Project name: a0846f970e9da4 [mutate: SA1025G]

Status: done

submitted: 2019-12-03 17:50:43, status changed: 2019-12-26 13:50:43
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Chain sequence(s) A: SVSIYPSSAEVLKACRNLGKNGLSNSSILLDKCPPPRPPSSPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFCTNPNNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWHCESNRSHTTIAKYAQYQASSFQESLREENEKRSHHKDHSDSESTSSDNSGRRRKGPFKTIKFGTNIDLSDDKKWKLQLHELTKLPAFVRVVSAGNLLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFCEKNNLNFLMGSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNVGPLTACQYKLAVERYEWNKLQSVKSIVPMVHLSWNMARNIKVSDPKLFEMIKYCLLRTLKQCQTLREALIAAGKEIIWHGRTKEEPAHYCSICEVEVFDLLFVTNESNSRKTYIVHCQDCARKTSGNLENFVVLEQYKMEDLMQVYDQFTLAPP
B: RKQLATKAARSAPATG
Distance of aggregation 10 Å
Dynamic mode No
Mutated residues SA1025G
Energy difference between WT (input) and mutated protein (by FoldX) 1.82028 kcal/mol

CAUTION: Your mutation/s can destabilize the protein structure

Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive.

Show buried residues

Minimal score value
-5.2484
Maximal score value
2.3424
Average score
-0.8526
Total score value
-446.74

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
886 S A 0.8751
887 V A 2.1721
888 S A 1.6166
889 I A 2.3424
890 Y A 1.1044
891 P A 0.0815
892 S A -0.9695
893 S A 0.0000
894 A A -1.3358
895 E A -1.8076
896 V A 0.0000
897 L A -1.4427
898 K A -2.0674
899 A A -1.2942
900 C A -1.4810
901 R A -2.7866
902 N A -2.0221
903 L A -0.3493
904 G A -1.3674
905 K A -2.5370
906 N A -2.2985
907 G A -1.2076
908 L A -0.2278
909 S A -1.2270
910 N A -1.6401
911 S A -0.3861
912 S A 0.1351
913 I A 0.9055
914 L A 0.5995
915 L A 0.5876
916 D A -1.7514
917 K A -1.8015
918 C A -0.5196
919 P A -0.6730
920 P A -1.0045
921 P A -1.5360
922 R A -2.2054
923 P A -1.3772
924 P A -0.8658
925 S A -0.6324
926 S A -0.1623
927 P A 0.2726
928 Y A 1.0004
929 P A 0.4515
930 P A -0.1935
931 L A -0.8294
932 P A -1.8680
933 K A -3.3328
934 D A -3.5771
935 K A -3.4278
936 L A 0.0000
937 N A -2.5327
938 P A -1.6100
939 P A -0.9165
940 T A -0.3948
941 P A -0.1591
942 S A 0.3568
943 I A 0.6618
944 Y A 0.7982
945 L A -1.0152
946 E A -2.5151
947 N A -2.7663
948 K A -2.5726
949 R A -2.1622
950 D A -1.2468
951 A A 0.0000
952 F A 1.2109
953 F A 1.4848
954 P A 0.6552
955 P A 0.0914
956 L A 0.0000
957 H A -0.5555
958 Q A -1.2551
959 F A -0.6358
960 C A 0.0000
961 T A -0.8166
962 N A -1.3274
963 P A -1.2885
964 N A -1.6486
965 N A -0.9405
966 P A 0.0000
967 V A 0.0000
968 T A 0.0000
969 V A 0.0000
970 I A 0.0000
971 R A -0.2733
972 G A -0.8847
973 L A 0.0000
974 A A 0.0000
975 G A -1.9127
976 A A 0.0000
977 L A 0.0000
978 K A -2.6591
979 L A 0.0000
980 D A -2.2139
981 L A -1.0497
982 G A -0.9761
983 L A -0.3775
984 F A 0.0000
985 S A -0.8297
986 T A -1.2197
987 K A -2.3550
988 T A -1.5445
989 L A 0.0000
990 V A -2.3136
991 E A -2.6511
992 A A -1.6896
993 N A -1.6778
994 N A -2.6910
995 E A -2.6330
996 H A -1.2595
997 M A -0.2756
998 V A 0.0000
999 E A 0.0000
1000 V A 0.0000
1001 R A 0.0000
1002 T A -1.1189
1003 Q A 0.0000
1004 L A -0.4791
1005 L A -0.1371
1006 Q A -0.2848
1007 P A -0.3584
1008 A A -0.1401
1009 D A -0.6286
1010 E A -0.9099
1011 N A 0.0000
1012 W A -0.7773
1013 D A -0.9784
1014 P A -0.8043
1015 T A -0.5184
1016 G A 0.0000
1017 T A -1.0089
1018 K A -1.8160
1019 K A -1.3320
1020 I A -0.5856
1021 W A 0.0000
1022 H A -1.0805
1023 C A 0.0000
1024 E A -1.3412
1025 G A 0.0000 mutated: SA1025G
1026 N A -1.8464
1027 R A -2.5094
1028 S A -1.7814
1029 H A -1.3501
1030 T A -1.0576
1031 T A -1.3923
1032 I A 0.0000
1033 A A -2.2600
1034 K A -2.4215
1035 Y A 0.0000
1036 A A 0.0000
1037 Q A -1.6804
1038 Y A -0.6934
1039 Q A 0.0000
1040 A A -0.6894
1041 S A -0.7244
1042 S A -0.3965
1043 F A 0.2085
1044 Q A -1.4309
1045 E A -2.6304
1046 S A -1.8450
1047 L A -2.1709
1048 R A -4.3791
1049 E A -4.7162
1050 E A -4.4138
1051 N A -4.7181
1052 E A -4.9669
1053 K A -5.2484
1054 R A -4.4210
1055 S A -3.1041
1056 H A -2.9558
1057 H A -3.1908
1058 K A -3.8533
1059 D A -3.5558
1060 H A -2.6441
1061 S A -2.0136
1062 D A -2.5348
1063 S A -2.3049
1064 E A -2.8649
1065 S A -2.9048
1066 T A -2.4962
1067 S A -2.5014
1068 S A -3.9091
1069 D A -4.5874
1070 N A -4.1407
1071 S A -2.7559
1072 G A -2.2171
1073 R A -3.9698
1074 R A -4.4350
1075 R A -4.0838
1076 K A -3.2016
1077 G A 0.0000
1078 P A -1.2983
1079 F A -1.0652
1080 K A -1.5117
1081 T A -0.8047
1082 I A 0.0000
1083 K A -0.9943
1084 F A 0.0000
1085 G A 0.0000
1086 T A 0.0000
1087 N A 0.0000
1088 I A 0.0000
1089 D A -0.3109
1090 L A 0.0000
1091 S A -1.4899
1092 D A -2.7974
1093 D A -3.7119
1094 K A -3.4493
1095 K A -2.4877
1096 W A 0.0000
1097 K A -2.6881
1098 L A -0.2595
1099 Q A 0.0000
1100 L A -1.1077
1101 H A -1.1510
1102 E A 0.0000
1103 L A 0.0000
1104 T A -0.6237
1105 K A -1.4880
1106 L A 0.0000
1107 P A 0.0000
1108 A A 0.2148
1109 F A 0.1530
1110 V A 0.0000
1111 R A -0.0358
1112 V A 0.7824
1113 V A 1.5728
1114 S A 0.6299
1115 A A 0.0949
1116 G A -0.0044
1117 N A 0.0000
1118 L A 0.0000
1119 L A 0.0000
1120 S A 0.1623
1121 H A -0.4840
1122 V A 0.0000
1123 G A -1.4534
1124 H A -1.2935
1125 T A -0.5642
1126 I A 0.0000
1127 L A -0.1265
1128 G A -0.1872
1129 M A 0.0000
1130 N A 0.1074
1131 T A -0.1231
1132 V A 0.0000
1133 Q A 0.0000
1134 L A 0.0000
1135 Y A 0.1532
1136 M A 0.0000
1137 K A 0.0000
1138 V A 0.0000
1139 P A 0.4295
1140 G A 0.2227
1141 S A 0.0000
1142 R A 0.0000
1143 T A -0.0494
1144 P A 0.0000
1145 G A 0.0000
1146 H A -0.1834
1147 Q A -0.5093
1148 E A -0.5960
1149 N A -0.8570
1150 N A 0.0000
1151 N A 0.0000
1152 F A 0.0000
1153 C A 0.0000
1154 S A -0.1443
1155 V A 0.0000
1156 N A 0.0000
1157 I A 0.0000
1158 N A 0.0000
1159 I A 0.0000
1160 G A 0.0000
1161 P A -0.5982
1162 G A -0.4854
1163 D A -0.6188
1164 C A 0.0000
1165 E A 0.0000
1166 W A 0.0000
1167 F A 0.0000
1168 V A 0.0000
1169 V A 0.0000
1170 P A -0.6055
1171 E A -0.9025
1172 G A -0.4152
1173 Y A 0.0000
1174 W A 0.0000
1175 G A 0.0000
1176 V A -0.6335
1177 L A 0.0000
1178 N A -1.7741
1179 D A -3.1269
1180 F A -2.2915
1181 C A 0.0000
1182 E A -4.0640
1183 K A -3.7098
1184 N A -2.8024
1185 N A -3.0627
1186 L A -2.1556
1187 N A -1.8269
1188 F A 0.0000
1189 L A 0.2580
1190 M A 0.8573
1191 G A -0.1303
1192 S A 0.0000
1193 W A 0.0000
1194 W A 0.0000
1195 P A 0.0000
1196 N A -1.0619
1197 L A 0.0000
1198 E A -2.6171
1199 D A -2.0004
1200 L A 0.0000
1201 Y A -1.9364
1202 E A -2.6154
1203 A A -1.4311
1204 N A -1.8074
1205 V A 0.0000
1206 P A 0.0000
1207 V A 0.0000
1208 Y A -0.7692
1209 R A -0.9847
1210 F A 0.0000
1211 I A 0.4173
1212 Q A 0.0000
1213 R A -1.3329
1214 P A -0.9472
1215 G A 0.0000
1216 D A 0.0000
1217 L A 0.0000
1218 V A 0.0000
1219 W A 0.0000
1220 I A 0.0000
1221 N A 0.0000
1222 A A 0.0000
1223 G A 0.0000
1224 T A 0.0000
1225 V A 0.0000
1226 H A 0.0000
1227 W A 0.0000
1228 V A 0.0000
1229 Q A 0.0000
1230 A A 0.0000
1231 I A 1.0120
1232 G A 0.3623
1233 W A 0.4714
1234 C A 0.0000
1235 N A 0.0000
1236 N A 0.0000
1237 I A 0.0000
1238 A A 0.0000
1239 W A 0.0000
1240 N A 0.0000
1241 V A 0.0000
1242 G A 0.0000
1243 P A 0.0000
1244 L A 0.4615
1245 T A -0.2178
1246 A A -0.7781
1247 C A -0.3647
1248 Q A 0.0000
1249 Y A 0.0000
1250 K A -1.5484
1251 L A 0.0000
1252 A A 0.0000
1253 V A -1.1626
1254 E A -2.5152
1255 R A 0.0000
1256 Y A 0.0000
1257 E A -1.6997
1258 W A 0.0000
1259 N A 0.0000
1260 K A -1.1768
1261 L A 0.0411
1262 Q A -0.4995
1263 S A -0.5760
1264 V A -0.4125
1265 K A -1.0927
1266 S A 0.0000
1267 I A 0.0000
1268 V A 0.0000
1269 P A 0.0000
1270 M A 0.0000
1271 V A 0.1809
1272 H A -0.1017
1273 L A 0.0000
1274 S A 0.0000
1275 W A 0.0000
1276 N A -0.8570
1277 M A 0.0000
1278 A A 0.0000
1279 R A -1.9618
1280 N A -1.8520
1281 I A -1.4464
1282 K A -2.0286
1283 V A 0.0000
1284 S A -1.2333
1285 D A -1.9219
1286 P A -1.6562
1287 K A -2.3679
1288 L A 0.0000
1289 F A -1.1185
1290 E A -0.9365
1291 M A -0.6499
1292 I A 0.0000
1293 K A 0.0000
1294 Y A 0.4798
1295 C A 0.0000
1296 L A 0.0000
1297 L A 0.0000
1298 R A -1.1383
1299 T A -0.6907
1300 L A 0.0000
1301 K A -1.1394
1302 Q A -1.8346
1303 C A 0.0000
1304 Q A 0.0000
1305 T A -1.2225
1306 L A -0.5938
1307 R A -0.8719
1308 E A -1.0421
1309 A A -0.2680
1310 L A 0.0000
1311 I A 0.8072
1312 A A 0.2719
1313 A A -0.1934
1314 G A -0.3914
1315 K A -0.9195
1316 E A -1.0619
1317 I A 0.4172
1318 I A 1.4134
1319 W A 0.7264
1320 H A 0.0000
1321 G A -0.6016
1322 R A -1.6566
1323 T A -1.9480
1324 K A -3.0044
1325 E A -3.1315
1326 E A -2.0988
1327 P A -1.3655
1328 A A 0.0000
1329 H A 0.0000
1330 Y A -0.1603
1331 C A 0.0000
1332 S A 0.1445
1333 I A 1.0806
1334 C A -0.1602
1335 E A -0.6657
1336 V A -0.2727
1337 E A -0.3333
1338 V A 0.0000
1339 F A 0.1317
1340 D A 0.0000
1341 L A 0.0000
1342 L A 0.0000
1343 F A 0.0000
1344 V A 0.0000
1345 T A -0.8888
1346 N A -1.9889
1347 E A -1.9349
1348 S A -1.5620
1349 N A -2.2635
1350 S A -2.5073
1351 R A -3.2642
1352 K A -3.4695
1353 T A -2.1776
1354 Y A -1.1908
1355 I A -0.0116
1356 V A 0.0000
1357 H A 0.0000
1358 C A 0.0000
1359 Q A -1.8888
1360 D A -3.0048
1361 C A 0.0000
1362 A A 0.0000
1363 R A -3.9785
1364 K A -3.3555
1365 T A -2.3394
1366 S A -2.5923
1367 G A -2.7670
1368 N A -2.9104
1369 L A 0.0000
1370 E A -3.1126
1371 N A -2.3028
1372 F A 0.0000
1373 V A -0.2303
1374 V A 0.0000
1375 L A 0.0000
1376 E A 0.0000
1377 Q A 0.0000
1378 Y A 0.0000
1379 K A -2.0722
1380 M A 0.0000
1381 E A -2.7923
1382 D A -2.4222
1383 L A 0.0000
1384 M A -1.8662
1385 Q A -2.7176
1386 V A -1.9475
1387 Y A 0.0000
1388 D A -2.1574
1389 Q A -2.1066
1390 F A 0.0000
1391 T A -0.7541
1392 L A -0.2701
1393 A A -0.5656
1394 P A -0.5970
17 R B -2.4746
18 K B -2.4933
19 Q B -2.1724
20 L B -0.9795
21 A B -0.8233
22 T B -0.9230
23 K B -1.7684
24 A B -0.8863
25 A B -0.6971
26 R B -0.7170
28 S B -0.3685
29 A B -0.2208
30 P B -0.2679
31 A B -0.8296
32 T B -0.9580

 

Laboratory of Theory of Biopolymers 2015