | |
186 | S | B | 0.0000 | |
187 | S | B | 0.0000 | |
188 | V | B | 0.0000 | |
189 | V | B | 0.0000 | |
190 | T | B | -0.1213 | |
191 | V | B | 0.0000 | |
192 | P | B | -0.5908 | |
193 | S | B | -0.6172 | |
194 | S | B | -0.5220 | |
195 | S | B | -0.4731 | |
196 | L | B | -0.6258 | |
197 | G | B | -0.9567 | |
198 | T | B | -0.6119 | |
199 | Q | B | -1.0227 | |
200 | T | B | -1.0268 | |
201 | Y | B | 0.0000 | |
202 | I | B | -1.3232 | |
203 | C | B | 0.0000 | |
204 | N | B | 0.0000 | |
205 | V | B | 0.0000 | |
206 | N | B | -1.7477 | |
207 | H | B | 0.0000 | |
208 | K | B | -2.6849 | |
209 | P | B | -1.5495 | |
210 | S | B | -1.7995 | |
211 | N | B | -2.4109 | |
212 | T | B | -2.0232 | |
213 | K | B | -2.6757 | |
214 | V | B | -1.7784 | |
215 | D | B | -2.5399 | |
216 | K | B | -2.2052 | |
217 | K | B | -2.4620 | |
218 | V | B | 0.0000 | |
219 | E | B | -2.0461 | |
220 | P | B | -0.9224 | |
529 | P | C | -1.3501 | |
530 | R | C | -2.0201 | |
531 | E | C | -1.4200 | |
532 | Y | C | 0.3054 | |
533 | V | C | 0.6076 | |
534 | N | C | -0.9753 | |
535 | A | C | -1.1913 | |
536 | R | C | -1.9326 | |
537 | H | C | -1.4834 | |
538 | C | C | -0.2777 | |
539 | L | C | -0.4573 | |
540 | P | C | -0.9315 | |
541 | C | C | 0.0000 | |
542 | H | C | -1.0095 | |
543 | P | C | -0.9800 | |
544 | E | C | -0.6632 | |
545 | C | C | 0.0000 | |
546 | Q | C | -1.0703 | |
547 | P | C | -1.0614 | |
548 | Q | C | -0.8066 | |
549 | N | C | -1.4516 | |
550 | G | C | -0.8672 | |
551 | S | C | 0.0780 | |
552 | V | C | 1.3921 | |
553 | T | C | 0.0000 | |
554 | C | C | 0.0000 | |
555 | F | C | 2.2742 | |
556 | G | C | 0.0000 | |
557 | P | C | 0.1305 | |
558 | E | C | 0.0000 | |
559 | A | C | 0.0000 | |
560 | D | C | 0.1037 | |
561 | Q | C | 0.5720 | |
562 | C | C | 0.7968 | |
563 | V | C | 1.2671 | |
564 | A | C | 0.1020 | |
565 | C | C | -0.1513 | |
566 | A | C | -0.5696 | |
567 | H | C | -1.1311 | |
568 | Y | C | -0.6470 | |
569 | K | C | -0.6563 | |
570 | D | C | 0.0000 | |
571 | P | C | 0.0000 | |
572 | P | C | 0.0000 | |
573 | F | C | 0.0000 | |
574 | C | C | 0.0000 | |
575 | V | C | -0.5118 | |
576 | A | C | -0.9677 | |
577 | R | C | -1.7531 | |
578 | C | C | 0.0000 | |
579 | P | C | 0.1164 | |
580 | S | C | 0.6170 | |
591 | I | C | 2.1040 | |
592 | W | C | 2.3404 | |
593 | K | C | 0.0000 | |
594 | F | C | 0.6585 | |
595 | P | C | -0.8084 | |
596 | D | C | -1.6608 | |
597 | E | C | -2.8224 | |
598 | E | C | -2.8205 | |
599 | G | C | -1.6361 | |
600 | A | C | 0.0000 | |
601 | C | C | 0.0000 | |
602 | Q | C | 0.0219 | |
603 | P | C | 0.0000 | |
604 | C | C | 1.3008 | |
605 | P | C | 0.8178 | |
606 | I | C | 1.4878 | |
607 | N | C | 0.1721 |