Project name: w00t!

Chain sequence(s)	A: MEEKIDRKDFFSVELENGQVEPESSPIYRNPSYSKGELSNLQGLNANNLWELFVNSVNKYKNKKCLGTRKLNRDGTYGEYVFKSYEELKEEALNIGINILKMDLCPIRKYEDNEYQKEISMMGILSRNREEWYLTEHACNAFGICLAPLYDTLGEDNLKFILVQTQLKSLCISNDSLEKIISIIERSIIDSTRDSILIKNLICFDHPTTEINQRAKNLDINLILFKNLQEKVSKKDKEIYKPKKIKPDDMCSIHFTSGTTGYPKGAILTHRCFLACVKSSYEHLFSEKEIQLDNEDAHLSYLPMAHIFERLIVMNAYYLGIPIGIFSGSVTRLMSDSQELKPTILVCVPQVLTRIIQTVNDKISQSNFLVRTVFHKALKQKESIIKTKGDPTHWLWDRIIFSNTRQILGGKLKAIISGAAPLGLEVNHKIQAIFCCKLIEGFGMSECIGTLGTRYSYAHLGTVGGPFSDVEVKLTSVLEMGYDSTKEPRRGLLKIRGNSVCKGYFRDIINSKELIDSNGWLDTGDIAERQQDGSFKIIDRKKSLFKLSQGEYISPERIEGIYLSSSSLIQHVYVYGQSTDRFLVALIFPNEQALRKWSEDKGMNTLSLSLEELCESHELFDELNDSFHKAELSSNLFGFERIHKFKVIPEVLSTSNGLLTPTMKIVRNKVNSKYKEVLNTLRSQI
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.9921
• Maximal score value: 2.0073
• Average score: -0.6245
• Total score value: -427.7974

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	0.0000
2	E	A	-2.9135
3	E	A	-2.4133
4	K	A	-2.8928
5	I	A	0.0000
6	D	A	0.0000
7	R	A	-2.7489
8	K	A	-2.1602
9	D	A	-1.2061
10	F	A	1.1875
11	F	A	1.2848
12	S	A	0.6844
13	V	A	0.4004
14	E	A	-1.5354
15	L	A	-1.2726
16	E	A	-2.7519
17	N	A	-2.8018
18	G	A	-2.3097
19	Q	A	-2.2818
20	V	A	-1.7640
21	E	A	-2.8240
22	P	A	-2.2100
23	E	A	-2.1936
24	S	A	-1.3204
25	S	A	-1.1366
26	P	A	0.0000
27	I	A	0.0000
28	Y	A	-0.5552
29	R	A	-1.5200
30	N	A	-1.4298
31	P	A	-0.5084
32	S	A	-0.6603
33	Y	A	-0.1850
34	S	A	0.0000
35	K	A	-1.4697
36	G	A	-1.1297
37	E	A	-2.0710
38	L	A	-1.2255
39	S	A	0.0000
40	N	A	-1.0777
41	L	A	-0.7321
42	Q	A	0.0000
43	G	A	-0.5568
44	L	A	0.0000
45	N	A	-0.1908
46	A	A	-0.5735
47	N	A	-0.8660
48	N	A	0.0000
49	L	A	0.0000
50	W	A	0.0000
51	E	A	-0.5234
52	L	A	0.0000
53	F	A	0.0000
54	V	A	-0.4613
55	N	A	0.0000
56	S	A	0.0000
57	V	A	0.0000
58	N	A	-2.2933
59	K	A	-2.6467
60	Y	A	-2.6381
61	K	A	-3.6497
62	N	A	-3.8475
63	K	A	-3.0226
64	K	A	-2.3563
65	C	A	0.0000
66	L	A	0.0000
67	G	A	0.0000
68	T	A	0.0000
69	R	A	0.0000
70	K	A	-1.0108
71	L	A	0.0000
72	N	A	-2.0979
73	R	A	-2.8145
74	D	A	-2.7964
75	G	A	-1.4568
76	T	A	-1.1106
77	Y	A	0.4064
78	G	A	-0.4187
79	E	A	-1.4141
80	Y	A	0.2683
81	V	A	0.9381
82	F	A	1.2871
83	K	A	-0.3992
84	S	A	-2.1350
85	Y	A	0.0000
86	E	A	-3.9921
87	E	A	-2.6978
88	L	A	0.0000
89	K	A	-2.1272
90	E	A	-2.7734
91	E	A	-2.1023
92	A	A	0.0000
93	L	A	0.0000
94	N	A	0.0000
95	I	A	0.0000
96	G	A	0.0000
97	I	A	-0.9185
98	N	A	0.0000
99	I	A	0.0000
100	L	A	-0.7746
101	K	A	-2.0041
102	M	A	-1.5927
103	D	A	-2.2788
104	L	A	0.0000
105	C	A	-0.5088
106	P	A	0.0000
107	I	A	0.1884
108	R	A	-2.0591
109	K	A	-2.4203
110	Y	A	-1.2301
111	E	A	-2.8928
112	D	A	-3.7571
113	N	A	-3.0302
114	E	A	-2.7088
115	Y	A	-1.5977
116	Q	A	-1.4212
117	K	A	-1.2722
118	E	A	0.0000
119	I	A	-0.0911
120	S	A	0.0000
121	M	A	0.0000
122	M	A	0.0000
123	G	A	0.0000
124	I	A	0.0000
125	L	A	0.0000
126	S	A	0.0000
127	R	A	-1.3802
128	N	A	-0.8372
129	R	A	0.0000
130	E	A	0.0000
131	E	A	-0.4964
132	W	A	0.0000
133	Y	A	0.0000
134	L	A	0.0000
135	T	A	0.0000
136	E	A	0.0000
137	H	A	0.0000
138	A	A	0.0000
139	C	A	0.0000
140	N	A	0.0000
141	A	A	-0.3906
142	F	A	0.0000
143	G	A	0.0000
144	I	A	0.0000
145	C	A	0.0000
146	L	A	0.0000
147	A	A	0.0000
148	P	A	0.0000
149	L	A	0.0000
150	Y	A	-0.0517
151	D	A	-0.3597
152	T	A	-0.6002
153	L	A	-0.5136
154	G	A	-1.1672
155	E	A	-1.9017
156	D	A	-1.6743
157	N	A	-0.8855
158	L	A	0.0000
159	K	A	-0.5386
160	F	A	1.1706
161	I	A	0.0000
162	L	A	0.0000
163	V	A	0.1868
164	Q	A	-0.4742
165	T	A	0.0000
166	Q	A	0.0574
167	L	A	0.0000
168	K	A	0.0000
169	S	A	0.0000
170	L	A	0.0000
171	C	A	0.0000
172	I	A	0.0000
173	S	A	0.0000
174	N	A	-1.8383
175	D	A	-2.6531
176	S	A	-1.7782
177	L	A	0.0000
178	E	A	-1.6154
179	K	A	-1.9399
180	I	A	-1.1112
181	I	A	0.0000
182	S	A	-0.6485
183	I	A	-0.2576
184	I	A	0.0000
185	E	A	-1.2208
186	R	A	-1.7876
187	S	A	-1.1220
188	I	A	-0.1711
189	I	A	0.0000
190	D	A	0.0000
191	S	A	0.0000
192	T	A	-1.5705
193	R	A	-2.5123
194	D	A	-2.3935
195	S	A	-0.2535
196	I	A	0.9708
197	L	A	0.8979
198	I	A	-0.1784
199	K	A	-1.3003
200	N	A	0.0000
201	L	A	0.0000
202	I	A	0.0000
203	C	A	0.0000
204	F	A	0.0000
205	D	A	0.0000
206	H	A	-1.4232
207	P	A	-0.8831
208	T	A	-0.4528
209	T	A	0.0000
210	E	A	-1.0551
211	I	A	0.3824
212	N	A	-1.5436
213	Q	A	-2.4462
214	R	A	-2.5887
215	A	A	-1.7971
216	K	A	-2.5904
217	N	A	0.0000
218	L	A	-0.8855
219	D	A	-0.3375
220	I	A	0.7307
221	N	A	-0.3691
222	L	A	0.0000
223	I	A	0.6339
224	L	A	0.0000
225	F	A	0.0000
226	K	A	-0.9303
227	N	A	-1.1713
228	L	A	0.0000
229	Q	A	0.0000
230	E	A	-3.1096
231	K	A	-3.0804
232	V	A	0.0000
233	S	A	-2.8863
234	K	A	-3.5747
235	K	A	-3.1435
236	D	A	0.0000
237	K	A	-2.8150
238	E	A	-2.2492
239	I	A	0.1944
240	Y	A	0.5619
241	K	A	-0.4697
242	P	A	0.0000
243	K	A	-1.5289
244	K	A	-2.5057
245	I	A	0.0000
246	K	A	-2.6199
247	P	A	-1.8808
248	D	A	-2.1605
249	D	A	-1.6359
250	M	A	-0.7683
251	C	A	0.0000
252	S	A	0.0000
253	I	A	0.0000
254	H	A	0.0000
255	F	A	0.0000
256	T	A	-0.1386
257	S	A	-0.2020
258	G	A	-0.5386
259	T	A	-0.7754
260	T	A	-0.9168
261	G	A	-0.6108
262	Y	A	0.2738
263	P	A	-0.2685
264	K	A	-0.7078
265	G	A	0.0000
266	A	A	0.0000
267	I	A	-0.4776
268	L	A	0.0000
269	T	A	0.0000
270	H	A	0.0000
271	R	A	-0.9130
272	C	A	0.0000
273	F	A	0.0000
274	L	A	0.0000
275	A	A	0.0000
276	C	A	0.0000
277	V	A	0.0000
278	K	A	0.0000
279	S	A	0.0000
280	S	A	0.0000
281	Y	A	0.0000
282	E	A	-1.6874
283	H	A	0.0000
284	L	A	-1.1176
285	F	A	0.0000
286	S	A	-2.3669
287	E	A	-3.1098
288	K	A	-3.2608
289	E	A	-3.1779
290	I	A	-2.1278
291	Q	A	-1.9245
292	L	A	0.0000
293	D	A	-1.4813
294	N	A	-1.8312
295	E	A	-2.2214
296	D	A	0.0000
297	A	A	-0.8542
298	H	A	0.0000
299	L	A	0.0000
300	S	A	0.0000
301	Y	A	0.0000
302	L	A	0.0000
303	P	A	-0.2812
304	M	A	0.0000
305	A	A	0.0000
306	H	A	0.0000
307	I	A	0.3169
308	F	A	0.3786
309	E	A	0.0000
310	R	A	0.0000
311	L	A	0.2668
312	I	A	0.0000
313	V	A	0.0000
314	M	A	0.0000
315	N	A	0.0000
316	A	A	0.0000
317	Y	A	0.0000
318	Y	A	0.0000
319	L	A	0.0000
320	G	A	0.0000
321	I	A	0.0000
322	P	A	0.0000
323	I	A	0.0000
324	G	A	0.0000
325	I	A	0.0000
326	F	A	0.0000
327	S	A	-0.8597
328	G	A	-0.7262
329	S	A	-0.4886
330	V	A	0.0000
331	T	A	-0.6569
332	R	A	-0.7564
333	L	A	0.0000
334	M	A	0.0000
335	S	A	0.0000
336	D	A	0.0000
337	S	A	0.0000
338	Q	A	0.0000
339	E	A	-0.8836
340	L	A	0.0000
341	K	A	-1.2024
342	P	A	0.0000
343	T	A	0.0000
344	I	A	0.0000
345	L	A	0.0000
346	V	A	0.0000
347	C	A	0.0000
348	V	A	0.0000
349	P	A	-0.1285
350	Q	A	-0.2902
351	V	A	0.0000
352	L	A	0.0000
353	T	A	-0.2704
354	R	A	-0.6070
355	I	A	0.0000
356	I	A	0.0000
357	Q	A	-0.3500
358	T	A	0.0000
359	V	A	0.0000
360	N	A	-1.0016
361	D	A	-1.7822
362	K	A	-2.1035
363	I	A	0.0000
364	S	A	0.0000
365	Q	A	-1.1088
366	S	A	-0.8737
367	N	A	0.0000
368	F	A	0.4905
369	L	A	0.0000
370	V	A	0.0000
371	R	A	-2.0540
372	T	A	-0.7558
373	V	A	-0.7538
374	F	A	0.0000
375	H	A	-1.8684
376	K	A	-2.3785
377	A	A	0.0000
378	L	A	0.0640
379	K	A	-1.4553
380	Q	A	-1.6707
381	K	A	-1.1382
382	E	A	-1.1340
383	S	A	-0.5665
384	I	A	0.7773
385	I	A	0.3420
386	K	A	-1.0675
387	T	A	0.0000
388	K	A	0.0000
389	G	A	0.0000
390	D	A	0.0000
391	P	A	0.0000
392	T	A	-0.0774
393	H	A	-0.2362
394	W	A	1.1412
395	L	A	0.6853
396	W	A	0.1537
397	D	A	-0.9174
398	R	A	-1.7188
399	I	A	-0.1881
400	I	A	0.0000
401	F	A	-1.3201
402	S	A	-1.5842
403	N	A	0.0000
404	T	A	0.0000
405	R	A	-1.7468
406	Q	A	-1.8134
407	I	A	-0.8819
408	L	A	0.0000
409	G	A	-1.3527
410	G	A	-1.4301
411	K	A	-1.5949
412	L	A	0.0000
413	K	A	-0.8474
414	A	A	0.0000
415	I	A	0.0000
416	I	A	0.0000
417	S	A	0.0000
418	G	A	0.0000
419	A	A	0.0598
420	A	A	-0.1440
421	P	A	-0.1577
422	L	A	0.0000
423	G	A	0.1276
424	L	A	0.5859
425	E	A	-0.7469
426	V	A	-0.3499
427	N	A	0.0000
428	H	A	-1.3038
429	K	A	-1.1872
430	I	A	0.0000
431	Q	A	-1.1905
432	A	A	-0.7985
433	I	A	0.0000
434	F	A	0.0000
435	C	A	-0.7691
436	C	A	0.0000
437	K	A	-0.9392
438	L	A	0.0000
439	I	A	0.0000
440	E	A	0.0000
441	G	A	-0.0478
442	F	A	0.1399
443	G	A	0.0880
444	M	A	0.1221
445	S	A	0.0000
446	E	A	-0.3580
447	C	A	0.0000
448	I	A	0.0000
449	G	A	0.0556
450	T	A	0.0000
451	L	A	0.0000
452	G	A	0.0000
453	T	A	0.0000
454	R	A	-1.2003
455	Y	A	-1.3225
456	S	A	-1.1842
457	Y	A	-0.2320
458	A	A	0.1311
459	H	A	0.0000
460	L	A	0.1975
461	G	A	0.2393
462	T	A	0.0000
463	V	A	0.0000
464	G	A	0.0000
465	G	A	0.0000
466	P	A	0.0000
467	F	A	0.0000
468	S	A	0.0000
469	D	A	0.0000
470	V	A	0.0000
471	E	A	0.0000
472	V	A	0.0000
473	K	A	0.0000
474	L	A	0.0000
475	T	A	0.0000
476	S	A	0.0000
477	V	A	0.0000
478	L	A	0.6247
479	E	A	-0.9488
480	M	A	0.0026
481	G	A	-0.0838
482	Y	A	0.5317
483	D	A	0.0000
484	S	A	-0.7320
485	T	A	-1.6461
486	K	A	-2.7248
487	E	A	-2.2360
488	P	A	0.0000
489	R	A	-2.5858
490	R	A	-2.1392
491	G	A	0.0000
492	L	A	0.0000
493	L	A	0.0000
494	K	A	0.0000
495	I	A	0.0000
496	R	A	0.0000
497	G	A	-0.3551
498	N	A	-0.5640
499	S	A	0.0000
500	V	A	-0.3241
501	C	A	0.0000
502	K	A	-1.7577
503	G	A	-0.5753
504	Y	A	-0.2333
505	F	A	-0.6471
506	R	A	-1.1028
507	D	A	0.1672
508	I	A	1.5987
509	I	A	1.4595
510	N	A	-0.1826
511	S	A	-0.5215
512	K	A	-1.4121
513	E	A	-1.8554
514	L	A	-0.7648
515	I	A	-1.1938
516	D	A	-1.4103
517	S	A	-1.6642
518	N	A	-1.6775
519	G	A	-1.2430
520	W	A	0.0000
521	L	A	0.0000
522	D	A	-0.4163
523	T	A	0.0000
524	G	A	-0.8090
525	D	A	0.0000
526	I	A	0.0000
527	A	A	0.0000
528	E	A	-1.7550
529	R	A	0.0000
530	Q	A	-2.1391
531	Q	A	-2.5830
532	D	A	-2.4664
533	G	A	-1.3024
534	S	A	0.0000
535	F	A	0.0000
536	K	A	-0.7507
537	I	A	0.0000
538	I	A	0.0000
539	D	A	0.0000
540	R	A	-1.3861
541	K	A	-1.7264
542	K	A	-2.2563
543	S	A	0.0000
544	L	A	0.0000
545	F	A	-1.0174
546	K	A	-1.9327
547	L	A	-1.1489
548	S	A	-1.1135
549	Q	A	-1.9987
550	G	A	-1.6788
551	E	A	-1.3003
552	Y	A	-0.7819
553	I	A	0.0000
554	S	A	0.0000
555	P	A	0.0000
556	E	A	-0.7507
557	R	A	-1.0236
558	I	A	0.0000
559	E	A	0.0000
560	G	A	-0.0266
561	I	A	0.3088
562	Y	A	0.0000
563	L	A	0.1938
564	S	A	-0.0041
565	S	A	-0.9656
566	S	A	0.0000
567	S	A	-0.6848
568	L	A	-0.3170
569	I	A	0.0000
570	Q	A	-0.3688
571	H	A	-0.1650
572	V	A	0.0000
573	Y	A	0.0000
574	V	A	0.0000
575	Y	A	0.0000
576	G	A	-0.1813
577	Q	A	0.0000
578	S	A	-1.0793
579	T	A	-1.2939
580	D	A	-2.3918
581	R	A	-2.0282
582	F	A	0.2773
583	L	A	0.0000
584	V	A	0.0000
585	A	A	0.0000
586	L	A	0.0000
587	I	A	0.0000
588	F	A	0.0000
589	P	A	0.0000
590	N	A	0.0000
591	E	A	0.0000
592	Q	A	-0.6219
593	A	A	0.3775
594	L	A	0.5789
595	R	A	-1.0222
596	K	A	-1.6131
597	W	A	-0.8493
598	S	A	0.0000
599	E	A	-2.7954
600	D	A	-2.7236
601	K	A	-2.1096
602	G	A	-0.9555
603	M	A	0.0000
604	N	A	-0.3588
605	T	A	0.6154
606	L	A	1.5559
607	S	A	0.7539
608	L	A	0.3418
609	S	A	-0.6928
610	L	A	-0.8831
611	E	A	-2.9636
612	E	A	-2.5175
613	L	A	-1.1729
614	C	A	-1.7109
615	E	A	-3.0017
616	S	A	-2.6174
617	H	A	-2.6965
618	E	A	-2.7829
619	L	A	0.0000
620	F	A	-1.7522
621	D	A	-2.8182
622	E	A	-2.4689
623	L	A	0.0000
624	N	A	-1.9409
625	D	A	-2.4423
626	S	A	0.0000
627	F	A	0.0000
628	H	A	-1.2392
629	K	A	-0.9675
630	A	A	0.0000
631	E	A	0.0000
632	L	A	0.6852
633	S	A	-0.3018
634	S	A	-0.2627
635	N	A	-0.5031
636	L	A	0.0000
637	F	A	2.0073
638	G	A	1.2950
639	F	A	1.7947
640	E	A	0.7287
641	R	A	0.2131
642	I	A	0.0000
643	H	A	-0.5386
644	K	A	-0.6622
645	F	A	-0.3498
646	K	A	-0.6225
647	V	A	0.0000
648	I	A	-0.8504
649	P	A	-1.0024
650	E	A	-1.7303
651	V	A	0.0000
652	L	A	0.0000
653	S	A	-1.0065
654	T	A	-0.7895
655	S	A	-1.0935
656	N	A	-1.3984
657	G	A	-0.9121
658	L	A	-0.8317
659	L	A	0.0000
660	T	A	0.0000
661	P	A	-0.2809
662	T	A	0.0000
663	M	A	-0.0132
664	K	A	-0.2737
665	I	A	0.0000
666	V	A	0.0000
667	R	A	-1.2726
668	N	A	-1.8842
669	K	A	-2.1112
670	V	A	0.0000
671	N	A	-1.7153
672	S	A	-2.0698
673	K	A	-2.3236
674	Y	A	0.0000
675	K	A	-2.2325
676	E	A	-2.3250
677	V	A	-0.6540
678	L	A	-0.8920
679	N	A	-1.5048
680	T	A	-0.2170
681	L	A	0.2584
682	R	A	-1.5013
683	S	A	-0.7000
684	Q	A	-0.4540
685	I	A	1.1086