Project name: 2WCV [mutate: EA77L, EB77L, EC77L, ED77L, EE77L, EF77L, EG77L, EH77L, EI77L, EJ77L]

Status: done

submitted: 2017-09-13 11:04:43, status changed: 2017-09-13 11:28:35
Settings
Chain sequence(s) A: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
C: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
B: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
E: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
D: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
G: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
F: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
I: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
H: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
J: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
Distance of aggregation 10 Å
Dynamic mode No
Mutated residues EA77L, EB77L, EC77L, ED77L, EE77L, EF77L, EG77L, EH77L, EI77L, EJ77L
Energy difference between WT (input) and mutated protein (by FoldX) -2.45987 kcal/mol

Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive.

Show buried residues

Minimal score value
-3.7155
Maximal score value
1.4699
Average score
-0.4929
Total score value
-687.6054

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
1 M A 1.4699
2 L A 1.2603
3 K A -0.6434
4 T A -0.2068
5 I A 0.6701
6 S A 0.3480
7 P A 0.5483
8 L A 0.5338
9 I A 0.0000
10 S A -0.7339
11 P A -1.1126
12 E A -2.4394
13 L A 0.0000
14 L A -1.1468
15 K A -2.4379
16 V A 0.0000
17 L A 0.0000
18 A A -0.8463
19 E A -1.1282
20 M A 0.0000
21 G A 0.0000
22 H A 0.0000
23 G A -0.1053
24 D A 0.0000
25 E A -0.5856
26 I A 0.0000
27 I A 0.0000
28 F A 0.0000
29 S A 0.0000
30 D A 0.0000
31 A A -1.1215
32 H A -0.5904
33 F A 0.0000
34 P A 0.0000
35 A A 0.0000
36 H A -0.5908
37 S A -0.6833
38 M A -1.3017
39 G A -1.3265
40 P A -1.2596
41 Q A -0.9210
42 V A -0.3521
43 I A -0.8164
44 R A -1.2682
45 A A -1.0882
46 D A -2.1028
47 G A -1.4398
48 L A -0.6711
49 L A -0.4332
50 V A 0.0000
51 S A 0.0000
52 D A -0.7999
53 L A 0.0000
54 L A 0.0000
55 Q A -1.5741
56 A A 0.0000
57 I A 0.0000
58 I A -0.0982
59 P A -0.0745
60 L A 0.5163
61 F A 0.0000
62 E A -0.6156
63 L A -0.1540
64 D A 0.0000
65 S A -0.2266
66 Y A 0.0840
67 A A -0.2438
68 P A -0.3946
69 P A 0.0000
70 L A 0.0000
71 V A 0.0000
72 M A 0.0000
73 M A 0.0000
74 A A 0.1733
75 A A -0.2509
76 V A 0.0000
77 L A 0.0169 mutated: EA77L
78 G A -0.2522
79 D A -0.2335
80 T A -0.5182
81 L A -0.9937
82 D A -2.4725
83 P A -2.3103
84 E A -3.2420
85 V A 0.0000
86 E A -2.5409
87 R A -3.4242
88 R A -2.6470
89 Y A 0.0000
90 R A -2.8712
91 N A -2.5127
92 A A -1.8544
93 L A 0.0000
94 S A -0.9725
95 L A -0.6486
98 P A -0.0552
99 C A 0.0933
100 P A -0.3763
101 D A -1.4849
102 I A 0.0000
103 I A 0.4423
104 R A -0.0512
105 I A 0.2956
106 N A -0.1465
107 R A 0.0000
108 F A 0.4885
109 A A -0.2784
110 F A 0.0000
111 Y A -0.9576
112 E A -2.3592
113 R A -1.9742
114 A A 0.0000
115 Q A -2.6319
116 K A -2.7483
117 A A 0.0000
118 F A -0.7801
119 A A 0.0000
120 I A 0.0000
121 V A 0.0000
122 I A 0.0000
123 T A 0.0000
124 G A -1.3940
125 E A 0.0000
126 R A -2.0230
127 A A -1.6650
128 K A -1.4005
129 Y A 0.0000
130 G A 0.0000
131 N A 0.0000
132 I A 0.0000
133 L A 0.0000
134 L A 0.0000
135 K A -0.3888
136 K A 0.0000
137 G A 0.0000
138 V A -0.3310
139 T A -0.3938
140 P A -0.6023
1 M B 1.1962
2 L B 0.7121
3 K B -0.9363
4 T B -0.3911
5 I B 0.3749
6 S B 0.1490
7 P B 0.4139
8 L B 0.4679
9 I B 0.0000
10 S B -0.7025
11 P B -1.1022
12 E B -2.3082
13 L B 0.0000
14 L B -1.1334
15 K B -2.3595
16 V B 0.0000
17 L B 0.0000
18 A B -0.6343
19 E B -1.1261
20 M B 0.0000
21 G B 0.0000
22 H B -0.2230
23 G B 0.0473
24 D B 0.0000
25 E B -0.6276
26 I B 0.0000
27 I B 0.0000
28 F B 0.0000
29 S B 0.0000
30 D B 0.0000
31 A B -1.1369
32 H B 0.0000
33 F B 0.0000
34 P B 0.0000
35 A B 0.0000
36 H B -0.6496
37 S B -0.7770
38 M B -0.9071
39 G B -1.2981
40 P B -1.2681
41 Q B -1.0127
42 V B -0.4000
43 I B -0.8385
44 R B -1.2937
45 A B -1.0696
46 D B -2.0651
47 G B -1.3639
48 L B -0.3429
49 L B -0.2622
50 V B 0.0000
51 S B -1.1783
52 D B -0.7518
53 L B 0.0000
54 L B 0.0000
55 Q B -1.6631
56 A B 0.0000
57 I B 0.0000
58 I B 0.0000
59 P B -0.3344
60 L B 0.2938
61 F B 0.0000
62 E B -0.7427
63 L B -0.2374
64 D B 0.0000
65 S B -0.0802
66 Y B 0.2873
67 A B 0.1648
68 P B -0.3498
69 P B 0.0000
70 L B 0.0000
71 V B 0.0000
72 M B 0.0000
73 M B 0.0000
74 A B 0.0000
75 A B -0.1311
76 V B 0.5462
77 L B 0.8303 mutated: EB77L
78 G B 0.3626
79 D B 0.1288
80 T B -0.0230
81 L B -0.6585
82 D B -2.1036
83 P B -2.0293
84 E B -2.7283
85 V B 0.0000
86 E B -2.5307
87 R B -3.6572
88 R B -2.7930
89 Y B 0.0000
90 R B -3.1742
91 N B -2.7115
92 A B 0.0000
93 L B 0.0000
94 S B -1.1181
95 L B -0.5062
96 Q B -1.1063
97 A B -0.5519
98 P B -0.9230
99 C B -0.9962
100 P B -1.1384
101 D B -1.9933
102 I B 0.0000
103 I B -0.6722
104 R B -0.5157
105 I B 0.0000
106 N B -0.3750
107 R B -0.0840
108 F B 0.4255
109 A B 0.0000
110 F B 0.0000
111 Y B -0.2193
112 E B 0.0000
113 R B -0.8489
114 A B 0.0000
115 Q B -1.8040
116 K B -2.0991
117 A B 0.0000
118 F B 0.0000
119 A B 0.0000
120 I B 0.0000
121 V B 0.0000
122 I B 0.0000
123 T B 0.0000
124 G B -1.2823
125 E B 0.0000
126 R B -2.0708
127 A B -1.5257
128 K B -1.5849
129 Y B 0.0000
130 G B 0.0000
131 N B 0.0000
132 I B 0.0000
133 L B 0.0000
134 L B 0.0000
135 K B -0.4096
136 K B 0.0000
137 G B 0.0000
138 V B -0.2991
139 T B -0.4317
140 P B -0.5364
1 M C 1.4046
2 L C 1.0868
3 K C -0.7245
4 T C -0.2406
5 I C 0.6158
6 S C 0.4120
7 P C 0.6114
8 L C 0.6866
9 I C 0.0000
10 S C -0.6843
11 P C -1.1100
12 E C -2.3799
13 L C 0.0000
14 L C -1.1533
15 K C -2.4092
16 V C 0.0000
17 L C 0.0000
18 A C -0.8184
19 E C -1.0587
20 M C 0.0000
21 G C 0.0000
22 H C 0.0000
23 G C -0.1574
24 D C 0.0000
25 E C -0.7007
26 I C 0.0000
27 I C 0.0000
28 F C 0.0000
29 S C 0.0000
30 D C 0.0000
31 A C -1.0794
32 H C -0.6030
33 F C 0.0000
34 P C 0.0000
35 A C 0.0000
36 H C -0.5874
37 S C -0.9258
38 M C 0.0000
39 G C -1.4455
40 P C -1.2638
41 Q C -0.7937
42 V C -0.2608
43 I C -0.7384
44 R C -1.2125
45 A C -1.0335
46 D C -2.0532
47 G C -1.1897
48 L C -0.6081
49 L C -0.3722
50 V C 0.0000
51 S C -0.8146
52 D C -0.6794
53 L C 0.0000
54 L C 0.0000
55 Q C -1.3287
56 A C -0.3112
57 I C 0.0000
58 I C -0.1367
59 P C -0.1214
60 L C 0.4077
61 F C 0.0000
62 E C -0.8124
63 L C -0.3193
64 D C 0.0000
65 S C -0.1594
66 Y C 0.4602
67 A C 0.0054
68 P C -0.3898
69 P C 0.0000
70 L C 0.0000
71 V C 0.0000
72 M C 0.0000
73 M C 0.0000
74 A C -0.2173
75 A C -0.1489
76 V C 0.3814
77 L C 0.9753 mutated: EC77L
78 G C 0.0239
79 D C 0.0130
80 T C -0.2244
81 L C -0.6882
82 D C -2.0489
83 P C -2.1312
84 E C -3.0269
85 V C 0.0000
86 E C -2.3579
87 R C -3.4395
88 R C -2.5553
89 Y C 0.0000
90 R C -2.3554
91 N C -2.3865
92 A C 0.0000
93 L C 0.0000
94 S C -0.8986
97 A C -0.0999
98 P C -0.6828
99 C C -0.8388
100 P C -1.0092
101 D C -1.7402
102 I C 0.0000
103 I C 0.2032
104 R C -0.2821
105 I C -0.4933
106 N C -1.3514
107 R C -0.9804
108 F C 0.0000
109 A C -1.1076
110 F C 0.0000
111 Y C 0.0000
112 E C -1.8419
113 R C -2.1617
114 A C 0.0000
115 Q C -2.6754
116 K C -2.8191
117 A C 0.0000
118 F C -0.8649
119 A C 0.0000
120 I C 0.0000
121 V C 0.0000
122 I C 0.0000
123 T C 0.0000
124 G C 0.0000
125 E C 0.0000
126 R C -1.8977
127 A C -1.5320
128 K C -1.2176
129 Y C -0.6301
130 G C 0.0000
131 N C 0.0000
132 I C 0.0000
133 L C 0.0000
134 L C 0.0000
135 K C -0.4912
136 K C 0.0000
137 G C 0.0000
138 V C -0.4045
139 T C -0.5785
140 P C -0.7530
1 M D 1.3770
2 L D 1.1057
3 K D -0.7081
4 T D -0.2075
5 I D 0.6569
6 S D 0.2056
7 P D 0.4179
8 L D 0.2789
9 I D 0.0000
10 S D -0.7287
11 P D -1.1275
12 E D -2.4165
13 L D 0.0000
14 L D -1.2008
15 K D -2.4209
16 V D 0.0000
17 L D 0.0000
18 A D -0.8341
19 E D -1.1481
20 M D 0.0000
21 G D 0.0000
22 H D 0.0000
23 G D -0.1908
24 D D 0.0000
25 E D -0.6348
26 I D 0.0000
27 I D 0.0000
28 F D 0.0000
29 S D 0.0000
30 D D 0.0000
31 A D -1.0573
32 H D 0.0000
33 F D 0.0000
34 P D 0.0000
35 A D 0.0000
36 H D -0.5933
37 S D -0.7887
38 M D -1.0454
39 G D -1.3194
40 P D -1.2534
41 Q D -0.8997
42 V D -0.4700
43 I D -0.7421
44 R D -1.2965
45 A D -0.9499
46 D D -1.9606
47 G D -1.2856
48 L D -0.5131
49 L D -0.1654
50 V D 0.0000
51 S D 0.0000
52 D D -1.2457
53 L D 0.0000
54 L D 0.0000
55 Q D -1.5569
56 A D -0.4546
57 I D 0.0000
58 I D -0.1251
59 P D -0.1402
60 L D 0.4716
61 F D 0.0000
62 E D -0.5172
63 L D -0.0794
64 D D 0.0000
65 S D -0.0544
66 Y D 0.2515
67 A D -0.0266
68 P D -0.3049
69 P D 0.0000
70 L D 0.0000
71 V D 0.0000
72 M D 0.0000
73 M D 0.0000
74 A D -0.1986
75 A D -0.2875
76 V D 0.5575
77 L D 1.3227 mutated: ED77L
78 G D 0.1511
79 D D -0.4636
80 T D -0.5440
81 L D -1.1495
82 D D -2.5724
83 P D -2.4209
84 E D -3.2418
85 V D 0.0000
86 E D -2.4669
87 R D -3.5994
88 R D -2.8202
89 Y D 0.0000
90 R D -2.3433
91 N D -2.2327
92 A D 0.0000
93 L D 0.0000
94 S D -0.8975
95 L D -0.3367
96 Q D -0.9178
97 A D -0.5384
98 P D -0.8339
99 C D -0.8422
100 P D -1.0356
101 D D -1.8033
102 I D 0.0000
103 I D -0.0076
104 R D -0.4047
105 I D -0.4360
106 N D -1.1702
107 R D -0.6221
108 F D -0.1383
109 A D -0.4794
110 F D 0.0000
111 Y D -0.6599
112 E D -1.1766
113 R D -1.3281
114 A D 0.0000
115 Q D -2.1380
116 K D -2.4732
117 A D 0.0000
118 F D 0.0000
119 A D 0.0000
120 I D 0.0000
121 V D 0.0000
122 I D 0.0000
123 T D 0.0000
124 G D 0.0000
125 E D 0.0000
126 R D -1.9738
127 A D -1.6556
128 K D -1.5824
129 Y D 0.0000
130 G D 0.0000
131 N D 0.0000
132 I D 0.0000
133 L D 0.0000
134 L D 0.0000
135 K D -0.3383
136 K D 0.0000
137 G D 0.0000
138 V D -0.2627
139 T D -0.4116
140 P D -0.5813
1 M E 1.3809
2 L E 1.0510
3 K E -0.7541
4 T E -0.2781
5 I E 0.5723
6 S E 0.1781
7 P E 0.5387
8 L E 0.5633
9 I E 0.0000
10 S E -0.6889
11 P E -1.1169
12 E E -2.4389
13 L E 0.0000
14 L E -1.2305
15 K E -2.4405
16 V E 0.0000
17 L E 0.0000
18 A E -0.8393
19 E E -1.1678
20 M E 0.0000
21 G E 0.0000
22 H E 0.0000
23 G E -0.0983
24 D E 0.0000
25 E E -0.5441
26 I E 0.0000
27 I E 0.0000
28 F E 0.0000
29 S E 0.0000
30 D E 0.0000
31 A E -1.0632
32 H E -0.6182
33 F E 0.0000
34 P E 0.0000
35 A E 0.0000
36 H E -0.5843
37 S E -0.7949
38 M E 0.0000
39 G E -1.1643
40 P E -1.1211
41 Q E -0.9941
42 V E -0.3551
43 I E -0.8176
44 R E -1.2718
45 A E -1.1194
46 D E -2.0859
47 G E -1.2026
48 L E -0.5923
49 L E -0.1993
50 V E 0.0000
51 S E -0.9551
52 D E -0.6495
53 L E 0.0000
54 L E 0.0000
55 Q E -1.1406
56 A E 0.0000
57 I E 0.0000
58 I E 0.0000
59 P E 0.1349
60 L E 0.4469
61 F E 0.0000
62 E E -0.6788
63 L E -0.1940
64 D E 0.0000
65 S E -0.2303
66 Y E 0.0166
67 A E -0.1176
68 P E 0.0000
69 P E 0.0000
70 L E 0.0000
71 V E 0.0000
72 M E 0.0000
73 M E 0.0000
74 A E 0.1276
75 A E 0.2508
76 V E 1.0076
77 L E 1.3971 mutated: EE77L
78 G E 0.2564
79 D E 0.0632
80 T E -0.1313
81 L E -0.4600
82 D E -1.6947
83 P E -2.0386
84 E E -3.1244
85 V E 0.0000
86 E E -2.5230
87 R E -3.6036
88 R E -2.8138
89 Y E 0.0000
90 R E -2.4364
91 N E -2.2022
92 A E 0.0000
93 L E 0.0000
94 S E -0.2337
95 L E 1.0266
97 A E 0.4316
98 P E -0.3707
99 C E 0.0000
100 P E -0.9963
101 D E -1.9839
102 I E 0.0000
103 I E 0.0000
104 R E -0.7188
105 I E 0.0000
106 N E -0.1784
107 R E -0.1481
108 F E 0.1859
109 A E 0.0000
110 F E 0.0000
111 Y E 0.0000
112 E E 0.0000
113 R E -0.8773
114 A E 0.0000
115 Q E -1.3246
116 K E -2.0482
117 A E 0.0000
118 F E -0.7023
119 A E 0.0000
120 I E 0.0000
121 V E 0.0000
122 I E 0.0000
123 T E 0.0000
124 G E -1.2422
125 E E 0.0000
126 R E -1.8790
127 A E -1.3772
128 K E -1.0268
129 Y E 0.0000
130 G E 0.0000
131 N E 0.0000
132 I E 0.0000
133 L E 0.0000
134 L E 0.0000
135 K E -0.3720
136 K E 0.0000
137 G E 0.0000
138 V E -0.2007
139 T E -0.3795
140 P E -0.6332
1 M F 1.4332
2 L F 1.2021
3 K F -0.7074
4 T F -0.3103
5 I F 0.4528
6 S F 0.2548
7 P F 0.4694
8 L F 0.4187
9 I F 0.0000
10 S F -0.7326
11 P F -1.0874
12 E F -2.4998
13 L F 0.0000
14 L F -1.1881
15 K F -2.4013
16 V F 0.0000
17 L F 0.0000
18 A F -0.8296
19 E F -1.1715
20 M F 0.0000
21 G F 0.0000
22 H F 0.0000
23 G F -0.0821
24 D F 0.0000
25 E F 0.0000
26 I F 0.0000
27 I F 0.0000
28 F F 0.0000
29 S F 0.0000
30 D F 0.0000
31 A F -1.0864
32 H F 0.0000
33 F F 0.0000
34 P F 0.0000
35 A F 0.0000
36 H F -0.6691
37 S F -0.9250
38 M F 0.0000
39 G F -1.4557
40 P F -1.3495
41 Q F -0.9408
42 V F -0.3251
43 I F -0.8000
44 R F -1.4409
45 A F -1.0333
46 D F -2.0326
47 G F -1.3339
48 L F -0.5350
49 L F -0.2733
50 V F 0.0000
51 S F -1.1223
52 D F -0.9189
53 L F 0.0000
54 L F 0.0000
55 Q F -1.5705
56 A F 0.0000
57 I F 0.0000
58 I F -0.1046
59 P F -0.0871
60 L F 0.5147
61 F F 0.0000
62 E F -0.6512
63 L F -0.1590
64 D F 0.0000
65 S F -0.0182
66 Y F 0.3793
67 A F 0.0434
68 P F -0.2080
69 P F 0.0000
70 L F 0.0000
71 V F 0.0000
72 M F 0.0000
73 M F 0.0000
74 A F -0.0784
75 A F -0.3587
76 V F 0.0000
77 L F 0.8473 mutated: EF77L
78 G F -0.2207
79 D F -0.6814
80 T F -0.6044
81 L F -1.1461
82 D F -2.7017
83 P F -2.4519
84 E F -3.2894
85 V F 0.0000
86 E F -2.4467
87 R F -3.5434
88 R F -2.6089
89 Y F 0.0000
90 R F -2.7163
91 N F -2.5947
92 A F 0.0000
93 L F 0.0000
94 S F -1.3631
95 L F 0.0000
96 Q F -1.6845
97 A F -0.7068
98 P F -0.4685
99 C F -0.2932
100 P F -0.6359
101 D F -1.4855
102 I F -0.3769
103 I F 0.3307
104 R F -0.0994
105 I F -0.1671
106 N F -0.7431
107 R F 0.0000
108 F F -0.3210
109 A F -0.8787
110 F F 0.0000
111 Y F -1.3647
112 E F -2.6181
113 R F -2.0992
114 A F 0.0000
115 Q F -2.9189
116 K F -2.9091
117 A F 0.0000
118 F F 0.0000
119 A F 0.0000
120 I F 0.0000
121 V F 0.0000
122 I F 0.0000
123 T F 0.0000
124 G F 0.0000
125 E F 0.0000
126 R F -2.0252
127 A F -1.7845
128 K F -1.7360
129 Y F 0.0000
130 G F 0.0000
131 N F 0.0000
132 I F 0.0000
133 L F 0.0000
134 L F 0.0000
135 K F -0.3301
136 K F 0.0000
137 G F 0.0000
138 V F -0.2973
139 T F -0.4223
140 P F -0.6300
1 M G 1.2838
2 L G 0.8554
3 K G -0.8769
4 T G -0.3623
5 I G 0.4295
6 S G 0.1400
7 P G 0.4795
8 L G 0.5222
9 I G 0.0000
10 S G -0.5761
11 P G -0.9053
12 E G -1.9584
13 L G 0.0000
14 L G -1.0024
15 K G -2.2335
16 V G 0.0000
17 L G 0.0000
18 A G -0.6272
19 E G -1.0993
20 M G 0.0000
21 G G 0.0000
22 H G -0.2140
23 G G -0.2428
24 D G 0.0000
25 E G -0.6599
26 I G 0.0000
27 I G 0.0000
28 F G 0.0000
29 S G 0.0000
30 D G 0.0000
31 A G -1.1250
32 H G -0.6293
33 F G 0.0000
34 P G 0.0000
35 A G 0.0000
36 H G -0.6703
37 S G -0.8727
38 M G -1.2885
39 G G -1.3624
40 P G -1.3131
41 Q G -0.8916
42 V G -0.5210
43 I G 0.0000
44 R G -1.3273
45 A G -1.0594
46 D G -2.0511
47 G G -1.3526
48 L G -0.5110
49 L G -0.3240
50 V G 0.0000
51 S G -1.1227
52 D G -0.6775
53 L G 0.0000
54 L G 0.0000
55 Q G -1.6106
56 A G 0.0000
57 I G 0.0000
58 I G 0.0000
59 P G -0.3566
60 L G 0.3130
61 F G 0.0000
62 E G -0.6170
63 L G -0.1273
64 D G 0.0000
65 S G -0.0845
66 Y G 0.3159
67 A G 0.0474
68 P G -0.3708
69 P G 0.0000
70 L G 0.0000
71 V G 0.0000
72 M G 0.0000
73 M G 0.0000
74 A G 0.2057
75 A G 0.0406
76 V G 0.7981
77 L G 1.3754 mutated: EG77L
78 G G 0.1963
79 D G -0.1884
80 T G -0.2537
81 L G -0.6607
82 D G -1.8471
83 P G -2.0594
84 E G -3.1123
85 V G 0.0000
86 E G -2.4785
87 R G -3.6307
88 R G -2.7908
89 Y G 0.0000
90 R G -2.9182
91 N G -2.5566
92 A G 0.0000
93 L G 0.0000
94 S G -1.0524
95 L G -0.3976
96 Q G -1.0832
97 A G -0.5501
98 P G -0.8240
99 C G -0.8953
100 P G -1.0720
101 D G -1.9152
102 I G 0.0000
103 I G -0.0843
104 R G -0.5003
105 I G 0.1454
106 N G -0.0002
107 R G 0.3206
108 F G 1.3562
109 A G 0.0359
110 F G 0.0000
111 Y G -0.5306
112 E G -1.6384
113 R G -1.7363
114 A G 0.0000
115 Q G -2.6907
116 K G -2.7268
117 A G 0.0000
118 F G 0.0000
119 A G 0.0000
120 I G 0.0000
121 V G 0.0000
122 I G 0.0000
123 T G 0.0000
124 G G 0.0000
125 E G 0.0000
126 R G -2.0041
127 A G -1.6124
128 K G -1.3553
129 Y G 0.0000
130 G G 0.0000
131 N G 0.0000
132 I G 0.0000
133 L G 0.0000
134 L G 0.0000
135 K G -0.3948
136 K G 0.0000
137 G G 0.0000
138 V G -0.2835
139 T G -0.4279
140 P G -0.6049
1 M H 1.2800
2 L H 0.7417
3 K H -0.9062
4 T H -0.3658
5 I H 0.5129
6 S H 0.2584
7 P H 0.6724
8 L H 1.0210
9 I H 0.0000
10 S H -0.6129
11 P H -1.1212
12 E H -2.4278
13 L H 0.0000
14 L H -1.1851
15 K H -2.4078
16 V H 0.0000
17 L H 0.0000
18 A H -0.8038
19 E H -1.0860
20 M H 0.0000
21 G H 0.0000
22 H H 0.0000
23 G H -0.1365
24 D H 0.0000
25 E H 0.0000
26 I H 0.0000
27 I H 0.0000
28 F H 0.0000
29 S H 0.0000
30 D H 0.0000
31 A H -0.9885
32 H H -0.6123
33 F H 0.0000
34 P H 0.0000
35 A H 0.0000
36 H H -0.6533
37 S H -0.6128
38 M H 0.0000
39 G H -1.2076
40 P H -1.2020
41 Q H -1.0779
42 V H -0.3891
43 I H -0.7871
44 R H -1.2073
45 A H -0.8933
46 D H -1.7964
47 G H -1.0388
48 L H -0.3142
49 L H -0.2607
50 V H 0.0000
51 S H -1.0852
52 D H -0.7412
53 L H 0.0000
54 L H 0.0000
55 Q H -1.5051
56 A H 0.0000
57 I H 0.0000
58 I H 0.0000
59 P H -0.2552
60 L H 0.5284
61 F H 0.0000
62 E H -0.5884
63 L H -0.1940
64 D H 0.0000
65 S H -0.2934
66 Y H -0.0326
67 A H -0.1416
68 P H 0.0000
69 P H 0.0000
70 L H 0.0000
71 V H 0.0000
72 M H 0.0000
73 M H 0.0000
74 A H 0.1051
75 A H 0.1554
76 V H 0.8785
77 L H 1.2776 mutated: EH77L
78 G H 0.0819
79 D H -0.1665
80 T H -0.2239
81 L H -0.5554
82 D H -1.9114
83 P H -2.0360
84 E H -2.9705
85 V H 0.0000
86 E H -2.5350
87 R H -3.5173
88 R H -2.6181
89 Y H 0.0000
90 R H -2.5090
91 N H -2.3293
92 A H 0.0000
93 L H 0.0000
94 S H -0.9144
95 L H -0.4312
96 Q H -0.8990
97 A H -0.4820
98 P H -0.8365
99 C H 0.0000
100 P H -1.1668
101 D H -2.2651
102 I H 0.0000
103 I H 0.0000
104 R H -0.6508
105 I H 0.0000
106 N H -0.0207
107 R H -0.1741
108 F H 0.1914
109 A H 0.0000
110 F H 0.0000
111 Y H 0.0000
112 E H 0.0000
113 R H -0.7786
114 A H 0.0000
115 Q H -1.5161
116 K H -2.0368
117 A H 0.0000
118 F H -0.6405
119 A H 0.0000
120 I H 0.0000
121 V H 0.0000
122 I H 0.0000
123 T H 0.0000
124 G H 0.0000
125 E H 0.0000
126 R H -1.9289
127 A H -1.5225
128 K H -1.1651
129 Y H 0.0000
130 G H 0.0000
131 N H 0.0000
132 I H 0.0000
133 L H 0.0000
134 L H 0.0000
135 K H -0.3012
136 K H 0.0000
137 G H 0.0000
138 V H -0.3801
139 T H -0.4010
140 P H -0.6175
1 M I 1.2992
2 L I 0.9384
3 K I -0.8240
4 T I -0.3203
5 I I 0.4687
6 S I 0.1737
7 P I 0.3867
8 L I 0.4467
9 I I 0.0000
10 S I -0.6865
11 P I -1.0698
12 E I -2.3417
13 L I 0.0000
14 L I -1.0600
15 K I -2.3464
16 V I 0.0000
17 L I 0.0000
18 A I -0.8234
19 E I -1.1248
20 M I 0.0000
21 G I 0.0000
22 H I -0.2358
23 G I -0.1887
24 D I 0.0000
25 E I -0.6368
26 I I 0.0000
27 I I 0.0000
28 F I 0.0000
29 S I 0.0000
30 D I 0.0000
31 A I -1.1118
32 H I -0.6743
33 F I 0.0000
34 P I 0.0000
35 A I 0.0000
36 H I -0.5972
37 S I -0.8101
38 M I -1.3446
39 G I -1.3992
40 P I -1.2735
41 Q I -0.7945
42 V I -0.4539
43 I I -0.7661
44 R I -1.3749
45 A I -0.9975
46 D I -1.9927
47 G I -1.2936
48 L I -0.2737
49 L I -0.1091
50 V I 0.0000
51 S I 0.0000
52 D I -0.6957
53 L I 0.0000
54 L I 0.0000
55 Q I -1.0982
56 A I 0.0000
57 I I 0.0000
58 I I -0.0760
59 P I -0.1481
60 L I 0.4330
61 F I 0.0000
62 E I -0.6630
63 L I -0.2102
64 D I 0.0000
65 S I -0.2438
66 Y I -0.0396
67 A I -0.1787
68 P I -0.2760
69 P I -0.3549
70 L I 0.0000
71 V I 0.0000
72 M I 0.0000
73 M I 0.0000
74 A I 0.0108
75 A I -0.4000
76 V I 0.0000
77 L I 0.1676 mutated: EI77L
78 G I -0.1492
79 D I -0.2859
80 T I -0.5496
81 L I -1.3119
82 D I -2.7880
83 P I -2.5504
84 E I -3.1669
85 V I 0.0000
86 E I -2.7133
87 R I -3.7155
88 R I -2.6664
89 Y I 0.0000
90 R I -2.4541
91 N I -2.4607
92 A I 0.0000
93 L I 0.0000
94 S I -0.9099
95 L I -0.3076
96 Q I -1.0463
97 A I -0.5979
98 P I -0.8283
99 C I 0.0000
100 P I -0.6933
101 D I -0.9097
102 I I 0.0000
103 I I 0.1005
104 R I -0.2033
105 I I 0.0611
106 N I -0.3839
107 R I 0.0000
108 F I 0.3629
109 A I -0.5023
110 F I 0.0000
111 Y I -1.1299
112 E I -2.5448
113 R I -2.1626
114 A I 0.0000
115 Q I -2.9028
116 K I -2.9409
117 A I 0.0000
118 F I 0.0000
119 A I 0.0000
120 I I 0.0000
121 V I 0.0000
122 I I 0.0000
123 T I 0.0000
124 G I 0.0000
125 E I 0.0000
126 R I -2.0683
127 A I -1.7384
128 K I -1.6240
129 Y I 0.0000
130 G I 0.0000
131 N I 0.0000
132 I I 0.0000
133 L I 0.0000
134 L I 0.0000
135 K I -0.4311
136 K I 0.0000
137 G I 0.0000
138 V I -0.4193
139 T I -0.4584
140 P I -0.5838
1 M J 1.3116
2 L J 0.8562
3 K J -0.8513
4 T J -0.3226
5 I J 0.5681
6 S J 0.1742
7 P J 0.5419
8 L J 0.7487
9 I J 0.0000
10 S J -0.6595
11 P J -1.1148
12 E J -2.4240
13 L J 0.0000
14 L J -1.1766
15 K J -2.4256
16 V J 0.0000
17 L J 0.0000
18 A J -0.8245
19 E J -1.1554
20 M J 0.0000
21 G J 0.0000
22 H J 0.0000
23 G J -0.1178
24 D J 0.0000
25 E J -0.5535
26 I J 0.0000
27 I J 0.0000
28 F J 0.0000
29 S J 0.0000
30 D J 0.0000
31 A J -1.0834
32 H J -0.6611
33 F J 0.0000
34 P J 0.0000
35 A J 0.0000
36 H J -0.5217
37 S J -0.7031
38 M J -0.8993
39 G J -1.2281
40 P J -1.1105
41 Q J -0.8314
42 V J -0.2801
43 I J -0.8181
44 R J -1.3958
45 A J -1.1293
46 D J -2.1183
47 G J -1.2297
48 L J -0.4604
49 L J -0.2862
50 V J 0.0000
51 S J 0.0000
52 D J -0.7100
53 L J 0.0000
54 L J 0.0000
55 Q J -1.2820
56 A J 0.0000
57 I J 0.0000
58 I J 0.0000
59 P J -0.0461
60 L J 0.7665
61 F J 0.0000
62 E J -0.5026
63 L J -0.2138
64 D J 0.0000
65 S J -0.1344
66 Y J 0.3468
67 A J 0.0442
68 P J -0.4748
69 P J -0.5087
70 L J 0.0000
71 V J 0.0000
72 M J 0.0000
73 M J 0.0000
74 A J 0.3205
75 A J 0.3203
76 V J 1.1791
77 L J 1.2526 mutated: EJ77L
78 G J 0.0000
79 D J 0.0556
80 T J 0.1680
81 L J -0.1497
82 D J -1.3722
83 P J -1.6547
84 E J -2.9098
85 V J 0.0000
86 E J 0.0000
87 R J -3.3680
88 R J -2.5585
89 Y J 0.0000
90 R J -2.4163
91 N J -2.0128
92 A J 0.0000
93 L J 0.0000
94 S J -0.5662
95 L J 0.2830
96 Q J -0.6824
97 A J -0.3876
98 P J -0.2685
99 C J -0.6323
100 P J -1.0256
101 D J -1.8453
102 I J 0.0000
103 I J 0.0000
104 R J -0.3721
105 I J 0.0000
106 N J 0.2355
107 R J 0.5669
108 F J 1.3595
109 A J 0.0000
110 F J 0.0000
111 Y J 0.0169
112 E J -0.4524
113 R J 0.0000
114 A J 0.0000
115 Q J -1.9053
116 K J -2.2251
117 A J 0.0000
118 F J -0.7079
119 A J 0.0000
120 I J 0.0000
121 V J 0.0000
122 I J 0.0000
123 T J 0.0000
124 G J 0.0000
125 E J 0.0000
126 R J -1.9676
127 A J -1.5605
128 K J -1.3453
129 Y J -0.6492
130 G J 0.0000
131 N J 0.0000
132 I J 0.0000
133 L J 0.0000
134 L J 0.0000
135 K J -0.4467
136 K J -0.4451
137 G J 0.0000
138 V J -0.3392
139 T J -0.3739
140 P J -0.7013

 

Laboratory of Theory of Biopolymers 2015