Chain sequence(s) |
A: SVSIYPSSAEVLKACRNLGKNGLSNSSILLDKCPPPRPPSSPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFCTNPNNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWHCESNRSHTTIAKYAQYQASSFQESLREENEKRSHHKDHSDSESTSSDNSGRRRKGPFKTIKFGTNIDLSDDKKWKLQLHELTKLPAFVRVVSAGNLLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFCEKNNLNFLMGSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNVGPLTACQYKLAVERYEWNKLQSVKSIVPMVHLSWNMARNIKVSDPKLFEMIKYCLLRTLKQCQTLREALIAAGKEIIWHGRTKEEPAHYCSICEVEVFDLLFVTNESNSRKTYIVHCQDCARKTSGNLENFVVLEQYKMEDLMQVYDQFTLAPP B: RKQLATKAARSAPATG |
Distance of aggregation | 10 Å |
Dynamic mode | No |
Mutated residues | SA1025G |
Energy difference between WT (input) and mutated protein (by FoldX) | 1.82028 kcal/mol
CAUTION: Your mutation/s can destabilize the protein structure Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive. |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
886 | S | A | 0.8751 | |
887 | V | A | 2.1721 | |
888 | S | A | 1.6166 | |
889 | I | A | 2.3424 | |
890 | Y | A | 1.1044 | |
891 | P | A | 0.0815 | |
892 | S | A | -0.9695 | |
893 | S | A | 0.0000 | |
894 | A | A | -1.3358 | |
895 | E | A | -1.8076 | |
896 | V | A | 0.0000 | |
897 | L | A | -1.4427 | |
898 | K | A | -2.0674 | |
899 | A | A | -1.2942 | |
900 | C | A | -1.4810 | |
901 | R | A | -2.7866 | |
902 | N | A | -2.0221 | |
903 | L | A | -0.3493 | |
904 | G | A | -1.3674 | |
905 | K | A | -2.5370 | |
906 | N | A | -2.2985 | |
907 | G | A | -1.2076 | |
908 | L | A | -0.2278 | |
909 | S | A | -1.2270 | |
910 | N | A | -1.6401 | |
911 | S | A | -0.3861 | |
912 | S | A | 0.1351 | |
913 | I | A | 0.9055 | |
914 | L | A | 0.5995 | |
915 | L | A | 0.5876 | |
916 | D | A | -1.7514 | |
917 | K | A | -1.8015 | |
918 | C | A | -0.5196 | |
919 | P | A | -0.6730 | |
920 | P | A | -1.0045 | |
921 | P | A | -1.5360 | |
922 | R | A | -2.2054 | |
923 | P | A | -1.3772 | |
924 | P | A | -0.8658 | |
925 | S | A | -0.6324 | |
926 | S | A | -0.1623 | |
927 | P | A | 0.2726 | |
928 | Y | A | 1.0004 | |
929 | P | A | 0.4515 | |
930 | P | A | -0.1935 | |
931 | L | A | -0.8294 | |
932 | P | A | -1.8680 | |
933 | K | A | -3.3328 | |
934 | D | A | -3.5771 | |
935 | K | A | -3.4278 | |
936 | L | A | 0.0000 | |
937 | N | A | -2.5327 | |
938 | P | A | -1.6100 | |
939 | P | A | -0.9165 | |
940 | T | A | -0.3948 | |
941 | P | A | -0.1591 | |
942 | S | A | 0.3568 | |
943 | I | A | 0.6618 | |
944 | Y | A | 0.7982 | |
945 | L | A | -1.0152 | |
946 | E | A | -2.5151 | |
947 | N | A | -2.7663 | |
948 | K | A | -2.5726 | |
949 | R | A | -2.1622 | |
950 | D | A | -1.2468 | |
951 | A | A | 0.0000 | |
952 | F | A | 1.2109 | |
953 | F | A | 1.4848 | |
954 | P | A | 0.6552 | |
955 | P | A | 0.0914 | |
956 | L | A | 0.0000 | |
957 | H | A | -0.5555 | |
958 | Q | A | -1.2551 | |
959 | F | A | -0.6358 | |
960 | C | A | 0.0000 | |
961 | T | A | -0.8166 | |
962 | N | A | -1.3274 | |
963 | P | A | -1.2885 | |
964 | N | A | -1.6486 | |
965 | N | A | -0.9405 | |
966 | P | A | 0.0000 | |
967 | V | A | 0.0000 | |
968 | T | A | 0.0000 | |
969 | V | A | 0.0000 | |
970 | I | A | 0.0000 | |
971 | R | A | -0.2733 | |
972 | G | A | -0.8847 | |
973 | L | A | 0.0000 | |
974 | A | A | 0.0000 | |
975 | G | A | -1.9127 | |
976 | A | A | 0.0000 | |
977 | L | A | 0.0000 | |
978 | K | A | -2.6591 | |
979 | L | A | 0.0000 | |
980 | D | A | -2.2139 | |
981 | L | A | -1.0497 | |
982 | G | A | -0.9761 | |
983 | L | A | -0.3775 | |
984 | F | A | 0.0000 | |
985 | S | A | -0.8297 | |
986 | T | A | -1.2197 | |
987 | K | A | -2.3550 | |
988 | T | A | -1.5445 | |
989 | L | A | 0.0000 | |
990 | V | A | -2.3136 | |
991 | E | A | -2.6511 | |
992 | A | A | -1.6896 | |
993 | N | A | -1.6778 | |
994 | N | A | -2.6910 | |
995 | E | A | -2.6330 | |
996 | H | A | -1.2595 | |
997 | M | A | -0.2756 | |
998 | V | A | 0.0000 | |
999 | E | A | 0.0000 | |
1000 | V | A | 0.0000 | |
1001 | R | A | 0.0000 | |
1002 | T | A | -1.1189 | |
1003 | Q | A | 0.0000 | |
1004 | L | A | -0.4791 | |
1005 | L | A | -0.1371 | |
1006 | Q | A | -0.2848 | |
1007 | P | A | -0.3584 | |
1008 | A | A | -0.1401 | |
1009 | D | A | -0.6286 | |
1010 | E | A | -0.9099 | |
1011 | N | A | 0.0000 | |
1012 | W | A | -0.7773 | |
1013 | D | A | -0.9784 | |
1014 | P | A | -0.8043 | |
1015 | T | A | -0.5184 | |
1016 | G | A | 0.0000 | |
1017 | T | A | -1.0089 | |
1018 | K | A | -1.8160 | |
1019 | K | A | -1.3320 | |
1020 | I | A | -0.5856 | |
1021 | W | A | 0.0000 | |
1022 | H | A | -1.0805 | |
1023 | C | A | 0.0000 | |
1024 | E | A | -1.3412 | |
1025 | G | A | 0.0000 | mutated: SA1025G |
1026 | N | A | -1.8464 | |
1027 | R | A | -2.5094 | |
1028 | S | A | -1.7814 | |
1029 | H | A | -1.3501 | |
1030 | T | A | -1.0576 | |
1031 | T | A | -1.3923 | |
1032 | I | A | 0.0000 | |
1033 | A | A | -2.2600 | |
1034 | K | A | -2.4215 | |
1035 | Y | A | 0.0000 | |
1036 | A | A | 0.0000 | |
1037 | Q | A | -1.6804 | |
1038 | Y | A | -0.6934 | |
1039 | Q | A | 0.0000 | |
1040 | A | A | -0.6894 | |
1041 | S | A | -0.7244 | |
1042 | S | A | -0.3965 | |
1043 | F | A | 0.2085 | |
1044 | Q | A | -1.4309 | |
1045 | E | A | -2.6304 | |
1046 | S | A | -1.8450 | |
1047 | L | A | -2.1709 | |
1048 | R | A | -4.3791 | |
1049 | E | A | -4.7162 | |
1050 | E | A | -4.4138 | |
1051 | N | A | -4.7181 | |
1052 | E | A | -4.9669 | |
1053 | K | A | -5.2484 | |
1054 | R | A | -4.4210 | |
1055 | S | A | -3.1041 | |
1056 | H | A | -2.9558 | |
1057 | H | A | -3.1908 | |
1058 | K | A | -3.8533 | |
1059 | D | A | -3.5558 | |
1060 | H | A | -2.6441 | |
1061 | S | A | -2.0136 | |
1062 | D | A | -2.5348 | |
1063 | S | A | -2.3049 | |
1064 | E | A | -2.8649 | |
1065 | S | A | -2.9048 | |
1066 | T | A | -2.4962 | |
1067 | S | A | -2.5014 | |
1068 | S | A | -3.9091 | |
1069 | D | A | -4.5874 | |
1070 | N | A | -4.1407 | |
1071 | S | A | -2.7559 | |
1072 | G | A | -2.2171 | |
1073 | R | A | -3.9698 | |
1074 | R | A | -4.4350 | |
1075 | R | A | -4.0838 | |
1076 | K | A | -3.2016 | |
1077 | G | A | 0.0000 | |
1078 | P | A | -1.2983 | |
1079 | F | A | -1.0652 | |
1080 | K | A | -1.5117 | |
1081 | T | A | -0.8047 | |
1082 | I | A | 0.0000 | |
1083 | K | A | -0.9943 | |
1084 | F | A | 0.0000 | |
1085 | G | A | 0.0000 | |
1086 | T | A | 0.0000 | |
1087 | N | A | 0.0000 | |
1088 | I | A | 0.0000 | |
1089 | D | A | -0.3109 | |
1090 | L | A | 0.0000 | |
1091 | S | A | -1.4899 | |
1092 | D | A | -2.7974 | |
1093 | D | A | -3.7119 | |
1094 | K | A | -3.4493 | |
1095 | K | A | -2.4877 | |
1096 | W | A | 0.0000 | |
1097 | K | A | -2.6881 | |
1098 | L | A | -0.2595 | |
1099 | Q | A | 0.0000 | |
1100 | L | A | -1.1077 | |
1101 | H | A | -1.1510 | |
1102 | E | A | 0.0000 | |
1103 | L | A | 0.0000 | |
1104 | T | A | -0.6237 | |
1105 | K | A | -1.4880 | |
1106 | L | A | 0.0000 | |
1107 | P | A | 0.0000 | |
1108 | A | A | 0.2148 | |
1109 | F | A | 0.1530 | |
1110 | V | A | 0.0000 | |
1111 | R | A | -0.0358 | |
1112 | V | A | 0.7824 | |
1113 | V | A | 1.5728 | |
1114 | S | A | 0.6299 | |
1115 | A | A | 0.0949 | |
1116 | G | A | -0.0044 | |
1117 | N | A | 0.0000 | |
1118 | L | A | 0.0000 | |
1119 | L | A | 0.0000 | |
1120 | S | A | 0.1623 | |
1121 | H | A | -0.4840 | |
1122 | V | A | 0.0000 | |
1123 | G | A | -1.4534 | |
1124 | H | A | -1.2935 | |
1125 | T | A | -0.5642 | |
1126 | I | A | 0.0000 | |
1127 | L | A | -0.1265 | |
1128 | G | A | -0.1872 | |
1129 | M | A | 0.0000 | |
1130 | N | A | 0.1074 | |
1131 | T | A | -0.1231 | |
1132 | V | A | 0.0000 | |
1133 | Q | A | 0.0000 | |
1134 | L | A | 0.0000 | |
1135 | Y | A | 0.1532 | |
1136 | M | A | 0.0000 | |
1137 | K | A | 0.0000 | |
1138 | V | A | 0.0000 | |
1139 | P | A | 0.4295 | |
1140 | G | A | 0.2227 | |
1141 | S | A | 0.0000 | |
1142 | R | A | 0.0000 | |
1143 | T | A | -0.0494 | |
1144 | P | A | 0.0000 | |
1145 | G | A | 0.0000 | |
1146 | H | A | -0.1834 | |
1147 | Q | A | -0.5093 | |
1148 | E | A | -0.5960 | |
1149 | N | A | -0.8570 | |
1150 | N | A | 0.0000 | |
1151 | N | A | 0.0000 | |
1152 | F | A | 0.0000 | |
1153 | C | A | 0.0000 | |
1154 | S | A | -0.1443 | |
1155 | V | A | 0.0000 | |
1156 | N | A | 0.0000 | |
1157 | I | A | 0.0000 | |
1158 | N | A | 0.0000 | |
1159 | I | A | 0.0000 | |
1160 | G | A | 0.0000 | |
1161 | P | A | -0.5982 | |
1162 | G | A | -0.4854 | |
1163 | D | A | -0.6188 | |
1164 | C | A | 0.0000 | |
1165 | E | A | 0.0000 | |
1166 | W | A | 0.0000 | |
1167 | F | A | 0.0000 | |
1168 | V | A | 0.0000 | |
1169 | V | A | 0.0000 | |
1170 | P | A | -0.6055 | |
1171 | E | A | -0.9025 | |
1172 | G | A | -0.4152 | |
1173 | Y | A | 0.0000 | |
1174 | W | A | 0.0000 | |
1175 | G | A | 0.0000 | |
1176 | V | A | -0.6335 | |
1177 | L | A | 0.0000 | |
1178 | N | A | -1.7741 | |
1179 | D | A | -3.1269 | |
1180 | F | A | -2.2915 | |
1181 | C | A | 0.0000 | |
1182 | E | A | -4.0640 | |
1183 | K | A | -3.7098 | |
1184 | N | A | -2.8024 | |
1185 | N | A | -3.0627 | |
1186 | L | A | -2.1556 | |
1187 | N | A | -1.8269 | |
1188 | F | A | 0.0000 | |
1189 | L | A | 0.2580 | |
1190 | M | A | 0.8573 | |
1191 | G | A | -0.1303 | |
1192 | S | A | 0.0000 | |
1193 | W | A | 0.0000 | |
1194 | W | A | 0.0000 | |
1195 | P | A | 0.0000 | |
1196 | N | A | -1.0619 | |
1197 | L | A | 0.0000 | |
1198 | E | A | -2.6171 | |
1199 | D | A | -2.0004 | |
1200 | L | A | 0.0000 | |
1201 | Y | A | -1.9364 | |
1202 | E | A | -2.6154 | |
1203 | A | A | -1.4311 | |
1204 | N | A | -1.8074 | |
1205 | V | A | 0.0000 | |
1206 | P | A | 0.0000 | |
1207 | V | A | 0.0000 | |
1208 | Y | A | -0.7692 | |
1209 | R | A | -0.9847 | |
1210 | F | A | 0.0000 | |
1211 | I | A | 0.4173 | |
1212 | Q | A | 0.0000 | |
1213 | R | A | -1.3329 | |
1214 | P | A | -0.9472 | |
1215 | G | A | 0.0000 | |
1216 | D | A | 0.0000 | |
1217 | L | A | 0.0000 | |
1218 | V | A | 0.0000 | |
1219 | W | A | 0.0000 | |
1220 | I | A | 0.0000 | |
1221 | N | A | 0.0000 | |
1222 | A | A | 0.0000 | |
1223 | G | A | 0.0000 | |
1224 | T | A | 0.0000 | |
1225 | V | A | 0.0000 | |
1226 | H | A | 0.0000 | |
1227 | W | A | 0.0000 | |
1228 | V | A | 0.0000 | |
1229 | Q | A | 0.0000 | |
1230 | A | A | 0.0000 | |
1231 | I | A | 1.0120 | |
1232 | G | A | 0.3623 | |
1233 | W | A | 0.4714 | |
1234 | C | A | 0.0000 | |
1235 | N | A | 0.0000 | |
1236 | N | A | 0.0000 | |
1237 | I | A | 0.0000 | |
1238 | A | A | 0.0000 | |
1239 | W | A | 0.0000 | |
1240 | N | A | 0.0000 | |
1241 | V | A | 0.0000 | |
1242 | G | A | 0.0000 | |
1243 | P | A | 0.0000 | |
1244 | L | A | 0.4615 | |
1245 | T | A | -0.2178 | |
1246 | A | A | -0.7781 | |
1247 | C | A | -0.3647 | |
1248 | Q | A | 0.0000 | |
1249 | Y | A | 0.0000 | |
1250 | K | A | -1.5484 | |
1251 | L | A | 0.0000 | |
1252 | A | A | 0.0000 | |
1253 | V | A | -1.1626 | |
1254 | E | A | -2.5152 | |
1255 | R | A | 0.0000 | |
1256 | Y | A | 0.0000 | |
1257 | E | A | -1.6997 | |
1258 | W | A | 0.0000 | |
1259 | N | A | 0.0000 | |
1260 | K | A | -1.1768 | |
1261 | L | A | 0.0411 | |
1262 | Q | A | -0.4995 | |
1263 | S | A | -0.5760 | |
1264 | V | A | -0.4125 | |
1265 | K | A | -1.0927 | |
1266 | S | A | 0.0000 | |
1267 | I | A | 0.0000 | |
1268 | V | A | 0.0000 | |
1269 | P | A | 0.0000 | |
1270 | M | A | 0.0000 | |
1271 | V | A | 0.1809 | |
1272 | H | A | -0.1017 | |
1273 | L | A | 0.0000 | |
1274 | S | A | 0.0000 | |
1275 | W | A | 0.0000 | |
1276 | N | A | -0.8570 | |
1277 | M | A | 0.0000 | |
1278 | A | A | 0.0000 | |
1279 | R | A | -1.9618 | |
1280 | N | A | -1.8520 | |
1281 | I | A | -1.4464 | |
1282 | K | A | -2.0286 | |
1283 | V | A | 0.0000 | |
1284 | S | A | -1.2333 | |
1285 | D | A | -1.9219 | |
1286 | P | A | -1.6562 | |
1287 | K | A | -2.3679 | |
1288 | L | A | 0.0000 | |
1289 | F | A | -1.1185 | |
1290 | E | A | -0.9365 | |
1291 | M | A | -0.6499 | |
1292 | I | A | 0.0000 | |
1293 | K | A | 0.0000 | |
1294 | Y | A | 0.4798 | |
1295 | C | A | 0.0000 | |
1296 | L | A | 0.0000 | |
1297 | L | A | 0.0000 | |
1298 | R | A | -1.1383 | |
1299 | T | A | -0.6907 | |
1300 | L | A | 0.0000 | |
1301 | K | A | -1.1394 | |
1302 | Q | A | -1.8346 | |
1303 | C | A | 0.0000 | |
1304 | Q | A | 0.0000 | |
1305 | T | A | -1.2225 | |
1306 | L | A | -0.5938 | |
1307 | R | A | -0.8719 | |
1308 | E | A | -1.0421 | |
1309 | A | A | -0.2680 | |
1310 | L | A | 0.0000 | |
1311 | I | A | 0.8072 | |
1312 | A | A | 0.2719 | |
1313 | A | A | -0.1934 | |
1314 | G | A | -0.3914 | |
1315 | K | A | -0.9195 | |
1316 | E | A | -1.0619 | |
1317 | I | A | 0.4172 | |
1318 | I | A | 1.4134 | |
1319 | W | A | 0.7264 | |
1320 | H | A | 0.0000 | |
1321 | G | A | -0.6016 | |
1322 | R | A | -1.6566 | |
1323 | T | A | -1.9480 | |
1324 | K | A | -3.0044 | |
1325 | E | A | -3.1315 | |
1326 | E | A | -2.0988 | |
1327 | P | A | -1.3655 | |
1328 | A | A | 0.0000 | |
1329 | H | A | 0.0000 | |
1330 | Y | A | -0.1603 | |
1331 | C | A | 0.0000 | |
1332 | S | A | 0.1445 | |
1333 | I | A | 1.0806 | |
1334 | C | A | -0.1602 | |
1335 | E | A | -0.6657 | |
1336 | V | A | -0.2727 | |
1337 | E | A | -0.3333 | |
1338 | V | A | 0.0000 | |
1339 | F | A | 0.1317 | |
1340 | D | A | 0.0000 | |
1341 | L | A | 0.0000 | |
1342 | L | A | 0.0000 | |
1343 | F | A | 0.0000 | |
1344 | V | A | 0.0000 | |
1345 | T | A | -0.8888 | |
1346 | N | A | -1.9889 | |
1347 | E | A | -1.9349 | |
1348 | S | A | -1.5620 | |
1349 | N | A | -2.2635 | |
1350 | S | A | -2.5073 | |
1351 | R | A | -3.2642 | |
1352 | K | A | -3.4695 | |
1353 | T | A | -2.1776 | |
1354 | Y | A | -1.1908 | |
1355 | I | A | -0.0116 | |
1356 | V | A | 0.0000 | |
1357 | H | A | 0.0000 | |
1358 | C | A | 0.0000 | |
1359 | Q | A | -1.8888 | |
1360 | D | A | -3.0048 | |
1361 | C | A | 0.0000 | |
1362 | A | A | 0.0000 | |
1363 | R | A | -3.9785 | |
1364 | K | A | -3.3555 | |
1365 | T | A | -2.3394 | |
1366 | S | A | -2.5923 | |
1367 | G | A | -2.7670 | |
1368 | N | A | -2.9104 | |
1369 | L | A | 0.0000 | |
1370 | E | A | -3.1126 | |
1371 | N | A | -2.3028 | |
1372 | F | A | 0.0000 | |
1373 | V | A | -0.2303 | |
1374 | V | A | 0.0000 | |
1375 | L | A | 0.0000 | |
1376 | E | A | 0.0000 | |
1377 | Q | A | 0.0000 | |
1378 | Y | A | 0.0000 | |
1379 | K | A | -2.0722 | |
1380 | M | A | 0.0000 | |
1381 | E | A | -2.7923 | |
1382 | D | A | -2.4222 | |
1383 | L | A | 0.0000 | |
1384 | M | A | -1.8662 | |
1385 | Q | A | -2.7176 | |
1386 | V | A | -1.9475 | |
1387 | Y | A | 0.0000 | |
1388 | D | A | -2.1574 | |
1389 | Q | A | -2.1066 | |
1390 | F | A | 0.0000 | |
1391 | T | A | -0.7541 | |
1392 | L | A | -0.2701 | |
1393 | A | A | -0.5656 | |
1394 | P | A | -0.5970 | |
17 | R | B | -2.4746 | |
18 | K | B | -2.4933 | |
19 | Q | B | -2.1724 | |
20 | L | B | -0.9795 | |
21 | A | B | -0.8233 | |
22 | T | B | -0.9230 | |
23 | K | B | -1.7684 | |
24 | A | B | -0.8863 | |
25 | A | B | -0.6971 | |
26 | R | B | -0.7170 | |
28 | S | B | -0.3685 | |
29 | A | B | -0.2208 | |
30 | P | B | -0.2679 | |
31 | A | B | -0.8296 | |
32 | T | B | -0.9580 |