| Chain sequence(s) |
B: ELPQMTQQLNSDDMQEQLSATVKFRQILSREHRPPIDVVIQAGVVPRLVEFMRENQPEMLQLEAAWALTNIASGTSAQTKVVVDADAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSNKPSLIRTATWTLSNLCRGKKPQPDWSVVSQALPTLAKLIYSMDTETLVDACWAISYLSDGPQEAIQAVIDVRIPKRLVELLSHESTLVQTPALRAVGNIVTGNDLQTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPPLVKLLEVAEDKTKKEACWAISNASSGGLQRPDIIRYLVSQGCIKPLCDLLEIADNRIIEVTLDALENILKMGEADKEARGLNINENADFIEKAGGMEKIFNCQQNENDKIYEKAYKIIETYFG D: AKRVADAQIQRETYDSNTPSTKVASSAVMNRRKIAMPKR |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 88 | E | B | -2.1414 | |
| 89 | L | B | -1.3982 | |
| 90 | P | B | -1.5691 | |
| 91 | Q | B | -2.2475 | |
| 92 | M | B | 0.0000 | |
| 93 | T | B | -1.7047 | |
| 94 | Q | B | -2.2436 | |
| 95 | Q | B | -2.3202 | |
| 96 | L | B | 0.0000 | |
| 97 | N | B | -2.4165 | |
| 98 | S | B | -2.6252 | |
| 99 | D | B | -3.1446 | |
| 100 | D | B | -3.2182 | |
| 101 | M | B | -1.9458 | |
| 102 | Q | B | -2.2196 | |
| 103 | E | B | -2.4130 | |
| 104 | Q | B | 0.0000 | |
| 105 | L | B | -0.5662 | |
| 106 | S | B | -0.6413 | |
| 107 | A | B | 0.0000 | |
| 108 | T | B | 0.0000 | |
| 109 | V | B | -0.2730 | |
| 110 | K | B | -0.8759 | |
| 111 | F | B | 0.0000 | |
| 112 | R | B | -1.0023 | |
| 113 | Q | B | -1.4964 | |
| 114 | I | B | -1.1011 | |
| 115 | L | B | 0.0000 | |
| 116 | S | B | -2.2598 | |
| 117 | R | B | -3.6786 | |
| 118 | E | B | -3.6568 | |
| 119 | H | B | -3.3899 | |
| 120 | R | B | -3.3456 | |
| 121 | P | B | -2.5606 | |
| 122 | P | B | -1.0918 | |
| 123 | I | B | 0.0000 | |
| 124 | D | B | -1.0189 | |
| 125 | V | B | -0.0245 | |
| 126 | V | B | 0.0000 | |
| 127 | I | B | -0.4235 | |
| 128 | Q | B | -1.1555 | |
| 129 | A | B | -0.6340 | |
| 130 | G | B | -0.7779 | |
| 131 | V | B | 0.0000 | |
| 132 | V | B | 0.0000 | |
| 133 | P | B | -1.2243 | |
| 134 | R | B | -1.1502 | |
| 135 | L | B | 0.0000 | |
| 136 | V | B | 0.0000 | |
| 137 | E | B | -2.5615 | |
| 138 | F | B | 0.0000 | |
| 139 | M | B | 0.0000 | |
| 140 | R | B | -3.8731 | |
| 141 | E | B | -3.9634 | |
| 142 | N | B | -3.2753 | |
| 143 | Q | B | -2.5843 | |
| 144 | P | B | -1.5979 | |
| 145 | E | B | -2.2075 | |
| 146 | M | B | -0.2317 | |
| 147 | L | B | 0.0000 | |
| 148 | Q | B | 0.0000 | |
| 149 | L | B | -0.3258 | |
| 150 | E | B | -0.1547 | |
| 151 | A | B | 0.0000 | |
| 152 | A | B | 0.0000 | |
| 153 | W | B | -0.0608 | |
| 154 | A | B | 0.0000 | |
| 155 | L | B | 0.0000 | |
| 156 | T | B | 0.0000 | |
| 157 | N | B | -0.6220 | |
| 158 | I | B | 0.0000 | |
| 159 | A | B | 0.0000 | |
| 160 | S | B | -0.4731 | |
| 161 | G | B | -0.8306 | |
| 162 | T | B | -0.7974 | |
| 163 | S | B | -0.8834 | |
| 164 | A | B | -0.7629 | |
| 165 | Q | B | -0.7547 | |
| 166 | T | B | 0.0000 | |
| 167 | K | B | -1.8263 | |
| 168 | V | B | -1.0422 | |
| 169 | V | B | 0.0000 | |
| 170 | V | B | -1.5978 | |
| 171 | D | B | -2.5521 | |
| 172 | A | B | -2.0103 | |
| 173 | D | B | -2.4078 | |
| 174 | A | B | 0.0000 | |
| 175 | V | B | 0.0000 | |
| 176 | P | B | -0.9296 | |
| 177 | L | B | -1.3562 | |
| 178 | F | B | 0.0000 | |
| 179 | I | B | 0.0000 | |
| 180 | Q | B | -1.2046 | |
| 181 | L | B | 0.0000 | |
| 182 | L | B | 0.0000 | |
| 183 | Y | B | 0.5768 | |
| 184 | T | B | -0.2132 | |
| 185 | G | B | -0.7329 | |
| 186 | S | B | -0.4937 | |
| 187 | V | B | -0.4017 | |
| 188 | E | B | -1.6312 | |
| 189 | V | B | 0.0000 | |
| 190 | K | B | -0.6453 | |
| 191 | E | B | -0.9184 | |
| 192 | Q | B | -0.4939 | |
| 193 | A | B | 0.0000 | |
| 194 | I | B | 0.0000 | |
| 195 | W | B | 0.2764 | |
| 196 | A | B | 0.0000 | |
| 197 | L | B | 0.0000 | |
| 198 | G | B | 0.0000 | |
| 199 | N | B | -0.3731 | |
| 200 | V | B | 0.0000 | |
| 201 | A | B | 0.0000 | |
| 202 | G | B | -0.9388 | |
| 203 | D | B | -1.2990 | |
| 204 | S | B | -1.1271 | |
| 205 | T | B | -1.7310 | |
| 206 | D | B | -2.1131 | |
| 207 | Y | B | -1.4025 | |
| 208 | R | B | 0.0000 | |
| 209 | D | B | -2.0160 | |
| 210 | Y | B | -1.0950 | |
| 211 | V | B | 0.0000 | |
| 212 | L | B | 0.0000 | |
| 213 | Q | B | -1.8132 | |
| 214 | C | B | -1.1083 | |
| 215 | N | B | -2.0581 | |
| 216 | A | B | 0.0000 | |
| 217 | M | B | 0.0000 | |
| 218 | E | B | -2.0857 | |
| 219 | P | B | 0.0000 | |
| 220 | I | B | 0.0000 | |
| 221 | L | B | -0.6891 | |
| 222 | G | B | -0.7104 | |
| 223 | L | B | 0.0000 | |
| 224 | F | B | -0.8785 | |
| 225 | N | B | -1.7167 | |
| 226 | S | B | -1.5312 | |
| 227 | N | B | -2.2120 | |
| 228 | K | B | -2.0386 | |
| 229 | P | B | -1.2758 | |
| 230 | S | B | -1.1777 | |
| 231 | L | B | 0.0000 | |
| 232 | I | B | -0.9366 | |
| 233 | R | B | -1.2528 | |
| 234 | T | B | -0.4724 | |
| 235 | A | B | 0.0000 | |
| 236 | T | B | 0.0000 | |
| 237 | W | B | -0.1137 | |
| 238 | T | B | 0.0000 | |
| 239 | L | B | 0.0000 | |
| 240 | S | B | 0.0000 | |
| 241 | N | B | 0.0000 | |
| 242 | L | B | 0.0000 | |
| 243 | C | B | 0.0000 | |
| 244 | R | B | -0.7461 | |
| 245 | G | B | -1.1036 | |
| 246 | K | B | -1.6599 | |
| 247 | K | B | -2.2693 | |
| 248 | P | B | -2.2503 | |
| 249 | Q | B | -1.8359 | |
| 250 | P | B | 0.0000 | |
| 251 | D | B | -1.8354 | |
| 252 | W | B | -0.8949 | |
| 253 | S | B | -0.5913 | |
| 254 | V | B | -1.0011 | |
| 255 | V | B | 0.0000 | |
| 256 | S | B | -0.6160 | |
| 257 | Q | B | -1.1205 | |
| 258 | A | B | 0.0000 | |
| 259 | L | B | 0.0000 | |
| 260 | P | B | -1.1050 | |
| 261 | T | B | -0.7981 | |
| 262 | L | B | 0.0000 | |
| 263 | A | B | -0.9913 | |
| 264 | K | B | -1.5265 | |
| 265 | L | B | 0.0000 | |
| 266 | I | B | 0.0000 | |
| 267 | Y | B | 0.9311 | |
| 268 | S | B | 0.4281 | |
| 269 | M | B | 1.0068 | |
| 270 | D | B | -0.1669 | |
| 271 | T | B | -0.4489 | |
| 272 | E | B | -1.2357 | |
| 273 | T | B | 0.0000 | |
| 274 | L | B | 0.0000 | |
| 275 | V | B | 0.0000 | |
| 276 | D | B | 0.0000 | |
| 277 | A | B | 0.0000 | |
| 278 | C | B | 0.0000 | |
| 279 | W | B | 0.0000 | |
| 280 | A | B | 0.0000 | |
| 281 | I | B | 0.0000 | |
| 282 | S | B | 0.0000 | |
| 283 | Y | B | 0.0000 | |
| 284 | L | B | 0.0000 | |
| 285 | S | B | 0.0000 | |
| 286 | D | B | 0.0000 | |
| 287 | G | B | -0.6588 | |
| 288 | P | B | -1.4404 | |
| 289 | Q | B | -2.2351 | |
| 290 | E | B | -2.4869 | |
| 291 | A | B | 0.0000 | |
| 292 | I | B | 0.0000 | |
| 293 | Q | B | -1.7956 | |
| 294 | A | B | -1.6735 | |
| 295 | V | B | 0.0000 | |
| 296 | I | B | 0.0000 | |
| 297 | D | B | -2.3591 | |
| 298 | V | B | -1.8694 | |
| 299 | R | B | -2.9633 | |
| 300 | I | B | 0.0000 | |
| 301 | P | B | 0.0000 | |
| 302 | K | B | -2.8284 | |
| 303 | R | B | -2.0627 | |
| 304 | L | B | 0.0000 | |
| 305 | V | B | 0.0000 | |
| 306 | E | B | -2.4426 | |
| 307 | L | B | 0.0000 | |
| 308 | L | B | 0.0000 | |
| 309 | S | B | -1.0590 | |
| 310 | H | B | -1.4192 | |
| 311 | E | B | -1.8576 | |
| 312 | S | B | -0.6667 | |
| 313 | T | B | -0.1417 | |
| 314 | L | B | 0.6067 | |
| 315 | V | B | 0.0000 | |
| 316 | Q | B | -0.4000 | |
| 317 | T | B | 0.0000 | |
| 318 | P | B | 0.0000 | |
| 319 | A | B | 0.0000 | |
| 320 | L | B | 0.0000 | |
| 321 | R | B | 0.0000 | |
| 322 | A | B | 0.0000 | |
| 323 | V | B | 0.0000 | |
| 324 | G | B | 0.0000 | |
| 325 | N | B | 0.0000 | |
| 326 | I | B | 0.0000 | |
| 327 | V | B | 0.0000 | |
| 328 | T | B | -0.2432 | |
| 329 | G | B | 0.0000 | |
| 330 | N | B | -1.2365 | |
| 331 | D | B | -1.6035 | |
| 332 | L | B | 0.4556 | |
| 333 | Q | B | 0.0000 | |
| 334 | T | B | 0.0000 | |
| 335 | Q | B | -0.8710 | |
| 336 | V | B | -0.5603 | |
| 337 | V | B | 0.0000 | |
| 338 | I | B | -0.5190 | |
| 339 | N | B | -1.4453 | |
| 340 | A | B | -1.6503 | |
| 341 | G | B | -1.1269 | |
| 342 | V | B | 0.0000 | |
| 343 | L | B | 0.0000 | |
| 344 | P | B | -0.6467 | |
| 345 | A | B | 0.0000 | |
| 346 | L | B | 0.0000 | |
| 347 | R | B | -0.8012 | |
| 348 | L | B | 0.5597 | |
| 349 | L | B | 0.0000 | |
| 350 | L | B | 0.0000 | |
| 351 | S | B | -0.3184 | |
| 352 | S | B | -0.5047 | |
| 353 | P | B | -0.7817 | |
| 354 | K | B | -1.3800 | |
| 355 | E | B | -1.7839 | |
| 356 | N | B | -1.6384 | |
| 357 | I | B | 0.0000 | |
| 358 | K | B | -1.1340 | |
| 359 | K | B | -1.3475 | |
| 360 | E | B | -0.6068 | |
| 361 | A | B | 0.0000 | |
| 362 | C | B | 0.0000 | |
| 363 | W | B | 0.0000 | |
| 364 | T | B | 0.0000 | |
| 365 | I | B | 0.0000 | |
| 366 | S | B | 0.0000 | |
| 367 | N | B | 0.0000 | |
| 368 | I | B | 0.0000 | |
| 369 | T | B | 0.0000 | |
| 370 | A | B | -0.7213 | |
| 371 | G | B | -1.5650 | |
| 372 | N | B | -2.3583 | |
| 373 | T | B | -1.9772 | |
| 374 | E | B | -2.3725 | |
| 375 | Q | B | 0.0000 | |
| 376 | I | B | 0.0000 | |
| 377 | Q | B | -1.8843 | |
| 378 | A | B | -1.5769 | |
| 379 | V | B | 0.0000 | |
| 380 | I | B | 0.0000 | |
| 381 | D | B | -2.2907 | |
| 382 | A | B | 0.0000 | |
| 383 | N | B | -2.0874 | |
| 384 | L | B | 0.0000 | |
| 385 | I | B | 0.0000 | |
| 386 | P | B | -0.9418 | |
| 387 | P | B | -1.3150 | |
| 388 | L | B | 0.0000 | |
| 389 | V | B | 0.0000 | |
| 390 | K | B | -1.8395 | |
| 391 | L | B | 0.0000 | |
| 392 | L | B | 0.0000 | |
| 393 | E | B | -2.2163 | |
| 394 | V | B | -0.0352 | |
| 395 | A | B | -1.2530 | |
| 396 | E | B | -2.4011 | |
| 397 | D | B | -1.8863 | |
| 398 | K | B | -1.7567 | |
| 399 | T | B | 0.0000 | |
| 400 | K | B | -1.5171 | |
| 401 | K | B | -1.2345 | |
| 402 | E | B | 0.0000 | |
| 403 | A | B | 0.0000 | |
| 404 | C | B | 0.0000 | |
| 405 | W | B | -0.0538 | |
| 406 | A | B | 0.0000 | |
| 407 | I | B | 0.0000 | |
| 408 | S | B | 0.0000 | |
| 409 | N | B | -0.3525 | |
| 410 | A | B | 0.0000 | |
| 411 | S | B | 0.0000 | |
| 412 | S | B | -0.4612 | |
| 413 | G | B | 0.0000 | |
| 414 | G | B | 0.0000 | |
| 415 | L | B | 0.3606 | |
| 416 | Q | B | -1.1202 | |
| 417 | R | B | -1.7947 | |
| 418 | P | B | -1.8480 | |
| 419 | D | B | -2.6942 | |
| 420 | I | B | 0.0000 | |
| 421 | I | B | 0.0000 | |
| 422 | R | B | -2.4967 | |
| 423 | Y | B | -1.2330 | |
| 424 | L | B | 0.0000 | |
| 425 | V | B | -0.7197 | |
| 426 | S | B | -0.7415 | |
| 427 | Q | B | -0.8802 | |
| 428 | G | B | -0.8537 | |
| 429 | C | B | 0.0000 | |
| 430 | I | B | 0.0000 | |
| 431 | K | B | -2.4683 | |
| 432 | P | B | 0.0000 | |
| 433 | L | B | 0.0000 | |
| 434 | C | B | 0.0000 | |
| 435 | D | B | -2.0586 | |
| 436 | L | B | 0.0000 | |
| 437 | L | B | 0.0000 | |
| 438 | E | B | -2.0733 | |
| 439 | I | B | -1.1406 | |
| 440 | A | B | -1.1704 | |
| 441 | D | B | -1.5693 | |
| 442 | N | B | -2.3132 | |
| 443 | R | B | -2.2660 | |
| 444 | I | B | 0.0000 | |
| 445 | I | B | 0.0000 | |
| 446 | E | B | -1.9659 | |
| 447 | V | B | 0.0000 | |
| 448 | T | B | 0.0000 | |
| 449 | L | B | 0.0000 | |
| 450 | D | B | -1.1989 | |
| 451 | A | B | 0.0000 | |
| 452 | L | B | 0.0000 | |
| 453 | E | B | 0.0000 | |
| 454 | N | B | 0.0000 | |
| 455 | I | B | 0.0000 | |
| 456 | L | B | 0.0000 | |
| 457 | K | B | -0.6119 | |
| 458 | M | B | 0.0000 | |
| 459 | G | B | 0.0000 | |
| 460 | E | B | -1.4342 | |
| 461 | A | B | -1.4890 | |
| 462 | D | B | -1.8421 | |
| 463 | K | B | -2.1784 | |
| 464 | E | B | -2.7629 | |
| 465 | A | B | -2.0293 | |
| 466 | R | B | -2.7116 | |
| 467 | G | B | -1.8051 | |
| 468 | L | B | -0.8316 | |
| 469 | N | B | -1.0458 | |
| 470 | I | B | -0.1598 | |
| 471 | N | B | 0.0000 | |
| 472 | E | B | -1.6327 | |
| 473 | N | B | 0.0000 | |
| 474 | A | B | 0.0000 | |
| 475 | D | B | -2.2548 | |
| 476 | F | B | -1.6684 | |
| 477 | I | B | 0.0000 | |
| 478 | E | B | -3.0299 | |
| 479 | K | B | -2.6300 | |
| 480 | A | B | -2.1281 | |
| 481 | G | B | -2.0385 | |
| 482 | G | B | 0.0000 | |
| 483 | M | B | 0.0000 | |
| 484 | E | B | -2.3722 | |
| 485 | K | B | -1.9727 | |
| 486 | I | B | 0.0000 | |
| 487 | F | B | -0.7156 | |
| 488 | N | B | -1.5520 | |
| 489 | C | B | 0.0000 | |
| 490 | Q | B | 0.0000 | |
| 491 | Q | B | -0.9870 | |
| 492 | N | B | -2.0791 | |
| 493 | E | B | -2.5673 | |
| 494 | N | B | -3.2321 | |
| 495 | D | B | -3.8523 | |
| 496 | K | B | -3.7913 | |
| 497 | I | B | 0.0000 | |
| 498 | Y | B | 0.0000 | |
| 499 | E | B | -3.5583 | |
| 500 | K | B | -2.5365 | |
| 501 | A | B | 0.0000 | |
| 502 | Y | B | -1.8574 | |
| 503 | K | B | -2.4612 | |
| 504 | I | B | 0.0000 | |
| 505 | I | B | 0.0000 | |
| 506 | E | B | -1.9015 | |
| 507 | T | B | -1.3860 | |
| 508 | Y | B | -0.8861 | |
| 509 | F | B | 0.0000 | |
| 510 | G | B | -1.4466 | |
| 2 | A | D | -0.0405 | |
| 3 | K | D | -0.1590 | |
| 4 | R | D | 0.2085 | |
| 5 | V | D | 1.1245 | |
| 6 | A | D | -0.0976 | |
| 7 | D | D | -1.3670 | |
| 8 | A | D | -0.5846 | |
| 9 | Q | D | -0.4298 | |
| 10 | I | D | -0.4816 | |
| 11 | Q | D | -0.8440 | |
| 12 | R | D | -1.1320 | |
| 13 | E | D | -1.9281 | |
| 14 | T | D | -1.1908 | |
| 15 | Y | D | -1.3169 | |
| 16 | D | D | -2.4437 | |
| 17 | S | D | -1.6398 | |
| 18 | N | D | -2.1515 | |
| 25 | T | D | -0.4048 | |
| 26 | P | D | -0.5877 | |
| 27 | S | D | -0.7379 | |
| 28 | T | D | -1.1582 | |
| 29 | K | D | -1.6148 | |
| 30 | V | D | 0.1164 | |
| 31 | A | D | 0.0000 | |
| 32 | S | D | -0.1737 | |
| 33 | S | D | -0.2686 | |
| 34 | A | D | -0.2177 | |
| 35 | V | D | -0.0544 | |
| 36 | M | D | -1.0054 | |
| 37 | N | D | -1.9988 | |
| 38 | R | D | -2.4201 | |
| 39 | R | D | -2.1939 | |
| 40 | K | D | -2.1184 | |
| 41 | I | D | -0.7015 | |
| 42 | A | D | 0.0000 | |
| 43 | M | D | 0.0384 | |
| 44 | P | D | -1.4276 | |
| 45 | K | D | -2.6780 | |
| 46 | R | D | -3.0587 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine