Project name: 6039ee25ffe595e

Chain sequence(s)	A: CERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKKDFLTLEHLIYSFQVAKGMEFLASRKIHRDLAARNILLSEKNVVKIGLARDIYKPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFRRLKEGTRMRAPDYTTPEMYQTMLDCWHGESSQRPTFSELVEHLGNLLQANA
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.2885
• Maximal score value: 1.2078
• Average score: -0.8469
• Total score value: -233.7328

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
815	C	A	-1.0250
816	E	A	-2.4742
817	R	A	-2.2802
818	L	A	-1.2469
819	P	A	-1.1889
820	Y	A	-1.4519
821	D	A	-2.2183
822	A	A	-1.7626
823	S	A	-1.6323
824	K	A	-2.2985
825	W	A	-1.2272
826	E	A	-1.3881
827	F	A	0.0000
828	P	A	-1.3020
829	R	A	-2.1299
830	D	A	-2.5908
831	R	A	-1.9684
832	L	A	-1.8647
833	K	A	-2.2237
834	L	A	-1.1703
835	G	A	-1.4237
836	K	A	-1.5609
837	P	A	-0.8086
838	L	A	0.0683
839	G	A	-0.8493
840	R	A	-1.8007
841	G	A	-0.9835
842	A	A	-0.2136
843	F	A	0.1122
844	G	A	-0.8198
845	Q	A	-0.9891
846	V	A	-0.3511
847	I	A	0.0000
848	E	A	-1.2766
849	A	A	0.0000
850	D	A	-1.8969
851	A	A	0.0000
852	F	A	-0.2887
853	G	A	-0.6867
854	I	A	-0.7976
855	D	A	-1.3717
856	K	A	-1.7897
857	T	A	-1.0025
858	A	A	-0.3398
859	T	A	-0.4933
861	R	A	-1.6705
862	T	A	-1.4728
863	V	A	0.0000
864	A	A	0.0000
865	V	A	0.0000
866	K	A	-0.3202
867	M	A	-0.4831
868	L	A	-0.7475
869	K	A	-1.9911
870	E	A	-2.4177
871	G	A	-1.6023
872	A	A	-1.2083
873	T	A	-1.4054
874	H	A	-1.9242
875	S	A	-1.5825
876	E	A	-1.5293
877	H	A	-2.0994
878	R	A	-2.9226
879	A	A	-1.5934
880	L	A	0.0000
881	M	A	0.0000
882	S	A	-1.3947
883	E	A	-0.8577
884	L	A	0.0000
885	K	A	0.0000
886	I	A	-0.1557
887	L	A	0.0620
888	I	A	-0.1424
889	H	A	-0.6931
890	I	A	-0.6560
891	G	A	-0.7638
892	H	A	-0.7057
893	H	A	0.0575
894	L	A	1.2078
895	N	A	0.0000
896	V	A	0.0000
897	V	A	0.2828
898	N	A	0.0000
899	L	A	0.0000
900	L	A	0.0441
901	G	A	0.0000
902	A	A	0.0000
903	C	A	0.0000
904	T	A	-1.0139
905	K	A	-1.8486
906	P	A	-1.2705
907	G	A	-1.1221
908	G	A	-1.0098
909	P	A	-1.0034
910	L	A	0.0000
911	M	A	0.0000
912	V	A	0.0000
913	I	A	0.0000
914	V	A	0.0000
915	E	A	-0.4570
916	F	A	-0.3781
917	C	A	0.0000
918	K	A	-1.1612
919	F	A	0.4393
920	G	A	0.0248
921	N	A	-0.5265
922	L	A	0.0000
923	S	A	0.0000
924	T	A	-0.5991
925	Y	A	-0.3230
926	L	A	0.0000
927	R	A	-1.9712
928	S	A	-1.4142
929	K	A	0.0000
930	R	A	-1.9481
931	N	A	-2.1279
932	E	A	-2.1452
933	F	A	-0.6712
934	V	A	-0.1486
935	P	A	0.0545
936	Y	A	0.0025
937	K	A	-1.1801
995	K	A	-2.5241
996	D	A	-2.4901
997	F	A	-1.4493
998	L	A	0.0000
999	T	A	0.0000
1000	L	A	0.0000
1001	E	A	-0.7004
1002	H	A	-0.4757
1003	L	A	0.0000
1004	I	A	0.0000
1006	Y	A	0.0000
1007	S	A	0.0000
1008	F	A	-0.2323
1009	Q	A	-0.1162
1010	V	A	0.0000
1011	A	A	0.0000
1012	K	A	-0.8076
1013	G	A	0.0000
1014	M	A	0.0000
1015	E	A	-1.2688
1016	F	A	-0.7273
1017	L	A	-0.9041
1018	A	A	-1.3702
1019	S	A	-1.3243
1020	R	A	-2.3724
1021	K	A	-2.5157
1023	I	A	0.0000
1024	H	A	0.0000
1025	R	A	-1.0973
1026	D	A	-0.5291
1027	L	A	0.0000
1028	A	A	0.0000
1029	A	A	0.0000
1030	R	A	-1.1594
1031	N	A	-0.7131
1032	I	A	0.0000
1033	L	A	0.1444
1034	L	A	0.0000
1035	S	A	-0.9038
1036	E	A	-1.7365
1037	K	A	-2.2989
1038	N	A	-1.5249
1039	V	A	-0.5285
1040	V	A	0.0000
1041	K	A	0.0000
1042	I	A	0.0000
1044	G	A	-0.4836
1047	L	A	-0.2509
1048	A	A	-1.0445
1049	R	A	-2.5221
1050	D	A	-2.3646
1051	I	A	0.3773
1052	Y	A	-0.6952
1053	K	A	-2.0226
1066	P	A	-0.1347
1067	L	A	0.5047
1068	K	A	0.1279
1069	W	A	-0.0127
1070	M	A	0.0000
1071	A	A	0.0000
1072	P	A	0.0000
1073	E	A	-1.0546
1074	T	A	0.0000
1075	I	A	0.1646
1076	F	A	0.4454
1077	D	A	-1.8164
1078	R	A	-2.2113
1079	V	A	-0.8516
1080	Y	A	-0.7470
1081	T	A	-0.0226
1082	I	A	0.1810
1083	Q	A	-0.4464
1084	S	A	0.0000
1085	D	A	0.0000
1086	V	A	0.0000
1087	W	A	0.0000
1088	S	A	0.0000
1089	F	A	0.0000
1090	G	A	0.0000
1091	V	A	0.0000
1092	L	A	0.0000
1093	L	A	0.0000
1094	W	A	0.0000
1095	E	A	0.0000
1096	I	A	0.0000
1097	F	A	0.0000
1098	S	A	0.0000
1099	L	A	0.0000
1100	G	A	0.0000
1101	A	A	-0.6130
1102	S	A	-0.3681
1103	P	A	0.0000
1104	Y	A	0.0000
1105	P	A	-0.7681
1106	G	A	-0.6281
1107	V	A	-0.5034
1108	K	A	-1.7029
1109	I	A	-0.6419
1110	D	A	-2.0655
1111	E	A	-3.1653
1112	E	A	-3.0806
1113	F	A	0.0000
1115	R	A	-4.2885
1116	R	A	-3.7614
1117	L	A	0.0000
1118	K	A	-3.7186
1119	E	A	-3.7549
1120	G	A	-2.5446
1121	T	A	-2.0279
1122	R	A	-1.4406
1123	M	A	0.0000
1124	R	A	-2.0763
1125	A	A	-1.3683
1126	P	A	0.0000
1127	D	A	-1.8701
1128	Y	A	-0.6451
1129	T	A	-0.7616
1130	T	A	-0.8845
1131	P	A	-1.1520
1132	E	A	-1.8604
1133	M	A	0.0000
1134	Y	A	-1.1171
1135	Q	A	-1.7139
1136	T	A	0.0000
1137	M	A	0.0000
1138	L	A	-0.8260
1139	D	A	-1.3361
1140	C	A	0.0000
1141	W	A	0.0000
1142	H	A	-1.8680
1143	G	A	-2.5772
1144	E	A	-2.7450
1145	S	A	-1.7230
1146	S	A	-1.5574
1147	Q	A	-2.2941
1148	R	A	0.0000
1149	P	A	-1.2750
1150	T	A	-0.9480
1151	F	A	0.0000
1152	S	A	-1.7664
1153	E	A	-2.6363
1154	L	A	0.0000
1155	V	A	-1.7890
1156	E	A	-2.7860
1157	H	A	-2.0553
1158	L	A	0.0000
1159	G	A	-1.5755
1160	N	A	-1.8100
1161	L	A	-1.1953
1162	L	A	-0.9360
1163	Q	A	-1.4808
1164	A	A	-0.8385
1165	N	A	-0.6552
1166	A	A	-0.5395