Project name: 604fb6feb53cb5f

Chain sequence(s)	A: NYCFAGKTSSISDLKEVPRKNITLIRGLVYEGQVSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDISAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEY
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.437
• Maximal score value: 1.4748
• Average score: -0.5727
• Total score value: -162.0647

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1095	N	A	-0.9073
1096	Y	A	0.0000
1097	C	A	-0.3556
1098	F	A	0.0000
1099	A	A	-1.0855
1100	G	A	-1.2186
1101	K	A	-1.7600
1102	T	A	-1.1833
1103	S	A	0.0000
1104	S	A	-0.0852
1105	I	A	0.5498
1106	S	A	-0.4648
1107	D	A	-1.4372
1108	L	A	0.0000
1109	K	A	-2.0602
1110	E	A	-1.7147
1111	V	A	-1.1066
1112	P	A	-1.3767
1113	R	A	-1.3920
1114	K	A	-1.9828
1115	N	A	-1.2678
1116	I	A	-0.4359
1117	T	A	-0.2610
1118	L	A	0.8647
1119	I	A	0.6309
1120	R	A	-0.5939
1121	G	A	0.3177
1122	L	A	1.4748
1130	V	A	1.2232
1131	Y	A	0.8884
1132	E	A	-0.0928
1133	G	A	0.0000
1134	Q	A	-0.6386
1135	V	A	-0.5250
1136	S	A	-0.6398
1144	P	A	-0.3826
1145	L	A	-0.0917
1146	Q	A	-1.0663
1147	V	A	0.0000
1148	A	A	0.0000
1149	V	A	0.0000
1150	K	A	-0.3828
1151	T	A	-0.2953
1152	L	A	0.0000
1153	P	A	-0.6661
1154	E	A	-0.9403
1155	V	A	0.5590
1156	C	A	-0.6219
1157	S	A	-1.5867
1158	E	A	-2.5038
1159	Q	A	-2.4040
1160	D	A	-2.0910
1161	E	A	-1.9465
1162	L	A	-0.6212
1163	D	A	-1.4731
1164	F	A	0.0000
1165	L	A	0.1409
1166	M	A	0.0000
1167	E	A	-1.0064
1168	A	A	0.0000
1169	L	A	0.0000
1170	I	A	0.0000
1171	I	A	0.0000
1172	S	A	-1.1052
1173	K	A	-1.2309
1174	F	A	0.0000
1175	N	A	-1.8863
1176	H	A	-1.5072
1177	Q	A	-1.5837
1178	N	A	0.0000
1179	I	A	0.0000
1180	V	A	0.0000
1181	R	A	-1.4464
1182	C	A	-0.5896
1183	I	A	-0.0937
1184	G	A	0.0000
1185	V	A	0.0000
1186	S	A	0.0000
1187	L	A	-0.5024
1188	Q	A	-1.1163
1189	S	A	-0.2866
1190	L	A	0.5664
1191	P	A	-0.0137
1192	R	A	-0.7029
1193	F	A	0.0000
1194	I	A	0.0000
1195	L	A	0.0000
1196	L	A	-0.2737
1197	E	A	-0.5089
1198	L	A	-0.2379
1199	M	A	0.0000
1200	A	A	0.2045
1201	G	A	-0.0094
1202	G	A	-0.2708
1203	D	A	-1.1323
1204	L	A	0.0000
1205	K	A	-1.5746
1206	S	A	-1.7078
1207	F	A	0.0000
1208	L	A	0.0000
1209	R	A	-2.6145
1210	E	A	-2.8791
1211	T	A	-1.9945
1212	R	A	-1.6526
1213	P	A	0.0000
1214	R	A	-0.9163
1215	P	A	-0.6712
1216	S	A	-1.0609
1217	Q	A	-1.7166
1218	P	A	-1.0043
1219	S	A	-0.7431
1220	S	A	-0.9711
1221	L	A	0.0000
1222	A	A	-0.1746
1223	M	A	0.0000
1224	L	A	-0.1150
1225	D	A	-0.6013
1226	L	A	0.0000
1227	L	A	0.0000
1228	H	A	-1.2401
1229	V	A	0.0000
1230	A	A	0.0000
1231	R	A	-1.2616
1232	D	A	0.0000
1233	I	A	0.0000
1234	A	A	0.0000
1235	C	A	-0.2325
1236	G	A	0.0000
1237	C	A	0.0000
1238	Q	A	-0.8199
1239	Y	A	-1.1296
1240	L	A	0.0000
1241	E	A	-1.6378
1242	E	A	-2.4133
1243	N	A	-1.5980
1244	H	A	-1.6423
1245	F	A	-0.5930
1246	I	A	0.1071
1247	H	A	0.0000
1248	R	A	0.0745
1249	D	A	0.0000
1250	I	A	0.0000
1251	A	A	0.0000
1252	A	A	0.0000
1253	R	A	-2.2118
1254	N	A	0.0000
1255	C	A	0.0000
1256	L	A	-0.2822
1257	L	A	0.0000
1258	T	A	0.1865
1259	C	A	0.2571
1260	P	A	-0.2407
1261	G	A	-0.3810
1262	P	A	-0.5888
1263	G	A	-0.6911
1264	R	A	-0.3206
1265	V	A	0.0714
1266	A	A	0.0000
1267	K	A	0.0000
1268	I	A	0.0000
1269	G	A	-0.8592
1270	D	A	-1.1711
1271	F	A	0.0000
1272	G	A	-0.8722
1273	M	A	-0.3064
1274	A	A	0.0000
1275	R	A	-1.0217
1276	D	A	-1.3706
1277	I	A	0.3977
1278	S	A	-0.1064
1289	A	A	0.5674
1290	M	A	1.4109
1291	L	A	1.3619
1292	P	A	0.6117
1293	V	A	0.2743
1294	K	A	0.0000
1295	W	A	0.2504
1296	M	A	0.0000
1297	P	A	0.0000
1298	P	A	0.0000
1299	E	A	-0.3324
1300	A	A	0.0000
1301	F	A	0.4437
1302	M	A	0.2930
1303	E	A	-1.1263
1304	G	A	-0.4267
1305	I	A	0.5526
1306	F	A	0.4238
1307	T	A	0.1152
1308	S	A	-0.6625
1309	K	A	-1.2244
1310	T	A	0.0000
1311	D	A	0.0000
1312	T	A	0.0000
1313	W	A	0.0000
1314	S	A	0.0000
1315	F	A	0.0000
1316	G	A	0.0000
1317	V	A	0.0000
1318	L	A	0.0000
1319	L	A	0.0000
1320	W	A	0.0000
1321	E	A	0.0000
1322	I	A	0.0000
1323	F	A	0.0000
1324	S	A	-0.3066
1325	L	A	0.0000
1326	G	A	0.0000
1327	Y	A	1.1700
1328	M	A	1.0256
1329	P	A	0.0000
1330	Y	A	0.0000
1331	P	A	-0.0447
1332	S	A	-0.8215
1333	K	A	-1.5640
1334	S	A	-1.8659
1335	N	A	-2.2380
1336	Q	A	-2.8423
1337	E	A	-3.2419
1338	V	A	0.0000
1339	L	A	-1.6187
1340	E	A	-2.5982
1341	F	A	-1.4330
1342	V	A	0.0000
1343	T	A	-0.6204
1344	S	A	-0.8480
1345	G	A	-0.9422
1346	G	A	-0.8080
1347	R	A	-0.9345
1348	M	A	0.0000
1349	D	A	-2.1289
1350	P	A	-1.7879
1351	P	A	0.0000
1352	K	A	-2.2044
1353	N	A	-1.3945
1354	C	A	-1.2221
1355	P	A	0.0000
1356	G	A	-1.2495
1357	P	A	-1.2030
1358	V	A	0.0000
1359	Y	A	-1.2935
1360	R	A	-2.1712
1361	I	A	0.0000
1362	M	A	0.0000
1363	T	A	-1.2700
1364	Q	A	-1.4589
1365	C	A	0.0000
1366	W	A	0.0000
1367	Q	A	-1.9913
1368	H	A	-1.9424
1369	Q	A	-2.7092
1370	P	A	-2.4443
1371	E	A	-3.3143
1372	D	A	-3.4370
1373	R	A	0.0000
1374	P	A	0.0000
1375	N	A	-1.0674
1376	F	A	0.0000
1377	A	A	-0.4442
1378	I	A	-0.2809
1379	I	A	0.0000
1380	L	A	-0.9678
1381	E	A	-1.7164
1382	R	A	-1.4643
1383	I	A	0.0000
1384	E	A	-2.1979
1385	Y	A	-0.6817
1386	C	A	0.0000
1387	T	A	-1.4664
1388	Q	A	-1.6566
1389	D	A	-1.9171
1390	P	A	-1.9967
1391	D	A	-2.6275
1392	V	A	0.0000
1393	I	A	-1.0525
1394	N	A	-1.7103
1395	T	A	-0.9586
1396	A	A	-0.1790
1397	L	A	0.0000
1398	P	A	-0.1640
1399	I	A	0.5873
1400	E	A	0.0998
1401	Y	A	1.0573