Project name: Young-In Chi [mutate: HA1060L]

Status: done

submitted: 2019-12-03 15:22:12, status changed: 2019-12-24 15:08:11
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Chain sequence(s) A: SVSIYPSSAEVLKACRNLGKNGLSNSSILLDKCPPPRPPSSPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFCTNPNNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWHCESNRSHTTIAKYAQYQASSFQESLREENEKRSHHKDHSDSESTSSDNSGRRRKGPFKTIKFGTNIDLSDDKKWKLQLHELTKLPAFVRVVSSAGNLLSHVGHTILGMNTVQQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDDFCEKNNLNFLMGSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNVGPLTACCQYKLAVERYEWNKLQSVKSIVPMVHLSWNMARRNIKVSDPKLFEMIKYCLLRTLKQCQTLREALIAAGKEIIWHGRTKEEPAHYCSICEVEVFDLLFVTNESNSRKTYIVHCQDCARKTSGNLENFVVLEQQYKMEDLMQVYDQFTLAPP
Distance of aggregation 10 Å
Dynamic mode No
Mutated residues HA1060L
Energy difference between WT (input) and mutated protein (by FoldX) -0.193036 kcal/mol

Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive.

Show buried residues

Minimal score value
-5.2672
Maximal score value
2.349
Average score
-0.8457
Total score value
-431.3006

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
886 S A 0.8486
887 V A 2.1698
888 S A 1.5773
889 I A 2.3490
890 Y A 1.0868
891 P A 0.0128
892 S A -1.0988
893 S A 0.0000
894 A A -1.4790
895 E A -2.0912
896 V A 0.0000
897 L A -1.5692
898 K A -2.4589
899 A A -1.5721
900 C A -1.6713
901 R A -2.9553
902 N A -2.1114
903 L A -0.4208
904 G A -1.3714
905 K A -2.5402
906 N A -2.3017
907 G A -1.2108
908 L A -0.2401
909 S A -1.3045
910 N A -1.6663
911 S A -0.3933
912 S A 0.1309
913 I A 0.8747
914 L A 0.8660
915 L A 0.6830
916 D A -1.7026
917 K A -1.7900
918 C A -0.5870
919 P A -0.7052
920 P A -1.0215
921 P A -1.5524
922 R A -2.1776
923 P A -1.1927
924 P A -0.8220
925 S A -0.5296
926 S A -0.1473
927 P A 0.2128
928 Y A 0.9965
929 P A 0.4526
930 P A -0.2334
931 L A -0.9288
932 P A -1.9938
933 K A -3.5993
934 D A -3.7270
935 K A -3.5486
936 L A 0.0000
937 N A -2.5449
938 P A -1.5957
939 P A -0.8829
940 T A -0.3579
941 P A -0.1609
942 S A 0.3331
943 I A 0.6002
944 Y A 0.8029
945 L A -0.8872
946 E A -2.3620
947 N A -2.4703
948 K A -2.3473
949 R A -1.9748
950 D A -1.0342
951 A A 0.0000
952 F A 1.1425
953 F A 1.6035
954 P A 0.6749
955 P A 0.0633
956 L A 0.0000
957 H A -0.3223
958 Q A -1.2780
959 F A -0.4547
960 C A 0.0000
961 T A -0.7728
962 N A -1.2300
963 P A -1.2586
964 N A -1.6257
965 N A -0.9104
966 P A 0.0000
967 V A 0.0000
968 T A 0.0000
969 V A 0.0000
970 I A 0.0000
971 R A -0.2264
972 G A -0.8359
973 L A 0.0000
974 A A 0.0000
975 G A -1.9279
976 A A 0.0000
977 L A 0.0000
978 K A -2.6119
979 L A 0.0000
980 D A -2.2298
981 L A -1.0432
982 G A -0.9767
983 L A -0.3198
984 F A 0.0000
985 S A -0.7976
986 T A -1.2526
987 K A -2.2769
988 T A -1.5072
989 L A 0.0000
990 V A -2.1400
991 E A -2.5312
992 A A -1.8042
993 N A -1.8388
994 N A -2.4693
995 E A -2.5395
996 H A -1.4055
997 M A -0.6541
998 V A 0.0000
999 E A -1.3851
1000 V A 0.0000
1001 R A -2.3586
1002 T A -1.6834
1003 Q A 0.0000
1004 L A -0.4327
1005 L A -0.1091
1006 Q A 0.0000
1007 P A -0.2515
1008 A A -0.0729
1009 D A -0.5757
1010 E A -0.9739
1011 N A 0.0000
1012 W A -0.7024
1013 D A -0.8454
1014 P A -0.6696
1015 T A -0.4187
1016 G A 0.0000
1017 T A -0.9357
1018 K A -1.7582
1019 K A -1.3355
1020 I A -0.5792
1021 W A 0.0000
1022 H A -1.1982
1023 C A 0.0000
1024 E A -1.5648
1025 S A -1.9384
1026 N A -2.7840
1027 R A -3.0458
1028 S A -1.9901
1029 H A -1.1380
1030 T A -0.9202
1031 T A -1.4321
1032 I A 0.0000
1033 A A -2.1647
1034 K A -2.3097
1035 Y A 0.0000
1036 A A 0.0000
1037 Q A -1.6483
1038 Y A -0.6357
1039 Q A 0.0000
1040 A A -0.6556
1041 S A -0.6664
1042 S A -0.3738
1043 F A 0.1996
1044 Q A -1.4412
1045 E A -2.6448
1046 S A -1.8711
1047 L A -2.2194
1048 R A -4.4064
1049 E A -4.7640
1050 E A -4.4516
1051 N A -4.7433
1052 E A -4.9849
1053 K A -5.2672
1054 R A -4.4428
1055 S A -3.1510
1056 H A -2.9840
1057 H A -2.9712
1058 K A -3.3608
1059 D A -2.5702
1060 L A -0.2498 mutated: HA1060L
1061 S A -0.9086
1062 D A -1.9625
1063 S A -1.7835
1064 E A -2.6017
1065 S A -2.6360
1066 T A -2.5945
1067 S A -2.6361
1068 S A -4.0492
1069 D A -4.8312
1070 N A -4.2572
1071 S A -2.8725
1072 G A -2.3127
1073 R A -4.1684
1074 R A -4.8332
1075 R A -4.2669
1076 K A -3.2779
1077 G A 0.0000
1078 P A -1.2706
1079 F A -1.0758
1080 K A -1.7027
1081 T A -0.9000
1082 I A 0.0000
1083 K A -1.3953
1084 F A 0.0000
1085 G A 0.0000
1086 T A 0.0000
1087 N A -1.3259
1088 I A 0.0000
1089 D A -0.8958
1090 L A 0.0000
1091 S A -1.2178
1092 D A -2.5276
1093 D A -3.2997
1094 K A -3.4489
1095 K A -2.9904
1096 W A 0.0000
1097 K A -2.6112
1098 L A -0.1008
1099 Q A 0.0000
1100 L A -1.0618
1101 H A -1.0765
1102 E A 0.0000
1103 L A 0.0000
1104 T A -0.5701
1105 K A -1.3969
1106 L A 0.0000
1107 P A 0.0000
1108 A A 0.2468
1109 F A 0.2516
1110 V A 0.0000
1111 R A -0.0451
1112 V A 0.7559
1113 V A 1.5581
1114 S A 0.6168
1115 A A 0.0749
1116 G A -0.0440
1117 N A 0.0000
1118 L A 0.0000
1119 L A 0.0000
1120 S A 0.1517
1121 H A -0.6141
1122 V A 0.0000
1123 G A -1.5131
1124 H A -1.1531
1125 T A -0.1498
1126 I A 0.0000
1127 L A 1.1551
1128 G A 0.1715
1129 M A 0.0000
1130 N A 0.4850
1131 T A 0.4377
1132 V A 0.0000
1133 Q A -0.5422
1134 L A 0.0000
1135 Y A -0.3138
1136 M A 0.0000
1137 K A 0.0000
1138 V A 0.0000
1139 P A 0.4373
1140 G A 0.2548
1141 S A 0.0000
1142 R A 0.0000
1143 T A -0.1420
1144 P A -0.3306
1145 G A 0.0000
1146 H A -0.2438
1147 Q A -0.5404
1148 E A -0.6168
1149 N A -0.8015
1150 N A 0.0000
1151 N A 0.0000
1152 F A 0.0000
1153 C A 0.0000
1154 S A 0.0000
1155 V A 0.0000
1156 N A 0.0000
1157 I A 0.0000
1158 N A 0.0000
1159 I A 0.0000
1160 G A 0.0000
1161 P A -0.5588
1162 G A -0.4207
1163 D A -0.5447
1164 C A 0.0000
1165 E A 0.0000
1166 W A 0.0000
1167 F A 0.0000
1168 V A 0.0000
1169 V A 0.0000
1170 P A -0.5918
1171 E A -0.8674
1172 G A -0.3648
1173 Y A 0.0000
1174 W A -0.3260
1175 G A 0.0000
1176 V A -0.2498
1177 L A 0.0000
1178 N A 0.0000
1179 D A -2.2907
1180 F A -1.8841
1181 C A 0.0000
1182 E A -3.8142
1183 K A -3.5933
1184 N A -2.9352
1185 N A -3.1242
1186 L A -2.1063
1187 N A -1.5975
1188 F A 0.0000
1189 L A 0.3804
1190 M A 0.8443
1191 G A -0.1312
1192 S A -0.3870
1193 W A 0.0000
1194 W A 0.0000
1195 P A 0.0000
1196 N A -1.0757
1197 L A 0.0000
1198 E A -2.6173
1199 D A -2.0665
1200 L A 0.0000
1201 Y A -1.9954
1202 E A -2.6769
1203 A A -1.4644
1204 N A -1.6991
1205 V A 0.0000
1206 P A 0.0000
1207 V A 0.0000
1208 Y A -0.6520
1209 R A -0.7923
1210 F A 0.0000
1211 I A 0.4594
1212 Q A 0.0000
1213 R A -1.1396
1214 P A -0.8497
1215 G A 0.0000
1216 D A 0.0000
1217 L A 0.0000
1218 V A 0.0000
1219 W A 0.0000
1220 I A 0.0000
1221 N A 0.0000
1222 A A 0.0000
1223 G A 0.0000
1224 T A 0.0000
1225 V A 0.0000
1226 H A 0.0000
1227 W A 0.0000
1228 V A 0.0000
1229 Q A 0.0000
1230 A A 0.0000
1231 I A 1.0359
1232 G A 0.4040
1233 W A 0.4906
1234 C A 0.0000
1235 N A 0.0000
1236 N A 0.0000
1237 I A 0.0000
1238 A A 0.0000
1239 W A 0.0000
1240 N A 0.0000
1241 V A 0.0000
1242 G A 0.0000
1243 P A 0.0000
1244 L A 0.4216
1245 T A -0.2405
1246 A A -0.7938
1247 C A -0.3365
1248 Q A 0.0000
1249 Y A 0.0000
1250 K A -1.5800
1251 L A 0.0000
1252 A A 0.0000
1253 V A -1.1647
1254 E A -2.6379
1255 R A 0.0000
1256 Y A 0.0000
1257 E A -1.8151
1258 W A -1.3726
1259 N A 0.0000
1260 K A -1.7330
1261 L A -0.2198
1262 Q A -0.6176
1263 S A -0.6717
1264 V A -0.4796
1265 K A -1.0532
1266 S A 0.0000
1267 I A 0.2966
1268 V A 0.0000
1269 P A 0.0000
1270 M A 0.0000
1271 V A 0.2654
1272 H A 0.0000
1273 L A 0.0000
1274 S A 0.0000
1275 W A 0.0000
1276 N A -1.1689
1277 M A 0.0000
1278 A A -1.8486
1279 R A -2.9229
1280 N A -2.3466
1281 I A 0.0000
1282 K A -2.3066
1283 V A 0.0000
1284 S A -1.3752
1285 D A -2.0109
1286 P A -1.7399
1287 K A -2.4045
1288 L A 0.0000
1289 F A -1.1949
1290 E A -1.0532
1291 M A -0.6797
1292 I A 0.0000
1293 K A 0.0000
1294 Y A 0.4297
1295 C A 0.0000
1296 L A 0.0000
1297 L A 0.0000
1298 R A -1.1204
1299 T A -0.6952
1300 L A 0.0000
1301 K A -1.3861
1302 Q A -1.6311
1303 C A 0.0000
1304 Q A 0.0000
1305 T A -1.0111
1306 L A -0.5053
1307 R A -0.8261
1308 E A -0.9976
1309 A A -0.0935
1310 L A 0.0000
1311 I A 0.6203
1312 A A 0.1699
1313 A A -0.3253
1314 G A -0.5178
1315 K A -1.2394
1316 E A -1.2260
1317 I A 0.1561
1318 I A 0.9721
1319 W A 0.8877
1320 H A 0.1246
1321 G A -0.4995
1322 R A -1.2497
1323 T A -1.8146
1324 K A -2.9419
1325 E A -3.0981
1326 E A -2.0917
1327 P A -1.2480
1328 A A 0.0000
1329 H A -0.1158
1330 Y A 0.2405
1331 C A 0.0000
1332 S A 0.8622
1333 I A 1.6915
1334 C A 0.1220
1335 E A -0.6018
1336 V A -0.1807
1337 E A 0.0000
1338 V A 0.0000
1339 F A 0.2136
1340 D A 0.0000
1341 L A 0.0000
1342 L A 0.0000
1343 F A 0.0000
1344 V A 0.0000
1345 T A -1.4121
1346 N A -3.0436
1347 E A -3.1620
1348 S A 0.0000
1349 N A -2.0723
1350 S A -2.5481
1351 R A -3.2533
1352 K A -2.7942
1353 T A -1.2648
1354 Y A -0.3995
1355 I A 0.9252
1356 V A 0.0000
1357 H A -0.0039
1358 C A 0.0000
1359 Q A -1.9010
1360 D A -2.8467
1361 C A 0.0000
1362 A A 0.0000
1363 R A -4.1624
1364 K A -3.3838
1365 T A -2.3026
1366 S A 0.0000
1367 G A -2.8592
1368 N A -2.8110
1369 L A 0.0000
1370 E A -3.0709
1371 N A -2.6976
1372 F A 0.0000
1373 V A -0.9265
1374 V A 0.0000
1375 L A 0.0000
1376 E A 0.0000
1377 Q A 0.0000
1378 Y A -1.0669
1379 K A -2.4248
1380 M A 0.0000
1381 E A -2.7536
1382 D A -2.9046
1383 L A 0.0000
1384 M A -1.9859
1385 Q A -3.0217
1386 V A -2.3265
1387 Y A 0.0000
1388 D A -2.2906
1389 Q A -2.3739
1390 F A 0.0000
1391 T A -0.9017
1392 L A -0.5510
1393 A A 0.0000
1394 P A -0.7410
1395 P A -0.7718

 

Laboratory of Theory of Biopolymers 2015