Project name: 6534c334206ff77

Chain sequence(s)	A: EEEGVEWGYEEGVEWGLVFPDANGEYQSPINLNSREARYDPSLLDVRLSPNYVVCRDCEVTNDGHTIQVILKSKSVLPGGPLPQGHEFELYEVRFHWGRENQRGSEHTVNFKAFPMELHLIHWNSTLFGSIDEAVGKPHGIAIIALFVQIGKEHVGLKAVTEILQDIQYKGKSKTIPCFNPNTLLPDPLLRDYWVYEGSLTIPPCSEGVTWILFRYPLTISQLQIEEFRRLRTHVKGAELVEGCDGILGDNFRPTQPLSDRVIRAAFQ
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.8887
• Maximal score value: 1.2716
• Average score: -0.7475
• Total score value: -200.3298

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
23	E	A	-3.6827
24	E	A	-3.8887
25	E	A	-3.7007
26	G	A	-2.7841
27	V	A	-2.2422
28	E	A	-2.5765
29	W	A	-1.4885
30	G	A	-1.2228
31	Y	A	-1.0585
32	E	A	-2.3085
33	E	A	-3.0252
34	G	A	-2.0107
35	V	A	-0.5593
36	E	A	-1.1245
37	W	A	-0.4185
38	G	A	-0.2004
39	L	A	1.1575
40	V	A	0.7535
41	F	A	0.0036
42	P	A	-0.6148
43	D	A	-1.7405
44	A	A	-1.3547
45	N	A	-1.8563
46	G	A	-2.0756
47	E	A	-2.4601
48	Y	A	-1.4863
49	Q	A	0.0000
50	S	A	0.0000
51	P	A	0.0000
52	I	A	0.0000
53	N	A	-0.2144
54	L	A	0.0000
55	N	A	-1.6719
56	S	A	-2.4938
57	R	A	-3.3177
58	E	A	-3.1197
59	A	A	-2.4300
60	R	A	-2.6197
61	Y	A	-1.3457
62	D	A	0.0000
63	P	A	-0.7891
64	S	A	-0.6744
65	L	A	0.0000
66	L	A	-0.4755
67	D	A	-1.5700
68	V	A	-0.6200
69	R	A	-1.5209
70	L	A	0.0000
71	S	A	-0.7593
72	P	A	-0.9590
73	N	A	-1.4524
74	Y	A	-0.7545
75	V	A	-0.1930
76	V	A	-0.4094
77	C	A	0.0000
78	R	A	-2.8929
79	D	A	-3.2033
80	C	A	0.0000
81	E	A	-2.1180
82	V	A	0.0000
83	T	A	-1.2601
84	N	A	0.0000
85	D	A	-0.9579
86	G	A	0.0000
87	H	A	-0.5830
88	T	A	0.0000
89	I	A	0.0000
90	Q	A	-0.4200
91	V	A	0.0000
92	I	A	-0.6216
93	L	A	0.0000
94	K	A	-2.8722
95	S	A	-1.4710
96	K	A	-2.1901
97	S	A	0.0000
98	V	A	-1.0476
99	L	A	0.0000
100	P	A	-1.2417
101	G	A	0.0000
102	G	A	-0.7398
103	P	A	-0.6044
104	L	A	0.0000
105	P	A	-1.0899
106	Q	A	-1.7242
107	G	A	-1.3947
108	H	A	-1.4767
109	E	A	-1.8083
110	F	A	0.0000
111	E	A	-1.3477
112	L	A	0.0000
113	Y	A	-0.2558
114	E	A	0.0000
115	V	A	0.0000
116	R	A	-0.2707
117	F	A	0.0000
118	H	A	0.0000
119	W	A	0.0000
120	G	A	0.0000
121	R	A	-1.9334
122	E	A	-2.6775
123	N	A	-2.3560
124	Q	A	-2.5719
125	R	A	-1.9454
126	G	A	0.0000
127	S	A	0.0000
128	E	A	0.0000
129	H	A	0.0000
130	T	A	-0.2128
131	V	A	-0.6030
132	N	A	-1.1216
133	F	A	0.5289
134	K	A	-1.2251
135	A	A	-0.9491
136	F	A	-0.9758
137	P	A	0.0000
138	M	A	0.0000
139	E	A	0.0000
140	L	A	0.0000
141	H	A	0.0000
142	L	A	0.0000
143	I	A	0.0000
144	H	A	0.0000
145	W	A	-0.4565
146	N	A	0.0000
147	S	A	-0.2347
148	T	A	-0.2430
149	L	A	0.3799
150	F	A	-0.2682
151	G	A	-0.7886
152	S	A	-1.0812
153	I	A	-1.0408
154	D	A	-2.5563
155	E	A	-2.5999
156	A	A	0.0000
157	V	A	-1.2325
158	G	A	-1.7232
159	K	A	-1.8971
160	P	A	-1.2153
161	H	A	-1.3575
162	G	A	0.0000
163	I	A	0.0000
164	A	A	0.0000
165	I	A	0.0000
166	I	A	0.0000
167	A	A	0.0000
168	L	A	0.0000
169	F	A	0.0000
170	V	A	0.0000
171	Q	A	-0.9775
172	I	A	-0.6546
173	G	A	-1.3695
174	K	A	-2.2849
175	E	A	-1.5163
176	H	A	-0.4273
177	V	A	0.8749
178	G	A	0.1803
179	L	A	0.0000
180	K	A	-1.0279
181	A	A	-0.6229
182	V	A	0.0000
183	T	A	0.0000
184	E	A	-2.3174
185	I	A	0.0000
186	L	A	0.0000
187	Q	A	-2.1707
188	D	A	-1.7337
189	I	A	0.0000
190	Q	A	-1.6957
191	Y	A	-1.3195
192	K	A	-1.3583
193	G	A	-1.3705
194	K	A	-1.9091
195	S	A	-1.7274
196	K	A	-1.4745
197	T	A	-1.3994
198	I	A	0.0000
199	P	A	-1.2919
200	C	A	-0.9313
201	F	A	0.0000
202	N	A	-0.4310
203	P	A	0.0000
204	N	A	-1.1569
205	T	A	-0.3646
206	L	A	0.0000
207	L	A	0.0000
208	P	A	0.0000
209	D	A	-0.6383
210	P	A	0.0315
211	L	A	1.2716
212	L	A	0.7967
213	R	A	-0.1205
214	D	A	-0.5876
215	Y	A	0.0000
216	W	A	0.0000
217	V	A	0.0000
218	Y	A	0.0000
219	E	A	-1.5487
220	G	A	0.0000
221	S	A	0.0000
222	L	A	-0.0122
223	T	A	0.0000
224	I	A	0.3409
225	P	A	0.0000
226	P	A	-0.2660
227	C	A	0.0000
228	S	A	0.0000
229	E	A	-1.5182
230	G	A	-1.3250
231	V	A	0.0000
232	T	A	0.0000
233	W	A	0.0000
234	I	A	0.0000
235	L	A	0.0000
236	F	A	0.0000
237	R	A	-1.3061
238	Y	A	0.1384
239	P	A	0.1074
240	L	A	0.0000
241	T	A	-0.8411
242	I	A	0.0000
243	S	A	-0.9016
244	Q	A	-0.5586
245	L	A	0.6267
246	Q	A	0.0000
247	I	A	0.0000
248	E	A	-0.8896
249	E	A	-1.3932
250	F	A	0.0000
251	R	A	-1.4585
252	R	A	-2.1197
253	L	A	0.0000
254	R	A	-1.3145
255	T	A	-0.5655
256	H	A	-0.4678
257	V	A	-0.1896
258	K	A	-1.7202
259	G	A	-1.1030
260	A	A	-0.5973
261	E	A	-1.1899
262	L	A	0.2333
263	V	A	-0.1051
264	E	A	-1.9447
265	G	A	-1.8538
266	C	A	-1.3629
267	D	A	-1.4835
268	G	A	0.0000
269	I	A	-0.7774
270	L	A	0.0000
271	G	A	0.0000
272	D	A	-0.6267
273	N	A	0.0000
274	F	A	0.3056
275	R	A	0.0000
276	P	A	-0.2300
277	T	A	-0.2623
278	Q	A	-0.5369
279	P	A	-0.7735
280	L	A	-0.3781
281	S	A	-1.0744
282	D	A	-1.6339
283	R	A	-0.6891
284	V	A	0.1759
285	I	A	0.0000
286	R	A	-1.5500
287	A	A	0.0000
288	A	A	-0.7739
289	F	A	-0.6091
290	Q	A	-1.2771