Project name: 7376781d23c5c00

Chain sequence(s)	H: EVQLVESGGGLVQPGGSLRLSCAASGYTFTNYGMNWVRQAPGKGLEWVGWINTYTGEPTYAADFKRRFTFSLDTSKSTAYLQMNSLRAEDTAVYYCAKYPHYYGSSHWYFDVWGQGTLVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK; K: EVQLVESGGGLVQPGGSLRLSCAASGYTFTNYGMNWVRQAPGKGLEWVGWINTYTGEPTYAADFKRRFTFSLDTSKSTAYLQMNSLRAEDTAVYYCAKYPHYYGSSHWYFDVWGQGTLVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK; J: DIQMTQSPSSLSASVGDRVTITCSASQDISNYLNWYQQKPGKAPKVLIYFTSSLHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSTVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE; L: DIQMTQSPSSLSASVGDRVTITCSASQDISNYLNWYQQKPGKAPKVLIYFTSSLHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSTVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE; W: VVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPK; V: VVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.8748
• Maximal score value: 1.438
• Average score: -0.7446
• Total score value: -781.7849

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	D	L	-2.1841
2	I	L	0.0000
3	Q	L	-2.0560
4	M	L	0.0000
5	T	L	-0.9025
6	Q	L	0.0000
7	S	L	-0.4755
8	P	L	-0.6953
9	S	L	-0.9896
10	S	L	-1.0954
11	L	L	-0.7813
12	S	L	-1.0882
13	A	L	-1.0924
14	S	L	-0.9159
15	V	L	0.1450
16	G	L	-0.7225
17	D	L	-1.6629
18	R	L	-2.2882
19	V	L	0.0000
20	T	L	-0.6305
21	I	L	0.0000
22	T	L	-0.5737
23	C	L	0.0000
24	S	L	-1.4870
25	A	L	0.0000
26	S	L	-2.0243
27	Q	L	-2.7566
28	D	L	-2.7489
29	I	L	0.0000
30	S	L	-1.0286
31	N	L	-0.4467
32	Y	L	0.4733
33	L	L	0.0000
34	N	L	0.0000
35	W	L	0.0000
36	Y	L	0.0000
37	Q	L	0.0000
38	Q	L	-1.3446
39	K	L	-1.8152
40	P	L	-1.5162
41	G	L	-1.8389
42	K	L	-2.5512
43	A	L	-1.5523
44	P	L	0.0000
45	K	L	-1.5248
46	V	L	0.0000
47	L	L	0.0000
48	I	L	0.0000
49	Y	L	0.6764
50	F	L	1.0317
51	T	L	0.0000
52	S	L	0.0294
53	S	L	0.2673
54	L	L	0.3210
55	H	L	-0.3376
56	S	L	-0.3757
57	G	L	-0.4923
58	V	L	-0.2980
59	P	L	-0.3116
60	S	L	-0.3879
61	R	L	-0.7742
62	F	L	0.0000
63	S	L	-0.2974
64	G	L	-0.1549
65	S	L	-0.7004
66	G	L	-1.1605
67	S	L	-1.2421
68	G	L	-1.8035
69	T	L	-2.1327
70	D	L	-2.4937
71	F	L	0.0000
72	T	L	-0.6786
73	L	L	0.0000
74	T	L	-0.6040
75	I	L	0.0000
76	S	L	-1.3847
77	S	L	-1.1745
78	L	L	0.0000
79	Q	L	-0.7217
80	P	L	-1.3394
81	E	L	-1.3872
82	D	L	0.0000
83	F	L	-1.2067
84	A	L	0.0000
85	T	L	0.0000
86	Y	L	0.0000
87	Y	L	0.0000
88	C	L	0.0000
89	Q	L	0.0000
90	Q	L	0.0000
91	Y	L	0.0000
92	S	L	-0.2688
93	T	L	-0.2750
94	V	L	-0.2082
95	P	L	-0.4771
96	W	L	0.0000
97	T	L	-0.8752
98	F	L	0.0000
99	G	L	0.0000
100	Q	L	-1.8253
101	G	L	0.0000
102	T	L	0.0000
103	K	L	-2.0696
104	V	L	0.0000
105	E	L	-1.3376
106	I	L	0.0000
107	K	L	-1.6597
108	R	L	-1.1485
109	T	L	-0.3568
110	V	L	-0.0896
111	A	L	-0.2183
112	A	L	-0.2080
113	P	L	0.0000
114	S	L	-0.1478
115	V	L	0.0000
116	F	L	0.0556
117	I	L	0.0541
118	F	L	0.0000
119	P	L	-0.4518
120	P	L	-0.8448
121	S	L	-1.9146
122	D	L	-3.0754
123	E	L	-3.2551
124	Q	L	0.0000
125	L	L	-2.3512
126	K	L	-2.9046
127	S	L	-1.8127
128	G	L	-1.3069
129	T	L	-1.0847
130	A	L	0.0000
131	S	L	0.0000
132	V	L	0.0000
133	V	L	0.0000
134	C	L	0.0000
135	L	L	0.0000
136	L	L	0.0000
137	N	L	0.0000
138	N	L	-0.9160
139	F	L	0.0000
140	Y	L	-1.2963
141	P	L	-1.8686
142	R	L	-3.1372
143	E	L	-3.2630
144	A	L	-2.3510
145	K	L	-2.4993
146	V	L	-1.1655
147	Q	L	-0.7727
148	W	L	0.0000
149	K	L	-0.8069
150	V	L	0.0000
151	D	L	-2.1072
152	N	L	-1.6685
153	A	L	-0.3610
154	L	L	0.5924
155	Q	L	-0.4362
156	S	L	-0.7212
157	G	L	-1.3702
158	N	L	-1.7710
159	S	L	-1.6144
160	Q	L	-1.6509
161	E	L	-2.0046
162	S	L	-1.0705
163	V	L	-0.9176
164	T	L	0.0000
165	E	L	-2.2318
166	Q	L	0.0000
167	D	L	-1.9616
168	S	L	-2.0485
169	K	L	-2.5171
170	D	L	-1.9693
171	S	L	0.0000
172	T	L	0.0000
173	Y	L	0.0000
174	S	L	0.0000
175	L	L	0.0000
176	S	L	0.0000
177	S	L	0.0000
178	T	L	-0.8149
179	L	L	0.0000
180	T	L	-0.5638
181	L	L	-0.9350
182	S	L	-1.2108
183	K	L	-2.1991
184	A	L	-2.0923
185	D	L	-2.9731
186	Y	L	0.0000
187	E	L	-3.8560
188	K	L	-3.8748
189	H	L	-3.2742
190	K	L	-3.1807
191	V	L	-1.2459
192	Y	L	0.0000
193	A	L	-0.7343
194	C	L	0.0000
195	E	L	-1.2511
196	V	L	0.0000
197	T	L	-1.2590
198	H	L	0.0000
199	Q	L	-1.8224
200	G	L	-0.5519
201	L	L	-0.2725
202	S	L	-0.4627
203	S	L	-0.3781
204	P	L	-0.5270
205	V	L	0.0205
206	T	L	-0.5595
207	K	L	-0.8176
208	S	L	-0.5959
209	F	L	-0.8721
210	N	L	-1.8786
211	R	L	-2.6021
212	G	L	-2.2026
213	E	L	-2.5292
1	E	H	-1.8307
2	V	H	-0.6682
3	Q	H	-0.7249
4	L	H	0.0000
5	V	H	0.9649
6	E	H	0.0000
7	S	H	-0.4249
8	G	H	-0.8537
9	G	H	-0.6991
10	G	H	-0.3857
11	L	H	-0.1375
12	V	H	0.0000
13	Q	H	-1.7416
14	P	H	-1.7386
15	G	H	-1.5717
16	G	H	0.0000
17	S	H	-1.1644
18	L	H	-1.1565
19	R	H	-2.0739
20	L	H	0.0000
21	S	H	-0.3332
22	C	H	0.0000
23	A	H	-0.0278
24	A	H	0.0000
25	S	H	-0.6801
26	G	H	-0.9617
27	Y	H	-0.2931
28	T	H	0.0054
29	F	H	0.0000
30	T	H	0.1948
31	N	H	0.0000
32	Y	H	0.0000
33	G	H	0.0000
34	M	H	0.0000
35	N	H	0.0000
36	W	H	0.0000
37	V	H	0.0000
38	R	H	-0.6271
39	Q	H	-0.9554
40	A	H	-1.2391
41	P	H	-1.0051
42	G	H	-1.4799
43	K	H	-2.4121
44	G	H	-1.7180
45	L	H	0.0000
46	E	H	-1.2947
47	W	H	0.0000
48	V	H	0.0000
49	G	H	0.0000
50	W	H	0.0000
51	I	H	0.0000
52	N	H	0.0000
53	T	H	0.0000
54	Y	H	0.2288
55	T	H	-0.4445
56	G	H	-0.9468
57	E	H	-2.0210
58	P	H	-1.3931
59	T	H	-0.9166
60	Y	H	-0.9951
61	A	H	0.0000
62	A	H	-1.7539
63	D	H	-2.6281
64	F	H	0.0000
65	K	H	-3.1545
66	R	H	-3.2944
67	R	H	-2.3352
68	F	H	0.0000
69	T	H	-1.1144
70	F	H	0.0000
71	S	H	-0.3849
72	L	H	-0.3913
73	D	H	-1.0928
74	T	H	-0.9277
75	S	H	-1.2298
76	K	H	-2.0056
77	S	H	-1.0830
78	T	H	0.0000
79	A	H	0.0000
80	Y	H	-0.4503
81	L	H	0.0000
82	Q	H	-1.2476
83	M	H	0.0000
84	N	H	-1.7092
85	S	H	-1.5796
86	L	H	0.0000
87	R	H	-2.8729
88	A	H	-2.0077
89	E	H	-2.3840
90	D	H	0.0000
91	T	H	-0.8565
92	A	H	0.0000
93	V	H	0.1791
94	Y	H	0.0000
95	Y	H	0.0000
96	C	H	0.0000
97	A	H	0.0000
98	K	H	0.0000
99	Y	H	0.0000
100	P	H	0.0000
101	H	H	-0.1292
102	Y	H	0.0000
103	Y	H	0.7870
104	G	H	-0.0401
105	S	H	-0.1409
106	S	H	0.0062
107	H	H	0.2619
108	W	H	0.0000
109	Y	H	0.0000
110	F	H	0.0000
111	D	H	-0.5408
112	V	H	-0.1508
113	W	H	-0.3339
114	G	H	0.0000
115	Q	H	-1.2836
116	G	H	-0.6261
117	T	H	-0.0926
118	L	H	0.1277
119	V	H	0.0000
120	T	H	-0.5823
121	V	H	0.0000
122	S	H	-0.8876
123	S	H	-0.7327
124	A	H	-0.4301
125	S	H	-0.5458
126	T	H	-0.7526
127	K	H	-1.2848
128	G	H	-1.4479
129	P	H	-0.6856
130	S	H	-0.5439
131	V	H	0.0000
132	F	H	0.0000
133	P	H	-1.3563
134	L	H	0.0000
135	A	H	-1.2647
136	P	H	0.0000
137	S	H	-0.5994
144	G	H	-0.6516
145	T	H	-0.5211
146	A	H	-0.2622
147	A	H	0.0000
148	L	H	0.0000
149	G	H	0.0000
150	C	H	0.0000
151	L	H	0.0000
152	V	H	0.0000
153	K	H	-0.3748
154	D	H	-0.5560
155	Y	H	0.0000
156	F	H	-0.3043
157	P	H	0.0000
158	E	H	-0.6707
159	P	H	-0.7162
160	V	H	-0.6338
161	T	H	-0.5862
162	V	H	-0.3387
163	S	H	-0.3636
164	W	H	0.0000
165	N	H	-0.7560
166	S	H	-0.6373
167	G	H	-0.4390
168	A	H	-0.1944
169	L	H	0.0180
170	T	H	-0.1647
171	S	H	-0.2270
172	G	H	-0.3317
173	V	H	0.1276
174	H	H	-0.3249
175	T	H	0.0294
176	F	H	0.0000
177	P	H	-0.3269
178	A	H	0.1967
179	V	H	0.5257
180	L	H	1.2987
181	Q	H	0.2709
182	S	H	-0.0647
183	S	H	-0.2347
184	G	H	0.0491
185	L	H	0.1029
186	Y	H	0.4136
187	S	H	0.0000
188	L	H	0.0000
189	S	H	0.0000
190	S	H	0.0000
191	V	H	0.0000
192	V	H	0.0000
193	T	H	-0.1772
194	V	H	0.0000
195	P	H	-0.5779
196	S	H	-0.5567
197	S	H	-0.5841
198	S	H	-0.5351
199	L	H	-0.7503
200	G	H	-0.9291
201	T	H	-0.6255
202	Q	H	-1.0994
203	T	H	-1.0463
204	Y	H	0.0000
205	I	H	-1.3095
206	C	H	0.0000
207	N	H	-1.5038
208	V	H	0.0000
209	N	H	-1.9304
210	H	H	0.0000
211	K	H	-2.8037
212	P	H	-1.6096
213	S	H	-1.8224
214	N	H	-2.6452
215	T	H	-2.0776
216	K	H	-2.7059
217	V	H	-1.6444
218	D	H	-2.5863
219	K	H	-2.2619
220	K	H	-2.5968
221	V	H	0.0000
222	E	H	-2.8799
223	P	H	-1.9134
224	K	H	-2.2922
14	V	V	1.4380
15	V	V	0.2301
16	K	V	-1.2814
17	F	V	0.0000
18	M	V	-0.9103
19	D	V	-1.9226
20	V	V	0.0000
21	Y	V	-1.1239
22	Q	V	-1.8898
23	R	V	-2.1073
24	S	V	0.0000
25	Y	V	-0.4749
26	C	V	-0.6705
27	H	V	-1.1671
28	P	V	-1.0456
29	I	V	-0.9555
30	E	V	-1.9007
31	T	V	-1.0550
32	L	V	-0.4955
33	V	V	-0.7156
34	D	V	-1.2762
35	I	V	0.0000
36	F	V	0.1114
37	Q	V	-1.5470
38	E	V	-1.1261
39	Y	V	-0.4493
40	P	V	-0.6887
41	D	V	-1.5205
42	E	V	-0.3838
43	I	V	0.8041
44	E	V	-0.9671
45	Y	V	0.1272
46	I	V	0.9801
47	F	V	0.0000
48	K	V	-0.1024
49	P	V	0.0000
50	S	V	-0.2228
51	C	V	0.0000
52	V	V	0.0000
53	P	V	-0.7781
54	L	V	0.0000
55	M	V	-0.9945
56	R	V	-1.0230
57	C	V	-0.7438
58	G	V	-0.3307
59	G	V	-0.4929
60	C	V	-0.6884
61	C	V	-1.3059
62	N	V	-1.2263
63	D	V	-2.8073
64	E	V	-3.0731
65	G	V	-2.6379
66	L	V	-2.6891
67	E	V	-2.6149
68	C	V	-1.0699
69	V	V	-1.2503
70	P	V	-2.1149
71	T	V	-2.4012
72	E	V	-3.7232
73	E	V	-3.5568
74	S	V	-2.0664
75	N	V	-1.3899
76	I	V	0.3050
77	T	V	0.2804
78	M	V	0.0000
79	Q	V	-0.2417
80	I	V	0.0000
81	M	V	0.0000
82	R	V	0.0000
83	I	V	0.0000
84	K	V	-0.7000
85	P	V	-1.2429
86	H	V	-1.4338
87	Q	V	-0.7584
88	G	V	0.0000
89	Q	V	0.0000
90	H	V	0.0000
91	I	V	0.0000
92	G	V	0.0000
93	E	V	-0.0948
94	M	V	0.0000
95	S	V	-0.0322
96	F	V	0.0000
97	L	V	-0.4840
98	Q	V	-1.6387
99	H	V	-2.4724
100	N	V	-2.7848
101	K	V	-3.3061
102	C	V	-2.2781
103	E	V	-2.0702
104	C	V	0.0000
105	R	V	-2.8023
106	P	V	-2.6080
107	K	V	-2.9160
14	V	W	1.4279
15	V	W	0.3163
16	K	W	-1.1065
17	F	W	0.0000
18	M	W	-0.3525
19	D	W	-1.5555
20	V	W	0.0000
21	Y	W	-0.8951
22	Q	W	-1.7041
23	R	W	-1.9617
24	S	W	0.0000
25	Y	W	-0.5220
26	C	W	-0.6686
27	H	W	-1.1932
28	P	W	-1.1409
29	I	W	-1.0404
30	E	W	-1.8742
31	T	W	-1.0613
32	L	W	-0.5257
33	V	W	-0.8345
34	D	W	-1.5616
35	I	W	0.0000
36	F	W	0.0507
37	Q	W	-1.6393
38	E	W	-1.1808
39	Y	W	-0.5118
40	P	W	-0.7106
41	D	W	-1.5016
42	E	W	-0.3582
43	I	W	0.7839
44	E	W	-0.9837
45	Y	W	0.1333
46	I	W	0.8855
47	F	W	0.0000
48	K	W	-0.1298
49	P	W	0.0000
50	S	W	-0.2594
51	C	W	0.0000
52	V	W	0.0000
53	P	W	-0.8214
54	L	W	0.0000
55	M	W	-1.0797
56	R	W	-1.0820
57	C	W	-0.7765
58	G	W	-0.2433
59	G	W	-0.5025
60	C	W	-0.7879
61	C	W	0.0000
62	N	W	-1.3975
63	D	W	-2.9507
64	E	W	-3.2156
65	G	W	-2.7308
66	L	W	-2.7246
67	E	W	-2.6424
68	C	W	-1.0776
69	V	W	-1.1816
70	P	W	-2.1132
71	T	W	-2.3047
72	E	W	-3.6530
73	E	W	-3.7127
74	S	W	-2.2676
75	N	W	-1.5384
76	I	W	0.2299
77	T	W	0.3106
78	M	W	0.0000
79	Q	W	-0.2972
80	I	W	0.0000
81	M	W	0.0000
82	R	W	0.0000
83	I	W	0.0000
84	K	W	-0.7320
85	P	W	-1.2959
86	H	W	-1.4736
87	Q	W	-0.7801
88	G	W	0.0000
89	Q	W	0.0000
90	H	W	0.0000
91	I	W	0.0000
92	G	W	0.0000
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