Project name: 679f39c8b767e13

Chain sequence(s)	H: QVHLQESGPELVRPGASVKISCKTSGYVFSSSWMNWVKQRPGQGLKWIGRIYPGNGNTNYNEKFKGKATLTADKSSNTAYMQLSSLTSVDSAVYFCATSSAYWGQGTLLTVSAAKTTPPSVYPLAPGNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKIVPR; L: DIQMTQTTSSLSASLGDRVTFSCSASQDISNYLNWYQQKPDGTIKLLIYYTSSLRSGVPSRFSGSGSGTDYSLTINNLEPEDIATYFCQQYSRLPFTFGSGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.5093
• Maximal score value: 1.5759
• Average score: -0.726
• Total score value: -306.3877

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	D	L	-2.3488
2	I	L	0.0000
3	Q	L	-1.9289
4	M	L	0.0000
5	T	L	-0.7849
6	Q	L	-0.5345
7	T	L	-0.2150
8	T	L	-0.4419
9	S	L	-0.7639
10	S	L	-0.9540
11	L	L	-0.4269
12	S	L	-0.7357
13	A	L	0.0000
14	S	L	-1.7666
15	L	L	-1.4813
16	G	L	-2.4461
17	D	L	-3.2971
18	R	L	-3.5093
19	V	L	0.0000
20	T	L	-0.5129
21	F	L	0.0000
22	S	L	-0.5717
23	C	L	0.0000
24	S	L	-1.6071
25	A	L	-1.7679
26	S	L	-2.0091
27	Q	L	-2.7089
28	D	L	-2.7593
29	I	L	0.0000
30	S	L	-0.7830
31	N	L	-0.3669
32	Y	L	0.5290
33	L	L	0.0000
34	N	L	0.0000
35	W	L	0.0000
36	Y	L	0.0000
37	Q	L	0.0000
38	Q	L	-1.2533
39	K	L	-1.8804
40	P	L	-1.8761
41	D	L	-2.3364
42	G	L	-1.4874
43	T	L	-1.3720
44	I	L	0.0000
45	K	L	-1.6761
46	L	L	0.0000
47	L	L	0.0000
48	I	L	0.0000
49	Y	L	1.4027
50	Y	L	1.5759
51	T	L	0.0000
52	S	L	0.2079
53	S	L	0.5003
54	L	L	0.5881
55	R	L	-0.2629
56	S	L	-0.3884
57	G	L	-0.5146
58	V	L	-0.4089
59	P	L	-0.4771
60	S	L	-0.5480
61	R	L	-1.3784
62	F	L	0.0000
63	S	L	-0.4201
64	G	L	-0.0447
65	S	L	-0.7012
66	G	L	-1.1786
67	S	L	-1.3912
68	G	L	-1.7843
69	T	L	-2.1247
70	D	L	-2.5263
71	Y	L	0.0000
72	S	L	-0.7225
73	L	L	0.0000
74	T	L	-0.7776
75	I	L	0.0000
76	N	L	-3.0466
77	N	L	-3.2791
78	L	L	0.0000
79	E	L	-3.2902
80	P	L	-2.5270
81	E	L	-2.9252
82	D	L	0.0000
83	I	L	0.0000
84	A	L	0.0000
85	T	L	-1.0595
86	Y	L	0.0000
87	F	L	0.0000
88	C	L	0.0000
89	Q	L	0.0000
90	Q	L	0.0000
91	Y	L	0.3911
92	S	L	-0.6617
93	R	L	-1.4500
94	L	L	-0.4215
95	P	L	-0.8213
96	F	L	-0.3084
97	T	L	-0.6943
98	F	L	0.0000
99	G	L	0.0000
100	S	L	-0.8466
101	G	L	0.0000
102	T	L	0.0000
103	K	L	-1.9887
104	L	L	0.0000
105	E	L	-1.5902
106	I	L	0.0000
107	K	L	-1.8130
108	R	L	-1.7550
109	A	L	-1.4381
110	D	L	-2.5064
111	A	L	-1.2799
112	A	L	-0.7161
113	P	L	0.0000
114	T	L	-0.1185
115	V	L	0.0000
116	S	L	0.0214
117	I	L	0.0510
118	F	L	0.0000
119	P	L	0.0000
120	P	L	0.0000
121	S	L	0.0000
122	S	L	-1.0689
123	E	L	-1.4534
124	Q	L	0.0000
125	L	L	-1.0052
126	T	L	-0.7765
127	S	L	-0.8092
128	G	L	-1.1565
129	G	L	-1.0669
130	A	L	0.0000
131	S	L	0.0000
132	V	L	0.0000
133	V	L	0.0000
134	C	L	0.0000
135	F	L	0.0000
136	L	L	0.0000
137	N	L	0.0000
138	N	L	-0.7388
139	F	L	0.0000
140	Y	L	0.0000
141	P	L	-2.2460
142	K	L	-2.4818
143	D	L	-2.8198
144	I	L	-1.8419
145	N	L	-1.9045
146	V	L	0.0000
147	K	L	-1.3857
148	W	L	0.0000
149	K	L	-2.2663
150	I	L	0.0000
151	D	L	-2.6957
152	G	L	-2.0877
153	S	L	-2.1918
154	E	L	-3.1104
155	R	L	-2.6201
156	Q	L	-2.4667
157	N	L	-2.0426
158	G	L	-0.9375
159	V	L	-0.5487
160	L	L	-0.0908
161	N	L	-0.2689
162	S	L	0.3335
163	W	L	0.4107
164	T	L	-0.6131
165	D	L	-2.1181
166	Q	L	0.0000
167	D	L	-1.9441
168	S	L	-2.3944
169	K	L	-2.7463
170	D	L	-1.8115
171	S	L	0.0000
172	T	L	0.0000
173	Y	L	0.0000
174	S	L	0.0000
175	M	L	0.0000
176	S	L	0.0000
177	S	L	0.0000
178	T	L	0.0000
179	L	L	0.0000
180	T	L	-0.2806
181	L	L	0.0000
182	T	L	-1.5339
183	K	L	-2.3555
184	D	L	-3.1031
185	E	L	-2.4832
186	Y	L	0.0000
187	E	L	-2.7392
188	R	L	-3.1189
189	H	L	-2.4772
190	N	L	-2.4341
191	S	L	-1.9344
192	Y	L	0.0000
193	T	L	-0.8802
194	C	L	0.0000
195	E	L	0.0000
196	A	L	0.0000
197	T	L	-0.9247
198	H	L	0.0000
199	K	L	-2.6300
200	T	L	-1.3509
201	S	L	-0.7440
202	T	L	-0.5687
203	S	L	-0.1099
204	P	L	-0.2309
205	I	L	0.6570
206	V	L	0.8686
207	K	L	-0.0033
208	S	L	-0.3219
209	F	L	-0.9761
210	N	L	-2.0905
211	R	L	-2.3207
212	N	L	-2.5732
213	E	L	-2.5387
214	C	L	-1.1014
1	Q	H	-1.3436
2	V	H	-0.4371
3	H	H	-1.4433
4	L	H	0.0000
5	Q	H	-1.7071
6	E	H	0.0000
7	S	H	-1.0081
8	G	H	-0.8974
9	P	H	-0.6084
10	E	H	-1.1019
11	L	H	-0.7947
12	V	H	-1.1619
13	R	H	-2.1313
14	P	H	-1.2755
15	G	H	-1.1015
16	A	H	-0.8139
17	S	H	-0.9858
18	V	H	-1.1600
19	K	H	-1.7457
20	I	H	0.0000
21	S	H	0.0000
22	C	H	0.0000
23	K	H	-1.9230
24	T	H	0.0000
25	S	H	-0.9811
26	G	H	-0.5676
27	Y	H	0.5592
28	V	H	1.4624
29	F	H	0.0000
30	S	H	-0.4388
31	S	H	0.2502
32	S	H	0.2534
33	W	H	-0.0995
34	M	H	0.0000
35	N	H	0.0000
36	W	H	0.0000
37	V	H	0.0000
38	K	H	-0.9358
39	Q	H	-1.5394
40	R	H	-2.3043
41	P	H	-1.7712
42	G	H	-1.7406
43	Q	H	-2.2661
44	G	H	-1.4906
45	L	H	0.0000
46	K	H	-1.2193
47	W	H	0.0000
48	I	H	0.0000
49	G	H	0.0000
50	R	H	-0.4255
51	I	H	0.0000
52	Y	H	-0.5696
53	P	H	0.0000
54	G	H	-1.4248
55	N	H	-1.9817
56	G	H	-1.7091
57	N	H	-1.6666
58	T	H	-0.8505
59	N	H	-0.7451
60	Y	H	-1.1357
61	N	H	0.0000
62	E	H	-3.1950
63	K	H	-3.2220
64	F	H	0.0000
65	K	H	-3.1531
66	G	H	-2.0196
67	K	H	-1.6898
68	A	H	0.0000
69	T	H	-0.8508
70	L	H	0.0000
71	T	H	-0.7133
72	A	H	-1.3627
73	D	H	-2.0739
74	K	H	-2.5051
75	S	H	-1.5784
76	S	H	-1.6776
77	N	H	-1.9056
78	T	H	0.0000
79	A	H	0.0000
80	Y	H	-0.5616
81	M	H	0.0000
82	Q	H	-1.2479
83	L	H	0.0000
84	S	H	-0.8568
85	S	H	-0.7946
86	L	H	0.0000
87	T	H	-0.1270
88	S	H	0.3380
89	V	H	1.3864
90	D	H	0.0000
91	S	H	0.0657
92	A	H	0.0000
93	V	H	-0.2710
94	Y	H	0.0000
95	F	H	0.0000
96	C	H	0.0000
97	A	H	0.0000
98	T	H	0.0000
99	S	H	-0.1698
100	S	H	-0.0976
104	A	H	0.0000
105	Y	H	-0.1354
106	W	H	-0.5044
107	G	H	0.0000
108	Q	H	-1.2530
109	G	H	0.0000
110	T	H	0.0000
111	L	H	-0.1135
112	L	H	0.0000
113	T	H	-0.2239
114	V	H	0.0000
115	S	H	-0.9705
116	A	H	-1.0392
117	A	H	-1.3579
118	K	H	-2.1020
119	T	H	-0.8960
120	T	H	-0.6975
121	P	H	-0.6043
122	P	H	-0.3304
123	S	H	-0.3995
124	V	H	0.0000
125	Y	H	0.0000
126	P	H	-0.4919
127	L	H	0.0000
128	A	H	0.0000
129	P	H	-0.3356
130	G	H	-1.1137
136	N	H	-1.1857
137	S	H	-0.5696
138	M	H	0.1742
139	V	H	0.0878
140	T	H	0.2211
141	L	H	0.0000
142	G	H	0.0000
143	C	H	0.0000
144	L	H	0.0000
145	V	H	0.0000
146	K	H	-0.3369
147	G	H	-0.3983
148	Y	H	0.0000
149	F	H	0.0000
150	P	H	0.0000
151	E	H	-0.3941
152	P	H	-0.3745
153	V	H	-0.1950
154	T	H	-0.2037
155	V	H	-0.2064
156	T	H	-0.4396
157	W	H	0.0000
158	N	H	-1.0310
159	S	H	-0.8766
160	G	H	-0.6949
161	S	H	-0.5483
162	L	H	-0.2121
163	S	H	-0.3837
164	S	H	-0.5085
165	G	H	-0.2971
166	V	H	0.1843
167	H	H	0.0000
168	T	H	0.1767
169	F	H	0.0000
170	P	H	-0.0161
171	A	H	0.2769
172	V	H	0.6693
173	L	H	0.3240
174	Q	H	-1.0684
175	S	H	-1.3106
176	D	H	-2.0070
177	L	H	-0.6202
178	Y	H	0.0105
179	T	H	0.1518
180	L	H	0.0000
181	S	H	0.0000
182	S	H	0.0000
183	S	H	0.0000
184	V	H	0.0000
185	T	H	0.1476
186	V	H	0.0000
187	P	H	-0.1851
188	S	H	-0.5239
189	S	H	-0.6737
190	P	H	-0.8927
191	R	H	0.0000
192	P	H	-0.6578
193	S	H	-1.1511
194	E	H	-2.0040
195	T	H	-1.1272
196	V	H	0.0000
197	T	H	-1.1928
198	C	H	0.0000
199	N	H	-1.4228
200	V	H	0.0000
201	A	H	-0.8777
202	H	H	0.0000
203	P	H	-0.8671
204	A	H	-0.6819
205	S	H	-0.6481
206	S	H	-0.7097
207	T	H	-0.8786
208	K	H	-1.8525
209	V	H	-1.1159
210	D	H	-2.3199
211	K	H	-1.3822
212	K	H	-1.5300
213	I	H	0.0000
214	V	H	0.5272
215	P	H	-0.5923
216	R	H	-1.5561