| Chain sequence(s) |
A: SKYKLIMLRHGEGAWNKENRFCSWVDQKLNSEGMEEARNCGKQLKALNFEFDLVFTSVLNRSIHTAWLILEELGQEWVPVESSWRLNERHYGALIGLNREQMALNHGEEQVRLWRRSYNVTPPPIEESHPYYQEIYNDRRYKVCDVPLDQLPRSESLKDVLERLLPYWNERIAPEVLRGKTILISAHGNSSRALLKHLEGISDEDIINITLPTGVPILLELDENLRAVGPHQFLGDQEAIQAAIKKVEDQGKVKQ B: SKYKLIMLRHGEGAWNKENRFCSWVDQKLNSEGMEEARNCGKQLKALNFEFDLVFTSVLNRSIHTAWLILEELGQEWVPVESSWRLNERHYGALIGLNREQMALNHGEEQVRLWRRSYNVTPPPIEESHPYYQEIYNDRRYKVCDVPLDQLPRSESLKDVLERLLPYWNERIAPEVLRGKTILISAHGNSSRALLKHLEGISDEDIINITLPTGVPILLELDENLRAVGPHQFLGDQEAIQAAIKKVEDQGKV |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 2 | S | A | -1.6346 | |
| 3 | K | A | -2.8199 | |
| 4 | Y | A | -2.3198 | |
| 5 | K | A | -2.1347 | |
| 6 | L | A | 0.0000 | |
| 7 | I | A | 0.0000 | |
| 8 | M | A | 0.0000 | |
| 9 | L | A | 0.0000 | |
| 10 | R | A | -0.2604 | |
| 11 | H | A | 0.0000 | |
| 12 | G | A | 0.0000 | |
| 13 | E | A | -1.9129 | |
| 14 | G | A | -1.6913 | |
| 15 | A | A | -1.5962 | |
| 16 | W | A | -1.6300 | |
| 17 | N | A | -2.1202 | |
| 18 | K | A | -2.7869 | |
| 19 | E | A | -2.5818 | |
| 20 | N | A | -2.0900 | |
| 21 | R | A | -1.5165 | |
| 22 | F | A | 0.0000 | |
| 23 | C | A | -0.2171 | |
| 24 | S | A | 0.0000 | |
| 25 | W | A | 0.0000 | |
| 26 | V | A | 0.0000 | |
| 27 | D | A | -1.4334 | |
| 28 | Q | A | -1.2559 | |
| 29 | K | A | -1.7550 | |
| 30 | L | A | 0.0000 | |
| 31 | N | A | -1.7445 | |
| 32 | S | A | -1.8885 | |
| 33 | E | A | -2.9532 | |
| 34 | G | A | 0.0000 | |
| 35 | M | A | -2.2515 | |
| 36 | E | A | -3.5288 | |
| 37 | E | A | -2.8582 | |
| 38 | A | A | 0.0000 | |
| 39 | R | A | -3.5571 | |
| 40 | N | A | -3.3522 | |
| 41 | C | A | 0.0000 | |
| 42 | G | A | 0.0000 | |
| 43 | K | A | -3.1695 | |
| 44 | Q | A | -1.8799 | |
| 45 | L | A | 0.0000 | |
| 46 | K | A | -2.2770 | |
| 47 | A | A | -0.8864 | |
| 48 | L | A | -0.3042 | |
| 49 | N | A | -1.7059 | |
| 50 | F | A | -1.3255 | |
| 51 | E | A | -2.2923 | |
| 52 | F | A | 0.0000 | |
| 53 | D | A | -0.9409 | |
| 54 | L | A | -0.4379 | |
| 55 | V | A | 0.0000 | |
| 56 | F | A | 0.0000 | |
| 57 | T | A | 0.0000 | |
| 58 | S | A | 0.0000 | |
| 59 | V | A | 0.0000 | |
| 60 | L | A | 0.0000 | |
| 61 | N | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | S | A | 0.0000 | |
| 64 | I | A | 0.0000 | |
| 65 | H | A | 0.0000 | |
| 66 | T | A | 0.0000 | |
| 67 | A | A | 0.0000 | |
| 68 | W | A | 0.0000 | |
| 69 | L | A | -0.7993 | |
| 70 | I | A | 0.0000 | |
| 71 | L | A | 0.0000 | |
| 72 | E | A | -0.8987 | |
| 73 | E | A | 0.0000 | |
| 74 | L | A | 0.0000 | |
| 75 | G | A | -0.7677 | |
| 76 | Q | A | 0.0000 | |
| 77 | E | A | 0.0000 | |
| 78 | W | A | -0.0674 | |
| 79 | V | A | 0.0000 | |
| 80 | P | A | -0.1761 | |
| 81 | V | A | 0.0073 | |
| 82 | E | A | -0.5130 | |
| 83 | S | A | -0.2477 | |
| 84 | S | A | -0.4609 | |
| 85 | W | A | 0.0000 | |
| 86 | R | A | -0.6431 | |
| 87 | L | A | 0.0000 | |
| 88 | N | A | 0.0000 | |
| 89 | E | A | 0.0000 | |
| 90 | R | A | 0.0000 | |
| 91 | H | A | 0.0000 | |
| 92 | Y | A | 0.0000 | |
| 93 | G | A | 0.0000 | |
| 94 | A | A | -0.7537 | |
| 95 | L | A | 0.0000 | |
| 96 | I | A | 0.0000 | |
| 97 | G | A | -0.1608 | |
| 98 | L | A | -0.2790 | |
| 99 | N | A | -1.2924 | |
| 100 | R | A | -1.8111 | |
| 101 | E | A | -2.3233 | |
| 102 | Q | A | -1.4687 | |
| 103 | M | A | 0.0000 | |
| 104 | A | A | 0.0000 | |
| 105 | L | A | -0.5917 | |
| 106 | N | A | -1.6439 | |
| 107 | H | A | -1.9581 | |
| 108 | G | A | -1.9475 | |
| 109 | E | A | -2.5498 | |
| 110 | E | A | -2.8771 | |
| 111 | Q | A | -2.0382 | |
| 112 | V | A | 0.0000 | |
| 113 | R | A | -2.1477 | |
| 114 | L | A | -0.6813 | |
| 115 | W | A | -0.4065 | |
| 116 | R | A | 0.0000 | |
| 117 | R | A | 0.0000 | |
| 118 | S | A | 0.0000 | |
| 119 | Y | A | -1.3308 | |
| 120 | N | A | -1.4691 | |
| 121 | V | A | -0.1667 | |
| 122 | T | A | -0.2936 | |
| 123 | P | A | 0.0000 | |
| 124 | P | A | -0.4752 | |
| 125 | P | A | -1.1280 | |
| 126 | I | A | 0.0000 | |
| 127 | E | A | -3.0966 | |
| 128 | E | A | -3.1713 | |
| 129 | S | A | -1.9693 | |
| 130 | H | A | -1.7131 | |
| 131 | P | A | -1.2960 | |
| 132 | Y | A | -1.4513 | |
| 133 | Y | A | 0.0000 | |
| 134 | Q | A | -3.1580 | |
| 135 | E | A | -2.9477 | |
| 136 | I | A | 0.0000 | |
| 137 | Y | A | 0.0000 | |
| 138 | N | A | -2.6915 | |
| 139 | D | A | -2.0434 | |
| 140 | R | A | -1.2353 | |
| 141 | R | A | 0.0000 | |
| 142 | Y | A | 0.0000 | |
| 143 | K | A | -1.5860 | |
| 144 | V | A | 0.4540 | |
| 145 | C | A | -0.3560 | |
| 146 | D | A | -1.4549 | |
| 147 | V | A | -1.1163 | |
| 148 | P | A | -1.4130 | |
| 149 | L | A | -1.7590 | |
| 150 | D | A | -2.5517 | |
| 151 | Q | A | -2.0629 | |
| 152 | L | A | 0.0000 | |
| 153 | P | A | -0.9067 | |
| 154 | R | A | -1.3826 | |
| 155 | S | A | -0.6376 | |
| 156 | E | A | 0.0000 | |
| 157 | S | A | 0.0000 | |
| 158 | L | A | 0.0000 | |
| 159 | K | A | -1.9313 | |
| 160 | D | A | -1.8501 | |
| 161 | V | A | 0.0000 | |
| 162 | L | A | 0.0000 | |
| 163 | E | A | -2.2316 | |
| 164 | R | A | 0.0000 | |
| 165 | L | A | 0.0000 | |
| 166 | L | A | -1.1819 | |
| 167 | P | A | -1.5331 | |
| 168 | Y | A | 0.0000 | |
| 169 | W | A | 0.0000 | |
| 170 | N | A | -2.4259 | |
| 171 | E | A | -3.1840 | |
| 172 | R | A | -2.9126 | |
| 173 | I | A | 0.0000 | |
| 174 | A | A | 0.0000 | |
| 175 | P | A | -1.6012 | |
| 176 | E | A | -1.8273 | |
| 177 | V | A | 0.0000 | |
| 178 | L | A | -1.0665 | |
| 179 | R | A | -2.0041 | |
| 180 | G | A | -2.0112 | |
| 181 | K | A | -2.0270 | |
| 182 | T | A | -1.4546 | |
| 183 | I | A | 0.0000 | |
| 184 | L | A | 0.0000 | |
| 185 | I | A | 0.0000 | |
| 186 | S | A | 0.0000 | |
| 187 | A | A | 0.0000 | |
| 188 | H | A | 0.0000 | |
| 189 | G | A | 0.0000 | |
| 190 | N | A | 0.0000 | |
| 191 | S | A | 0.0000 | |
| 192 | S | A | 0.0000 | |
| 193 | R | A | 0.0000 | |
| 194 | A | A | 0.0000 | |
| 195 | L | A | 0.0000 | |
| 196 | L | A | 0.0000 | |
| 197 | K | A | 0.0000 | |
| 198 | H | A | -0.9686 | |
| 199 | L | A | 0.0000 | |
| 200 | E | A | -1.1468 | |
| 201 | G | A | -1.3406 | |
| 202 | I | A | -1.2161 | |
| 203 | S | A | -1.8702 | |
| 204 | D | A | -2.6269 | |
| 205 | E | A | -3.4019 | |
| 206 | D | A | -3.1990 | |
| 207 | I | A | 0.0000 | |
| 208 | I | A | -1.6332 | |
| 209 | N | A | -2.0196 | |
| 210 | I | A | -0.5402 | |
| 211 | T | A | 0.0000 | |
| 212 | L | A | 0.0000 | |
| 213 | P | A | 0.0000 | |
| 214 | T | A | -0.1322 | |
| 215 | G | A | -1.0299 | |
| 216 | V | A | -0.3839 | |
| 217 | P | A | 0.0000 | |
| 218 | I | A | 0.0000 | |
| 219 | L | A | -0.6089 | |
| 220 | L | A | 0.0000 | |
| 221 | E | A | -2.0425 | |
| 222 | L | A | 0.0000 | |
| 223 | D | A | -2.6261 | |
| 224 | E | A | -2.8632 | |
| 225 | N | A | -2.6500 | |
| 226 | L | A | -2.1461 | |
| 227 | R | A | -2.8661 | |
| 228 | A | A | 0.0000 | |
| 229 | V | A | -0.8344 | |
| 230 | G | A | -0.6243 | |
| 231 | P | A | -0.7002 | |
| 232 | H | A | -0.8106 | |
| 233 | Q | A | -1.2532 | |
| 234 | F | A | -0.7743 | |
| 235 | L | A | -0.5513 | |
| 236 | G | A | -1.6058 | |
| 237 | D | A | -2.9456 | |
| 238 | Q | A | -3.0270 | |
| 239 | E | A | -3.1202 | |
| 240 | A | A | -2.1643 | |
| 241 | I | A | 0.0000 | |
| 242 | Q | A | -2.5670 | |
| 243 | A | A | -2.2091 | |
| 244 | A | A | -1.8381 | |
| 245 | I | A | -1.9031 | |
| 246 | K | A | -3.2868 | |
| 247 | K | A | -3.2965 | |
| 248 | V | A | -2.2445 | |
| 249 | E | A | -2.9295 | |
| 250 | D | A | -3.6750 | |
| 251 | Q | A | -3.1522 | |
| 252 | G | A | 0.0000 | |
| 253 | K | A | -2.6755 | |
| 254 | V | A | -1.5698 | |
| 255 | K | A | -2.4770 | |
| 256 | Q | A | -2.0172 | |
| 2 | S | B | -1.6165 | |
| 3 | K | B | -2.6410 | |
| 4 | Y | B | -2.3597 | |
| 5 | K | B | -2.2756 | |
| 6 | L | B | 0.0000 | |
| 7 | I | B | 0.0000 | |
| 8 | M | B | 0.0000 | |
| 9 | L | B | 0.0000 | |
| 10 | R | B | -0.2755 | |
| 11 | H | B | 0.0000 | |
| 12 | G | B | 0.0000 | |
| 13 | E | B | -1.6806 | |
| 14 | G | B | 0.0000 | |
| 15 | A | B | -1.6364 | |
| 16 | W | B | 0.0000 | |
| 17 | N | B | -2.1380 | |
| 18 | K | B | -2.9169 | |
| 19 | E | B | -2.9459 | |
| 20 | N | B | 0.0000 | |
| 21 | R | B | -1.5114 | |
| 22 | F | B | 0.0000 | |
| 23 | C | B | -0.0572 | |
| 24 | S | B | 0.0000 | |
| 25 | W | B | 0.0000 | |
| 26 | V | B | -0.6897 | |
| 27 | D | B | -1.2206 | |
| 28 | Q | B | -1.0884 | |
| 29 | K | B | -1.5901 | |
| 30 | L | B | 0.0000 | |
| 31 | N | B | -1.5740 | |
| 32 | S | B | -1.7278 | |
| 33 | E | B | -2.6836 | |
| 34 | G | B | 0.0000 | |
| 35 | M | B | -1.9712 | |
| 36 | E | B | -3.2837 | |
| 37 | E | B | -2.6232 | |
| 38 | A | B | 0.0000 | |
| 39 | R | B | -3.1832 | |
| 40 | N | B | -3.2332 | |
| 41 | C | B | 0.0000 | |
| 42 | G | B | 0.0000 | |
| 43 | K | B | -3.2999 | |
| 44 | Q | B | -2.1383 | |
| 45 | L | B | 0.0000 | |
| 46 | K | B | -2.9605 | |
| 47 | A | B | -1.3013 | |
| 48 | L | B | -0.8388 | |
| 49 | N | B | -2.0684 | |
| 50 | F | B | -1.6607 | |
| 51 | E | B | -2.4807 | |
| 52 | F | B | 0.0000 | |
| 53 | D | B | -1.0055 | |
| 54 | L | B | -0.5602 | |
| 55 | V | B | 0.0000 | |
| 56 | F | B | 0.0000 | |
| 57 | T | B | 0.0000 | |
| 58 | S | B | 0.0000 | |
| 59 | V | B | 0.0000 | |
| 60 | L | B | 0.0000 | |
| 61 | N | B | 0.0000 | |
| 62 | R | B | 0.0000 | |
| 63 | S | B | 0.0000 | |
| 64 | I | B | 0.0000 | |
| 65 | H | B | 0.0000 | |
| 66 | T | B | 0.0000 | |
| 67 | A | B | 0.0000 | |
| 68 | W | B | 0.0000 | |
| 69 | L | B | -0.7012 | |
| 70 | I | B | 0.0000 | |
| 71 | L | B | 0.0000 | |
| 72 | E | B | -0.7979 | |
| 73 | E | B | 0.0000 | |
| 74 | L | B | 0.0000 | |
| 75 | G | B | -0.8852 | |
| 76 | Q | B | 0.0000 | |
| 77 | E | B | 0.0000 | |
| 78 | W | B | 0.0000 | |
| 79 | V | B | 0.0000 | |
| 80 | P | B | -0.2721 | |
| 81 | V | B | -0.0096 | |
| 82 | E | B | -0.4814 | |
| 83 | S | B | -0.2254 | |
| 84 | S | B | -0.4066 | |
| 85 | W | B | 0.0000 | |
| 86 | R | B | -0.5904 | |
| 87 | L | B | 0.0000 | |
| 88 | N | B | 0.0000 | |
| 89 | E | B | 0.0000 | |
| 90 | R | B | 0.0000 | |
| 91 | H | B | 0.0000 | |
| 92 | Y | B | 0.0000 | |
| 93 | G | B | 0.0000 | |
| 94 | A | B | -0.6253 | |
| 95 | L | B | 0.2163 | |
| 96 | I | B | 0.0000 | |
| 97 | G | B | 0.0110 | |
| 98 | L | B | -0.0030 | |
| 99 | N | B | -1.2854 | |
| 100 | R | B | -1.7563 | |
| 101 | E | B | -1.9297 | |
| 102 | Q | B | -1.4678 | |
| 103 | M | B | 0.0000 | |
| 104 | A | B | 0.0000 | |
| 105 | L | B | 0.1013 | |
| 106 | N | B | -1.3790 | |
| 107 | H | B | -1.9712 | |
| 108 | G | B | -1.8150 | |
| 109 | E | B | -2.5112 | |
| 110 | E | B | -3.0354 | |
| 111 | Q | B | -2.0305 | |
| 112 | V | B | 0.0000 | |
| 113 | R | B | -2.6704 | |
| 114 | L | B | -0.8193 | |
| 115 | W | B | -0.4411 | |
| 116 | R | B | 0.0000 | |
| 117 | R | B | -0.4801 | |
| 118 | S | B | 0.0000 | |
| 119 | Y | B | 0.0000 | |
| 120 | N | B | -1.7262 | |
| 121 | V | B | -0.3344 | |
| 122 | T | B | -0.4740 | |
| 123 | P | B | 0.0000 | |
| 124 | P | B | -0.5497 | |
| 125 | P | B | -1.1516 | |
| 126 | I | B | 0.0000 | |
| 127 | E | B | -3.0506 | |
| 128 | E | B | -3.0701 | |
| 129 | S | B | -1.9060 | |
| 130 | H | B | -1.5901 | |
| 131 | P | B | -1.2010 | |
| 132 | Y | B | -1.2751 | |
| 133 | Y | B | 0.0000 | |
| 134 | Q | B | -2.6729 | |
| 135 | E | B | -2.6398 | |
| 136 | I | B | 0.0000 | |
| 137 | Y | B | 0.0000 | |
| 138 | N | B | -2.4699 | |
| 139 | D | B | -1.8482 | |
| 140 | R | B | -1.1311 | |
| 141 | R | B | 0.0000 | |
| 142 | Y | B | 0.0000 | |
| 143 | K | B | -1.5103 | |
| 144 | V | B | 0.4978 | |
| 145 | C | B | -0.4541 | |
| 146 | D | B | -1.5885 | |
| 147 | V | B | -1.1734 | |
| 148 | P | B | -1.3964 | |
| 149 | L | B | -1.6301 | |
| 150 | D | B | -2.4960 | |
| 151 | Q | B | -2.2068 | |
| 152 | L | B | 0.0000 | |
| 153 | P | B | -0.8874 | |
| 154 | R | B | -1.3750 | |
| 155 | S | B | -0.6318 | |
| 156 | E | B | 0.0000 | |
| 157 | S | B | 0.0000 | |
| 158 | L | B | 0.0000 | |
| 159 | K | B | -2.1549 | |
| 160 | D | B | -1.9176 | |
| 161 | V | B | 0.0000 | |
| 162 | L | B | -1.2735 | |
| 163 | E | B | -2.1767 | |
| 164 | R | B | 0.0000 | |
| 165 | L | B | 0.0000 | |
| 166 | L | B | -1.0839 | |
| 167 | P | B | -1.5040 | |
| 168 | Y | B | 0.0000 | |
| 169 | W | B | 0.0000 | |
| 170 | N | B | -2.5838 | |
| 171 | E | B | -3.2318 | |
| 172 | R | B | -2.9179 | |
| 173 | I | B | 0.0000 | |
| 174 | A | B | 0.0000 | |
| 175 | P | B | -1.6401 | |
| 176 | E | B | -1.8836 | |
| 177 | V | B | 0.0000 | |
| 178 | L | B | -1.1619 | |
| 179 | R | B | -1.9970 | |
| 180 | G | B | -1.9892 | |
| 181 | K | B | -1.9550 | |
| 182 | T | B | -1.5046 | |
| 183 | I | B | 0.0000 | |
| 184 | L | B | 0.0000 | |
| 185 | I | B | 0.0000 | |
| 186 | S | B | 0.0000 | |
| 187 | A | B | 0.0000 | |
| 188 | H | B | 0.0000 | |
| 189 | G | B | 0.0000 | |
| 190 | N | B | -0.1392 | |
| 191 | S | B | 0.0000 | |
| 192 | S | B | 0.0000 | |
| 193 | R | B | 0.0000 | |
| 194 | A | B | 0.0000 | |
| 195 | L | B | 0.0000 | |
| 196 | L | B | 0.0000 | |
| 197 | K | B | 0.0000 | |
| 198 | H | B | -0.6404 | |
| 199 | L | B | 0.0000 | |
| 200 | E | B | -0.7952 | |
| 201 | G | B | -1.2258 | |
| 202 | I | B | -1.2130 | |
| 203 | S | B | -1.9650 | |
| 204 | D | B | -2.9768 | |
| 205 | E | B | -3.5027 | |
| 206 | D | B | -3.1884 | |
| 207 | I | B | 0.0000 | |
| 208 | I | B | -1.5780 | |
| 209 | N | B | -1.8482 | |
| 210 | I | B | -0.4940 | |
| 211 | T | B | -0.6456 | |
| 212 | L | B | 0.0000 | |
| 213 | P | B | 0.0000 | |
| 214 | T | B | -0.2766 | |
| 215 | G | B | -0.7906 | |
| 216 | V | B | -0.3883 | |
| 217 | P | B | 0.0000 | |
| 218 | I | B | 0.0000 | |
| 219 | L | B | 0.0000 | |
| 220 | L | B | 0.0000 | |
| 221 | E | B | -1.5638 | |
| 222 | L | B | 0.0000 | |
| 223 | D | B | -2.4507 | |
| 224 | E | B | -2.9391 | |
| 225 | N | B | -2.6659 | |
| 226 | L | B | -1.9349 | |
| 227 | R | B | -1.9729 | |
| 228 | A | B | -0.9702 | |
| 229 | V | B | 0.4283 | |
| 230 | G | B | -0.0892 | |
| 231 | P | B | -0.4480 | |
| 232 | H | B | -0.6331 | |
| 233 | Q | B | -1.1754 | |
| 234 | F | B | -0.8876 | |
| 235 | L | B | 0.0000 | |
| 236 | G | B | -1.8561 | |
| 237 | D | B | -3.1483 | |
| 238 | Q | B | -3.3049 | |
| 239 | E | B | -3.2172 | |
| 240 | A | B | -2.2144 | |
| 241 | I | B | 0.0000 | |
| 242 | Q | B | -2.5639 | |
| 243 | A | B | -2.0163 | |
| 244 | A | B | -1.8691 | |
| 245 | I | B | -1.9226 | |
| 246 | K | B | -3.3530 | |
| 247 | K | B | -3.3575 | |
| 248 | V | B | -2.2728 | |
| 249 | E | B | -3.1429 | |
| 250 | D | B | -3.6359 | |
| 251 | Q | B | -3.2621 | |
| 252 | G | B | 0.0000 | |
| 253 | K | B | -2.0443 | |
| 254 | V | B | 0.5143 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine