Chain sequence(s) |
A: SRLRVIAEIRHGDIFHSANIVSSIEFDRDDELFATAGVSRCIKVFDFSSVVNEPADMQCPIVEMSTRSKLSCLSWNKHEKNHIASSDYEGIVTVWDVTTRQSLMEYEEHEKRAWSVDFSRTEPSMLVSGSDDCKVKVWCTRQEASVINIDMKANICCCVKYNPGSSNYIAVGSADHHIHYYDLRNISQPLHVFSGHKKAVSYVKFLSNNELASASTDSTLRLWDVKDNLPVRTFRGHTNEKNFVGLTVNSEYLACGSETNEVYVYHKEITRPVTSHRFGSPDMDDAEEEAGSYFISAVCWKSDSPTMLTANSQGTIKVLVLA U: SDQIVPEY |
Distance of aggregation | 10 Å |
Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
354 | S | A | -0.9532 | |
355 | R | A | -2.2371 | |
356 | L | A | 0.0000 | |
357 | R | A | -1.7609 | |
358 | V | A | -0.2958 | |
359 | I | A | 0.3356 | |
360 | A | A | 0.0000 | |
361 | E | A | -1.5447 | |
362 | I | A | 0.0000 | |
363 | R | A | -2.1043 | |
364 | H | A | -1.6207 | |
365 | G | A | -1.6387 | |
366 | D | A | -2.2107 | |
367 | I | A | 0.0000 | |
368 | F | A | 0.0543 | |
369 | H | A | -1.0246 | |
370 | S | A | -0.8893 | |
371 | A | A | -0.6182 | |
372 | N | A | -0.6914 | |
373 | I | A | -0.0304 | |
374 | V | A | 0.0000 | |
375 | S | A | 0.0000 | |
376 | S | A | 0.0000 | |
377 | I | A | 0.0000 | |
378 | E | A | -0.4804 | |
379 | F | A | 0.0000 | |
380 | D | A | 0.0000 | |
381 | R | A | -3.3153 | |
382 | D | A | -3.1342 | |
383 | D | A | 0.0000 | |
384 | E | A | -2.3788 | |
385 | L | A | -1.1173 | |
386 | F | A | 0.0000 | |
387 | A | A | 0.0000 | |
388 | T | A | 0.0000 | |
389 | A | A | 0.0000 | |
390 | G | A | 0.0000 | |
391 | V | A | 0.0000 | |
392 | S | A | -1.2884 | |
393 | R | A | -2.2954 | |
394 | C | A | -1.4707 | |
395 | I | A | 0.0000 | |
396 | K | A | -0.3101 | |
397 | V | A | 0.0000 | |
398 | F | A | 0.0000 | |
399 | D | A | -0.0515 | |
400 | F | A | -0.5734 | |
401 | S | A | -0.9161 | |
402 | S | A | -0.8173 | |
403 | V | A | 0.0000 | |
404 | V | A | -0.6349 | |
405 | N | A | -1.6993 | |
406 | E | A | -2.1054 | |
407 | P | A | -1.4912 | |
408 | A | A | -1.4717 | |
409 | D | A | -1.9796 | |
410 | M | A | -0.4954 | |
411 | Q | A | -0.5005 | |
412 | C | A | 0.6074 | |
413 | P | A | 1.0361 | |
414 | I | A | 1.9157 | |
415 | V | A | 0.3594 | |
416 | E | A | -0.8261 | |
417 | M | A | 0.0000 | |
418 | S | A | -1.5582 | |
419 | T | A | 0.0000 | |
420 | R | A | -2.5816 | |
421 | S | A | 0.0000 | |
422 | K | A | -1.8958 | |
423 | L | A | 0.0000 | |
424 | S | A | 0.0000 | |
425 | C | A | 0.0092 | |
426 | L | A | 0.0000 | |
427 | S | A | 0.0000 | |
428 | W | A | 0.0000 | |
429 | N | A | 0.0000 | |
430 | K | A | -2.8590 | |
431 | H | A | -2.8289 | |
432 | E | A | -2.5991 | |
433 | K | A | -2.5806 | |
434 | N | A | -1.6564 | |
435 | H | A | -1.3225 | |
436 | I | A | 0.0000 | |
437 | A | A | 0.0000 | |
438 | S | A | 0.0000 | |
439 | S | A | 0.0000 | |
440 | D | A | 0.0000 | |
441 | Y | A | -1.7933 | |
442 | E | A | -3.2221 | |
443 | G | A | 0.0000 | |
444 | I | A | 0.0000 | |
445 | V | A | 0.0000 | |
446 | T | A | 0.0000 | |
447 | V | A | 0.0000 | |
448 | W | A | -0.6914 | |
449 | D | A | -1.1373 | |
450 | V | A | 0.0000 | |
451 | T | A | -0.6133 | |
452 | T | A | -1.1008 | |
453 | R | A | -2.1195 | |
454 | Q | A | -1.7314 | |
455 | S | A | -0.9066 | |
456 | L | A | 0.0271 | |
457 | M | A | -1.2549 | |
458 | E | A | -2.3920 | |
459 | Y | A | 0.0000 | |
460 | E | A | -3.4406 | |
461 | E | A | -2.6539 | |
462 | H | A | 0.0000 | |
463 | E | A | -3.5176 | |
464 | K | A | -3.1723 | |
465 | R | A | -2.2623 | |
466 | A | A | 0.0000 | |
467 | W | A | 0.0000 | |
468 | S | A | 0.0000 | |
469 | V | A | 0.0000 | |
470 | D | A | 0.0000 | |
471 | F | A | 0.0000 | |
472 | S | A | 0.0000 | |
473 | R | A | -2.7054 | |
474 | T | A | -1.7959 | |
475 | E | A | -1.9162 | |
476 | P | A | -1.7867 | |
477 | S | A | -1.4635 | |
478 | M | A | -0.6705 | |
479 | L | A | 0.0000 | |
480 | V | A | 0.0000 | |
481 | S | A | 0.0000 | |
482 | G | A | 0.0000 | |
483 | S | A | 0.0000 | |
484 | D | A | 0.0000 | |
485 | D | A | -1.8012 | |
486 | C | A | -1.5400 | |
487 | K | A | -1.9590 | |
488 | V | A | 0.0000 | |
489 | K | A | 0.0000 | |
490 | V | A | 0.0000 | |
491 | W | A | 0.0000 | |
492 | C | A | 0.0000 | |
493 | T | A | -1.6873 | |
494 | R | A | -2.7724 | |
495 | Q | A | -2.8352 | |
496 | E | A | -3.1301 | |
497 | A | A | -1.5535 | |
498 | S | A | -0.6269 | |
499 | V | A | 0.4143 | |
500 | I | A | 0.4239 | |
501 | N | A | -0.5560 | |
502 | I | A | 0.0000 | |
503 | D | A | -2.3377 | |
504 | M | A | -1.9375 | |
505 | K | A | -2.1443 | |
506 | A | A | 0.0000 | |
507 | N | A | -0.9106 | |
508 | I | A | 0.0000 | |
509 | C | A | 0.0000 | |
510 | C | A | 0.0000 | |
511 | V | A | 0.0000 | |
512 | K | A | -0.3155 | |
513 | Y | A | 0.0000 | |
514 | N | A | 0.0000 | |
515 | P | A | -1.1784 | |
516 | G | A | -1.1666 | |
517 | S | A | -0.9908 | |
518 | S | A | -1.1811 | |
519 | N | A | -1.2349 | |
520 | Y | A | -0.3313 | |
521 | I | A | 0.0000 | |
522 | A | A | 0.0000 | |
523 | V | A | 0.0000 | |
524 | G | A | 0.0000 | |
525 | S | A | 0.0000 | |
526 | A | A | 0.0000 | |
527 | D | A | 0.0000 | |
528 | H | A | -1.1212 | |
529 | H | A | -0.5913 | |
530 | I | A | 0.0000 | |
531 | H | A | 0.0000 | |
532 | Y | A | 0.0000 | |
533 | Y | A | 0.0000 | |
534 | D | A | -1.0785 | |
535 | L | A | 0.0000 | |
536 | R | A | -2.4396 | |
537 | N | A | -2.1808 | |
538 | I | A | -1.1282 | |
539 | S | A | -1.2436 | |
540 | Q | A | -1.0772 | |
541 | P | A | -0.1090 | |
542 | L | A | 0.4089 | |
543 | H | A | -0.0105 | |
544 | V | A | 0.8319 | |
545 | F | A | 0.0000 | |
546 | S | A | -0.4961 | |
547 | G | A | -1.1728 | |
548 | H | A | 0.0000 | |
549 | K | A | -2.1600 | |
550 | K | A | -1.9572 | |
551 | A | A | 0.0000 | |
552 | V | A | 0.0000 | |
553 | S | A | 0.0000 | |
554 | Y | A | 0.0240 | |
555 | V | A | 0.0000 | |
556 | K | A | -0.4314 | |
557 | F | A | -0.5787 | |
558 | L | A | 0.0000 | |
559 | S | A | -1.0764 | |
560 | N | A | -1.6446 | |
561 | N | A | -2.1092 | |
562 | E | A | -1.2230 | |
563 | L | A | 0.0000 | |
564 | A | A | 0.0000 | |
565 | S | A | 0.0000 | |
566 | A | A | 0.0000 | |
567 | S | A | 0.0000 | |
568 | T | A | 0.0000 | |
569 | D | A | -1.8011 | |
570 | S | A | -1.5960 | |
571 | T | A | 0.0000 | |
572 | L | A | 0.0000 | |
573 | R | A | -0.6899 | |
574 | L | A | 0.0000 | |
575 | W | A | 0.0000 | |
576 | D | A | -1.6840 | |
577 | V | A | 0.0000 | |
578 | K | A | -3.2141 | |
579 | D | A | -3.1248 | |
580 | N | A | -2.0140 | |
581 | L | A | -0.4276 | |
582 | P | A | -0.2506 | |
583 | V | A | 0.0111 | |
584 | R | A | -0.5001 | |
585 | T | A | -1.1002 | |
586 | F | A | 0.0000 | |
587 | R | A | -2.5804 | |
588 | G | A | -1.8549 | |
589 | H | A | 0.0000 | |
590 | T | A | -1.1305 | |
591 | N | A | 0.0000 | |
592 | E | A | -2.5250 | |
593 | K | A | -2.4551 | |
594 | N | A | 0.0000 | |
595 | F | A | 0.0000 | |
596 | V | A | 0.0000 | |
597 | G | A | 0.0000 | |
598 | L | A | 0.0000 | |
599 | T | A | 0.0000 | |
600 | V | A | -0.3369 | |
601 | N | A | -1.0599 | |
602 | S | A | -1.0606 | |
603 | E | A | -1.9356 | |
604 | Y | A | -0.7953 | |
605 | L | A | 0.0000 | |
606 | A | A | 0.0000 | |
607 | C | A | 0.0000 | |
608 | G | A | 0.0000 | |
609 | S | A | 0.0000 | |
610 | E | A | -1.0105 | |
611 | T | A | -0.7851 | |
612 | N | A | 0.0000 | |
613 | E | A | -1.0645 | |
614 | V | A | 0.0000 | |
615 | Y | A | -0.4023 | |
616 | V | A | 0.0000 | |
617 | Y | A | 0.0000 | |
618 | H | A | -0.9589 | |
619 | K | A | -1.5156 | |
620 | E | A | -1.8420 | |
621 | I | A | -0.5247 | |
622 | T | A | -1.4927 | |
623 | R | A | -2.3447 | |
624 | P | A | -1.0374 | |
625 | V | A | -0.2730 | |
626 | T | A | -0.6900 | |
627 | S | A | -1.0618 | |
628 | H | A | -1.6912 | |
629 | R | A | -2.0722 | |
630 | F | A | 0.0000 | |
631 | G | A | -1.7464 | |
632 | S | A | -1.6695 | |
633 | P | A | -2.0892 | |
634 | D | A | -2.2211 | |
635 | M | A | 0.0000 | |
636 | D | A | -4.3835 | |
637 | D | A | -4.3343 | |
638 | A | A | -2.8954 | |
639 | E | A | -4.5754 | |
640 | E | A | -4.0767 | |
641 | E | A | -3.0559 | |
642 | A | A | -2.0507 | |
643 | G | A | -1.4209 | |
644 | S | A | -1.4283 | |
645 | Y | A | 0.0000 | |
646 | F | A | 0.0000 | |
647 | I | A | 0.0000 | |
648 | S | A | 0.0000 | |
649 | A | A | 0.0000 | |
650 | V | A | 0.0000 | |
651 | C | A | -0.0960 | |
652 | W | A | 0.0000 | |
653 | K | A | -1.3104 | |
654 | S | A | -1.6784 | |
655 | D | A | -2.2560 | |
656 | S | A | -1.1258 | |
657 | P | A | -0.7060 | |
658 | T | A | 0.0000 | |
659 | M | A | 0.0000 | |
660 | L | A | 0.0000 | |
661 | T | A | 0.0000 | |
662 | A | A | 0.0000 | |
663 | N | A | 0.0000 | |
664 | S | A | -0.1118 | |
665 | Q | A | -0.1847 | |
666 | G | A | 0.0000 | |
667 | T | A | -0.8421 | |
668 | I | A | 0.0000 | |
669 | K | A | 0.0000 | |
670 | V | A | 0.0000 | |
671 | L | A | 0.0000 | |
672 | V | A | -0.2525 | |
673 | L | A | -0.6461 | |
674 | A | A | -0.7865 | |
354 | S | U | -0.2541 | |
355 | D | U | -0.2922 | |
356 | Q | U | 0.0000 | |
357 | I | U | -0.4733 | |
358 | V | U | 0.0000 | |
359 | P | U | -0.7879 | |
360 | E | U | -1.4354 | |
361 | Y | U | 0.2838 |