Project name: PRO_10p_2osl

Chain sequence(s)	A: QIVLSQSPAILSASPGEKVTMTCRASSSVSYIHWFQQKPGSSPKPWIYATSNLASGVPVRFSGSGSGTSYSLTISRVEAEDAATYYCQQWTSNPPTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECQVQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGRGLEWIGAIYPGNGDTSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCARSTYYGGDWYFNVWGAGTTVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.7485
• Maximal score value: 1.7579
• Average score: -0.664
• Total score value: -288.8595

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	A	-1.0247
2	I	A	0.1413
3	V	A	1.0866
4	L	A	0.0000
5	S	A	-0.5935
6	Q	A	-0.7132
7	S	A	-0.4405
8	P	A	0.1871
9	A	A	0.4078
10	I	A	1.3916
11	L	A	0.4489
12	S	A	-0.5140
13	A	A	0.0000
14	S	A	-2.1348
15	P	A	-2.3533
16	G	A	-2.7029
17	E	A	-3.1340
18	K	A	-3.0315
19	V	A	0.0000
20	T	A	-0.4567
21	M	A	0.0000
22	T	A	-0.6858
23	C	A	0.0000
24	R	A	-1.7684
25	A	A	-0.5861
26	S	A	-0.2993
27	S	A	-0.4862
28	S	A	-0.6263
29	V	A	0.0000
30	S	A	-0.1429
31	Y	A	0.3647
32	I	A	0.0000
33	H	A	0.0000
34	W	A	0.0000
35	F	A	0.0000
36	Q	A	0.0000
37	Q	A	-0.8008
38	K	A	0.0000
39	P	A	-0.8788
40	G	A	-0.6850
41	S	A	-0.6967
42	S	A	-0.5155
43	P	A	0.0000
44	K	A	-1.4098
45	P	A	-0.7005
46	W	A	0.0000
47	I	A	0.0000
48	Y	A	0.0561
49	A	A	-0.0548
50	T	A	0.0000
51	S	A	-0.5853
52	N	A	-0.9695
53	L	A	-0.0128
54	A	A	-0.4775
55	S	A	-0.6342
56	G	A	-0.2400
57	V	A	0.0000
58	P	A	0.6207
59	V	A	1.3764
60	R	A	-0.3720
61	F	A	0.0000
62	S	A	-0.1277
63	G	A	-0.4642
64	S	A	-0.5780
65	G	A	-0.7238
66	S	A	-0.6381
67	G	A	-0.6486
68	T	A	-0.9656
69	S	A	-1.1311
70	Y	A	0.0000
71	S	A	-0.6023
72	L	A	0.0000
73	T	A	-0.7761
74	I	A	0.0000
75	S	A	-2.0958
76	R	A	-3.2531
77	V	A	0.0000
78	E	A	-3.0729
79	A	A	0.0000
80	E	A	-2.6831
81	D	A	0.0000
82	A	A	-1.8602
83	A	A	0.0000
84	T	A	-0.6062
85	Y	A	0.0000
86	Y	A	-0.3979
87	C	A	0.0000
88	Q	A	0.0000
89	Q	A	0.0000
90	W	A	-0.0382
91	T	A	-0.2332
92	S	A	-0.9622
93	N	A	-1.5187
94	P	A	0.0000
95	P	A	0.0000
96	T	A	-0.1212
97	F	A	0.0000
98	G	A	0.0000
99	G	A	-0.9523
100	G	A	-0.4999
101	T	A	0.0000
102	K	A	-1.0152
103	L	A	0.0000
104	E	A	-1.2111
105	I	A	0.0000
106	K	A	-2.0502
107	R	A	-1.2431
108	T	A	-0.2164
109	V	A	0.1667
110	A	A	0.0699
111	A	A	-0.2033
112	P	A	0.0000
113	S	A	-0.1460
114	V	A	0.0000
115	F	A	-0.0418
116	I	A	0.0000
117	F	A	0.0000
118	P	A	-0.3526
119	P	A	0.0000
120	S	A	-1.5217
121	D	A	-2.8480
122	E	A	-2.7790
123	Q	A	0.0000
124	L	A	-1.7951
125	K	A	-2.0884
126	S	A	-1.3981
127	G	A	-1.2979
128	T	A	-1.0482
129	A	A	0.0000
130	S	A	0.0000
131	V	A	0.0000
132	V	A	0.0000
133	C	A	0.0000
134	L	A	0.0000
135	L	A	0.0000
136	N	A	0.0000
137	N	A	-0.6237
138	F	A	0.0000
139	Y	A	0.0000
140	P	A	-1.8009
141	R	A	-2.7448
142	E	A	-3.2216
143	A	A	-2.4174
144	K	A	-2.5536
145	V	A	-1.3793
146	Q	A	-0.8073
147	W	A	0.0000
148	K	A	-0.6974
149	V	A	0.0000
150	D	A	-2.2604
151	N	A	-1.8111
152	A	A	-0.5299
153	L	A	0.1574
154	Q	A	-0.4583
155	S	A	-0.7420
156	G	A	-1.3234
157	N	A	-1.5481
158	S	A	-1.3331
159	Q	A	-2.0204
160	E	A	-2.1358
161	S	A	-0.9804
162	V	A	-0.7108
163	T	A	-0.9218
164	E	A	-2.0073
165	Q	A	0.0000
166	D	A	-2.1529
167	S	A	-2.5040
168	K	A	-2.7542
169	D	A	-1.9821
170	S	A	0.0000
171	T	A	0.0000
172	Y	A	0.0000
173	S	A	0.0000
174	L	A	0.0000
175	S	A	0.0000
176	S	A	0.0000
177	T	A	-0.3641
178	L	A	0.4401
179	T	A	0.1557
180	L	A	-0.2222
181	S	A	-1.0408
182	K	A	-1.9180
183	A	A	-1.6375
184	D	A	-2.3690
185	Y	A	0.0000
186	E	A	-3.7485
187	K	A	-3.6929
188	H	A	-3.3508
189	K	A	-3.6290
190	V	A	0.0000
191	Y	A	0.0000
192	A	A	0.0000
193	C	A	0.0000
194	E	A	-0.7758
195	V	A	0.0000
196	T	A	-1.2265
197	H	A	0.0000
198	Q	A	-1.7842
199	G	A	-0.4360
200	L	A	-0.2889
201	S	A	-0.4727
202	S	A	-0.4511
203	P	A	-0.5733
204	V	A	0.0491
205	T	A	-0.3502
206	K	A	-0.5185
207	S	A	-0.6560
208	F	A	-1.1367
209	N	A	-2.1366
210	R	A	-2.8521
211	G	A	-2.4488
212	E	A	-2.5478
1	Q	A	-0.9729
2	V	A	0.0632
3	Q	A	-0.9237
4	L	A	0.0000
5	Q	A	-1.9342
6	Q	A	-1.1984
7	P	A	-0.9508
8	G	A	-0.9952
9	A	A	-0.8029
10	E	A	-0.7818
11	L	A	-0.4339
12	V	A	0.0000
13	K	A	-1.8642
14	P	A	-1.3230
15	G	A	-1.1525
16	A	A	-1.0007
17	S	A	-1.2086
18	V	A	0.0000
19	K	A	-1.8070
20	M	A	0.0000
21	S	A	-0.9577
22	C	A	0.0000
23	K	A	-1.8953
24	A	A	0.0000
25	S	A	-0.9084
26	G	A	-0.5369
27	Y	A	-0.0558
28	T	A	0.0458
29	F	A	0.0000
30	T	A	-0.6755
31	S	A	0.0185
32	Y	A	0.3979
33	N	A	-0.3123
34	M	A	0.0000
35	H	A	0.0000
36	W	A	0.0000
37	V	A	0.0000
38	K	A	0.0000
39	Q	A	-0.5904
40	T	A	0.0000
41	P	A	-1.0458
42	G	A	-1.5806
43	R	A	-2.5263
44	G	A	-1.4131
45	L	A	0.0000
46	E	A	-0.8888
47	W	A	0.0000
48	I	A	0.0000
49	G	A	0.0000
50	A	A	0.0000
51	I	A	0.0000
52	Y	A	-0.6715
53	P	A	0.0000
54	G	A	-1.3584
55	N	A	-2.1224
56	G	A	-2.0703
57	D	A	-2.3518
58	T	A	-1.1534
59	S	A	-0.9505
60	Y	A	-1.1692
61	N	A	0.0000
62	Q	A	-2.6497
63	K	A	-2.8521
64	F	A	0.0000
65	K	A	-2.8498
66	G	A	-1.9337
67	K	A	-1.7062
68	A	A	0.0000
69	T	A	-0.9052
70	L	A	0.0000
71	T	A	-0.6081
72	A	A	-1.2079
73	D	A	-1.7639
74	K	A	-2.3830
75	S	A	-1.3377
76	S	A	-1.2704
77	S	A	-1.3708
78	T	A	0.0000
79	A	A	0.0000
80	Y	A	-0.6076
81	M	A	0.0000
82	Q	A	-1.3990
83	L	A	0.0000
84	S	A	-0.9092
85	S	A	-0.8780
86	L	A	0.0000
87	T	A	-1.1976
88	S	A	-1.1350
89	E	A	-2.1260
90	D	A	0.0000
91	S	A	-0.5961
92	A	A	0.0000
93	V	A	0.2802
94	Y	A	0.0000
95	Y	A	0.0000
96	C	A	0.0000
97	A	A	0.0000
98	R	A	0.0000
99	S	A	0.0000
100	T	A	0.0000
101	Y	A	1.7579
102	Y	A	1.6317
103	G	A	0.3752
104	G	A	0.0808
105	D	A	0.5381
106	W	A	1.0580
107	Y	A	0.0000
108	F	A	0.0000
109	N	A	-0.1702
110	V	A	-0.0787
111	W	A	-0.2619
112	G	A	0.0000
113	A	A	-0.4662
114	G	A	-0.3533
115	T	A	0.0000
116	T	A	-0.2257
117	V	A	0.0000
118	T	A	-0.3383
119	V	A	-0.7160
120	S	A	-0.5878
121	A	A	-0.5899
122	A	A	-0.4480
123	S	A	-0.6450
124	T	A	-0.9583
125	K	A	-1.1229
126	G	A	-1.4146
127	P	A	-0.6726
128	S	A	-0.5334
129	V	A	0.0000
130	F	A	0.0000
131	P	A	-1.1505
132	L	A	0.0000
133	A	A	-0.8889
134	P	A	0.0000
135	S	A	-1.1485
136	S	A	-1.1029
137	K	A	-1.2089
138	S	A	-0.7543
139	T	A	-0.6834
140	S	A	-0.7277
141	G	A	-0.7726
142	G	A	-0.7573
143	T	A	-0.5595
144	A	A	-0.3028
145	A	A	0.0000
146	L	A	0.0000
147	G	A	0.0000
148	C	A	0.0000
149	L	A	0.0000
150	V	A	0.0000
151	K	A	0.0000
152	D	A	-0.6789
153	Y	A	0.0000
154	F	A	0.0000
155	P	A	0.0000
156	E	A	-0.8022
157	P	A	-0.7647
158	V	A	-0.3444
159	T	A	-0.5092
160	V	A	-0.1608
161	S	A	-0.3972
162	W	A	0.0000
163	N	A	-0.8154
164	S	A	-0.6765
165	G	A	-0.5360
166	A	A	-0.2580
167	L	A	-0.0358
168	T	A	-0.2273
169	S	A	-0.2479
170	G	A	-0.3134
171	V	A	0.0363
172	H	A	-0.3353
173	T	A	0.0285
174	F	A	0.0000
175	P	A	-0.0877
176	A	A	0.4620
177	V	A	0.4980
178	L	A	1.2003
179	Q	A	0.0265
180	S	A	-0.1755
181	S	A	-0.3502
182	G	A	-0.1439
183	L	A	0.0117
184	Y	A	0.3877
185	S	A	0.0000
186	L	A	0.3617
187	S	A	0.0000
188	S	A	0.0000
189	V	A	0.0000
190	V	A	0.0000
191	T	A	-0.1819
192	V	A	0.0000
193	P	A	-0.4960
194	S	A	-0.5689
195	S	A	-0.5888
196	S	A	-0.5588
197	L	A	-0.7577
198	G	A	-0.8693
199	T	A	-0.7104
200	Q	A	-1.0131
201	T	A	-1.0281
202	Y	A	0.0000
203	I	A	-1.2017
204	C	A	0.0000
205	N	A	-1.6209
206	V	A	0.0000
207	N	A	-1.7591
208	H	A	0.0000
209	K	A	-2.7324
210	P	A	-1.6477
211	S	A	-1.8169
212	N	A	-2.4951
213	T	A	-2.0629
214	K	A	-2.7593
215	V	A	-1.5748
216	D	A	-2.6221
217	K	A	-2.2852
218	K	A	-2.5744
219	V	A	0.0000
220	E	A	-2.5977
221	P	A	-1.8377
222	K	A	-1.9164
223	S	A	-1.2069