Project name: 4gqs teste 1

Chain sequence(s)	A: LPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPIHH
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.3534
• Maximal score value: 2.6069
• Average score: -0.7873
• Total score value: -365.3114

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
29	L	A	0.8746
30	P	A	0.0000
31	P	A	0.4039
32	G	A	0.3011
33	P	A	0.2906
34	T	A	-0.0188
35	P	A	1.0111
36	L	A	1.8033
37	P	A	1.1771
38	V	A	2.6069
39	I	A	2.5753
40	G	A	0.0000
41	N	A	0.0000
42	I	A	1.9773
43	L	A	1.6689
44	Q	A	-0.0085
45	I	A	0.0000
46	D	A	-1.6084
47	I	A	-0.3832
48	K	A	-1.7191
49	D	A	-1.1757
50	V	A	-0.7372
51	S	A	-0.9018
52	K	A	-2.0974
53	S	A	0.0000
54	L	A	0.0000
55	T	A	-1.1985
56	N	A	-1.5711
57	L	A	0.0000
58	S	A	-0.6504
59	K	A	-1.0226
60	I	A	1.0620
61	Y	A	0.5810
62	G	A	-0.0680
63	P	A	-0.4457
64	V	A	0.0000
65	F	A	0.0000
66	T	A	0.0000
67	L	A	0.0000
68	Y	A	0.8204
69	F	A	1.2420
70	G	A	1.4101
71	L	A	1.6075
72	E	A	0.1478
73	R	A	-0.3284
74	M	A	0.0000
75	V	A	0.0000
76	V	A	0.0000
77	L	A	0.0000
78	H	A	-0.6651
79	G	A	-0.9086
80	Y	A	-1.5692
81	E	A	-2.4145
82	V	A	0.0000
83	V	A	0.0000
84	K	A	-1.9110
85	E	A	-2.4269
86	A	A	0.0000
87	L	A	0.0000
88	I	A	-0.3612
89	D	A	-1.8242
90	L	A	-1.1983
91	G	A	-1.4512
92	E	A	-2.2107
93	E	A	-1.9459
94	F	A	0.0000
95	S	A	0.0000
96	G	A	0.0000
97	R	A	-0.4958
98	G	A	0.0000
99	H	A	-0.8677
100	F	A	-0.5889
101	P	A	0.0000
102	L	A	0.0000
103	A	A	0.0000
104	E	A	-2.0644
105	R	A	-1.7798
106	A	A	-1.2768
107	N	A	-1.5473
108	R	A	-2.4576
109	G	A	-1.5125
110	F	A	-1.0204
111	G	A	0.0000
112	I	A	0.0000
113	V	A	0.3692
114	F	A	-0.2588
115	S	A	0.0000
116	N	A	-2.1200
117	G	A	-2.2996
118	K	A	-2.7767
119	R	A	-2.3598
120	W	A	0.0000
121	K	A	-3.5343
122	E	A	-2.7736
123	I	A	0.0000
124	R	A	-1.8794
125	R	A	-2.2513
126	F	A	0.0000
127	S	A	0.0000
128	L	A	-0.2848
129	M	A	-0.3594
130	T	A	0.0000
131	L	A	-0.4129
132	R	A	-1.2940
133	N	A	-1.2032
134	F	A	0.1806
135	G	A	-0.3642
136	M	A	0.0000
137	G	A	-1.6026
138	K	A	-2.4762
139	R	A	-2.7589
140	S	A	0.0000
141	I	A	0.0000
142	E	A	-1.3967
143	D	A	-2.2675
144	R	A	-2.2123
145	V	A	0.0000
146	Q	A	-1.9747
147	E	A	-2.9001
148	E	A	0.0000
149	A	A	0.0000
150	R	A	-2.9048
151	C	A	-2.3565
152	L	A	0.0000
153	V	A	-2.1927
154	E	A	-3.3559
155	E	A	-2.9395
156	L	A	0.0000
157	R	A	-3.8942
158	K	A	-3.7636
159	T	A	-2.7261
160	K	A	-2.9348
161	A	A	-1.6522
162	S	A	-1.1941
163	P	A	-0.8926
164	C	A	-0.9604
165	D	A	-1.3237
166	P	A	0.0000
167	T	A	0.2771
168	F	A	1.1228
169	I	A	0.0000
170	L	A	0.0000
171	G	A	0.2425
172	C	A	0.0000
173	A	A	0.0000
174	P	A	0.0000
175	C	A	0.0000
176	N	A	0.0000
177	V	A	0.0000
178	I	A	0.0000
179	C	A	0.0000
180	S	A	0.0000
181	I	A	0.0000
182	I	A	0.0000
183	F	A	0.0000
184	Q	A	-2.2532
185	K	A	-2.4920
186	R	A	-1.8710
187	F	A	-1.6653
188	D	A	-2.4319
189	Y	A	0.0000
190	K	A	-2.7948
191	D	A	-2.7474
192	Q	A	-2.5337
193	Q	A	-2.1361
194	F	A	0.0000
195	L	A	-1.9734
196	N	A	-2.4104
197	L	A	0.0000
198	M	A	0.0000
199	E	A	-2.6871
200	K	A	-1.6072
201	L	A	0.0000
202	N	A	-2.1652
203	E	A	-2.0268
204	N	A	0.0000
205	I	A	-0.8150
206	R	A	-1.9299
207	I	A	-0.9341
208	V	A	-0.1620
209	S	A	-0.4923
210	T	A	-0.3934
211	P	A	0.0642
212	W	A	0.5019
213	I	A	0.0000
214	Q	A	0.3790
215	I	A	1.1825
216	C	A	0.0000
217	N	A	0.3017
218	N	A	0.4672
219	F	A	1.2457
220	P	A	0.3385
221	T	A	0.4232
222	I	A	0.8622
223	I	A	0.0000
224	D	A	-0.5714
225	Y	A	1.3671
226	F	A	1.7993
227	P	A	0.0227
228	G	A	-0.4625
229	T	A	-0.3816
230	H	A	0.0000
231	N	A	-1.3707
232	K	A	-2.1820
233	L	A	0.0000
234	L	A	-0.6789
235	K	A	-1.2350
236	N	A	0.0000
237	L	A	0.0423
238	A	A	0.2816
239	F	A	1.3222
240	M	A	0.0000
241	E	A	-0.4772
242	S	A	-0.4181
243	D	A	-1.3554
244	I	A	0.0000
245	L	A	-1.5040
246	E	A	-3.1394
247	K	A	-2.7712
248	V	A	0.0000
249	K	A	-3.7025
250	E	A	-3.8901
251	H	A	0.0000
252	Q	A	-2.9716
253	E	A	-3.4507
254	S	A	-2.1882
255	M	A	-2.0758
256	D	A	-2.2396
257	I	A	-0.8331
258	N	A	-1.6420
259	N	A	-1.9219
260	P	A	-1.6272
261	R	A	-1.9926
262	D	A	0.0000
263	F	A	0.0000
264	I	A	0.0000
265	D	A	0.0000
266	C	A	-0.3137
267	F	A	0.0000
268	L	A	0.0000
269	I	A	-1.3502
270	K	A	-1.6672
271	M	A	-2.0976
272	E	A	-2.9910
273	K	A	-3.6898
274	E	A	-3.9479
275	K	A	-4.3534
276	Q	A	-3.8128
277	N	A	-3.7158
278	Q	A	-3.1198
279	Q	A	-2.7468
280	S	A	-2.5359
281	E	A	-1.5531
282	F	A	0.0000
283	T	A	-0.6659
284	I	A	-0.4673
285	E	A	-1.5097
286	N	A	0.0000
287	L	A	0.0000
288	V	A	0.0000
289	I	A	0.0000
290	T	A	0.0000
291	A	A	0.0000
292	A	A	-0.1099
293	D	A	-0.0384
294	L	A	0.0808
295	L	A	0.0000
296	G	A	-0.2775
297	A	A	-0.1006
298	G	A	-0.2613
299	T	A	0.0000
300	E	A	-0.7006
301	T	A	-0.2965
302	T	A	0.0000
303	S	A	-0.1544
304	T	A	0.0000
305	T	A	0.0000
306	L	A	0.0000
307	R	A	-0.0206
308	Y	A	0.0000
309	A	A	0.0000
310	L	A	0.0000
311	L	A	0.0000
312	L	A	0.0000
313	L	A	0.0000
314	L	A	0.0000
315	K	A	-2.3716
316	H	A	-1.3433
317	P	A	-1.7955
318	E	A	-2.1167
319	V	A	0.0000
320	T	A	0.0000
321	A	A	-1.7642
322	K	A	-2.5851
323	V	A	0.0000
324	Q	A	-2.4741
325	E	A	-3.6070
326	E	A	-2.7996
327	I	A	0.0000
328	E	A	-4.0129
329	R	A	-3.4915
330	V	A	-1.7844
331	V	A	-2.1110
332	G	A	-3.0032
333	R	A	-3.6648
334	N	A	-2.5772
335	R	A	-1.9611
336	S	A	-1.3392
337	P	A	0.0000
338	C	A	-0.6021
339	M	A	-0.8470
340	Q	A	-1.6041
341	D	A	0.0000
342	R	A	-1.5122
343	G	A	-1.5348
344	H	A	-1.9163
345	M	A	0.0000
346	P	A	-1.0903
347	Y	A	-0.9878
348	T	A	0.0000
349	D	A	0.0000
350	A	A	0.0000
351	V	A	0.0000
352	V	A	0.0000
353	H	A	0.0000
354	E	A	0.0000
355	V	A	0.0000
356	Q	A	0.0000
357	R	A	0.0000
358	Y	A	-0.1580
359	I	A	0.0000
360	D	A	0.0000
361	L	A	0.5843
362	I	A	0.6399
363	P	A	0.0000
364	T	A	0.3685
365	S	A	0.0000
366	L	A	0.5528
367	P	A	0.0863
368	H	A	0.0000
369	A	A	0.0000
370	V	A	0.0000
371	T	A	-1.6809
372	C	A	-2.1192
373	D	A	-2.7996
374	V	A	0.0000
375	K	A	-2.2172
376	F	A	-1.6510
377	R	A	-2.3569
378	N	A	-1.8834
379	Y	A	-0.5695
380	L	A	-0.6951
381	I	A	0.0000
382	P	A	-1.5721
383	K	A	-2.6076
384	G	A	-1.7573
385	T	A	0.0000
386	T	A	0.0000
387	I	A	0.0000
388	L	A	0.2266
389	T	A	0.0000
390	S	A	0.0000
391	L	A	0.0000
392	T	A	-0.3250
393	S	A	-0.6293
394	V	A	0.0000
395	L	A	0.0000
396	H	A	-1.6474
397	D	A	-2.3413
398	N	A	-3.2726
399	K	A	-3.0686
400	E	A	-2.3282
401	F	A	0.0000
402	P	A	-2.5484
403	N	A	-2.6421
404	P	A	-2.3526
405	E	A	-2.2613
406	M	A	-0.7433
407	F	A	0.0000
408	D	A	-1.0792
409	P	A	0.0000
410	R	A	-2.4028
411	H	A	-1.7732
412	F	A	0.0000
413	L	A	-2.4250
414	D	A	-2.8456
415	E	A	-2.9309
416	G	A	-1.9325
417	G	A	-2.1570
418	N	A	-2.5139
419	F	A	-2.3598
420	K	A	-3.2678
421	K	A	-2.8751
422	S	A	-1.9017
423	N	A	-1.7100
424	Y	A	0.0000
425	F	A	-0.5068
426	M	A	0.0000
427	P	A	0.2872
428	F	A	0.3772
429	S	A	0.2876
430	A	A	0.0000
431	G	A	-0.3811
432	K	A	-1.2082
433	R	A	0.0000
434	I	A	0.4987
435	C	A	0.5298
436	V	A	0.4434
437	G	A	-0.1454
438	E	A	-0.5673
439	G	A	-0.8919
440	L	A	-0.5346
441	A	A	-0.2906
442	R	A	-0.4420
443	M	A	-0.2766
444	E	A	0.0000
445	L	A	0.0000
446	F	A	0.0000
447	L	A	0.0000
448	F	A	0.0000
449	L	A	0.0000
450	T	A	0.0000
451	F	A	0.0000
452	I	A	0.0000
453	L	A	0.0000
454	Q	A	-1.4661
455	N	A	-1.1420
456	F	A	0.0000
457	N	A	-0.7619
458	L	A	-0.8684
459	K	A	-1.5358
460	S	A	-0.3179
461	L	A	1.2492
462	I	A	0.6755
463	D	A	-1.9344
464	P	A	-2.3749
465	K	A	-3.3250
466	D	A	-3.2758
467	L	A	-1.7979
468	D	A	-2.3659
469	T	A	0.0000
470	T	A	-0.3330
471	P	A	0.6577
472	V	A	1.7134
473	V	A	0.6494
474	N	A	-0.4871
475	G	A	-0.3008
476	F	A	0.5388
477	A	A	0.5467
478	S	A	0.0000
479	V	A	1.2838
480	P	A	0.0000
481	P	A	1.1522
482	F	A	1.5864
483	Y	A	0.4014
484	Q	A	-0.7772
485	L	A	0.0000
486	C	A	-0.8840
487	F	A	0.0000
488	I	A	-0.6962
489	P	A	-0.8403
490	I	A	-0.5562
491	H	A	-1.5274
492	H	A	-1.5838