Project name: 5I9D
Status: done
submitted: 2018-10-10 15:59:16, status changed: 2018-10-10 16:15:16
Settings
Chain sequence(s)
|
A: LRVAPTVVTYNTLIDGLCKAGKLDEALKLFEEMVEKGIKPDVVTYNTLIDGLCKAGKLDEALKLFEEMVEKGIKPDVVTYNTLIDGLCKAGKLDEALKLFEEMVEKGIKPDVVTYNTLIDGLCKAGKLDEALKLFEEMVEKGIKPDVVTYSTLIDGLCKAGKLDEALKLFEEMVEKGIKPNVVTYSTLIDGLCKAGKLDEALKLFEMKGIKPNVVTYNTLIDGLCKAGKLDEALKLFEEMKGIKPDVVTYNTLIDGLCKAGKLDEALKLFEEMVEKGIKPDVVTYNTLIDGLCKAGKLDEALKLFEEMVEKGIKPDVVTYNTLIDGLCKAGLDEALKLFEEMVEKGIKPDELTYRRVVEY
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-3.5338
-
Maximal score value
-
2.167
-
Average score
-
-1.1176
-
Total score value
-
-402.3334
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
42 |
L |
A |
1.0144 |
|
43 |
R |
A |
-0.4647 |
|
47 |
V |
A |
1.4697 |
|
48 |
A |
A |
0.7013 |
|
49 |
P |
A |
0.4966 |
|
50 |
T |
A |
0.7672 |
|
51 |
V |
A |
1.0573 |
|
52 |
V |
A |
2.1670 |
|
53 |
T |
A |
1.0057 |
|
54 |
Y |
A |
0.0000 |
|
55 |
N |
A |
0.0000 |
|
56 |
T |
A |
0.4768 |
|
57 |
L |
A |
0.5511 |
|
58 |
I |
A |
0.0000 |
|
59 |
D |
A |
-1.8805 |
|
60 |
G |
A |
-1.6060 |
|
61 |
L |
A |
-2.0602 |
|
62 |
C |
A |
-2.5745 |
|
63 |
K |
A |
-2.8590 |
|
64 |
A |
A |
-2.2084 |
|
65 |
G |
A |
-2.6180 |
|
66 |
K |
A |
-3.1996 |
|
67 |
L |
A |
-2.9719 |
|
68 |
D |
A |
-3.3972 |
|
69 |
E |
A |
-3.4308 |
|
70 |
A |
A |
0.0000 |
|
71 |
L |
A |
-2.0727 |
|
72 |
K |
A |
-3.1006 |
|
73 |
L |
A |
-1.6811 |
|
74 |
F |
A |
-1.3384 |
|
75 |
E |
A |
-2.5970 |
|
76 |
E |
A |
-2.2764 |
|
77 |
M |
A |
0.0000 |
|
78 |
V |
A |
-1.2189 |
|
79 |
E |
A |
-2.8175 |
|
80 |
K |
A |
-2.8756 |
|
81 |
G |
A |
-1.7586 |
|
82 |
I |
A |
-1.4264 |
|
83 |
K |
A |
-1.7880 |
|
84 |
P |
A |
0.0000 |
|
85 |
D |
A |
-0.4437 |
|
86 |
V |
A |
0.5329 |
|
87 |
V |
A |
1.6784 |
|
88 |
T |
A |
0.0000 |
|
89 |
Y |
A |
0.0000 |
|
90 |
N |
A |
0.0000 |
|
91 |
T |
A |
-0.3019 |
|
92 |
L |
A |
0.0000 |
|
93 |
I |
A |
0.0000 |
|
94 |
D |
A |
-1.5329 |
|
95 |
G |
A |
0.0000 |
|
96 |
L |
A |
0.0000 |
|
97 |
C |
A |
-2.1865 |
|
98 |
K |
A |
-2.6454 |
|
99 |
A |
A |
-1.7722 |
|
100 |
G |
A |
-2.2676 |
|
101 |
K |
A |
-2.7056 |
|
102 |
L |
A |
0.0000 |
|
103 |
D |
A |
-3.2263 |
|
104 |
E |
A |
-3.3563 |
|
105 |
A |
A |
0.0000 |
|
106 |
L |
A |
-2.0928 |
|
107 |
K |
A |
-3.1705 |
|
108 |
L |
A |
0.0000 |
|
109 |
F |
A |
-1.6161 |
|
110 |
E |
A |
-2.6187 |
|
111 |
E |
A |
-2.3075 |
|
112 |
M |
A |
0.0000 |
|
113 |
V |
A |
-1.2101 |
|
114 |
E |
A |
-2.8374 |
|
115 |
K |
A |
-2.9524 |
|
116 |
G |
A |
-1.8847 |
|
117 |
I |
A |
0.0000 |
|
118 |
K |
A |
-1.9440 |
|
119 |
P |
A |
0.0000 |
|
120 |
D |
A |
-0.4122 |
|
121 |
V |
A |
0.6155 |
|
122 |
V |
A |
1.8548 |
|
123 |
T |
A |
0.0000 |
|
124 |
Y |
A |
0.0000 |
|
125 |
N |
A |
0.0000 |
|
126 |
T |
A |
0.0000 |
|
127 |
L |
A |
0.0000 |
|
128 |
I |
A |
0.0000 |
|
129 |
D |
A |
-0.9884 |
|
130 |
G |
A |
-1.4953 |
|
131 |
L |
A |
0.0000 |
|
132 |
C |
A |
-1.8221 |
|
133 |
K |
A |
-2.4104 |
|
134 |
A |
A |
-1.6166 |
|
135 |
G |
A |
-1.9012 |
|
136 |
K |
A |
-2.2952 |
|
137 |
L |
A |
-2.2286 |
|
138 |
D |
A |
-3.1088 |
|
139 |
E |
A |
-3.3539 |
|
140 |
A |
A |
0.0000 |
|
141 |
L |
A |
-2.0672 |
|
142 |
K |
A |
-3.1788 |
|
143 |
L |
A |
0.0000 |
|
144 |
F |
A |
-1.5191 |
|
145 |
E |
A |
-2.3535 |
|
146 |
E |
A |
-1.8674 |
|
147 |
M |
A |
0.0000 |
|
148 |
V |
A |
-0.6038 |
|
149 |
E |
A |
-2.3391 |
|
150 |
K |
A |
-2.2745 |
|
151 |
G |
A |
-1.3783 |
|
152 |
I |
A |
-0.8810 |
|
153 |
K |
A |
-1.6753 |
|
154 |
P |
A |
0.0000 |
|
155 |
D |
A |
-0.1360 |
|
156 |
V |
A |
0.3675 |
|
157 |
V |
A |
1.3804 |
|
158 |
T |
A |
0.0000 |
|
159 |
Y |
A |
0.0000 |
|
160 |
N |
A |
0.3729 |
|
161 |
T |
A |
0.0000 |
|
162 |
L |
A |
0.0000 |
|
163 |
I |
A |
0.0000 |
|
164 |
D |
A |
0.0000 |
|
165 |
G |
A |
0.0000 |
|
166 |
L |
A |
0.0000 |
|
167 |
C |
A |
-1.5487 |
|
168 |
K |
A |
-1.8726 |
|
169 |
A |
A |
-1.3141 |
|
170 |
G |
A |
-1.8565 |
|
171 |
K |
A |
-2.2791 |
|
172 |
L |
A |
-2.1754 |
|
173 |
D |
A |
-2.8836 |
|
174 |
E |
A |
-2.9666 |
|
175 |
A |
A |
0.0000 |
|
176 |
L |
A |
-1.8747 |
|
177 |
K |
A |
-2.9234 |
|
178 |
L |
A |
0.0000 |
|
179 |
F |
A |
-1.3656 |
|
180 |
E |
A |
-2.5352 |
|
181 |
E |
A |
-1.8467 |
|
182 |
M |
A |
0.0000 |
|
183 |
V |
A |
-0.5067 |
|
184 |
E |
A |
-2.1820 |
|
185 |
K |
A |
-1.7696 |
|
186 |
G |
A |
-1.2358 |
|
187 |
I |
A |
-0.7517 |
|
188 |
K |
A |
-1.6109 |
|
189 |
P |
A |
-0.6996 |
|
190 |
D |
A |
-0.6992 |
|
191 |
V |
A |
-0.3153 |
|
192 |
V |
A |
0.4850 |
|
193 |
T |
A |
0.0000 |
|
194 |
Y |
A |
0.0000 |
|
195 |
S |
A |
0.0000 |
|
196 |
T |
A |
0.0000 |
|
197 |
L |
A |
0.0000 |
|
198 |
I |
A |
0.0000 |
|
199 |
D |
A |
0.0000 |
|
200 |
G |
A |
0.0000 |
|
201 |
L |
A |
0.0000 |
|
202 |
C |
A |
-1.8414 |
|
203 |
K |
A |
-2.3835 |
|
204 |
A |
A |
-1.5267 |
|
205 |
G |
A |
-1.9791 |
|
206 |
K |
A |
-2.2347 |
|
207 |
L |
A |
-2.0896 |
|
208 |
D |
A |
-2.9396 |
|
209 |
E |
A |
-3.1559 |
|
210 |
A |
A |
0.0000 |
|
211 |
L |
A |
-1.9220 |
|
212 |
K |
A |
-3.1413 |
|
213 |
L |
A |
-1.8190 |
|
214 |
F |
A |
-2.0004 |
|
215 |
E |
A |
-3.1837 |
|
216 |
E |
A |
-2.9003 |
|
217 |
M |
A |
0.0000 |
|
218 |
V |
A |
-2.1209 |
|
219 |
E |
A |
-3.3374 |
|
220 |
K |
A |
-3.2273 |
|
221 |
G |
A |
-2.3461 |
|
222 |
I |
A |
-1.7087 |
|
223 |
K |
A |
-2.0148 |
|
224 |
P |
A |
0.0000 |
|
225 |
N |
A |
-0.7987 |
|
226 |
V |
A |
-0.1799 |
|
227 |
V |
A |
0.0000 |
|
228 |
T |
A |
0.0000 |
|
229 |
Y |
A |
0.2435 |
|
230 |
S |
A |
0.0000 |
|
231 |
T |
A |
0.0000 |
|
232 |
L |
A |
0.0000 |
|
233 |
I |
A |
0.0000 |
|
234 |
D |
A |
-1.1500 |
|
235 |
G |
A |
0.0000 |
|
236 |
L |
A |
0.0000 |
|
237 |
C |
A |
0.0000 |
|
238 |
K |
A |
-2.7538 |
|
239 |
A |
A |
-1.5731 |
|
240 |
G |
A |
-1.9925 |
|
241 |
K |
A |
-2.3127 |
|
242 |
L |
A |
-2.0692 |
|
243 |
D |
A |
-2.8758 |
|
244 |
E |
A |
-2.7010 |
|
245 |
A |
A |
0.0000 |
|
246 |
L |
A |
-1.7981 |
|
247 |
K |
A |
-2.7873 |
|
248 |
L |
A |
-1.4698 |
|
249 |
F |
A |
0.0000 |
|
250 |
E |
A |
-2.3505 |
|
252 |
M |
A |
-1.5195 |
|
255 |
K |
A |
-2.2545 |
|
256 |
G |
A |
-1.8256 |
|
257 |
I |
A |
-1.4423 |
|
258 |
K |
A |
-1.9483 |
|
259 |
P |
A |
-1.1288 |
|
260 |
N |
A |
-0.7885 |
|
261 |
V |
A |
-0.0343 |
|
262 |
V |
A |
0.5764 |
|
263 |
T |
A |
0.0000 |
|
264 |
Y |
A |
0.0000 |
|
265 |
N |
A |
0.0000 |
|
266 |
T |
A |
-0.3973 |
|
267 |
L |
A |
0.0000 |
|
268 |
I |
A |
0.0000 |
|
269 |
D |
A |
-2.2177 |
|
270 |
G |
A |
0.0000 |
|
271 |
L |
A |
0.0000 |
|
272 |
C |
A |
0.0000 |
|
273 |
K |
A |
-3.0033 |
|
274 |
A |
A |
-1.8135 |
|
275 |
G |
A |
-2.1872 |
|
276 |
K |
A |
-2.6742 |
|
277 |
L |
A |
0.0000 |
|
278 |
D |
A |
-3.1883 |
|
279 |
E |
A |
-3.5338 |
|
280 |
A |
A |
0.0000 |
|
281 |
L |
A |
-2.0416 |
|
282 |
K |
A |
-2.8471 |
|
283 |
L |
A |
0.0000 |
|
284 |
F |
A |
-1.5860 |
|
285 |
E |
A |
-2.4077 |
|
286 |
E |
A |
-1.4659 |
|
287 |
M |
A |
-0.1641 |
|
290 |
K |
A |
-2.1882 |
|
291 |
G |
A |
-1.5657 |
|
292 |
I |
A |
-1.5297 |
|
293 |
K |
A |
-2.3773 |
|
294 |
P |
A |
-1.5464 |
|
295 |
D |
A |
-1.8070 |
|
296 |
V |
A |
-0.0919 |
|
297 |
V |
A |
1.3722 |
|
298 |
T |
A |
0.0000 |
|
299 |
Y |
A |
0.0000 |
|
300 |
N |
A |
0.0000 |
|
301 |
T |
A |
-0.2929 |
|
302 |
L |
A |
0.0000 |
|
303 |
I |
A |
0.0000 |
|
304 |
D |
A |
-2.1418 |
|
305 |
G |
A |
0.0000 |
|
306 |
L |
A |
0.0000 |
|
307 |
C |
A |
0.0000 |
|
308 |
K |
A |
-2.8248 |
|
309 |
A |
A |
-1.7089 |
|
310 |
G |
A |
-2.0624 |
|
311 |
K |
A |
-2.3729 |
|
312 |
L |
A |
-2.1706 |
|
313 |
D |
A |
-2.8783 |
|
314 |
E |
A |
-2.8616 |
|
315 |
A |
A |
0.0000 |
|
316 |
L |
A |
-1.8790 |
|
317 |
K |
A |
-3.1236 |
|
318 |
L |
A |
0.0000 |
|
319 |
F |
A |
-1.7685 |
|
320 |
E |
A |
-2.8974 |
|
321 |
E |
A |
-2.5996 |
|
322 |
M |
A |
0.0000 |
|
323 |
V |
A |
-1.1620 |
|
324 |
E |
A |
-2.7332 |
|
325 |
K |
A |
-2.7457 |
|
326 |
G |
A |
-1.8383 |
|
327 |
I |
A |
0.0000 |
|
328 |
K |
A |
-2.3371 |
|
329 |
P |
A |
0.0000 |
|
330 |
D |
A |
-1.5388 |
|
331 |
V |
A |
-0.2390 |
|
332 |
V |
A |
1.4899 |
|
333 |
T |
A |
0.0000 |
|
334 |
Y |
A |
0.0000 |
|
335 |
N |
A |
0.0000 |
|
336 |
T |
A |
0.0000 |
|
337 |
L |
A |
0.0000 |
|
338 |
I |
A |
0.0000 |
|
339 |
D |
A |
-1.2230 |
|
340 |
G |
A |
-1.7167 |
|
341 |
L |
A |
0.0000 |
|
342 |
C |
A |
0.0000 |
|
343 |
K |
A |
-2.4238 |
|
344 |
A |
A |
-1.6232 |
|
345 |
G |
A |
-2.0796 |
|
346 |
K |
A |
-2.5130 |
|
347 |
L |
A |
-2.1111 |
|
348 |
D |
A |
-2.8912 |
|
349 |
E |
A |
-2.7984 |
|
350 |
A |
A |
0.0000 |
|
351 |
L |
A |
-2.0908 |
|
352 |
K |
A |
-3.0142 |
|
353 |
L |
A |
0.0000 |
|
354 |
F |
A |
0.0000 |
|
355 |
E |
A |
-2.7115 |
|
356 |
E |
A |
-2.2759 |
|
357 |
M |
A |
0.0000 |
|
358 |
V |
A |
-0.8557 |
|
359 |
E |
A |
-2.5760 |
|
360 |
K |
A |
-2.5149 |
|
361 |
G |
A |
-1.6282 |
|
362 |
I |
A |
-1.4240 |
|
363 |
K |
A |
-1.9705 |
|
364 |
P |
A |
0.0000 |
|
365 |
D |
A |
-0.0497 |
|
366 |
V |
A |
0.5055 |
|
367 |
V |
A |
1.5929 |
|
368 |
T |
A |
0.0000 |
|
369 |
Y |
A |
0.0000 |
|
370 |
N |
A |
0.2684 |
|
371 |
T |
A |
0.0000 |
|
372 |
L |
A |
0.0000 |
|
373 |
I |
A |
0.0000 |
|
374 |
D |
A |
-0.9386 |
|
375 |
G |
A |
0.0000 |
|
376 |
L |
A |
0.0000 |
|
377 |
C |
A |
-1.1757 |
|
378 |
K |
A |
-1.9898 |
|
379 |
A |
A |
-1.2443 |
|
380 |
G |
A |
-1.0172 |
|
382 |
L |
A |
-0.8109 |
|
383 |
D |
A |
-2.1225 |
|
384 |
E |
A |
-2.2632 |
|
385 |
A |
A |
0.0000 |
|
386 |
L |
A |
-1.3085 |
|
387 |
K |
A |
-2.9158 |
|
388 |
L |
A |
0.0000 |
|
389 |
F |
A |
-1.2183 |
|
390 |
E |
A |
-2.4718 |
|
391 |
E |
A |
-1.9955 |
|
392 |
M |
A |
0.0000 |
|
393 |
V |
A |
-0.7088 |
|
394 |
E |
A |
-2.3304 |
|
395 |
K |
A |
-2.1947 |
|
396 |
G |
A |
-1.3738 |
|
397 |
I |
A |
-1.1428 |
|
398 |
K |
A |
-1.7134 |
|
399 |
P |
A |
-0.6577 |
|
400 |
D |
A |
-1.4068 |
|
401 |
E |
A |
-2.0519 |
|
402 |
L |
A |
-0.6044 |
|
403 |
T |
A |
0.0000 |
|
404 |
Y |
A |
-0.4414 |
|
405 |
R |
A |
-1.9408 |
|
406 |
R |
A |
-1.1152 |
|
407 |
V |
A |
0.0000 |
|
408 |
V |
A |
0.9578 |
|
409 |
E |
A |
-1.0800 |
|
411 |
Y |
A |
1.2423 |
|