Chain sequence(s) |
A: MDTARIAVVGAGVVGLSTAVCISKLVPRCSVTIISDKFTPDTTSDVAAGMLIPHTYPDTPIHTQKQWFRETFNHLFAIANSAEAGDAGVHLVSGWQIFQSTPTEEVPFWADVVLGFRKMTEAELKKFPQYVFGQAFTTLKCECPAYLPWLEKRIKGSGGWTLTRRIEDLWELHPSFDIVVNCSGLGSRQLAGDSKIFPVRGQVLQVQAPWVEHFIRDGSGLTYIYPGTSHVTLGGTRQKGDWNLSPDAENSREILSRCCALEPSLHGACNIREKVGLRPYRPGVRLQTELLARDGQRLPVVHHYGHGSGGISVHWGTALEAARLVSECVHALRTPIPKSNL |
Distance of aggregation | 10 Å |
Dynamic mode | No |
Mutated residues | WA160S, TA161S |
Energy difference between WT (input) and mutated protein (by FoldX) | 1.37533 kcal/mol
CAUTION: Your mutation/s can destabilize the protein structure Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive. |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | M | A | 0.6617 | |
2 | D | A | -0.3526 | |
3 | T | A | -0.4918 | |
4 | A | A | 0.0000 | |
5 | R | A | -0.8497 | |
6 | I | A | 0.0000 | |
7 | A | A | 0.0000 | |
8 | V | A | 0.0000 | |
9 | V | A | 0.0000 | |
10 | G | A | -0.8062 | |
11 | A | A | 0.0000 | |
12 | G | A | -0.5061 | |
13 | V | A | 0.0000 | |
14 | V | A | 0.1664 | |
15 | G | A | 0.0000 | |
16 | L | A | 0.0000 | |
17 | S | A | 0.0000 | |
18 | T | A | 0.0000 | |
19 | A | A | 0.0000 | |
20 | V | A | 0.0000 | |
21 | C | A | 0.0000 | |
22 | I | A | 0.0000 | |
23 | S | A | 0.0000 | |
24 | K | A | -1.7335 | |
25 | L | A | 0.0000 | |
26 | V | A | 0.0000 | |
27 | P | A | -1.5815 | |
28 | R | A | -2.1112 | |
29 | C | A | -1.2342 | |
30 | S | A | -0.5919 | |
31 | V | A | 0.0000 | |
32 | T | A | 0.0053 | |
33 | I | A | 0.0000 | |
34 | I | A | 0.0000 | |
35 | S | A | 0.0000 | |
36 | D | A | -3.3254 | |
37 | K | A | -3.0501 | |
38 | F | A | -1.5274 | |
39 | T | A | -1.0861 | |
40 | P | A | -1.3215 | |
41 | D | A | -2.4444 | |
42 | T | A | -1.4817 | |
43 | T | A | -0.6564 | |
44 | S | A | -0.3751 | |
45 | D | A | 0.0000 | |
46 | V | A | -0.3711 | |
47 | A | A | -0.0524 | |
48 | A | A | 0.0227 | |
49 | G | A | 0.0000 | |
50 | M | A | -0.0038 | |
51 | L | A | 0.0000 | |
52 | I | A | 0.0000 | |
53 | P | A | 0.0000 | |
54 | H | A | -0.1142 | |
55 | T | A | 0.0257 | |
56 | Y | A | 0.4263 | |
57 | P | A | -0.7533 | |
58 | D | A | -1.8404 | |
59 | T | A | -0.9072 | |
60 | P | A | -0.8993 | |
61 | I | A | -0.9857 | |
62 | H | A | -1.8501 | |
63 | T | A | -1.4464 | |
64 | Q | A | 0.0000 | |
65 | K | A | -2.0212 | |
66 | Q | A | -2.4027 | |
67 | W | A | 0.0000 | |
68 | F | A | 0.0000 | |
69 | R | A | -3.2518 | |
70 | E | A | -2.6482 | |
71 | T | A | 0.0000 | |
72 | F | A | 0.0000 | |
73 | N | A | -1.6012 | |
74 | H | A | -0.9464 | |
75 | L | A | 0.0000 | |
76 | F | A | -0.0253 | |
77 | A | A | -0.2324 | |
78 | I | A | -0.3713 | |
79 | A | A | 0.0000 | |
80 | N | A | -1.3290 | |
81 | S | A | -0.7763 | |
82 | A | A | -0.8837 | |
83 | E | A | -1.4136 | |
84 | A | A | -1.3650 | |
85 | G | A | -1.7784 | |
86 | D | A | -2.0320 | |
87 | A | A | 0.0000 | |
88 | G | A | 0.0000 | |
89 | V | A | 0.0000 | |
90 | H | A | -0.9654 | |
91 | L | A | -0.0633 | |
92 | V | A | 0.0000 | |
93 | S | A | -0.2337 | |
94 | G | A | 0.0000 | |
95 | W | A | -0.2101 | |
96 | Q | A | 0.0000 | |
97 | I | A | 0.0000 | |
98 | F | A | -0.0229 | |
99 | Q | A | -0.6795 | |
100 | S | A | -0.1519 | |
101 | T | A | -0.1091 | |
102 | P | A | -0.5704 | |
103 | T | A | -0.6266 | |
104 | E | A | -1.1016 | |
105 | E | A | 0.0000 | |
106 | V | A | -0.3583 | |
107 | P | A | -0.3928 | |
108 | F | A | -0.8040 | |
109 | W | A | 0.0000 | |
110 | A | A | -0.5050 | |
111 | D | A | -1.5538 | |
112 | V | A | -1.2201 | |
113 | V | A | 0.0000 | |
114 | L | A | 0.9712 | |
115 | G | A | -0.0982 | |
116 | F | A | -0.2669 | |
117 | R | A | -0.8719 | |
118 | K | A | -1.0119 | |
119 | M | A | 0.0000 | |
120 | T | A | -1.4075 | |
121 | E | A | -2.2908 | |
122 | A | A | -1.9836 | |
123 | E | A | -1.9948 | |
124 | L | A | 0.0000 | |
125 | K | A | -2.9786 | |
126 | K | A | -3.0625 | |
127 | F | A | 0.0000 | |
128 | P | A | -1.3798 | |
129 | Q | A | -1.1492 | |
130 | Y | A | 0.0000 | |
131 | V | A | 0.7958 | |
132 | F | A | 0.3607 | |
133 | G | A | 0.0000 | |
134 | Q | A | 0.0000 | |
135 | A | A | 0.0000 | |
136 | F | A | 0.0000 | |
137 | T | A | 0.4241 | |
138 | T | A | 0.0000 | |
139 | L | A | 0.0000 | |
140 | K | A | 0.0000 | |
141 | C | A | 0.0000 | |
142 | E | A | -0.6658 | |
143 | C | A | 0.0000 | |
144 | P | A | -0.5105 | |
145 | A | A | -0.5874 | |
146 | Y | A | 0.0000 | |
147 | L | A | 0.0000 | |
148 | P | A | -0.7755 | |
149 | W | A | -1.0836 | |
150 | L | A | 0.0000 | |
151 | E | A | -1.4420 | |
152 | K | A | -2.1850 | |
153 | R | A | -1.9794 | |
154 | I | A | 0.0000 | |
155 | K | A | -2.1911 | |
156 | G | A | -1.7896 | |
157 | S | A | -1.5749 | |
158 | G | A | -1.1593 | |
159 | G | A | 0.0000 | |
160 | S | A | -0.4669 | mutated: WA160S |
161 | S | A | -0.0536 | mutated: TA161S |
162 | L | A | 0.0806 | |
163 | T | A | -1.1542 | |
164 | R | A | -2.3662 | |
165 | R | A | -3.2881 | |
166 | I | A | 0.0000 | |
167 | E | A | -3.1091 | |
168 | D | A | -2.5328 | |
169 | L | A | 0.0000 | |
170 | W | A | -1.2440 | |
171 | E | A | -1.5980 | |
172 | L | A | 0.0000 | |
173 | H | A | 0.0000 | |
174 | P | A | -0.7357 | |
175 | S | A | -0.6689 | |
176 | F | A | -0.8872 | |
177 | D | A | -1.7101 | |
178 | I | A | 0.0000 | |
179 | V | A | 0.0000 | |
180 | V | A | 0.0000 | |
181 | N | A | 0.0000 | |
182 | C | A | 0.0000 | |
183 | S | A | -0.4606 | |
184 | G | A | -0.0869 | |
185 | L | A | 0.0879 | |
186 | G | A | -0.6362 | |
187 | S | A | 0.0000 | |
188 | R | A | -1.4451 | |
189 | Q | A | -1.7086 | |
190 | L | A | -1.3621 | |
191 | A | A | -1.1109 | |
192 | G | A | -1.2196 | |
193 | D | A | -1.2670 | |
194 | S | A | -1.0990 | |
195 | K | A | -1.5017 | |
196 | I | A | 0.0000 | |
197 | F | A | -0.0225 | |
198 | P | A | 0.0000 | |
199 | V | A | 0.0000 | |
200 | R | A | 0.0000 | |
201 | G | A | 0.0000 | |
202 | Q | A | 0.0000 | |
203 | V | A | -0.4188 | |
204 | L | A | 0.0000 | |
205 | Q | A | -1.6346 | |
206 | V | A | 0.0000 | |
207 | Q | A | -1.2769 | |
208 | A | A | 0.0000 | |
209 | P | A | -0.4456 | |
210 | W | A | 0.3029 | |
211 | V | A | -0.5696 | |
212 | E | A | -1.6702 | |
213 | H | A | -0.9974 | |
214 | F | A | 0.0000 | |
215 | I | A | 0.0000 | |
216 | R | A | -0.3022 | |
217 | D | A | -0.4467 | |
218 | G | A | -0.6042 | |
219 | S | A | -0.9104 | |
220 | G | A | -0.8684 | |
221 | L | A | -0.2123 | |
222 | T | A | 0.0000 | |
223 | Y | A | -0.0474 | |
224 | I | A | 0.0000 | |
225 | Y | A | 0.0000 | |
226 | P | A | 0.0000 | |
227 | G | A | -0.9319 | |
228 | T | A | -0.8495 | |
229 | S | A | -0.6992 | |
230 | H | A | -1.0450 | |
231 | V | A | 0.0000 | |
232 | T | A | -0.7253 | |
233 | L | A | 0.0000 | |
234 | G | A | 0.0000 | |
235 | G | A | 0.0000 | |
236 | T | A | -1.3890 | |
237 | R | A | -2.8359 | |
238 | Q | A | -2.6511 | |
239 | K | A | -2.4115 | |
240 | G | A | -1.3175 | |
241 | D | A | -0.9515 | |
242 | W | A | 0.4846 | |
243 | N | A | -0.0794 | |
244 | L | A | 1.0483 | |
245 | S | A | 0.0319 | |
246 | P | A | -0.9057 | |
247 | D | A | -1.8668 | |
248 | A | A | -1.9701 | |
249 | E | A | -2.9999 | |
250 | N | A | 0.0000 | |
251 | S | A | -2.1957 | |
252 | R | A | -3.1378 | |
253 | E | A | -2.5659 | |
254 | I | A | 0.0000 | |
255 | L | A | -1.2795 | |
256 | S | A | -1.2854 | |
257 | R | A | -0.8725 | |
258 | C | A | 0.0000 | |
259 | C | A | -0.6730 | |
260 | A | A | -0.5166 | |
261 | L | A | 0.0000 | |
262 | E | A | -0.8827 | |
263 | P | A | -0.8522 | |
264 | S | A | -0.5928 | |
265 | L | A | 0.0000 | |
266 | H | A | -1.3456 | |
267 | G | A | -1.0773 | |
268 | A | A | -0.7358 | |
269 | C | A | -0.6370 | |
270 | N | A | -1.7856 | |
271 | I | A | -1.3889 | |
272 | R | A | -2.4894 | |
273 | E | A | -1.9437 | |
274 | K | A | -1.1169 | |
275 | V | A | -0.0771 | |
276 | G | A | 0.0000 | |
277 | L | A | 0.0000 | |
278 | R | A | -0.6000 | |
279 | P | A | 0.0619 | |
280 | Y | A | 0.0633 | |
281 | R | A | -0.4676 | |
282 | P | A | -0.5279 | |
283 | G | A | -0.4252 | |
284 | V | A | 0.0000 | |
285 | R | A | -0.6945 | |
286 | L | A | -0.5820 | |
287 | Q | A | -1.1682 | |
288 | T | A | -0.7626 | |
289 | E | A | -0.5143 | |
290 | L | A | 0.3179 | |
291 | L | A | -0.0725 | |
292 | A | A | -1.4686 | |
293 | R | A | -2.5713 | |
294 | D | A | -3.1042 | |
295 | G | A | -2.5580 | |
296 | Q | A | -3.0471 | |
297 | R | A | -2.7020 | |
298 | L | A | 0.0000 | |
299 | P | A | 0.0000 | |
300 | V | A | 0.0000 | |
301 | V | A | 0.0000 | |
302 | H | A | 0.0000 | |
303 | H | A | 0.0000 | |
304 | Y | A | 0.0000 | |
305 | G | A | 0.0000 | |
306 | H | A | 0.0000 | |
307 | G | A | -0.0107 | |
308 | S | A | -0.5862 | |
309 | G | A | -0.2536 | |
310 | G | A | -0.1699 | |
311 | I | A | 0.0000 | |
312 | S | A | 0.0000 | |
313 | V | A | 0.0000 | |
314 | H | A | 0.0000 | |
315 | W | A | -0.4324 | |
316 | G | A | 0.0000 | |
317 | T | A | 0.0000 | |
318 | A | A | 0.0000 | |
319 | L | A | -0.1726 | |
320 | E | A | -0.7998 | |
321 | A | A | 0.0000 | |
322 | A | A | 0.0000 | |
323 | R | A | -1.4427 | |
324 | L | A | -1.1542 | |
325 | V | A | 0.0000 | |
326 | S | A | -1.3426 | |
327 | E | A | -2.2587 | |
328 | C | A | -1.3917 | |
329 | V | A | 0.0000 | |
330 | H | A | -2.0155 | |
331 | A | A | -1.2842 | |
332 | L | A | -1.0531 | |
333 | R | A | -2.1226 | |
334 | T | A | -1.2303 | |
335 | P | A | -1.2376 | |
336 | I | A | -0.7167 | |
337 | P | A | -0.9514 | |
338 | K | A | -1.1780 | |
339 | S | A | -0.9336 | |
340 | N | A | -0.9853 | |
341 | L | A | 0.1833 |