Chain sequence(s) |
A: SVSIYPSSAEVLKACRNLGKNGLSNSSILLDKCPPPRPPSSPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFCTNPNNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWHCESNRSHTTIAKYAQYQASSFQESLREENEKRSHHKDHSDSESTSSDNSGRRRKGPFKTIKFGTNIDLSDDKKWKLQLHELTKLPAFVRVVSSAGNLLSHVGHTILGMNTVQQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDDFCEKNNLNFLMGSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNVGPLTACCQYKLAVERYEWNKLQSVKSIVPMVHLSWNMARRNIKVSDPKLFEMIKYCLLRTLKQCQTLREALIAAGKEIIWHGRTKEEPAHYCSICEVEVFDLLFVTNESNSRKTYIVHCQDCARKTSGNLENFVVLEQQYKMEDLMQVYDQFTLAPP |
Distance of aggregation | 10 Å |
Dynamic mode | No |
Mutated residues | HA1060L |
Energy difference between WT (input) and mutated protein (by FoldX) | -0.193036 kcal/mol
Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive. |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
886 | S | A | 0.8486 | |
887 | V | A | 2.1698 | |
888 | S | A | 1.5773 | |
889 | I | A | 2.3490 | |
890 | Y | A | 1.0868 | |
891 | P | A | 0.0128 | |
892 | S | A | -1.0988 | |
893 | S | A | 0.0000 | |
894 | A | A | -1.4790 | |
895 | E | A | -2.0912 | |
896 | V | A | 0.0000 | |
897 | L | A | -1.5692 | |
898 | K | A | -2.4589 | |
899 | A | A | -1.5721 | |
900 | C | A | -1.6713 | |
901 | R | A | -2.9553 | |
902 | N | A | -2.1114 | |
903 | L | A | -0.4208 | |
904 | G | A | -1.3714 | |
905 | K | A | -2.5402 | |
906 | N | A | -2.3017 | |
907 | G | A | -1.2108 | |
908 | L | A | -0.2401 | |
909 | S | A | -1.3045 | |
910 | N | A | -1.6663 | |
911 | S | A | -0.3933 | |
912 | S | A | 0.1309 | |
913 | I | A | 0.8747 | |
914 | L | A | 0.8660 | |
915 | L | A | 0.6830 | |
916 | D | A | -1.7026 | |
917 | K | A | -1.7900 | |
918 | C | A | -0.5870 | |
919 | P | A | -0.7052 | |
920 | P | A | -1.0215 | |
921 | P | A | -1.5524 | |
922 | R | A | -2.1776 | |
923 | P | A | -1.1927 | |
924 | P | A | -0.8220 | |
925 | S | A | -0.5296 | |
926 | S | A | -0.1473 | |
927 | P | A | 0.2128 | |
928 | Y | A | 0.9965 | |
929 | P | A | 0.4526 | |
930 | P | A | -0.2334 | |
931 | L | A | -0.9288 | |
932 | P | A | -1.9938 | |
933 | K | A | -3.5993 | |
934 | D | A | -3.7270 | |
935 | K | A | -3.5486 | |
936 | L | A | 0.0000 | |
937 | N | A | -2.5449 | |
938 | P | A | -1.5957 | |
939 | P | A | -0.8829 | |
940 | T | A | -0.3579 | |
941 | P | A | -0.1609 | |
942 | S | A | 0.3331 | |
943 | I | A | 0.6002 | |
944 | Y | A | 0.8029 | |
945 | L | A | -0.8872 | |
946 | E | A | -2.3620 | |
947 | N | A | -2.4703 | |
948 | K | A | -2.3473 | |
949 | R | A | -1.9748 | |
950 | D | A | -1.0342 | |
951 | A | A | 0.0000 | |
952 | F | A | 1.1425 | |
953 | F | A | 1.6035 | |
954 | P | A | 0.6749 | |
955 | P | A | 0.0633 | |
956 | L | A | 0.0000 | |
957 | H | A | -0.3223 | |
958 | Q | A | -1.2780 | |
959 | F | A | -0.4547 | |
960 | C | A | 0.0000 | |
961 | T | A | -0.7728 | |
962 | N | A | -1.2300 | |
963 | P | A | -1.2586 | |
964 | N | A | -1.6257 | |
965 | N | A | -0.9104 | |
966 | P | A | 0.0000 | |
967 | V | A | 0.0000 | |
968 | T | A | 0.0000 | |
969 | V | A | 0.0000 | |
970 | I | A | 0.0000 | |
971 | R | A | -0.2264 | |
972 | G | A | -0.8359 | |
973 | L | A | 0.0000 | |
974 | A | A | 0.0000 | |
975 | G | A | -1.9279 | |
976 | A | A | 0.0000 | |
977 | L | A | 0.0000 | |
978 | K | A | -2.6119 | |
979 | L | A | 0.0000 | |
980 | D | A | -2.2298 | |
981 | L | A | -1.0432 | |
982 | G | A | -0.9767 | |
983 | L | A | -0.3198 | |
984 | F | A | 0.0000 | |
985 | S | A | -0.7976 | |
986 | T | A | -1.2526 | |
987 | K | A | -2.2769 | |
988 | T | A | -1.5072 | |
989 | L | A | 0.0000 | |
990 | V | A | -2.1400 | |
991 | E | A | -2.5312 | |
992 | A | A | -1.8042 | |
993 | N | A | -1.8388 | |
994 | N | A | -2.4693 | |
995 | E | A | -2.5395 | |
996 | H | A | -1.4055 | |
997 | M | A | -0.6541 | |
998 | V | A | 0.0000 | |
999 | E | A | -1.3851 | |
1000 | V | A | 0.0000 | |
1001 | R | A | -2.3586 | |
1002 | T | A | -1.6834 | |
1003 | Q | A | 0.0000 | |
1004 | L | A | -0.4327 | |
1005 | L | A | -0.1091 | |
1006 | Q | A | 0.0000 | |
1007 | P | A | -0.2515 | |
1008 | A | A | -0.0729 | |
1009 | D | A | -0.5757 | |
1010 | E | A | -0.9739 | |
1011 | N | A | 0.0000 | |
1012 | W | A | -0.7024 | |
1013 | D | A | -0.8454 | |
1014 | P | A | -0.6696 | |
1015 | T | A | -0.4187 | |
1016 | G | A | 0.0000 | |
1017 | T | A | -0.9357 | |
1018 | K | A | -1.7582 | |
1019 | K | A | -1.3355 | |
1020 | I | A | -0.5792 | |
1021 | W | A | 0.0000 | |
1022 | H | A | -1.1982 | |
1023 | C | A | 0.0000 | |
1024 | E | A | -1.5648 | |
1025 | S | A | -1.9384 | |
1026 | N | A | -2.7840 | |
1027 | R | A | -3.0458 | |
1028 | S | A | -1.9901 | |
1029 | H | A | -1.1380 | |
1030 | T | A | -0.9202 | |
1031 | T | A | -1.4321 | |
1032 | I | A | 0.0000 | |
1033 | A | A | -2.1647 | |
1034 | K | A | -2.3097 | |
1035 | Y | A | 0.0000 | |
1036 | A | A | 0.0000 | |
1037 | Q | A | -1.6483 | |
1038 | Y | A | -0.6357 | |
1039 | Q | A | 0.0000 | |
1040 | A | A | -0.6556 | |
1041 | S | A | -0.6664 | |
1042 | S | A | -0.3738 | |
1043 | F | A | 0.1996 | |
1044 | Q | A | -1.4412 | |
1045 | E | A | -2.6448 | |
1046 | S | A | -1.8711 | |
1047 | L | A | -2.2194 | |
1048 | R | A | -4.4064 | |
1049 | E | A | -4.7640 | |
1050 | E | A | -4.4516 | |
1051 | N | A | -4.7433 | |
1052 | E | A | -4.9849 | |
1053 | K | A | -5.2672 | |
1054 | R | A | -4.4428 | |
1055 | S | A | -3.1510 | |
1056 | H | A | -2.9840 | |
1057 | H | A | -2.9712 | |
1058 | K | A | -3.3608 | |
1059 | D | A | -2.5702 | |
1060 | L | A | -0.2498 | mutated: HA1060L |
1061 | S | A | -0.9086 | |
1062 | D | A | -1.9625 | |
1063 | S | A | -1.7835 | |
1064 | E | A | -2.6017 | |
1065 | S | A | -2.6360 | |
1066 | T | A | -2.5945 | |
1067 | S | A | -2.6361 | |
1068 | S | A | -4.0492 | |
1069 | D | A | -4.8312 | |
1070 | N | A | -4.2572 | |
1071 | S | A | -2.8725 | |
1072 | G | A | -2.3127 | |
1073 | R | A | -4.1684 | |
1074 | R | A | -4.8332 | |
1075 | R | A | -4.2669 | |
1076 | K | A | -3.2779 | |
1077 | G | A | 0.0000 | |
1078 | P | A | -1.2706 | |
1079 | F | A | -1.0758 | |
1080 | K | A | -1.7027 | |
1081 | T | A | -0.9000 | |
1082 | I | A | 0.0000 | |
1083 | K | A | -1.3953 | |
1084 | F | A | 0.0000 | |
1085 | G | A | 0.0000 | |
1086 | T | A | 0.0000 | |
1087 | N | A | -1.3259 | |
1088 | I | A | 0.0000 | |
1089 | D | A | -0.8958 | |
1090 | L | A | 0.0000 | |
1091 | S | A | -1.2178 | |
1092 | D | A | -2.5276 | |
1093 | D | A | -3.2997 | |
1094 | K | A | -3.4489 | |
1095 | K | A | -2.9904 | |
1096 | W | A | 0.0000 | |
1097 | K | A | -2.6112 | |
1098 | L | A | -0.1008 | |
1099 | Q | A | 0.0000 | |
1100 | L | A | -1.0618 | |
1101 | H | A | -1.0765 | |
1102 | E | A | 0.0000 | |
1103 | L | A | 0.0000 | |
1104 | T | A | -0.5701 | |
1105 | K | A | -1.3969 | |
1106 | L | A | 0.0000 | |
1107 | P | A | 0.0000 | |
1108 | A | A | 0.2468 | |
1109 | F | A | 0.2516 | |
1110 | V | A | 0.0000 | |
1111 | R | A | -0.0451 | |
1112 | V | A | 0.7559 | |
1113 | V | A | 1.5581 | |
1114 | S | A | 0.6168 | |
1115 | A | A | 0.0749 | |
1116 | G | A | -0.0440 | |
1117 | N | A | 0.0000 | |
1118 | L | A | 0.0000 | |
1119 | L | A | 0.0000 | |
1120 | S | A | 0.1517 | |
1121 | H | A | -0.6141 | |
1122 | V | A | 0.0000 | |
1123 | G | A | -1.5131 | |
1124 | H | A | -1.1531 | |
1125 | T | A | -0.1498 | |
1126 | I | A | 0.0000 | |
1127 | L | A | 1.1551 | |
1128 | G | A | 0.1715 | |
1129 | M | A | 0.0000 | |
1130 | N | A | 0.4850 | |
1131 | T | A | 0.4377 | |
1132 | V | A | 0.0000 | |
1133 | Q | A | -0.5422 | |
1134 | L | A | 0.0000 | |
1135 | Y | A | -0.3138 | |
1136 | M | A | 0.0000 | |
1137 | K | A | 0.0000 | |
1138 | V | A | 0.0000 | |
1139 | P | A | 0.4373 | |
1140 | G | A | 0.2548 | |
1141 | S | A | 0.0000 | |
1142 | R | A | 0.0000 | |
1143 | T | A | -0.1420 | |
1144 | P | A | -0.3306 | |
1145 | G | A | 0.0000 | |
1146 | H | A | -0.2438 | |
1147 | Q | A | -0.5404 | |
1148 | E | A | -0.6168 | |
1149 | N | A | -0.8015 | |
1150 | N | A | 0.0000 | |
1151 | N | A | 0.0000 | |
1152 | F | A | 0.0000 | |
1153 | C | A | 0.0000 | |
1154 | S | A | 0.0000 | |
1155 | V | A | 0.0000 | |
1156 | N | A | 0.0000 | |
1157 | I | A | 0.0000 | |
1158 | N | A | 0.0000 | |
1159 | I | A | 0.0000 | |
1160 | G | A | 0.0000 | |
1161 | P | A | -0.5588 | |
1162 | G | A | -0.4207 | |
1163 | D | A | -0.5447 | |
1164 | C | A | 0.0000 | |
1165 | E | A | 0.0000 | |
1166 | W | A | 0.0000 | |
1167 | F | A | 0.0000 | |
1168 | V | A | 0.0000 | |
1169 | V | A | 0.0000 | |
1170 | P | A | -0.5918 | |
1171 | E | A | -0.8674 | |
1172 | G | A | -0.3648 | |
1173 | Y | A | 0.0000 | |
1174 | W | A | -0.3260 | |
1175 | G | A | 0.0000 | |
1176 | V | A | -0.2498 | |
1177 | L | A | 0.0000 | |
1178 | N | A | 0.0000 | |
1179 | D | A | -2.2907 | |
1180 | F | A | -1.8841 | |
1181 | C | A | 0.0000 | |
1182 | E | A | -3.8142 | |
1183 | K | A | -3.5933 | |
1184 | N | A | -2.9352 | |
1185 | N | A | -3.1242 | |
1186 | L | A | -2.1063 | |
1187 | N | A | -1.5975 | |
1188 | F | A | 0.0000 | |
1189 | L | A | 0.3804 | |
1190 | M | A | 0.8443 | |
1191 | G | A | -0.1312 | |
1192 | S | A | -0.3870 | |
1193 | W | A | 0.0000 | |
1194 | W | A | 0.0000 | |
1195 | P | A | 0.0000 | |
1196 | N | A | -1.0757 | |
1197 | L | A | 0.0000 | |
1198 | E | A | -2.6173 | |
1199 | D | A | -2.0665 | |
1200 | L | A | 0.0000 | |
1201 | Y | A | -1.9954 | |
1202 | E | A | -2.6769 | |
1203 | A | A | -1.4644 | |
1204 | N | A | -1.6991 | |
1205 | V | A | 0.0000 | |
1206 | P | A | 0.0000 | |
1207 | V | A | 0.0000 | |
1208 | Y | A | -0.6520 | |
1209 | R | A | -0.7923 | |
1210 | F | A | 0.0000 | |
1211 | I | A | 0.4594 | |
1212 | Q | A | 0.0000 | |
1213 | R | A | -1.1396 | |
1214 | P | A | -0.8497 | |
1215 | G | A | 0.0000 | |
1216 | D | A | 0.0000 | |
1217 | L | A | 0.0000 | |
1218 | V | A | 0.0000 | |
1219 | W | A | 0.0000 | |
1220 | I | A | 0.0000 | |
1221 | N | A | 0.0000 | |
1222 | A | A | 0.0000 | |
1223 | G | A | 0.0000 | |
1224 | T | A | 0.0000 | |
1225 | V | A | 0.0000 | |
1226 | H | A | 0.0000 | |
1227 | W | A | 0.0000 | |
1228 | V | A | 0.0000 | |
1229 | Q | A | 0.0000 | |
1230 | A | A | 0.0000 | |
1231 | I | A | 1.0359 | |
1232 | G | A | 0.4040 | |
1233 | W | A | 0.4906 | |
1234 | C | A | 0.0000 | |
1235 | N | A | 0.0000 | |
1236 | N | A | 0.0000 | |
1237 | I | A | 0.0000 | |
1238 | A | A | 0.0000 | |
1239 | W | A | 0.0000 | |
1240 | N | A | 0.0000 | |
1241 | V | A | 0.0000 | |
1242 | G | A | 0.0000 | |
1243 | P | A | 0.0000 | |
1244 | L | A | 0.4216 | |
1245 | T | A | -0.2405 | |
1246 | A | A | -0.7938 | |
1247 | C | A | -0.3365 | |
1248 | Q | A | 0.0000 | |
1249 | Y | A | 0.0000 | |
1250 | K | A | -1.5800 | |
1251 | L | A | 0.0000 | |
1252 | A | A | 0.0000 | |
1253 | V | A | -1.1647 | |
1254 | E | A | -2.6379 | |
1255 | R | A | 0.0000 | |
1256 | Y | A | 0.0000 | |
1257 | E | A | -1.8151 | |
1258 | W | A | -1.3726 | |
1259 | N | A | 0.0000 | |
1260 | K | A | -1.7330 | |
1261 | L | A | -0.2198 | |
1262 | Q | A | -0.6176 | |
1263 | S | A | -0.6717 | |
1264 | V | A | -0.4796 | |
1265 | K | A | -1.0532 | |
1266 | S | A | 0.0000 | |
1267 | I | A | 0.2966 | |
1268 | V | A | 0.0000 | |
1269 | P | A | 0.0000 | |
1270 | M | A | 0.0000 | |
1271 | V | A | 0.2654 | |
1272 | H | A | 0.0000 | |
1273 | L | A | 0.0000 | |
1274 | S | A | 0.0000 | |
1275 | W | A | 0.0000 | |
1276 | N | A | -1.1689 | |
1277 | M | A | 0.0000 | |
1278 | A | A | -1.8486 | |
1279 | R | A | -2.9229 | |
1280 | N | A | -2.3466 | |
1281 | I | A | 0.0000 | |
1282 | K | A | -2.3066 | |
1283 | V | A | 0.0000 | |
1284 | S | A | -1.3752 | |
1285 | D | A | -2.0109 | |
1286 | P | A | -1.7399 | |
1287 | K | A | -2.4045 | |
1288 | L | A | 0.0000 | |
1289 | F | A | -1.1949 | |
1290 | E | A | -1.0532 | |
1291 | M | A | -0.6797 | |
1292 | I | A | 0.0000 | |
1293 | K | A | 0.0000 | |
1294 | Y | A | 0.4297 | |
1295 | C | A | 0.0000 | |
1296 | L | A | 0.0000 | |
1297 | L | A | 0.0000 | |
1298 | R | A | -1.1204 | |
1299 | T | A | -0.6952 | |
1300 | L | A | 0.0000 | |
1301 | K | A | -1.3861 | |
1302 | Q | A | -1.6311 | |
1303 | C | A | 0.0000 | |
1304 | Q | A | 0.0000 | |
1305 | T | A | -1.0111 | |
1306 | L | A | -0.5053 | |
1307 | R | A | -0.8261 | |
1308 | E | A | -0.9976 | |
1309 | A | A | -0.0935 | |
1310 | L | A | 0.0000 | |
1311 | I | A | 0.6203 | |
1312 | A | A | 0.1699 | |
1313 | A | A | -0.3253 | |
1314 | G | A | -0.5178 | |
1315 | K | A | -1.2394 | |
1316 | E | A | -1.2260 | |
1317 | I | A | 0.1561 | |
1318 | I | A | 0.9721 | |
1319 | W | A | 0.8877 | |
1320 | H | A | 0.1246 | |
1321 | G | A | -0.4995 | |
1322 | R | A | -1.2497 | |
1323 | T | A | -1.8146 | |
1324 | K | A | -2.9419 | |
1325 | E | A | -3.0981 | |
1326 | E | A | -2.0917 | |
1327 | P | A | -1.2480 | |
1328 | A | A | 0.0000 | |
1329 | H | A | -0.1158 | |
1330 | Y | A | 0.2405 | |
1331 | C | A | 0.0000 | |
1332 | S | A | 0.8622 | |
1333 | I | A | 1.6915 | |
1334 | C | A | 0.1220 | |
1335 | E | A | -0.6018 | |
1336 | V | A | -0.1807 | |
1337 | E | A | 0.0000 | |
1338 | V | A | 0.0000 | |
1339 | F | A | 0.2136 | |
1340 | D | A | 0.0000 | |
1341 | L | A | 0.0000 | |
1342 | L | A | 0.0000 | |
1343 | F | A | 0.0000 | |
1344 | V | A | 0.0000 | |
1345 | T | A | -1.4121 | |
1346 | N | A | -3.0436 | |
1347 | E | A | -3.1620 | |
1348 | S | A | 0.0000 | |
1349 | N | A | -2.0723 | |
1350 | S | A | -2.5481 | |
1351 | R | A | -3.2533 | |
1352 | K | A | -2.7942 | |
1353 | T | A | -1.2648 | |
1354 | Y | A | -0.3995 | |
1355 | I | A | 0.9252 | |
1356 | V | A | 0.0000 | |
1357 | H | A | -0.0039 | |
1358 | C | A | 0.0000 | |
1359 | Q | A | -1.9010 | |
1360 | D | A | -2.8467 | |
1361 | C | A | 0.0000 | |
1362 | A | A | 0.0000 | |
1363 | R | A | -4.1624 | |
1364 | K | A | -3.3838 | |
1365 | T | A | -2.3026 | |
1366 | S | A | 0.0000 | |
1367 | G | A | -2.8592 | |
1368 | N | A | -2.8110 | |
1369 | L | A | 0.0000 | |
1370 | E | A | -3.0709 | |
1371 | N | A | -2.6976 | |
1372 | F | A | 0.0000 | |
1373 | V | A | -0.9265 | |
1374 | V | A | 0.0000 | |
1375 | L | A | 0.0000 | |
1376 | E | A | 0.0000 | |
1377 | Q | A | 0.0000 | |
1378 | Y | A | -1.0669 | |
1379 | K | A | -2.4248 | |
1380 | M | A | 0.0000 | |
1381 | E | A | -2.7536 | |
1382 | D | A | -2.9046 | |
1383 | L | A | 0.0000 | |
1384 | M | A | -1.9859 | |
1385 | Q | A | -3.0217 | |
1386 | V | A | -2.3265 | |
1387 | Y | A | 0.0000 | |
1388 | D | A | -2.2906 | |
1389 | Q | A | -2.3739 | |
1390 | F | A | 0.0000 | |
1391 | T | A | -0.9017 | |
1392 | L | A | -0.5510 | |
1393 | A | A | 0.0000 | |
1394 | P | A | -0.7410 | |
1395 | P | A | -0.7718 |