Project name: 2IV1 [mutate: DA66Y, DA68Y, EA69Y, DB66Y, DB68Y, EB69Y, DC66Y, DC68Y, EC69Y, DD66Y, DD68Y, ED69Y, DE66Y, DE68Y, EE69Y, DF66Y, DF68Y, EF69Y, DG66Y, DG68Y, EG69Y, DH66Y, DH68Y, EH69Y, DI66Y, DI68Y, EI69Y, DJ66Y, DJ68Y, EJ69Y]

Status: done

submitted: 2017-09-13 10:47:08, status changed: 2017-09-13 14:53:52
Settings
Chain sequence(s) A: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
C: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
B: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
E: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
D: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
G: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
F: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
I: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
H: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
J: MIQSQINRNIRLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKLDLDEDSILLLQMIPLRGCIDDRIPTDPTMYQFYEMLQVYGTTLKALVHEKFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF
Distance of aggregation 10 Å
Dynamic mode No
Mutated residues DA66Y, DA68Y, EA69Y, DB66Y, DB68Y, EB69Y, DC66Y, DC68Y, EC69Y, DD66Y, DD68Y, ED69Y, DE66Y, DE68Y, EE69Y, DF66Y, DF68Y, EF69Y, DG66Y, DG68Y, EG69Y, DH66Y, DH68Y, EH69Y, DI66Y, DI68Y, EI69Y, DJ66Y, DJ68Y, EJ69Y
Energy difference between WT (input) and mutated protein (by FoldX) 44.4638 kcal/mol
Show buried residues

Minimal score value
-3.3841
Maximal score value
2.2592
Average score
-0.4948
Total score value
-771.8683

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
1 M A 0.5182
2 I A 0.4610
3 Q A 0.0000
4 S A 0.0000
5 Q A 0.0000
6 I A -0.2048
7 N A -0.9901
8 R A -1.1358
9 N A -1.6790
10 I A -0.7612
11 R A 0.0000
12 L A -1.1192
13 D A -2.0188
14 L A 0.0000
15 A A 0.0000
16 D A -0.7740
17 A A -0.3797
18 I A 0.0000
19 L A 0.0000
20 L A -0.8395
21 S A -1.0312
22 K A 0.0000
23 A A 0.0000
24 K A -2.9733
25 K A -3.1143
26 D A -2.6885
27 L A -1.6408
28 S A 0.0000
29 F A 0.0000
30 A A -1.6547
31 E A -2.4181
32 I A 0.0000
33 A A 0.0000
34 D A -2.7838
35 G A -1.6054
36 T A -1.6350
37 G A -0.9656
38 L A -0.5767
39 A A -1.1033
40 E A -1.9260
41 A A 0.0000
42 F A 0.0000
43 V A 0.0000
44 T A 0.0000
45 A A 0.0000
46 A A 0.0000
47 L A 0.0000
48 L A 0.0000
49 G A 0.0000
50 Q A 0.0000
51 Q A 0.0000
52 A A -0.3542
53 L A 0.0000
54 P A -0.9165
55 A A -1.2694
56 D A -2.2646
57 A A 0.0000
58 A A 0.0000
59 R A -1.7159
60 L A -0.9537
61 V A 0.0000
62 G A 0.0000
63 A A 0.3239
64 K A -0.3840
65 L A 0.0000
66 Y A 1.4906 mutated: DA66Y
67 L A 1.4999
68 Y A 2.2592 mutated: DA68Y
69 Y A 1.6192 mutated: EA69Y
70 D A 0.4399
71 S A 0.0000
72 I A 0.5271
73 L A 0.1095
74 L A 0.0000
75 L A 0.0000
76 Q A -0.4718
77 M A 0.0000
78 I A 0.0000
79 P A 0.0000
80 L A 0.0000
81 R A 0.0000
82 G A 0.0000
83 C A 0.0000
84 I A 0.0000
85 D A -2.8537
86 D A -3.3841
87 R A -2.0634
88 I A 0.0000
89 P A 0.0000
90 T A -0.8408
91 D A 0.0000
92 P A 0.0000
93 T A 0.0000
94 M A 0.0000
95 Y A 0.0000
96 Q A 0.0000
97 F A 0.0000
98 Y A 0.0000
99 E A 0.0000
100 M A 0.0000
101 L A 0.0000
102 Q A 0.0000
103 V A 0.0000
104 Y A 0.0000
105 G A 0.0000
106 T A 0.0000
107 T A 0.0000
108 L A 0.0000
109 K A 0.0000
110 A A 0.0000
111 L A 0.0000
112 V A 0.0000
113 H A 0.0000
114 E A -0.1471
115 K A -1.0913
116 F A -0.6824
117 G A -0.2619
118 D A -0.5417
119 G A 0.0000
120 I A 0.0000
121 I A 0.0000
122 S A 0.0000
123 A A 0.0000
124 I A -0.6913
125 N A -1.3585
126 F A 0.0000
127 K A -1.9381
128 L A 0.0000
129 D A -2.5679
130 V A 0.0000
131 K A -2.7187
132 K A -2.3069
133 V A -0.9326
134 A A -0.8917
135 D A 0.0000
136 P A -1.3693
137 E A -2.2886
138 G A -1.6939
139 G A -1.3640
140 E A -1.5079
141 R A 0.0000
142 A A 0.0000
143 V A -1.1246
144 I A 0.0000
145 T A -1.1644
146 L A 0.0000
147 D A -1.2530
148 G A 0.0000
149 K A -1.0518
150 Y A -0.6226
151 L A -0.5506
152 P A -0.8941
153 T A -1.0336
154 K A -1.9235
155 P A -0.8358
156 F A -0.3210
1 M B 0.3800
2 I B 0.4317
3 Q B 0.0000
4 S B 0.0000
5 Q B 0.0000
6 I B -0.3011
7 N B -1.1434
8 R B -1.2727
9 N B -1.7713
10 I B -0.9700
11 R B 0.0000
12 L B -1.1362
13 D B -2.0305
14 L B 0.0000
15 A B 0.0000
16 D B 0.0000
17 A B -0.2699
18 I B 0.0000
19 L B 0.0000
20 L B -0.7119
21 S B -0.8806
22 K B 0.0000
23 A B 0.0000
24 K B -2.7903
25 K B -2.7357
26 D B -2.4713
27 L B -1.3617
28 S B 0.0000
29 F B 0.0000
30 A B -1.3802
31 E B -2.0126
32 I B 0.0000
33 A B 0.0000
34 D B -2.6201
35 G B -1.5434
36 T B -1.6112
37 G B -0.9140
38 L B -0.4922
39 A B -1.0151
40 E B -1.7469
41 A B 0.0000
42 F B 0.0000
43 V B 0.0000
44 T B 0.0000
45 A B 0.0000
46 A B 0.0000
47 L B 0.0000
48 L B 0.0000
49 G B 0.0000
50 Q B 0.0000
51 Q B 0.0000
52 A B -0.3849
53 L B 0.0000
54 P B -1.1160
55 A B -1.3271
56 D B -2.3280
57 A B 0.0000
58 A B 0.0000
59 R B -1.8933
60 L B -1.0645
61 V B 0.0000
62 G B 0.0000
63 A B 0.2729
64 K B -0.3208
65 L B 0.0000
66 Y B 1.5082 mutated: DB66Y
67 L B 1.4322
68 Y B 2.1934 mutated: DB68Y
69 Y B 1.4509 mutated: EB69Y
70 D B 0.1707
71 S B 0.6143
72 I B 0.3658
73 L B -0.1020
74 L B 0.0000
75 L B 0.0000
76 Q B -0.5553
77 M B 0.0000
78 I B 0.0000
79 P B 0.0000
80 L B -0.0766
81 R B 0.0000
82 G B 0.0000
83 C B 0.0000
84 I B 0.0000
85 D B -2.3030
86 D B -3.1201
87 R B -1.9962
88 I B 0.0000
89 P B 0.0000
90 T B 0.0000
91 D B 0.0000
92 P B 0.0000
93 T B 0.0000
94 M B 0.0000
95 Y B 0.0000
96 Q B 0.0000
97 F B 0.0000
98 Y B 0.0000
99 E B 0.0000
100 M B 0.0000
101 L B 0.0000
102 Q B 0.0000
103 V B 0.0000
104 Y B 0.0000
105 G B 0.0000
106 T B 0.0000
107 T B 0.0000
108 L B 0.0000
109 K B 0.0000
110 A B 0.0000
111 L B 0.0000
112 V B 0.0000
113 H B 0.0000
114 E B -0.2686
115 K B -1.2794
116 F B -0.8388
117 G B -0.3357
118 D B -0.5772
119 G B 0.0000
120 I B 0.0000
121 I B 0.0000
122 S B 0.0000
123 A B 0.0000
124 I B -0.6700
125 N B -1.2993
126 F B 0.0000
127 K B -1.9018
128 L B 0.0000
129 D B -2.5787
130 V B 0.0000
131 K B -2.6168
132 K B -2.1118
133 V B -0.8564
134 A B -0.9205
135 D B 0.0000
136 P B -1.3907
137 E B -2.3157
138 G B -1.7857
139 G B -1.4402
140 E B -1.5705
141 R B -1.3333
142 A B 0.0000
143 V B -1.1287
144 I B 0.0000
145 T B -0.9388
146 L B 0.0000
147 D B 0.0000
148 G B 0.0000
149 K B -1.0183
150 Y B 0.0000
151 L B -0.5983
152 P B -0.9202
153 T B -1.0474
154 K B -1.9119
155 P B -0.8026
156 F B -0.2443
1 M C 0.6175
2 I C 0.6341
3 Q C 0.0000
4 S C 0.0000
5 Q C 0.0000
6 I C 0.0000
7 N C -1.2314
8 R C -1.3074
9 N C -1.7869
10 I C -0.9876
11 R C 0.0000
12 L C -1.1294
13 D C -2.0211
14 L C 0.0000
15 A C 0.0000
16 D C 0.0000
17 A C -0.2699
18 I C 0.0000
19 L C 0.0000
20 L C -0.7522
21 S C -0.9084
22 K C 0.0000
23 A C 0.0000
24 K C -2.8280
25 K C -2.7909
26 D C -2.4820
27 L C -1.3854
28 S C 0.0000
29 F C 0.0000
30 A C -1.3917
31 E C -1.9839
32 I C 0.0000
33 A C 0.0000
34 D C -2.6254
35 G C -1.5481
36 T C -1.6557
37 G C -0.9497
38 L C -0.5033
39 A C -1.0271
40 E C -1.8323
41 A C 0.0000
42 F C 0.0000
43 V C 0.0000
44 T C 0.0000
45 A C 0.0000
46 A C 0.0000
47 L C 0.0000
48 L C 0.0000
49 G C 0.0000
50 Q C 0.0000
51 Q C 0.0000
52 A C -0.3780
53 L C 0.0000
54 P C -1.0708
55 A C -1.3120
56 D C -2.3239
57 A C 0.0000
58 A C 0.0000
59 R C -1.7816
60 L C -1.1279
61 V C 0.0000
62 G C 0.0000
63 A C 0.2275
64 K C -0.3277
65 L C 0.0000
66 Y C 1.4889 mutated: DC66Y
67 L C 1.3588
68 Y C 1.9093 mutated: DC68Y
69 Y C 1.2961 mutated: EC69Y
70 D C -0.0905
71 S C 0.0000
72 I C 0.0000
73 L C -0.1642
74 L C 0.0000
75 L C 0.0000
76 Q C -0.5164
77 M C 0.0000
78 I C 0.0000
79 P C 0.0000
80 L C -0.1428
81 R C 0.0000
82 G C 0.0000
83 C C 0.0000
84 I C 0.0000
85 D C -1.6169
86 D C -2.2349
87 R C -1.3054
88 I C 0.0000
89 P C 0.0000
90 T C -0.5844
91 D C 0.0000
92 P C 0.0000
93 T C 0.0000
94 M C 0.0000
95 Y C 0.0000
96 Q C 0.0000
97 F C 0.0000
98 Y C 0.0000
99 E C 0.0000
100 M C 0.0000
101 L C 0.0000
102 Q C 0.0000
103 V C 0.0000
104 Y C 0.0000
105 G C 0.0000
106 T C 0.0000
107 T C 0.0000
108 L C 0.0000
109 K C 0.0000
110 A C 0.0000
111 L C 0.0000
112 V C 0.0000
113 H C 0.0000
114 E C -0.0894
115 K C -0.8975
116 F C -0.6481
117 G C -0.2595
118 D C -0.5650
119 G C 0.0000
120 I C 0.0000
121 I C 0.0000
122 S C 0.0000
123 A C 0.0000
124 I C -0.6623
125 N C -1.2198
126 F C 0.0000
127 K C -1.7652
128 L C 0.0000
129 D C -2.5932
130 V C 0.0000
131 K C -2.6038
132 K C -2.0311
133 V C -0.8326
134 A C -0.8600
135 D C 0.0000
136 P C -1.3855
137 E C -2.2849
138 G C -1.7100
139 G C -1.3852
140 E C -1.4791
141 R C -1.1811
142 A C 0.0000
143 V C -1.0970
144 I C 0.0000
145 T C -1.0756
146 L C 0.0000
147 D C 0.0000
148 G C 0.0000
149 K C -1.0085
150 Y C 0.0000
151 L C -0.5704
152 P C -0.9045
153 T C -1.0323
154 K C -1.7891
155 P C -0.8900
156 F C -0.3775
1 M D 0.6361
2 I D 0.5836
3 Q D 0.0000
4 S D 0.0000
5 Q D 0.0000
6 I D 0.0000
7 N D -1.2396
8 R D -1.3177
9 N D -1.8409
10 I D -1.2113
11 R D 0.0000
12 L D -1.2093
13 D D -2.0973
14 L D 0.0000
15 A D 0.0000
16 D D -0.6616
17 A D -0.3571
18 I D 0.0000
19 L D 0.0000
20 L D -0.7692
21 S D -0.9169
22 K D 0.0000
23 A D 0.0000
24 K D -2.7988
25 K D -2.7065
26 D D -2.4349
27 L D -1.4198
28 S D 0.0000
29 F D 0.0000
30 A D -1.5268
31 E D -2.2306
32 I D 0.0000
33 A D 0.0000
34 D D -2.7024
35 G D -1.5859
36 T D -1.6317
37 G D -1.1051
38 L D -0.4912
39 A D -1.0539
40 E D -1.8006
41 A D 0.0000
42 F D 0.0000
43 V D 0.0000
44 T D 0.0000
45 A D 0.0000
46 A D 0.0000
47 L D 0.0000
48 L D 0.0000
49 G D 0.0000
50 Q D 0.0000
51 Q D 0.0000
52 A D -0.3726
53 L D 0.0000
54 P D -1.1113
55 A D -1.3130
56 D D -2.3646
57 A D 0.0000
58 A D 0.0000
59 R D -1.7354
60 L D -1.0838
61 V D 0.0000
62 G D 0.0000
63 A D 0.2172
64 K D -0.4480
65 L D 0.0000
66 Y D 1.4960 mutated: DD66Y
67 L D 1.4988
68 Y D 2.0679 mutated: DD68Y
69 Y D 1.5482 mutated: ED69Y
70 D D 0.3304
71 S D 0.6718
72 I D 0.4587
73 L D 0.0072
74 L D 0.0000
75 L D 0.0000
76 Q D -0.5160
77 M D 0.0000
78 I D 0.0000
79 P D 0.0000
80 L D 0.0000
81 R D 0.0000
82 G D 0.0000
83 C D 0.0000
84 I D 0.0000
85 D D -1.8654
86 D D -2.8114
87 R D -1.5887
88 I D 0.0000
89 P D 0.0000
90 T D 0.0000
91 D D 0.0000
92 P D 0.0000
93 T D 0.0000
94 M D 0.0000
95 Y D 0.0000
96 Q D 0.0000
97 F D 0.0000
98 Y D 0.0000
99 E D 0.0000
100 M D 0.0000
101 L D 0.0000
102 Q D 0.0000
103 V D 0.0000
104 Y D 0.0000
105 G D 0.0000
106 T D 0.0000
107 T D 0.0000
108 L D 0.0000
109 K D 0.0000
110 A D 0.0000
111 L D 0.0000
112 V D 0.0000
113 H D 0.0000
114 E D -0.2771
115 K D -1.2617
116 F D -0.7882
117 G D -0.4367
118 D D -0.5826
119 G D 0.0000
120 I D 0.0000
121 I D 0.0000
122 S D 0.0000
123 A D 0.0000
124 I D -0.6250
125 N D -1.1874
126 F D 0.0000
127 K D -1.7049
128 L D 0.0000
129 D D -2.5652
130 V D 0.0000
131 K D -2.6709
132 K D -2.2907
133 V D -0.9962
134 A D -0.9903
135 D D 0.0000
136 P D -1.3982
137 E D -2.3035
138 G D -1.7340
139 G D -1.4195
140 E D -1.6670
141 R D -1.3636
142 A D 0.0000
143 V D -1.2801
144 I D 0.0000
145 T D -1.1209
146 L D 0.0000
147 D D 0.0000
148 G D 0.0000
149 K D -0.8912
150 Y D 0.0000
151 L D -0.5765
152 P D -0.8799
153 T D -1.0558
154 K D -1.9334
155 P D -0.8286
156 F D -0.2712
1 M E 0.5334
2 I E 0.7285
3 Q E 0.0000
4 S E 0.0000
5 Q E 0.0000
6 I E -0.2692
7 N E -1.0923
8 R E -1.2211
9 N E -1.6953
10 I E -0.7823
11 R E 0.0000
12 L E -1.1378
13 D E -2.0231
14 L E 0.0000
15 A E 0.0000
16 D E -0.7900
17 A E -0.3683
18 I E 0.0000
19 L E 0.0000
20 L E -0.8374
21 S E -0.9820
22 K E 0.0000
23 A E 0.0000
24 K E -2.9104
25 K E -2.8644
26 D E -2.5420
27 L E 0.0000
28 S E 0.0000
29 F E 0.0000
30 A E -1.5584
31 E E -2.1710
32 I E 0.0000
33 A E 0.0000
34 D E -2.6747
35 G E -1.5578
36 T E -1.6374
37 G E -0.9662
38 L E -0.5494
39 A E -1.1153
40 E E -1.8518
41 A E 0.0000
42 F E 0.0000
43 V E 0.0000
44 T E 0.0000
45 A E 0.0000
46 A E 0.0000
47 L E 0.0000
48 L E 0.0000
49 G E 0.0000
50 Q E 0.0000
51 Q E 0.0000
52 A E -0.3607
53 L E 0.0000
54 P E -1.0940
55 A E -1.2825
56 D E -2.2819
57 A E 0.0000
58 A E 0.0000
59 R E -1.6381
60 L E -0.9707
61 V E 0.0000
62 G E 0.0000
63 A E 0.3133
64 K E -0.3536
65 L E 0.0000
66 Y E 1.5216 mutated: DE66Y
67 L E 1.4984
68 Y E 2.0158 mutated: DE68Y
69 Y E 1.4542 mutated: EE69Y
70 D E 0.1516
71 S E 0.6181
72 I E 0.4315
73 L E -0.0430
74 L E 0.0000
75 L E 0.0000
76 Q E -0.4216
77 M E 0.0000
78 I E 0.0000
79 P E 0.0000
80 L E 0.0000
81 R E 0.0000
82 G E 0.0000
83 C E 0.0000
84 I E 0.0000
85 D E -2.7011
86 D E -3.0162
87 R E -1.6407
88 I E -0.8467
89 P E 0.0000
90 T E -0.6323
91 D E 0.0000
92 P E 0.0000
93 T E 0.0000
94 M E 0.0000
95 Y E 0.0000
96 Q E 0.0000
97 F E 0.0000
98 Y E 0.0000
99 E E 0.0000
100 M E 0.0000
101 L E 0.0000
102 Q E 0.0000
103 V E 0.0000
104 Y E 0.0000
105 G E 0.0000
106 T E 0.0000
107 T E 0.0000
108 L E 0.0000
109 K E 0.0000
110 A E 0.0000
111 L E 0.0000
112 V E 0.0000
113 H E 0.0000
114 E E -0.2560
115 K E -1.2633
116 F E -0.8064
117 G E -0.4285
118 D E -0.5754
119 G E 0.0000
120 I E 0.0000
121 I E 0.0000
122 S E 0.0000
123 A E -0.4079
124 I E -0.6710
125 N E -1.3078
126 F E 0.0000
127 K E -2.2006
128 L E 0.0000
129 D E -2.7020
130 V E 0.0000
131 K E -2.4823
132 K E -1.8127
133 V E -0.6708
134 A E -0.8157
135 D E 0.0000
136 P E -1.3815
137 E E -2.3005
138 G E -1.7403
139 G E -1.3765
140 E E -1.4028
141 R E -1.0890
142 A E 0.0000
143 V E -1.0681
144 I E 0.0000
145 T E -1.0934
146 L E 0.0000
147 D E -1.5038
148 G E 0.0000
149 K E -1.1108
150 Y E 0.0000
151 L E -0.5867
152 P E -0.9124
153 T E -1.0059
154 K E -1.8652
155 P E -0.7900
156 F E -0.1620
1 M F 0.5505
2 I F 0.6651
3 Q F 0.0000
4 S F 0.0000
5 Q F 0.0000
6 I F 0.0000
7 N F -1.1154
8 R F -1.2726
9 N F -1.7172
10 I F -0.8208
11 R F 0.0000
12 L F -1.1844
13 D F -2.0261
14 L F 0.0000
15 A F 0.0000
16 D F -0.8419
17 A F -0.3453
18 I F 0.0000
19 L F 0.0000
20 L F -0.6127
21 S F -0.9156
22 K F 0.0000
23 A F 0.0000
24 K F -2.6855
25 K F -2.7304
26 D F -2.4483
27 L F -1.3745
28 S F 0.0000
29 F F 0.0000
30 A F -1.5510
31 E F -2.1259
32 I F 0.0000
33 A F 0.0000
34 D F -2.7022
35 G F -1.5659
36 T F -1.6131
37 G F -0.9329
38 L F -0.5241
39 A F -1.1003
40 E F -1.9269
41 A F 0.0000
42 F F 0.0000
43 V F 0.0000
44 T F 0.0000
45 A F 0.0000
46 A F 0.0000
47 L F 0.0000
48 L F 0.0000
49 G F 0.0000
50 Q F 0.0000
51 Q F 0.0000
52 A F -0.4079
53 L F 0.0000
54 P F -1.1160
55 A F -1.3650
56 D F -2.3530
57 A F 0.0000
58 A F 0.0000
59 R F -1.8120
60 L F -1.0803
61 V F 0.0000
62 G F 0.0000
63 A F 0.2036
64 K F -0.3941
65 L F 0.0000
66 Y F 1.4433 mutated: DF66Y
67 L F 1.3504
68 Y F 1.8464 mutated: DF68Y
69 Y F 1.2214 mutated: EF69Y
70 D F -0.2255
71 S F 0.3639
72 I F 0.0000
73 L F -0.2817
74 L F 0.0000
75 L F 0.0000
76 Q F -0.6191
77 M F 0.0000
78 I F 0.0000
79 P F 0.0000
80 L F 0.0000
81 R F 0.0000
82 G F 0.0000
83 C F 0.0000
84 I F 0.0000
85 D F -2.1918
86 D F -3.0699
87 R F -2.0365
88 I F 0.0000
89 P F 0.0000
90 T F 0.0000
91 D F 0.0000
92 P F 0.0000
93 T F 0.0000
94 M F 0.0000
95 Y F 0.0000
96 Q F 0.0000
97 F F 0.0000
98 Y F 0.0000
99 E F 0.0000
100 M F 0.0000
101 L F 0.0000
102 Q F 0.0000
103 V F 0.0000
104 Y F 0.0000
105 G F 0.0000
106 T F 0.0000
107 T F 0.0000
108 L F 0.0000
109 K F 0.0000
110 A F 0.0000
111 L F 0.0000
112 V F 0.0000
113 H F 0.0000
114 E F -0.2425
115 K F -1.2348
116 F F -0.7748
117 G F -0.4334
118 D F -0.5866
119 G F 0.0000
120 I F 0.0000
121 I F 0.0000
122 S F 0.0000
123 A F 0.0000
124 I F -0.5925
125 N F -1.1666
126 F F 0.0000
127 K F -1.8702
128 L F 0.0000
129 D F -2.6262
130 V F 0.0000
131 K F -2.7431
132 K F -2.3437
133 V F -1.0006
134 A F -0.9359
135 D F 0.0000
136 P F -1.3817
137 E F -2.2744
138 G F -1.6799
139 G F -1.3602
140 E F -1.5953
141 R F -1.3288
142 A F 0.0000
143 V F -1.1865
144 I F 0.0000
145 T F -0.9594
146 L F 0.0000
147 D F -1.1999
148 G F 0.0000
149 K F -1.1970
150 Y F 0.0000
151 L F 0.0000
152 P F -1.0207
153 T F -1.0909
154 K F -1.9916
155 P F -0.9153
156 F F -0.4785
1 M G 0.6192
2 I G 0.5757
3 Q G 0.0000
4 S G 0.0000
5 Q G 0.0000
6 I G -0.2301
7 N G -1.0358
8 R G -1.1977
9 N G -1.7124
10 I G -0.7979
11 R G 0.0000
12 L G -1.1111
13 D G -1.9571
14 L G 0.0000
15 A G 0.0000
16 D G 0.0000
17 A G -0.2735
18 I G 0.0000
19 L G 0.0000
20 L G -0.7589
21 S G -0.8671
22 K G 0.0000
23 A G 0.0000
24 K G -2.8026
25 K G -2.6976
26 D G -2.4662
27 L G -1.3979
28 S G -0.8296
29 F G 0.0000
30 A G -1.5101
31 E G -2.0937
32 I G 0.0000
33 A G 0.0000
34 D G -2.6724
35 G G -1.5573
36 T G -1.6315
37 G G -0.9558
38 L G -0.5303
39 A G -1.0742
40 E G -1.8788
41 A G 0.0000
42 F G 0.0000
43 V G 0.0000
44 T G 0.0000
45 A G 0.0000
46 A G 0.0000
47 L G 0.0000
48 L G 0.0000
49 G G 0.0000
50 Q G 0.0000
51 Q G 0.0000
52 A G -0.3428
53 L G 0.0000
54 P G -0.9270
55 A G -1.2682
56 D G -2.2944
57 A G 0.0000
58 A G 0.0000
59 R G -1.8122
60 L G -0.9904
61 V G 0.0000
62 G G 0.0000
63 A G 0.3117
64 K G -0.2970
65 L G 0.0000
66 Y G 1.5220 mutated: DG66Y
67 L G 1.4221
68 Y G 2.1381 mutated: DG68Y
69 Y G 1.3914 mutated: EG69Y
70 D G -0.0198
71 S G 0.5901
72 I G 0.4653
73 L G 0.0401
74 L G 0.0884
75 L G 0.0000
76 Q G -0.4120
77 M G 0.0000
78 I G 0.0000
79 P G 0.0000
80 L G 0.0000
81 R G 0.0000
82 G G 0.0000
83 C G 0.0000
84 I G 0.0000
85 D G -2.4276
86 D G -3.0810
87 R G -1.6850
88 I G 0.0000
89 P G 0.0000
90 T G -0.8039
91 D G 0.0000
92 P G 0.0000
93 T G 0.0000
94 M G 0.0000
95 Y G 0.0000
96 Q G 0.0000
97 F G 0.0000
98 Y G 0.0000
99 E G 0.0000
100 M G 0.0000
101 L G 0.0000
102 Q G 0.0000
103 V G 0.0000
104 Y G 0.0000
105 G G 0.0000
106 T G 0.0000
107 T G 0.0000
108 L G 0.0000
109 K G 0.0000
110 A G 0.0000
111 L G 0.0000
112 V G 0.0000
113 H G 0.0000
114 E G -0.2158
115 K G -1.1997
116 F G -0.5095
117 G G -0.3627
118 D G -0.5068
119 G G 0.0000
120 I G 0.0000
121 I G 0.0000
122 S G 0.0000
123 A G 0.0000
124 I G -0.5959
125 N G -1.1533
126 F G 0.0000
127 K G -1.8796
128 L G 0.0000
129 D G -2.6369
130 V G 0.0000
131 K G -2.7396
132 K G -2.2443
133 V G -1.0149
134 A G -0.9883
135 D G -1.5452
136 P G -1.4701
137 E G -2.3529
138 G G -1.7902
139 G G -1.4858
140 E G -1.6147
141 R G -1.3977
142 A G 0.0000
143 V G -1.3584
144 I G 0.0000
145 T G -1.1976
146 L G 0.0000
147 D G 0.0000
148 G G 0.0000
149 K G -0.8521
150 Y G -0.4045
151 L G -0.4270
152 P G -0.6205
153 T G -0.9800
154 K G -1.9043
155 P G -0.8382
156 F G -0.1704
1 M H 0.6728
2 I H 0.7397
3 Q H 0.0000
4 S H 0.0000
5 Q H 0.0000
6 I H -0.2978
7 N H -1.1371
8 R H -1.2297
9 N H -1.7313
10 I H -0.9033
11 R H 0.0000
12 L H -1.1063
13 D H -1.9932
14 L H 0.0000
15 A H 0.0000
16 D H 0.0000
17 A H -0.2580
18 I H 0.0000
19 L H 0.0000
20 L H -0.7100
21 S H -0.9024
22 K H 0.0000
23 A H 0.0000
24 K H -2.8358
25 K H -2.7823
26 D H -2.4907
27 L H -1.5548
28 S H 0.0000
29 F H 0.0000
30 A H -1.5766
31 E H -2.5824
32 I H 0.0000
33 A H 0.0000
34 D H -2.7593
35 G H -1.6381
36 T H -1.6305
37 G H -0.8864
38 L H -0.3738
39 A H -0.7432
40 E H -1.3529
41 A H 0.0000
42 F H 0.0000
43 V H 0.0000
44 T H 0.0000
45 A H 0.0000
46 A H 0.0000
47 L H 0.0000
48 L H 0.0000
49 G H 0.0000
50 Q H 0.0000
51 Q H 0.0000
52 A H -0.3995
53 L H 0.0000
54 P H -1.1252
55 A H -1.3607
56 D H -2.3307
57 A H 0.0000
58 A H 0.0000
59 R H -1.9674
60 L H -1.0996
61 V H 0.0000
62 G H 0.0000
63 A H 0.2223
64 K H -0.4854
65 L H 0.0000
66 Y H 1.4635 mutated: DH66Y
67 L H 1.3389
68 Y H 2.0815 mutated: DH68Y
69 Y H 1.2754 mutated: EH69Y
70 D H -0.0980
71 S H 0.0000
72 I H 0.0000
73 L H 0.0000
74 L H 0.0000
75 L H 0.0000
76 Q H -0.6284
77 M H 0.0000
78 I H 0.0000
79 P H 0.0000
80 L H -0.0668
81 R H 0.0000
82 G H 0.0000
83 C H 0.0000
84 I H 0.0000
85 D H -2.3642
86 D H -2.3395
87 R H -1.5316
88 I H 0.0000
89 P H 0.0000
90 T H -0.6206
91 D H 0.0000
92 P H 0.0000
93 T H 0.0000
94 M H 0.0000
95 Y H 0.0000
96 Q H 0.0000
97 F H 0.0000
98 Y H 0.0000
99 E H 0.0000
100 M H 0.0000
101 L H 0.0000
102 Q H 0.0000
103 V H 0.0000
104 Y H 0.0000
105 G H 0.0000
106 T H 0.0000
107 T H 0.0000
108 L H 0.0000
109 K H 0.0000
110 A H 0.0000
111 L H 0.0000
112 V H 0.0000
113 H H 0.0000
114 E H -0.2795
115 K H -1.2489
116 F H -0.7459
117 G H -0.4175
118 D H -0.5556
119 G H 0.0000
120 I H 0.0000
121 I H 0.0000
122 S H 0.0000
123 A H -0.3208
124 I H -0.6248
125 N H -1.1978
126 F H 0.0000
127 K H -1.7095
128 L H 0.0000
129 D H -2.2539
130 V H 0.0000
131 K H -2.6303
132 K H -2.2780
133 V H -0.9994
134 A H -0.9808
135 D H -1.5064
136 P H -1.4459
137 E H -2.3134
138 G H -1.7115
139 G H -1.4080
140 E H -1.6340
141 R H -1.3484
142 A H 0.0000
143 V H -1.1502
144 I H 0.0000
145 T H -1.0163
146 L H 0.0000
147 D H 0.0000
148 G H 0.0000
149 K H -0.8903
150 Y H -0.4932
151 L H -0.4796
152 P H -0.8569
153 T H -1.0044
154 K H -1.8958
155 P H -0.8222
156 F H -0.2538
1 M I 0.5063
2 I I 0.6637
3 Q I 0.0000
4 S I 0.0000
5 Q I 0.0000
6 I I -0.2568
7 N I -1.0795
8 R I -1.2001
9 N I -1.6590
10 I I -0.7602
11 R I 0.0000
12 L I -1.0707
13 D I -1.9621
14 L I 0.0000
15 A I 0.0000
16 D I 0.0000
17 A I -0.2677
18 I I 0.0000
19 L I 0.0000
20 L I -0.4249
21 S I -0.5551
22 K I 0.0000
23 A I 0.0000
24 K I -2.0303
25 K I -1.8883
26 D I -2.0496
27 L I -1.1312
28 S I 0.0000
29 F I 0.0000
30 A I -1.4975
31 E I -2.0650
32 I I 0.0000
33 A I 0.0000
34 D I -2.7314
35 G I -1.5708
36 T I -1.6051
37 G I -0.9879
38 L I -0.5908
39 A I -1.0777
40 E I -1.8317
41 A I 0.0000
42 F I 0.0000
43 V I 0.0000
44 T I 0.0000
45 A I 0.0000
46 A I 0.0000
47 L I 0.0000
48 L I 0.0000
49 G I 0.0000
50 Q I 0.0000
51 Q I 0.0000
52 A I -0.3772
53 L I 0.0000
54 P I -1.0781
55 A I -1.3274
56 D I -2.3190
57 A I 0.0000
58 A I 0.0000
59 R I -1.8415
60 L I -0.8619
61 V I 0.0000
62 G I 0.0000
63 A I 0.2136
64 K I -0.3229
65 L I 0.0000
66 Y I 1.4900 mutated: DI66Y
67 L I 1.2801
68 Y I 1.7605 mutated: DI68Y
69 Y I 0.9641 mutated: EI69Y
70 D I -0.0853
71 S I 0.3986
72 I I 0.0000
73 L I -0.2996
74 L I 0.0000
75 L I 0.0000
76 Q I -0.5532
77 M I 0.0000
78 I I 0.0000
79 P I 0.0000
80 L I -0.0610
81 R I 0.0000
82 G I 0.0000
83 C I 0.0000
84 I I 0.0000
85 D I -1.6559
86 D I -2.3247
87 R I -1.3342
88 I I 0.0000
89 P I 0.0000
90 T I -0.6384
91 D I 0.0000
92 P I 0.0000
93 T I 0.0000
94 M I 0.0000
95 Y I 0.0000
96 Q I 0.0000
97 F I 0.0000
98 Y I 0.0000
99 E I 0.0000
100 M I 0.0000
101 L I 0.0000
102 Q I 0.0000
103 V I 0.0000
104 Y I 0.0000
105 G I 0.0000
106 T I 0.0000
107 T I 0.0000
108 L I 0.0000
109 K I 0.0000
110 A I 0.0000
111 L I 0.0000
112 V I 0.0000
113 H I 0.0000
114 E I -0.2417
115 K I -1.2201
116 F I -0.7588
117 G I -0.4594
118 D I -0.6354
119 G I 0.0000
120 I I 0.0000
121 I I 0.0000
122 S I 0.0000
123 A I -0.3782
124 I I -0.5808
125 N I -1.2043
126 F I 0.0000
127 K I -1.7871
128 L I 0.0000
129 D I -1.8907
130 V I 0.0000
131 K I -1.9891
132 K I -2.1551
133 V I -0.7302
134 A I -0.8774
135 D I 0.0000
136 P I -1.3610
137 E I -2.2876
138 G I -1.7059
139 G I -1.3403
140 E I -1.5636
141 R I -1.2044
142 A I 0.0000
143 V I -0.8959
144 I I 0.0000
145 T I -0.9444
146 L I 0.0000
147 D I -1.3953
148 G I 0.0000
149 K I -1.2343
150 Y I -0.7624
151 L I 0.0000
152 P I -1.0120
153 T I -1.0868
154 K I -1.9315
155 P I -0.8147
156 F I -0.2280
1 M J 0.6412
2 I J 0.6022
3 Q J 0.0000
4 S J 0.0000
5 Q J 0.0000
6 I J -0.2940
7 N J -1.1274
8 R J -1.2675
9 N J -1.8071
10 I J -1.0249
11 R J 0.0000
12 L J -1.2405
13 D J -2.0855
14 L J 0.0000
15 A J 0.0000
16 D J -0.8108
17 A J -0.3648
18 I J 0.0000
19 L J 0.0000
20 L J -0.7971
21 S J -0.9243
22 K J 0.0000
23 A J 0.0000
24 K J -2.8117
25 K J -2.7482
26 D J -2.4587
27 L J -1.4634
28 S J 0.0000
29 F J 0.0000
30 A J -1.6110
31 E J -2.4160
32 I J 0.0000
33 A J 0.0000
34 D J -2.7517
35 G J -1.6095
36 T J -1.6439
37 G J -0.9266
38 L J -0.4821
39 A J -0.9968
40 E J -1.7192
41 A J 0.0000
42 F J 0.0000
43 V J 0.0000
44 T J 0.0000
45 A J 0.0000
46 A J 0.0000
47 L J 0.0000
48 L J 0.0000
49 G J 0.0000
50 Q J 0.0000
51 Q J 0.0000
52 A J -0.3665
53 L J 0.0000
54 P J -1.0688
55 A J -1.2148
56 D J -2.2337
57 A J 0.0000
58 A J 0.0000
59 R J -1.6516
60 L J -0.9905
61 V J 0.0000
62 G J 0.0000
63 A J 0.2787
64 K J -0.4324
65 L J 0.0000
66 Y J 1.5143 mutated: DJ66Y
67 L J 1.4271
68 Y J 2.1126 mutated: DJ68Y
69 Y J 1.3783 mutated: EJ69Y
70 D J -0.1259
71 S J 0.5159
72 I J 0.4351
73 L J -0.0053
74 L J 0.0000
75 L J 0.0000
76 Q J -0.4353
77 M J 0.0000
78 I J 0.0000
79 P J 0.0000
80 L J 0.0000
81 R J 0.0000
82 G J 0.0000
83 C J 0.0000
84 I J 0.0000
85 D J -2.8109
86 D J -3.2075
87 R J -1.8403
88 I J 0.0000
89 P J 0.0000
90 T J -0.6998
91 D J 0.0000
92 P J 0.0000
93 T J 0.0000
94 M J 0.0000
95 Y J 0.0000
96 Q J 0.0000
97 F J 0.0000
98 Y J 0.0000
99 E J 0.0000
100 M J 0.0000
101 L J 0.0000
102 Q J 0.0000
103 V J 0.0000
104 Y J 0.0000
105 G J 0.0000
106 T J 0.0000
107 T J 0.0000
108 L J 0.0000
109 K J 0.0000
110 A J 0.0000
111 L J 0.0000
112 V J 0.0000
113 H J 0.0000
114 E J -0.2972
115 K J -1.2255
116 F J -0.8117
117 G J -0.4490
118 D J -0.5992
119 G J 0.0000
120 I J 0.0000
121 I J 0.0000
122 S J 0.0000
123 A J -0.3222
124 I J -0.5906
125 N J -1.2128
126 F J 0.0000
127 K J -1.8510
128 L J 0.0000
129 D J -2.5984
130 V J 0.0000
131 K J -2.6617
132 K J -2.1607
133 V J -0.9223
134 A J -0.9594
135 D J 0.0000
136 P J -1.4163
137 E J -2.3346
138 G J -1.8261
139 G J -1.4576
140 E J -1.6564
141 R J -1.4260
142 A J 0.0000
143 V J -1.3247
144 I J 0.0000
145 T J -1.1454
146 L J 0.0000
147 D J -1.1418
148 G J 0.0000
149 K J -1.0002
150 Y J 0.0000
151 L J -0.6070
152 P J -0.9505
153 T J -1.0904
154 K J -1.9535
155 P J -0.8885
156 F J -0.3642

 

Laboratory of Theory of Biopolymers 2015