Project name: 688b8365fea287d

Chain sequence(s)	A: PPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQEPYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPF
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.8225
• Maximal score value: 1.7096
• Average score: -1.052
• Total score value: -408.1832

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
47	P	A	-0.7574
48	P	A	-1.2035
49	G	A	-1.4952
50	T	A	-1.8967
51	V	A	0.0000
52	D	A	-2.9211
53	K	A	-2.8248
54	K	A	-2.8765
55	M	A	-2.0124
56	V	A	0.0000
57	E	A	-2.5442
58	K	A	-1.7974
59	C	A	0.0000
60	W	A	-1.5045
61	K	A	-1.8777
62	L	A	0.0000
63	M	A	0.0000
64	D	A	-2.1125
65	K	A	-2.1761
66	V	A	0.0000
67	V	A	-1.7939
68	R	A	-2.4733
69	L	A	-1.3758
70	C	A	0.0000
71	Q	A	-2.0656
72	N	A	-1.7941
73	P	A	-1.6165
74	K	A	-2.3996
75	L	A	0.0000
76	A	A	-1.5307
77	L	A	0.0000
78	K	A	-2.6817
79	N	A	-2.1823
80	S	A	-0.9611
81	P	A	-0.3066
82	P	A	-0.0924
83	Y	A	-0.7382
84	I	A	0.0000
85	L	A	-1.7002
86	D	A	-2.2080
87	L	A	-1.0328
88	L	A	0.0000
89	P	A	-1.4038
90	D	A	-2.0545
91	T	A	0.0000
92	Y	A	-1.4054
93	Q	A	-2.0607
94	H	A	-1.7182
95	L	A	0.0000
96	R	A	-2.7185
97	T	A	-1.6535
98	I	A	0.0000
99	L	A	0.0000
100	S	A	-1.9920
101	R	A	-2.0780
102	Y	A	-2.3278
103	E	A	-3.0560
104	G	A	-2.5332
105	K	A	-3.0378
106	M	A	-2.9359
107	E	A	-3.2529
108	T	A	-2.0810
109	L	A	0.0000
110	G	A	0.0000
111	E	A	-3.1836
112	N	A	-2.3011
113	E	A	-2.7821
114	Y	A	0.0000
115	F	A	0.0000
116	R	A	-1.8927
117	V	A	0.0000
118	F	A	0.0000
119	M	A	0.0000
120	E	A	-1.3535
121	N	A	0.0000
122	L	A	0.0000
123	M	A	-0.9677
124	K	A	-1.4965
125	K	A	0.0000
126	T	A	0.0000
127	K	A	-0.6432
128	Q	A	-1.2013
129	T	A	0.0000
130	I	A	0.0000
131	S	A	-1.3277
132	L	A	0.0000
133	F	A	0.0000
134	K	A	-3.3619
135	E	A	-3.5902
136	G	A	-3.4655
137	K	A	-4.4315
138	E	A	-4.2886
139	R	A	-4.8225
140	M	A	0.0000
141	Y	A	-3.2596
142	E	A	-4.5863
143	E	A	-4.0712
144	N	A	-3.2498
145	S	A	-2.9893
146	Q	A	-2.5530
147	P	A	0.0000
148	R	A	-2.3107
149	R	A	-1.6270
150	N	A	0.0000
151	L	A	0.0000
152	T	A	0.0000
153	K	A	0.0000
154	L	A	0.0000
155	S	A	0.0000
156	L	A	0.0000
157	I	A	0.0000
158	F	A	0.0000
159	S	A	-0.1865
160	H	A	0.0000
161	M	A	0.0000
162	L	A	0.0000
163	A	A	-0.2510
164	E	A	0.0000
165	L	A	0.0000
166	K	A	-0.9592
167	G	A	-0.5485
168	I	A	0.0000
169	F	A	0.0000
170	P	A	-0.2267
171	S	A	-0.2976
172	G	A	0.0000
173	L	A	0.7196
174	F	A	0.2357
175	Q	A	-0.7276
176	G	A	0.0000
177	D	A	-2.7986
178	T	A	-1.8473
179	F	A	-1.6745
180	R	A	-2.0347
181	I	A	0.0000
182	T	A	-1.0600
183	K	A	-1.6414
184	A	A	-1.7543
185	D	A	-2.5646
186	A	A	0.0000
187	A	A	-2.4032
188	E	A	-3.2852
189	F	A	0.0000
190	W	A	0.0000
191	R	A	-3.2357
192	K	A	-2.9178
193	A	A	-1.8512
194	F	A	-1.8979
195	G	A	-2.8440
196	E	A	-3.5930
197	K	A	-3.2782
198	T	A	0.0000
199	I	A	0.0000
200	V	A	0.0000
201	P	A	-1.1553
202	W	A	0.0000
203	K	A	-2.4768
204	S	A	-1.4085
205	F	A	0.0000
206	R	A	-1.9814
207	Q	A	-2.3700
208	A	A	-1.6638
209	L	A	0.0000
210	H	A	-1.7013
211	E	A	-2.0495
212	V	A	-0.5387
213	H	A	-0.7621
214	P	A	-0.9803
215	I	A	0.0000
216	S	A	-0.4791
217	S	A	-0.6191
218	G	A	-0.5735
219	L	A	-0.9021
220	E	A	0.0000
221	A	A	-0.2950
222	M	A	-0.1659
223	A	A	0.0000
224	L	A	0.0000
225	K	A	-0.3622
226	S	A	-0.4535
227	T	A	0.0342
228	I	A	0.0000
229	D	A	0.0000
230	L	A	0.0075
231	T	A	0.0000
232	C	A	-0.3974
233	N	A	-1.1308
234	D	A	-2.0327
235	Y	A	-0.9750
236	I	A	0.0000
237	S	A	0.0000
238	V	A	0.0000
239	F	A	-0.0354
240	E	A	0.0000
241	F	A	0.0000
242	D	A	0.0000
243	I	A	0.0000
244	F	A	0.0000
245	T	A	0.0000
246	R	A	-0.5536
247	L	A	0.0000
248	F	A	0.0000
249	Q	A	-0.8135
250	P	A	-0.7357
251	W	A	-0.7318
252	S	A	-0.5435
253	S	A	0.0000
254	L	A	0.0000
255	L	A	0.0000
256	R	A	-0.7505
257	N	A	0.0000
258	W	A	0.0000
259	N	A	0.0000
260	S	A	-0.3965
261	L	A	0.0000
262	A	A	0.0000
263	V	A	0.0000
264	T	A	0.0890
265	H	A	0.0000
266	P	A	-0.5407
267	G	A	0.0000
268	Y	A	0.1895
269	M	A	0.0000
270	A	A	0.1451
271	F	A	0.4295
272	L	A	0.2399
273	T	A	0.0000
274	Y	A	0.5756
275	D	A	-0.6503
276	E	A	-0.8401
277	V	A	0.0000
278	K	A	-1.3239
279	A	A	-1.3200
280	R	A	-1.7258
281	L	A	0.0000
282	Q	A	-2.4447
283	K	A	-2.4539
284	F	A	-1.4470
285	I	A	-1.6554
286	H	A	-1.8642
287	K	A	-1.2456
288	P	A	-0.7285
289	G	A	0.0000
290	S	A	0.0000
291	Y	A	0.0000
292	I	A	0.0000
293	F	A	0.0000
294	R	A	0.0000
295	L	A	0.2228
296	S	A	0.0000
297	C	A	-0.1673
298	T	A	-0.7414
299	R	A	-1.6995
300	L	A	-0.7506
301	G	A	0.0000
302	Q	A	-1.1347
303	W	A	0.0000
304	A	A	0.0000
305	I	A	0.0000
306	G	A	0.0000
307	Y	A	0.3880
308	V	A	0.0000
309	T	A	-0.7662
310	A	A	-1.1385
311	D	A	-2.2690
312	G	A	-1.8400
313	N	A	-1.9144
314	I	A	0.0000
315	L	A	0.1578
316	Q	A	0.3490
317	T	A	0.1804
318	I	A	-0.2345
319	P	A	-1.0512
320	H	A	-1.9033
321	N	A	-2.3590
322	K	A	-2.5509
323	P	A	-1.5665
324	L	A	0.0000
325	F	A	0.0000
326	Q	A	-1.6787
327	A	A	0.0000
328	L	A	0.0000
329	I	A	-1.5824
330	D	A	-2.6693
331	G	A	-1.2891
332	F	A	-0.8769
333	R	A	-2.6138
334	E	A	-2.5874
335	G	A	-0.9741
336	F	A	0.5886
337	Y	A	0.0000
338	L	A	-0.1919
339	F	A	-0.7384
340	P	A	0.0000
341	D	A	0.0000
342	G	A	-1.5344
343	R	A	-2.6915
344	N	A	-2.6145
345	Q	A	-2.5394
346	N	A	-1.5751
347	P	A	-1.5794
348	D	A	-1.8733
349	L	A	0.0000
350	T	A	-1.1177
351	G	A	-1.1479
352	L	A	0.0000
353	C	A	-0.8045
354	E	A	-1.8904
355	P	A	-1.2433
356	T	A	-1.1706
357	P	A	-1.7199
358	Q	A	-2.4355
359	D	A	-2.8589
360	H	A	-2.0570
361	I	A	-0.7953
362	K	A	-1.6447
363	V	A	-1.0636
364	T	A	-1.5276
365	Q	A	-2.5504
366	E	A	-2.6109
367	P	A	-1.5004
368	Y	A	0.0000
369	E	A	-2.3526
370	L	A	-0.5551
371	Y	A	0.0000
372	C	A	-1.0055
373	E	A	-1.5902
374	M	A	-0.4484
375	G	A	-0.1790
376	S	A	-0.1610
377	T	A	-1.0905
378	F	A	-0.5230
379	Q	A	0.0000
380	L	A	-1.8325
381	C	A	0.0000
382	K	A	-1.8817
383	I	A	-0.5461
384	C	A	-1.0503
385	A	A	-1.6641
386	E	A	-2.7834
387	N	A	-3.2308
388	D	A	-3.3111
389	K	A	-2.4386
390	D	A	-2.5307
391	V	A	-1.7262
392	K	A	-1.7725
393	I	A	0.0000
394	E	A	-2.6063
395	P	A	-1.5177
396	C	A	-0.9655
397	G	A	-0.9131
398	H	A	-0.5540
399	L	A	-1.3451
400	M	A	0.0000
401	C	A	0.0000
402	T	A	-0.9458
403	S	A	-0.6663
404	C	A	-0.5210
405	L	A	0.0000
406	T	A	-1.0880
407	S	A	-1.1990
408	W	A	-1.5349
409	Q	A	-2.8477
410	E	A	-2.9815
411	S	A	-2.4192
412	E	A	-3.2649
413	G	A	-2.6051
414	Q	A	-2.7109
415	G	A	-2.5166
416	C	A	0.0000
417	P	A	0.0000
418	F	A	-0.1160
419	C	A	-0.7307
420	R	A	-2.2159
421	C	A	-1.7380
422	E	A	-2.8456
423	I	A	-2.1921
424	K	A	-2.4418
425	G	A	-2.0633
426	T	A	-2.0100
427	E	A	-2.1781
428	P	A	-1.1903
429	I	A	-0.8246
430	V	A	0.0000
431	V	A	0.7294
432	D	A	0.0385
433	P	A	0.2164
434	F	A	1.7096