Project name: halo

Chain sequence(s)	A: IKHVAFLNPQGNFDPADSYWTEHPDFGGQLVYVKEVSLALAEMGVQVDIITRRIKDENWPEFSGEIDYYQETNKVRIVRIPFGGDKFLPKEELWPYLHEYVNKIINFYREEGKFPQVVTTHYGDGGLAGVLLKNIKGLPFTFTGHSLGAQKMEKLNVNTSNFKEMDERFKFHRRIIAERLTMSYADKIIVSTSQERFGQYSHDLYRGAVNVEDDDKFSVIPPGVNTRVFDGEYGDKIKAKITKYLERDLGSERMELPAIIASSRLDQKKNHYGLVEAYVQNKELQDKANLVLTLRGIENPFEDYSRAGQEEKEILGKIIELIDNNDCRGKVSMFPLNSQQELAGCYAYLASKGSVFALTSFYEPFGLAPVEAMASGLPAVVTRNGGPAEILDGGKYGVLVDPEDPEDIARGLLKAFESEETWSAYQEKGKQRVEERYTWQETARGYLEVIQEIADR
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.338
• Maximal score value: 1.362
• Average score: -1.0719
• Total score value: -488.8091

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
7	I	A	0.0887
8	K	A	-1.2355
9	H	A	0.0000
10	V	A	0.0000
11	A	A	0.0000
12	F	A	0.0000
13	L	A	0.0000
14	N	A	0.0000
15	P	A	0.0000
16	Q	A	0.0000
17	G	A	0.0000
18	N	A	0.0000
19	F	A	0.0000
20	D	A	0.0000
21	P	A	-0.7040
22	A	A	-0.2759
23	D	A	-0.2197
24	S	A	-0.3100
25	Y	A	-0.3963
26	W	A	-0.3865
27	T	A	-0.9930
28	E	A	-1.8446
29	H	A	-1.2022
30	P	A	-0.8395
31	D	A	0.0000
32	F	A	0.0000
33	G	A	-0.6902
34	G	A	-0.5282
35	Q	A	-0.4441
36	L	A	0.0000
37	V	A	-0.0474
38	Y	A	0.0000
39	V	A	0.0000
40	K	A	0.0000
41	E	A	-0.5615
42	V	A	0.0000
43	S	A	0.0000
44	L	A	-1.0553
45	A	A	0.0000
46	L	A	0.0000
47	A	A	0.0000
48	E	A	-1.9457
49	M	A	-1.1606
50	G	A	-1.0792
51	V	A	0.0000
52	Q	A	-1.3570
53	V	A	0.0000
54	D	A	0.0000
55	I	A	0.0000
56	I	A	0.0000
57	T	A	0.0000
58	R	A	0.0000
59	R	A	-1.6290
60	I	A	0.0000
61	K	A	-3.5427
62	D	A	0.0000
63	E	A	-3.2659
64	N	A	-2.7074
65	W	A	-1.9669
66	P	A	-2.0498
67	E	A	-1.7890
68	F	A	0.0000
69	S	A	-1.7414
70	G	A	-1.0184
71	E	A	-0.7275
72	I	A	0.1451
73	D	A	-0.2429
74	Y	A	-0.3929
75	Y	A	0.0000
76	Q	A	-2.1842
77	E	A	-2.6522
78	T	A	-2.2458
79	N	A	-2.2206
80	K	A	-2.0742
81	V	A	0.0000
82	R	A	-0.5381
83	I	A	0.0000
84	V	A	0.0000
85	R	A	0.0000
86	I	A	0.0000
87	P	A	-1.3396
88	F	A	0.0000
89	G	A	-1.2553
90	G	A	-1.6866
91	D	A	-2.7917
92	K	A	-3.1779
93	F	A	-1.7638
94	L	A	-0.6982
95	P	A	-0.4409
96	K	A	-0.5655
97	E	A	-1.5082
98	E	A	-1.1955
99	L	A	0.0000
100	W	A	0.0000
101	P	A	-0.8451
102	Y	A	-0.7733
103	L	A	0.0000
104	H	A	-1.9627
105	E	A	-2.8004
106	Y	A	0.0000
107	V	A	0.0000
108	N	A	-2.5285
109	K	A	-2.5622
110	I	A	0.0000
111	I	A	0.0000
112	N	A	-2.5239
113	F	A	-2.0612
114	Y	A	0.0000
115	R	A	-3.7149
116	E	A	-3.5606
117	E	A	-2.9646
118	G	A	-2.8440
119	K	A	-2.7323
120	F	A	-1.3566
121	P	A	0.0000
122	Q	A	-0.7934
123	V	A	0.0000
124	V	A	0.0000
125	T	A	0.0000
126	T	A	0.0000
127	H	A	0.0000
128	Y	A	0.0000
129	G	A	0.0000
130	D	A	0.0000
131	G	A	0.0000
132	G	A	0.0000
133	L	A	0.4417
134	A	A	0.0000
135	G	A	0.0000
136	V	A	0.0000
137	L	A	-0.5750
138	L	A	0.0000
139	K	A	-0.8760
140	N	A	-1.0746
141	I	A	-0.2073
142	K	A	-1.0880
143	G	A	-1.0833
144	L	A	-0.6618
145	P	A	-0.9965
146	F	A	0.0000
147	T	A	0.0000
148	F	A	0.0000
149	T	A	0.0000
150	G	A	0.0000
151	H	A	-0.5507
152	S	A	-0.7234
153	L	A	0.0000
154	G	A	0.0000
155	A	A	0.0000
156	Q	A	-1.8928
157	K	A	-2.0631
158	M	A	-1.4615
159	E	A	-2.3939
160	K	A	-2.1192
161	L	A	-0.4167
162	N	A	-1.4537
163	V	A	-1.1261
164	N	A	-1.1918
165	T	A	-0.9337
166	S	A	-1.0867
167	N	A	-1.4134
168	F	A	-1.0471
169	K	A	-3.0818
170	E	A	-3.6884
171	M	A	0.0000
172	D	A	-3.2289
173	E	A	-4.1318
174	R	A	-3.6525
175	F	A	-2.6552
176	K	A	-2.8865
177	F	A	0.0000
178	H	A	-1.5573
179	R	A	-1.5457
180	R	A	0.0000
181	I	A	0.0000
182	I	A	1.3620
183	A	A	0.0000
184	E	A	0.0000
185	R	A	0.3593
186	L	A	1.0303
187	T	A	0.0000
188	M	A	0.0000
189	S	A	-0.0135
190	Y	A	0.3932
191	A	A	0.0000
192	D	A	-1.0694
193	K	A	0.0000
194	I	A	0.0000
195	I	A	0.0000
196	V	A	0.0000
197	S	A	-0.0822
198	T	A	-0.1372
199	S	A	-0.3092
200	Q	A	-1.0066
201	E	A	-0.6987
202	R	A	-0.6313
203	F	A	0.2626
204	G	A	-0.4768
205	Q	A	-0.9593
206	Y	A	0.0000
207	S	A	-1.2599
208	H	A	-1.4607
209	D	A	-2.3835
210	L	A	-0.8985
211	Y	A	0.0000
212	R	A	-2.8540
213	G	A	-1.8192
214	A	A	-0.9212
215	V	A	-1.5179
216	N	A	-2.6545
217	V	A	0.0000
218	E	A	-3.2291
219	D	A	-3.8355
220	D	A	-3.9303
221	D	A	-3.4757
222	K	A	-2.6771
223	F	A	0.0000
224	S	A	-0.1487
225	V	A	1.0110
226	I	A	0.0000
227	P	A	-0.1966
228	P	A	-0.2290
229	G	A	0.0000
230	V	A	0.0000
231	N	A	-1.2777
232	T	A	-1.9479
233	R	A	-2.6029
234	V	A	-2.1361
235	F	A	0.0000
236	D	A	-2.9412
237	G	A	-2.1136
238	E	A	-2.3325
239	Y	A	-1.9192
240	G	A	-2.2307
241	D	A	-3.0193
242	K	A	-2.9589
243	I	A	0.0000
244	K	A	-2.2727
245	A	A	-1.9936
246	K	A	-1.7219
247	I	A	0.0000
248	T	A	-1.8866
249	K	A	-2.7040
250	Y	A	0.0000
251	L	A	0.0000
252	E	A	-2.8672
253	R	A	-2.1367
254	D	A	-1.6724
255	L	A	0.0000
256	G	A	-1.8294
257	S	A	-2.0136
258	E	A	-2.5306
259	R	A	-2.5607
260	M	A	-1.8564
261	E	A	-2.4070
262	L	A	-1.6382
263	P	A	-0.9343
264	A	A	0.0000
265	I	A	0.0000
266	I	A	0.0000
267	A	A	0.0000
268	S	A	-0.6436
269	S	A	-1.2810
270	R	A	-2.7265
271	L	A	0.0000
272	D	A	-2.5895
273	Q	A	-2.7183
274	K	A	-1.9340
275	K	A	-1.3901
276	N	A	0.0000
277	H	A	0.0000
278	Y	A	-0.4229
279	G	A	0.0000
280	L	A	0.0000
281	V	A	0.0000
282	E	A	-1.2761
283	A	A	0.0000
284	Y	A	0.0000
285	V	A	0.0000
286	Q	A	-2.3950
287	N	A	-2.8801
288	K	A	-3.4557
289	E	A	-3.4408
290	L	A	0.0000
291	Q	A	-2.3930
292	D	A	-2.8572
293	K	A	-2.5043
294	A	A	0.0000
295	N	A	0.0000
296	L	A	0.0000
297	V	A	0.0000
298	L	A	0.0000
299	T	A	0.0000
300	L	A	0.0000
301	R	A	-3.0238
302	G	A	-2.3857
303	I	A	0.0000
304	E	A	-2.7741
305	N	A	0.0000
306	P	A	0.0000
307	F	A	-1.1616
308	E	A	-2.3816
309	D	A	-2.3946
310	Y	A	-1.8784
311	S	A	-1.7922
312	R	A	-2.6439
313	A	A	0.0000
314	G	A	-2.4047
315	Q	A	-3.1431
316	E	A	-3.5543
317	E	A	-3.4083
318	K	A	-3.2845
319	E	A	-3.7649
320	I	A	-2.6359
321	L	A	0.0000
322	G	A	-2.2664
323	K	A	-2.9999
324	I	A	0.0000
325	I	A	-1.9508
326	E	A	-3.4900
327	L	A	0.0000
328	I	A	0.0000
329	D	A	-4.3380
330	N	A	-3.5159
331	N	A	-3.2649
332	D	A	-3.7921
333	C	A	0.0000
334	R	A	-3.1025
335	G	A	-2.1281
336	K	A	-1.6117
337	V	A	0.0000
338	S	A	0.0000
339	M	A	0.0000
340	F	A	0.0000
341	P	A	0.0000
342	L	A	0.0000
343	N	A	-2.1884
344	S	A	-1.6899
345	Q	A	-1.5572
346	Q	A	-1.8742
347	E	A	-1.4636
348	L	A	-0.7062
349	A	A	0.0000
350	G	A	0.0000
351	C	A	0.0000
352	Y	A	0.0000
353	A	A	0.0000
354	Y	A	0.0000
355	L	A	0.0000
356	A	A	0.0000
357	S	A	-0.8845
358	K	A	-1.3891
359	G	A	-1.0743
360	S	A	0.0000
361	V	A	0.0000
362	F	A	0.0000
363	A	A	0.0000
364	L	A	0.0000
365	T	A	0.0000
366	S	A	0.0000
367	F	A	-0.4595
368	Y	A	0.6349
369	E	A	0.0453
370	P	A	0.2728
371	F	A	0.5559
372	G	A	0.3490
373	L	A	0.4129
374	A	A	0.1749
375	P	A	0.0000
376	V	A	0.0000
377	E	A	-0.4704
378	A	A	0.0000
379	M	A	0.0000
380	A	A	-1.5464
381	S	A	0.0000
382	G	A	0.0000
383	L	A	0.0000
384	P	A	0.0000
385	A	A	0.0000
386	V	A	0.0000
387	V	A	0.0000
388	T	A	0.0000
389	R	A	-2.1981
390	N	A	-0.9622
391	G	A	-0.5208
392	G	A	0.0000
393	P	A	0.0000
394	A	A	-2.1029
395	E	A	-2.6518
396	I	A	0.0000
397	L	A	0.0000
398	D	A	-2.5344
399	G	A	-2.2716
400	G	A	-1.9338
401	K	A	-2.4369
402	Y	A	-2.0216
403	G	A	0.0000
404	V	A	0.0000
405	L	A	-1.2482
406	V	A	0.0000
407	D	A	-2.3115
408	P	A	0.0000
409	E	A	-2.7156
410	D	A	-3.0503
411	P	A	-2.6811
412	E	A	-3.5196
413	D	A	-2.9057
414	I	A	0.0000
415	A	A	0.0000
416	R	A	-2.9648
417	G	A	0.0000
418	L	A	0.0000
419	L	A	-1.8409
420	K	A	-2.0034
421	A	A	0.0000
422	F	A	0.0000
423	E	A	-3.0215
424	S	A	-2.5495
425	E	A	-3.0973
426	E	A	-2.9814
427	T	A	-2.2006
428	W	A	-1.9560
429	S	A	-1.7806
430	A	A	-1.6394
431	Y	A	-1.5032
432	Q	A	-1.9017
433	E	A	-2.8329
434	K	A	-2.7439
435	G	A	0.0000
436	K	A	-2.8941
437	Q	A	-3.4574
438	R	A	-2.9854
439	V	A	0.0000
440	E	A	-3.4960
441	E	A	-2.9643
442	R	A	-3.0373
443	Y	A	-1.6441
444	T	A	0.0000
445	W	A	0.0000
446	Q	A	-2.0427
447	E	A	-2.4002
448	T	A	0.0000
449	A	A	0.0000
450	R	A	-2.5535
451	G	A	-1.5732
452	Y	A	0.0000
453	L	A	-1.5203
454	E	A	-2.6224
455	V	A	0.0000
456	I	A	0.0000
457	Q	A	-2.4414
458	E	A	-2.8927
459	I	A	0.0000
460	A	A	-2.0988
461	D	A	-3.2067
462	R	A	-3.1738