Project name: 4Q7Z
Status: done
submitted: 2018-02-20 14:34:18, status changed: 2018-02-20 14:44:45
Settings
Chain sequence(s)
|
A: IIGGHEVTPHSRPYMASVRFGGQHHCGGFLLRRARWVVSAAHCFSHRDLRTGLVVLGAHVLSTAEPTQQVFGIDALTTHPDYHPMTHHANDICLLRRLNGSAVLGPAVGLLRLPGRRARPPTAGTRCRVAGWGFVSDFEEELPPGLMEAKVRVLDPDVCNSSWKGHLTLTMLCTRSGDSHRRGFCSADSGGPLVCRNRAHGLVSFSGLWCGDPKTPDVYTQVSAFVAWIWDVVRRSS
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-3.2656
-
Maximal score value
-
1.9564
-
Average score
-
-0.6196
-
Total score value
-
-144.3693
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
16 |
I |
A |
0.0000 |
|
17 |
I |
A |
0.0000 |
|
18 |
G |
A |
-1.1506 |
|
19 |
G |
A |
-1.3700 |
|
20 |
H |
A |
-1.6919 |
|
21 |
E |
A |
-1.5898 |
|
22 |
V |
A |
0.0000 |
|
23 |
T |
A |
-0.6457 |
|
24 |
P |
A |
-0.5144 |
|
25 |
H |
A |
-0.5386 |
|
26 |
S |
A |
-0.4851 |
|
27 |
R |
A |
-0.4541 |
|
28 |
P |
A |
-0.2448 |
|
29 |
Y |
A |
0.0000 |
|
30 |
M |
A |
0.0000 |
|
31 |
A |
A |
0.0000 |
|
32 |
S |
A |
0.0000 |
|
33 |
V |
A |
0.0000 |
|
34 |
R |
A |
-0.9203 |
|
35 |
F |
A |
0.0000 |
|
36 |
G |
A |
-1.4486 |
|
38 |
G |
A |
-1.3312 |
|
39 |
Q |
A |
-1.7024 |
|
40 |
H |
A |
0.0000 |
|
41 |
H |
A |
-0.8470 |
|
42 |
C |
A |
0.0000 |
|
43 |
G |
A |
0.0000 |
|
44 |
G |
A |
0.0000 |
|
45 |
F |
A |
0.0000 |
|
46 |
L |
A |
0.0000 |
|
47 |
L |
A |
0.0000 |
|
48 |
R |
A |
-1.3463 |
|
49 |
A |
A |
-0.3787 |
|
50 |
R |
A |
-1.5838 |
|
51 |
W |
A |
0.0000 |
|
52 |
V |
A |
0.0000 |
|
53 |
V |
A |
0.0000 |
|
54 |
S |
A |
0.0000 |
|
55 |
A |
A |
0.0000 |
|
56 |
A |
A |
0.0000 |
|
57 |
H |
A |
-0.9006 |
|
58 |
C |
A |
0.0000 |
|
59 |
F |
A |
0.0000 |
|
60 |
S |
A |
-1.2636 |
|
61 |
H |
A |
-1.8998 |
|
62 |
R |
A |
-2.4992 |
|
62A |
D |
A |
-2.3157 |
|
62B |
L |
A |
-1.6256 |
|
62C |
R |
A |
-2.3983 |
|
63 |
T |
A |
-1.5361 |
|
64 |
G |
A |
-1.1747 |
|
65 |
L |
A |
0.0196 |
|
66 |
V |
A |
0.0000 |
|
67 |
V |
A |
0.0000 |
|
68 |
L |
A |
0.0000 |
|
69 |
G |
A |
0.0000 |
|
70 |
A |
A |
0.0000 |
|
71 |
H |
A |
0.0000 |
|
72 |
V |
A |
0.3700 |
|
73 |
L |
A |
-0.0022 |
|
74 |
S |
A |
-0.2484 |
|
75 |
T |
A |
-0.0440 |
|
76 |
A |
A |
-0.1507 |
|
77 |
E |
A |
-0.3533 |
|
78 |
P |
A |
-0.4724 |
|
79 |
T |
A |
-0.2984 |
|
80 |
Q |
A |
0.0432 |
|
81 |
Q |
A |
0.7575 |
|
82 |
V |
A |
1.6134 |
|
83 |
F |
A |
0.3542 |
|
84 |
G |
A |
-0.6485 |
|
85 |
I |
A |
-1.3116 |
|
86 |
D |
A |
-2.3448 |
|
87 |
A |
A |
-0.8486 |
|
88 |
L |
A |
0.0379 |
|
89 |
T |
A |
0.0258 |
|
90 |
T |
A |
-0.4347 |
|
91 |
H |
A |
-0.7850 |
|
92 |
P |
A |
-1.2030 |
|
93 |
D |
A |
-2.0529 |
|
94 |
Y |
A |
-1.1641 |
|
95 |
H |
A |
-1.1964 |
|
96 |
P |
A |
-0.4161 |
|
97 |
M |
A |
0.6537 |
|
98 |
T |
A |
-0.3412 |
|
99 |
H |
A |
-0.5777 |
|
100 |
A |
A |
-0.4043 |
|
101 |
N |
A |
-0.8816 |
|
102 |
D |
A |
0.0000 |
|
103 |
I |
A |
0.0000 |
|
104 |
C |
A |
0.0000 |
|
105 |
L |
A |
0.0000 |
|
106 |
L |
A |
0.0000 |
|
107 |
R |
A |
-1.4778 |
|
108 |
L |
A |
0.0000 |
|
109 |
N |
A |
-1.9218 |
|
110 |
G |
A |
-0.8442 |
|
111 |
S |
A |
-0.4496 |
|
112 |
A |
A |
0.0000 |
|
113 |
V |
A |
1.9564 |
|
114 |
L |
A |
1.5604 |
|
115 |
G |
A |
0.4849 |
|
116 |
P |
A |
-0.1540 |
|
117 |
A |
A |
0.0000 |
|
118 |
V |
A |
0.0000 |
|
119 |
G |
A |
0.3575 |
|
120 |
L |
A |
-0.2189 |
|
121 |
L |
A |
0.0000 |
|
122 |
R |
A |
-2.5049 |
|
123 |
L |
A |
0.0000 |
|
124 |
P |
A |
0.0000 |
|
124A |
G |
A |
-2.4094 |
|
125 |
R |
A |
-3.0442 |
|
126 |
R |
A |
-3.2092 |
|
127 |
A |
A |
-2.4087 |
|
128 |
R |
A |
-2.6008 |
|
129 |
P |
A |
-1.0378 |
|
130 |
P |
A |
-1.2561 |
|
131 |
T |
A |
-0.9136 |
|
132 |
A |
A |
-1.0291 |
|
133 |
G |
A |
-1.4747 |
|
134 |
T |
A |
0.0000 |
|
135 |
R |
A |
-3.1920 |
|
136 |
C |
A |
0.0000 |
|
137 |
R |
A |
-1.8199 |
|
138 |
V |
A |
0.0000 |
|
139 |
A |
A |
0.0000 |
|
140 |
G |
A |
0.0000 |
|
141 |
W |
A |
0.0000 |
|
142 |
G |
A |
0.0000 |
|
143 |
F |
A |
0.0926 |
|
144 |
V |
A |
0.0935 |
|
145 |
S |
A |
0.0370 |
|
147 |
D |
A |
0.0962 |
|
148 |
F |
A |
0.6011 |
|
149 |
E |
A |
-1.2460 |
|
150 |
E |
A |
-0.9493 |
|
151 |
L |
A |
0.7344 |
|
152 |
P |
A |
0.0651 |
|
153 |
P |
A |
-0.0627 |
|
154 |
G |
A |
0.0000 |
|
155 |
L |
A |
0.0000 |
|
156 |
M |
A |
-0.7422 |
|
157 |
E |
A |
0.0000 |
|
158 |
A |
A |
0.0000 |
|
159 |
K |
A |
-2.7656 |
|
160 |
V |
A |
0.0000 |
|
161 |
R |
A |
-3.1166 |
|
162 |
V |
A |
0.0000 |
|
163 |
L |
A |
-1.0394 |
|
164 |
D |
A |
-1.3614 |
|
165 |
P |
A |
-0.9444 |
|
166 |
D |
A |
-1.6712 |
|
167 |
V |
A |
-0.1231 |
|
168 |
C |
A |
0.0000 |
|
169 |
N |
A |
-1.4675 |
|
170 |
S |
A |
-1.4764 |
|
171 |
S |
A |
-1.3230 |
|
172 |
W |
A |
-1.6067 |
|
173 |
K |
A |
-2.1644 |
|
174 |
G |
A |
-1.9817 |
|
175 |
H |
A |
-1.7951 |
|
176 |
L |
A |
-0.8429 |
|
177 |
T |
A |
0.3257 |
|
178 |
L |
A |
1.4739 |
|
179 |
T |
A |
0.6837 |
|
180 |
M |
A |
0.0000 |
|
181 |
L |
A |
0.0000 |
|
182 |
C |
A |
0.0000 |
|
183 |
T |
A |
0.0000 |
|
184 |
R |
A |
-2.9170 |
|
185 |
S |
A |
-2.8826 |
|
186 |
G |
A |
-2.8897 |
|
186A |
D |
A |
-3.0496 |
|
186B |
S |
A |
-2.0270 |
|
187 |
H |
A |
-2.3780 |
|
188 |
R |
A |
-2.0237 |
|
188A |
R |
A |
-2.1951 |
|
189 |
G |
A |
0.0000 |
|
190 |
F |
A |
0.0000 |
|
191 |
C |
A |
0.0000 |
|
192 |
S |
A |
-0.4172 |
|
193 |
A |
A |
-0.0150 |
|
194 |
D |
A |
0.0000 |
|
195 |
S |
A |
0.0000 |
|
196 |
G |
A |
0.0000 |
|
197 |
G |
A |
0.0000 |
|
198 |
P |
A |
0.0000 |
|
199 |
L |
A |
0.0000 |
|
200 |
V |
A |
0.0000 |
|
201 |
C |
A |
0.0000 |
|
202 |
R |
A |
-3.1178 |
|
207 |
N |
A |
-3.0863 |
|
208 |
R |
A |
-2.8767 |
|
209 |
A |
A |
0.0000 |
|
210 |
H |
A |
-1.3182 |
|
211 |
G |
A |
0.0000 |
|
212 |
L |
A |
0.0000 |
|
213 |
V |
A |
0.0000 |
|
214 |
S |
A |
0.0000 |
|
215 |
F |
A |
0.1889 |
|
216 |
S |
A |
0.3881 |
|
217 |
G |
A |
0.7428 |
|
218 |
L |
A |
1.7136 |
|
219 |
W |
A |
1.2763 |
|
220 |
C |
A |
0.6169 |
|
221 |
G |
A |
-0.6909 |
|
222 |
D |
A |
0.0000 |
|
222A |
P |
A |
-1.4614 |
|
223 |
K |
A |
-1.6200 |
|
224 |
T |
A |
-0.8107 |
|
225 |
P |
A |
0.0000 |
|
226 |
D |
A |
0.0000 |
|
227 |
V |
A |
0.0000 |
|
228 |
Y |
A |
0.0000 |
|
229 |
T |
A |
0.0000 |
|
230 |
Q |
A |
-0.1666 |
|
231 |
V |
A |
0.0000 |
|
232 |
S |
A |
-1.3174 |
|
233 |
A |
A |
-0.5401 |
|
234 |
F |
A |
0.0000 |
|
235 |
V |
A |
0.0000 |
|
236 |
A |
A |
-0.8286 |
|
237 |
W |
A |
-0.5032 |
|
238 |
I |
A |
0.0000 |
|
239 |
W |
A |
-1.4411 |
|
240 |
D |
A |
-2.4351 |
|
241 |
V |
A |
0.0000 |
|
242 |
V |
A |
0.0000 |
|
243 |
R |
A |
-3.2656 |
|
244 |
R |
A |
-3.2463 |
|
245 |
S |
A |
-1.9733 |
|
246 |
S |
A |
-1.5563 |
|