Project name: H4-22

Chain sequence(s)	H: QVQLQQWGAGLLKPSETLSLTCAVYGGSFSGFYWNWIRQPPGKGLEWIGEINHSGTTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARGLYTWNLDSWGQGTLVTVSS; L: DIQMTQSPSSLSASVGDRVTITCRASQAIRNDLGWYQQKPGKAPKRLIYAASSLQSGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCLQHNSYPRTSGQGTKVEIK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.1591
• Maximal score value: 1.7445
• Average score: -0.5748
• Total score value: -128.7627

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	D	L	-2.0342
2	I	L	-1.6028
3	Q	L	-2.3059
4	M	L	0.0000
5	T	L	-1.5746
6	Q	L	0.0000
7	S	L	-0.8679
8	P	L	-0.5914
9	S	L	-0.8017
10	S	L	-0.6748
11	L	L	-0.2899
12	S	L	-0.5779
13	A	L	-0.7877
14	S	L	-0.8610
15	V	L	-0.0083
16	G	L	-0.8454
17	D	L	-1.7882
18	R	L	-2.2962
19	V	L	0.0000
20	T	L	-0.6295
21	I	L	0.0000
22	T	L	-0.9817
23	C	L	0.0000
24	R	L	-3.0510
25	A	L	0.0000
26	S	L	-2.0088
27	Q	L	-2.4141
28	A	L	-1.8657
29	I	L	0.0000
30	R	L	-2.8886
31	N	L	-2.2751
32	D	L	-1.4524
33	L	L	0.0000
34	G	L	0.0000
35	W	L	0.0000
36	Y	L	0.0000
37	Q	L	0.0000
38	Q	L	0.0000
39	K	L	-1.3321
40	P	L	-1.0706
41	G	L	-1.6452
42	K	L	-2.5524
43	A	L	-1.6331
44	P	L	0.0000
45	K	L	-1.6208
46	R	L	-0.9841
47	L	L	0.0000
48	I	L	0.0000
49	Y	L	0.0000
50	A	L	-0.5844
51	A	L	0.0000
52	S	L	-0.4680
53	S	L	-0.0331
54	L	L	0.1716
55	Q	L	-0.2788
56	S	L	-0.4324
57	G	L	-0.5400
58	V	L	-0.3774
59	P	L	-0.3455
60	S	L	-0.4309
61	R	L	-0.7461
62	F	L	0.0000
63	S	L	-0.3478
64	G	L	-0.3210
65	S	L	-0.8916
66	G	L	-1.6799
67	S	L	-2.0836
68	G	L	-2.2025
69	T	L	-2.4495
70	E	L	-3.1591
71	F	L	0.0000
72	T	L	-0.9379
73	L	L	0.0000
74	T	L	-0.6190
75	I	L	0.0000
76	S	L	-1.3494
77	S	L	-1.1570
78	L	L	0.0000
79	Q	L	-0.7492
80	P	L	-0.9207
81	E	L	-1.4633
82	D	L	0.0000
83	F	L	-0.1117
84	A	L	0.0000
85	T	L	-0.5790
86	Y	L	0.0000
87	Y	L	0.0000
88	C	L	0.0000
89	L	L	0.0000
90	Q	L	0.0000
91	H	L	-0.4723
92	N	L	-1.0978
93	S	L	-0.2440
94	Y	L	0.6764
95	P	L	0.0000
96	R	L	-0.4240
97	T	L	-0.8795
98	S	L	-0.8204
99	G	L	0.0000
100	Q	L	-1.9360
101	G	L	0.0000
102	T	L	0.0000
103	K	L	-1.1207
104	V	L	0.0000
105	E	L	-0.7184
106	I	L	-0.5808
107	K	L	-1.5153
1	Q	H	-1.4751
2	V	H	0.0000
3	Q	H	-1.5595
4	L	H	0.0000
5	Q	H	-1.5066
6	Q	H	-0.9382
7	W	H	0.1741
8	G	H	0.3417
9	A	H	0.6205
10	G	H	1.0696
11	L	H	1.2154
12	L	H	-0.3918
13	K	H	-1.9072
14	P	H	-1.5036
15	S	H	-1.3976
16	E	H	-1.7325
17	T	H	-1.3083
18	L	H	0.0000
19	S	H	-0.6237
20	L	H	0.0000
21	T	H	-0.3240
22	C	H	0.0000
23	A	H	0.0000
24	V	H	0.0000
25	Y	H	-0.0726
26	G	H	-0.6391
27	G	H	-0.8644
28	S	H	-0.5370
29	F	H	0.0000
30	S	H	-0.5984
31	G	H	-0.2267
32	F	H	0.6642
33	Y	H	0.3773
34	W	H	0.0000
35	N	H	0.0000
36	W	H	0.0000
37	I	H	0.0000
38	R	H	-0.5148
39	Q	H	-0.7636
40	P	H	0.0000
41	P	H	-0.8551
42	G	H	-1.4546
43	K	H	-2.4096
44	G	H	-1.6847
45	L	H	-1.1429
46	E	H	-1.4698
47	W	H	0.0000
48	I	H	0.0000
49	G	H	0.0000
50	E	H	-0.3350
51	I	H	0.0000
52	N	H	-0.5251
53	H	H	-0.9951
54	S	H	-0.7708
55	G	H	-0.6716
56	T	H	-0.5378
57	T	H	-0.5637
58	N	H	-0.6793
59	Y	H	-0.5248
60	N	H	0.0000
61	P	H	-0.8353
62	S	H	-0.9066
63	L	H	0.0000
64	K	H	-1.5320
65	S	H	-1.0395
66	R	H	-1.2057
67	V	H	0.0000
68	T	H	-0.8122
69	I	H	0.0000
70	S	H	-0.5480
71	V	H	-0.7407
72	D	H	-1.5236
73	T	H	-1.5198
74	S	H	-1.5210
75	K	H	-2.2618
76	N	H	-1.7657
77	Q	H	-1.3612
78	F	H	0.0000
79	S	H	-0.4123
80	L	H	0.0000
81	K	H	-1.1810
82	L	H	0.0000
82A	S	H	-1.0245
82B	S	H	-1.0603
82C	V	H	0.0000
83	T	H	-0.6771
84	A	H	-0.2765
85	A	H	0.0414
86	D	H	0.0000
87	T	H	0.4224
88	A	H	0.0000
89	V	H	0.5970
90	Y	H	0.0000
91	Y	H	0.0000
92	C	H	0.0000
93	A	H	0.0000
94	R	H	0.0000
95	G	H	0.7794
96	L	H	1.2652
97	Y	H	1.7445
98	T	H	1.0746
99	W	H	0.7665
100	N	H	0.0000
100A	L	H	0.0000
101	D	H	-0.3693
102	S	H	-0.8515
103	W	H	-1.0541
104	G	H	0.0000
105	Q	H	-1.9166
106	G	H	-0.7666
107	T	H	0.3536
108	L	H	1.5833
109	V	H	0.0000
110	T	H	0.6261
111	V	H	0.0000
112	S	H	-0.5189
113	S	H	-0.7600