Project name: mDASPO
Status: done
submitted: 2018-02-20 14:42:35, status changed: 2018-02-20 14:49:36
Settings
Chain sequence(s)
|
A: MDTVCIAVVGAGVIGLSTAACISQLVPGCTVTVISDRFTPDTTSNVAAGMLIPHTYADTPVPTQKRWFRETFEHLSEIAKSAEAADAGVHLVSGWQIFHSVPAEEVPFWADVVLGFRKMTEAELKRFPQYVFGQAFTTLKCETSAYLPWLERRIKGSGGLLLTWRIEDLWELQPSFDIVVNCSGLGSRRLVGDPMISPVRGQVLQARAPWVKHFIRDGGGLTYVYPGMSYVTLGGTRQKGDWNRSPDAELSREIFSRCCTLEPSLHRAYDIKEKVGLRPSRPGVRLQKEILVRGQQTLPVVHNYGHGSGGISVHWGSALEATRLVMECIHTLRTPASLSKL
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-3.5615
-
Maximal score value
-
2.0531
-
Average score
-
-0.5624
-
Total score value
-
-191.7706
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
1 |
M |
A |
0.1119 |
|
2 |
D |
A |
-1.3406 |
|
3 |
T |
A |
-0.7918 |
|
4 |
V |
A |
0.0000 |
|
5 |
C |
A |
-0.4124 |
|
6 |
I |
A |
0.0000 |
|
7 |
A |
A |
0.0000 |
|
8 |
V |
A |
0.0000 |
|
9 |
V |
A |
0.0000 |
|
10 |
G |
A |
-0.7620 |
|
11 |
A |
A |
0.0000 |
|
12 |
G |
A |
-0.3794 |
|
13 |
V |
A |
0.0000 |
|
14 |
I |
A |
0.1615 |
|
15 |
G |
A |
0.0000 |
|
16 |
L |
A |
0.0000 |
|
17 |
S |
A |
0.0000 |
|
18 |
T |
A |
0.0000 |
|
19 |
A |
A |
0.0000 |
|
20 |
A |
A |
-0.8372 |
|
21 |
C |
A |
0.0000 |
|
22 |
I |
A |
0.0000 |
|
23 |
S |
A |
-0.7054 |
|
24 |
Q |
A |
-1.2199 |
|
25 |
L |
A |
0.0000 |
|
26 |
V |
A |
0.0000 |
|
27 |
P |
A |
-0.6880 |
|
28 |
G |
A |
-0.9119 |
|
29 |
C |
A |
-0.6871 |
|
30 |
T |
A |
-0.2753 |
|
31 |
V |
A |
0.0000 |
|
32 |
T |
A |
0.8028 |
|
33 |
V |
A |
0.0000 |
|
34 |
I |
A |
0.0000 |
|
35 |
S |
A |
0.0000 |
|
36 |
D |
A |
-3.1740 |
|
37 |
R |
A |
-2.8509 |
|
38 |
F |
A |
-0.9796 |
|
39 |
T |
A |
0.0000 |
|
40 |
P |
A |
-0.7728 |
|
41 |
D |
A |
-1.3720 |
|
42 |
T |
A |
-0.9755 |
|
43 |
T |
A |
-0.4568 |
|
44 |
S |
A |
0.0000 |
|
45 |
N |
A |
0.0000 |
|
46 |
V |
A |
-0.1495 |
|
47 |
A |
A |
-0.0465 |
|
48 |
A |
A |
-0.0090 |
|
49 |
G |
A |
0.0000 |
|
50 |
M |
A |
0.0000 |
|
51 |
L |
A |
0.0000 |
|
52 |
I |
A |
0.1142 |
|
53 |
P |
A |
-0.2004 |
|
54 |
H |
A |
-0.4735 |
|
55 |
T |
A |
-0.3052 |
|
56 |
Y |
A |
0.0244 |
|
57 |
A |
A |
-0.4503 |
|
58 |
D |
A |
-0.7796 |
|
59 |
T |
A |
-0.3485 |
|
60 |
P |
A |
-0.3157 |
|
61 |
V |
A |
-0.3048 |
|
62 |
P |
A |
-0.7128 |
|
63 |
T |
A |
-0.6921 |
|
64 |
Q |
A |
-0.8417 |
|
65 |
K |
A |
-1.2219 |
|
66 |
R |
A |
-1.4878 |
|
67 |
W |
A |
0.0000 |
|
68 |
F |
A |
0.0000 |
|
69 |
R |
A |
-2.0076 |
|
70 |
E |
A |
-1.6888 |
|
71 |
T |
A |
0.0000 |
|
72 |
F |
A |
0.0000 |
|
73 |
E |
A |
-2.8134 |
|
74 |
H |
A |
-2.1501 |
|
75 |
L |
A |
0.0000 |
|
76 |
S |
A |
-1.9995 |
|
77 |
E |
A |
-2.8405 |
|
78 |
I |
A |
-2.0030 |
|
79 |
A |
A |
-1.8458 |
|
80 |
K |
A |
-2.3870 |
|
81 |
S |
A |
-1.6999 |
|
82 |
A |
A |
-1.4437 |
|
83 |
E |
A |
-2.5292 |
|
84 |
A |
A |
-2.0010 |
|
85 |
A |
A |
-1.6721 |
|
86 |
D |
A |
-2.4055 |
|
87 |
A |
A |
0.0000 |
|
88 |
G |
A |
0.0000 |
|
89 |
V |
A |
0.0000 |
|
90 |
H |
A |
-0.7455 |
|
91 |
L |
A |
0.4771 |
|
92 |
V |
A |
-0.0601 |
|
93 |
S |
A |
-0.0870 |
|
94 |
G |
A |
0.0000 |
|
95 |
W |
A |
-0.2589 |
|
96 |
Q |
A |
0.0000 |
|
97 |
I |
A |
0.0000 |
|
98 |
F |
A |
0.6622 |
|
99 |
H |
A |
0.0624 |
|
100 |
S |
A |
1.0615 |
|
101 |
V |
A |
1.6999 |
|
102 |
P |
A |
0.2700 |
|
103 |
A |
A |
-0.2064 |
|
104 |
E |
A |
-1.2786 |
|
105 |
E |
A |
0.0000 |
|
106 |
V |
A |
-0.1641 |
|
107 |
P |
A |
-0.4280 |
|
108 |
F |
A |
-0.2758 |
|
109 |
W |
A |
0.0000 |
|
110 |
A |
A |
-0.0162 |
|
111 |
D |
A |
-1.1430 |
|
112 |
V |
A |
0.0000 |
|
113 |
V |
A |
0.0000 |
|
114 |
L |
A |
1.0993 |
|
115 |
G |
A |
0.4267 |
|
116 |
F |
A |
0.8995 |
|
117 |
R |
A |
-0.9196 |
|
118 |
K |
A |
-1.6647 |
|
119 |
M |
A |
0.0000 |
|
120 |
T |
A |
-1.6891 |
|
121 |
E |
A |
-2.4110 |
|
122 |
A |
A |
-2.0358 |
|
123 |
E |
A |
-2.1565 |
|
124 |
L |
A |
-1.8630 |
|
125 |
K |
A |
-3.1050 |
|
126 |
R |
A |
-3.1866 |
|
127 |
F |
A |
0.0000 |
|
128 |
P |
A |
-1.5285 |
|
129 |
Q |
A |
-1.4344 |
|
130 |
Y |
A |
-0.2678 |
|
131 |
V |
A |
1.3139 |
|
132 |
F |
A |
1.1663 |
|
133 |
G |
A |
0.0000 |
|
134 |
Q |
A |
0.0000 |
|
135 |
A |
A |
0.0000 |
|
136 |
F |
A |
0.0000 |
|
137 |
T |
A |
0.7745 |
|
138 |
T |
A |
0.0000 |
|
139 |
L |
A |
0.0000 |
|
140 |
K |
A |
0.0000 |
|
141 |
C |
A |
0.0000 |
|
142 |
E |
A |
-0.5242 |
|
143 |
T |
A |
0.0000 |
|
144 |
S |
A |
-0.3616 |
|
145 |
A |
A |
-0.5112 |
|
146 |
Y |
A |
0.0000 |
|
147 |
L |
A |
0.0000 |
|
148 |
P |
A |
-1.0542 |
|
149 |
W |
A |
-1.7778 |
|
150 |
L |
A |
0.0000 |
|
151 |
E |
A |
-1.9927 |
|
152 |
R |
A |
-3.5357 |
|
153 |
R |
A |
-3.5615 |
|
154 |
I |
A |
0.0000 |
|
155 |
K |
A |
-3.0058 |
|
156 |
G |
A |
-2.5174 |
|
157 |
S |
A |
-1.8947 |
|
158 |
G |
A |
-1.0550 |
|
159 |
G |
A |
-0.6707 |
|
160 |
L |
A |
1.1981 |
|
161 |
L |
A |
1.0786 |
|
162 |
L |
A |
0.8235 |
|
163 |
T |
A |
-0.6713 |
|
164 |
W |
A |
-1.3099 |
|
165 |
R |
A |
-2.9085 |
|
166 |
I |
A |
0.0000 |
|
167 |
E |
A |
-2.1578 |
|
168 |
D |
A |
-1.8335 |
|
169 |
L |
A |
0.0000 |
|
170 |
W |
A |
-0.2658 |
|
171 |
E |
A |
-1.6477 |
|
172 |
L |
A |
0.0000 |
|
173 |
Q |
A |
-0.7600 |
|
174 |
P |
A |
-0.6305 |
|
175 |
S |
A |
-0.5786 |
|
176 |
F |
A |
-0.1395 |
|
177 |
D |
A |
-0.4462 |
|
178 |
I |
A |
0.0000 |
|
179 |
V |
A |
0.0000 |
|
180 |
V |
A |
0.0000 |
|
181 |
N |
A |
0.0000 |
|
182 |
C |
A |
0.0000 |
|
183 |
S |
A |
-0.6739 |
|
184 |
G |
A |
-0.2870 |
|
185 |
L |
A |
-0.4101 |
|
186 |
G |
A |
-0.9587 |
|
187 |
S |
A |
0.0000 |
|
188 |
R |
A |
-1.8753 |
|
189 |
R |
A |
-2.5107 |
|
190 |
L |
A |
0.0000 |
|
191 |
V |
A |
-0.8845 |
|
192 |
G |
A |
-1.0790 |
|
193 |
D |
A |
0.0000 |
|
194 |
P |
A |
-0.3116 |
|
195 |
M |
A |
0.0188 |
|
196 |
I |
A |
0.0000 |
|
197 |
S |
A |
-0.6604 |
|
198 |
P |
A |
0.0000 |
|
199 |
V |
A |
0.0000 |
|
200 |
R |
A |
0.0000 |
|
201 |
G |
A |
0.0000 |
|
202 |
Q |
A |
0.0000 |
|
203 |
V |
A |
0.0000 |
|
204 |
L |
A |
0.0000 |
|
205 |
Q |
A |
-0.9420 |
|
206 |
A |
A |
0.0000 |
|
207 |
R |
A |
-0.7492 |
|
208 |
A |
A |
0.0000 |
|
209 |
P |
A |
-0.2829 |
|
210 |
W |
A |
-0.0253 |
|
211 |
V |
A |
-0.6020 |
|
212 |
K |
A |
-1.6883 |
|
213 |
H |
A |
-1.0521 |
|
214 |
F |
A |
0.0000 |
|
215 |
I |
A |
0.0000 |
|
216 |
R |
A |
0.0000 |
|
217 |
D |
A |
0.0000 |
|
218 |
G |
A |
-0.3429 |
|
219 |
G |
A |
-0.5476 |
|
220 |
G |
A |
-0.5888 |
|
221 |
L |
A |
-0.1599 |
|
222 |
T |
A |
0.0000 |
|
223 |
Y |
A |
0.1030 |
|
224 |
V |
A |
0.0000 |
|
225 |
Y |
A |
0.0000 |
|
226 |
P |
A |
0.0000 |
|
227 |
G |
A |
-0.2563 |
|
228 |
M |
A |
0.1461 |
|
229 |
S |
A |
0.0545 |
|
230 |
Y |
A |
0.1052 |
|
231 |
V |
A |
0.0000 |
|
232 |
T |
A |
0.0000 |
|
233 |
L |
A |
0.0000 |
|
234 |
G |
A |
0.0000 |
|
235 |
G |
A |
0.0000 |
|
236 |
T |
A |
0.0000 |
|
237 |
R |
A |
-1.3562 |
|
238 |
Q |
A |
-1.7515 |
|
239 |
K |
A |
-2.2396 |
|
240 |
G |
A |
-1.4103 |
|
241 |
D |
A |
-1.2147 |
|
242 |
W |
A |
-0.2834 |
|
243 |
N |
A |
-1.4988 |
|
244 |
R |
A |
-2.1786 |
|
245 |
S |
A |
-1.4589 |
|
246 |
P |
A |
-1.4146 |
|
247 |
D |
A |
-1.7529 |
|
248 |
A |
A |
-1.6774 |
|
249 |
E |
A |
-2.6067 |
|
250 |
L |
A |
-1.5608 |
|
251 |
S |
A |
-1.7614 |
|
252 |
R |
A |
-2.6725 |
|
253 |
E |
A |
-1.7305 |
|
254 |
I |
A |
0.0000 |
|
255 |
F |
A |
-0.8933 |
|
256 |
S |
A |
-1.0378 |
|
257 |
R |
A |
-0.9332 |
|
258 |
C |
A |
0.0000 |
|
259 |
C |
A |
0.0000 |
|
260 |
T |
A |
-0.7202 |
|
261 |
L |
A |
0.0000 |
|
262 |
E |
A |
-0.8476 |
|
263 |
P |
A |
-1.0961 |
|
264 |
S |
A |
-1.0640 |
|
265 |
L |
A |
0.0000 |
|
266 |
H |
A |
-1.7780 |
|
267 |
R |
A |
-2.2970 |
|
268 |
A |
A |
-1.0787 |
|
269 |
Y |
A |
-0.2376 |
|
270 |
D |
A |
-1.2807 |
|
271 |
I |
A |
-0.8940 |
|
272 |
K |
A |
-2.1596 |
|
273 |
E |
A |
-1.8722 |
|
274 |
K |
A |
-1.3665 |
|
275 |
V |
A |
0.0000 |
|
276 |
G |
A |
-0.5987 |
|
277 |
L |
A |
-0.6988 |
|
278 |
R |
A |
-0.7024 |
|
279 |
P |
A |
0.0000 |
|
280 |
S |
A |
-0.6164 |
|
281 |
R |
A |
-0.3742 |
|
282 |
P |
A |
-0.3359 |
|
283 |
G |
A |
-0.1881 |
|
284 |
V |
A |
-0.0689 |
|
285 |
R |
A |
-0.3139 |
|
286 |
L |
A |
-0.3741 |
|
287 |
Q |
A |
-0.9699 |
|
288 |
K |
A |
-0.7465 |
|
289 |
E |
A |
0.3182 |
|
290 |
I |
A |
2.0531 |
|
291 |
L |
A |
1.6556 |
|
292 |
V |
A |
1.4534 |
|
293 |
R |
A |
-0.2741 |
|
294 |
G |
A |
-1.1150 |
|
295 |
Q |
A |
-1.5892 |
|
296 |
Q |
A |
-1.2591 |
|
297 |
T |
A |
0.2260 |
|
298 |
L |
A |
0.0000 |
|
299 |
P |
A |
0.7568 |
|
300 |
V |
A |
0.0000 |
|
301 |
V |
A |
0.0000 |
|
302 |
H |
A |
0.0000 |
|
303 |
N |
A |
0.0000 |
|
304 |
Y |
A |
0.0000 |
|
305 |
G |
A |
0.0000 |
|
306 |
H |
A |
0.0000 |
|
307 |
G |
A |
-0.4467 |
|
308 |
S |
A |
-0.4776 |
|
309 |
G |
A |
-0.2968 |
|
310 |
G |
A |
-0.1384 |
|
311 |
I |
A |
0.0000 |
|
312 |
S |
A |
0.0000 |
|
313 |
V |
A |
0.0000 |
|
314 |
H |
A |
0.0000 |
|
315 |
W |
A |
-0.2244 |
|
316 |
G |
A |
0.0000 |
|
317 |
S |
A |
0.0000 |
|
318 |
A |
A |
0.0000 |
|
319 |
L |
A |
-0.1068 |
|
320 |
E |
A |
-0.4194 |
|
321 |
A |
A |
0.0000 |
|
322 |
T |
A |
0.0000 |
|
323 |
R |
A |
-1.0748 |
|
324 |
L |
A |
0.0000 |
|
325 |
V |
A |
0.0000 |
|
326 |
M |
A |
-0.4939 |
|
327 |
E |
A |
-0.9998 |
|
328 |
C |
A |
0.0000 |
|
329 |
I |
A |
0.0000 |
|
330 |
H |
A |
-0.9036 |
|
331 |
T |
A |
-0.5566 |
|
332 |
L |
A |
-0.4086 |
|
333 |
R |
A |
-1.7187 |
|
334 |
T |
A |
-0.8877 |
|
335 |
P |
A |
-0.8718 |
|
336 |
A |
A |
-0.5780 |
|
337 |
S |
A |
-0.5367 |
|
338 |
L |
A |
-0.7519 |
|
339 |
S |
A |
-0.9727 |
|
340 |
K |
A |
-1.7208 |
|
341 |
L |
A |
-0.9085 |
|