Project name: 4GWG

Chain sequence(s)	A: AQADIALIGLAVMMGQNLLILNMNDHGFVVCAFNRTVSKVDDDFLANEAKGTKVVGAQSLKEMVSKLKKPRRIILLLVKAGQAVDDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDDLKAKGILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKKTIFQGIAAKVGTGEPCCDWVGDEGAGHFVKMMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANILKFQDTDGKHLLPKIRDSAGQKGTGKWTAISALEYYGVPVTLIGEAVFARCLSSLKDERIQASKKLKGPFQFDGDKKSFLEDIRKALYASKIISYAQGFMLLRQAATEEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSSAVENCQDDSWRRRAVSSTGVQAGIPMPCFTTALSFYDGYRHEMLPASLIQAQRDYFGAHTYELLAKPGQFIHTNWT
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.92
• Maximal score value: 1.4761
• Average score: -0.8105
• Total score value: -378.5181

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	A	A	-1.7851
2	Q	A	-1.8560
3	A	A	0.0000
4	D	A	-1.6051
5	I	A	0.0000
6	A	A	0.0000
7	L	A	0.0000
8	I	A	0.0000
9	G	A	0.0000
10	L	A	0.0000
11	A	A	0.5229
12	V	A	0.7100
13	M	A	0.1584
14	G	A	0.0000
15	Q	A	0.0000
16	N	A	-0.4982
17	L	A	0.0000
18	I	A	0.0000
19	L	A	0.0000
20	N	A	0.0000
21	M	A	0.0000
22	N	A	-1.4729
23	D	A	-2.2239
24	H	A	-1.6772
25	G	A	-1.4221
26	F	A	-0.7378
27	V	A	-0.7203
28	V	A	0.0000
29	C	A	0.0000
30	A	A	0.0000
31	F	A	0.0000
32	N	A	-1.4660
33	R	A	-2.0650
34	T	A	-1.1678
35	V	A	-1.4147
36	S	A	-1.7545
37	K	A	-2.1177
38	V	A	0.0000
39	D	A	-2.9906
40	D	A	-3.5418
41	F	A	0.0000
42	L	A	-2.3548
43	A	A	-2.6070
44	N	A	-3.4119
45	E	A	-3.0809
46	A	A	0.0000
47	K	A	-3.1186
48	G	A	-1.8682
49	T	A	-1.7003
50	K	A	-1.4581
51	V	A	0.0000
52	V	A	-0.2881
53	G	A	-0.7607
54	A	A	0.0000
55	Q	A	-2.3164
56	S	A	-1.9850
57	L	A	0.0000
58	K	A	-2.8350
59	E	A	-2.8720
60	M	A	0.0000
61	V	A	0.0000
62	S	A	-2.0174
63	K	A	-2.2419
64	L	A	0.0000
65	K	A	-3.2000
66	K	A	-2.9051
67	P	A	-1.9591
68	R	A	-1.9400
69	R	A	-1.0786
70	I	A	0.0000
71	I	A	0.0000
72	L	A	0.0000
73	L	A	0.0000
74	V	A	-1.0469
75	K	A	-1.9924
76	A	A	-1.6486
77	G	A	-1.6520
78	Q	A	-1.8519
79	A	A	-1.5871
80	V	A	0.0000
81	D	A	-1.8540
82	D	A	-2.2361
83	F	A	0.0000
84	I	A	0.0000
85	E	A	-2.6327
86	K	A	-2.3370
87	L	A	0.0000
88	V	A	-0.8967
89	P	A	-0.7915
90	L	A	-0.7830
91	L	A	-0.7092
92	D	A	-1.3166
93	T	A	-1.0827
94	G	A	-1.3616
95	D	A	0.0000
96	I	A	0.0000
97	I	A	0.0000
98	I	A	0.0000
99	D	A	0.0000
100	G	A	0.0000
101	G	A	0.0000
102	N	A	-1.7051
103	S	A	-1.6370
104	E	A	-1.7181
105	Y	A	0.0000
106	R	A	-2.6340
107	D	A	-2.0991
108	T	A	0.0000
109	T	A	-2.3479
110	R	A	-3.0372
111	R	A	0.0000
112	C	A	0.0000
113	R	A	-3.9200
114	D	A	-3.8768
115	L	A	0.0000
116	K	A	-3.8109
117	A	A	-2.6686
118	K	A	-3.0103
119	G	A	-1.9023
120	I	A	0.0000
121	L	A	0.0000
122	F	A	0.0000
123	V	A	0.0000
124	G	A	0.0000
125	S	A	0.0000
126	G	A	0.0000
127	V	A	-0.1714
128	S	A	0.0000
129	G	A	-0.7467
130	G	A	-1.3226
131	E	A	-1.7234
132	E	A	-2.1552
133	G	A	-1.1904
134	A	A	0.0000
135	R	A	-0.7559
136	Y	A	0.2381
137	G	A	-0.3139
138	P	A	0.0000
139	S	A	0.0000
140	L	A	0.0000
141	M	A	0.0000
142	P	A	0.0000
143	G	A	0.0000
144	G	A	0.0000
145	N	A	-2.4200
146	K	A	-2.9463
147	E	A	-3.0223
148	A	A	0.0000
149	W	A	0.0000
150	P	A	-1.4348
151	H	A	-1.5670
152	I	A	0.0000
153	K	A	-1.2002
154	T	A	-0.6795
155	I	A	0.0000
156	F	A	0.0000
157	Q	A	-0.8989
158	G	A	-0.8383
159	I	A	0.0000
160	A	A	0.0000
161	A	A	-0.6795
162	K	A	-1.7492
163	V	A	-1.2497
164	G	A	-1.0169
165	T	A	-0.9381
166	G	A	-1.4399
167	E	A	-1.7311
168	P	A	-1.3415
169	C	A	0.0000
170	C	A	0.0000
171	D	A	-0.8759
172	W	A	0.0000
173	V	A	0.0000
174	G	A	0.0000
175	D	A	-1.3055
176	E	A	-1.6722
177	G	A	0.0000
178	A	A	0.0000
179	G	A	0.0000
180	H	A	0.0000
181	F	A	0.0000
182	V	A	0.0000
183	K	A	-0.4794
184	M	A	0.0000
185	V	A	0.0000
186	H	A	0.0000
187	N	A	-0.3151
188	G	A	0.0000
189	I	A	0.0000
190	E	A	-0.3723
191	Y	A	-0.3840
192	G	A	0.0000
193	D	A	0.0000
194	M	A	0.1908
195	Q	A	-0.1177
196	L	A	0.0000
197	I	A	0.0000
198	C	A	0.3674
199	E	A	0.0000
200	A	A	0.0000
201	Y	A	-0.2816
202	H	A	-0.8939
203	L	A	0.0000
204	M	A	0.0000
205	K	A	-2.0731
206	D	A	-2.0109
207	V	A	0.0000
208	L	A	0.0000
209	G	A	-1.6060
210	M	A	-1.6284
211	A	A	-1.6601
212	Q	A	-1.7536
213	D	A	-3.0296
214	E	A	-3.4399
215	M	A	0.0000
216	A	A	0.0000
217	Q	A	-3.3409
218	A	A	0.0000
219	F	A	0.0000
220	E	A	-3.4604
221	D	A	-2.9026
222	W	A	0.0000
223	N	A	-2.8130
224	K	A	-3.0644
225	T	A	-1.8749
226	E	A	-1.5252
227	L	A	0.0000
228	D	A	-2.3074
229	S	A	0.0000
230	F	A	-0.2706
231	L	A	0.0000
232	I	A	0.0000
233	E	A	-2.2287
234	I	A	-0.3860
235	T	A	0.0000
236	A	A	0.0000
237	N	A	-1.1962
238	I	A	0.6641
239	L	A	0.0000
240	K	A	-1.7142
241	F	A	0.4136
242	Q	A	-1.5798
243	D	A	-1.8925
244	T	A	-1.6631
245	D	A	-2.8914
246	G	A	-2.3932
247	K	A	-2.8283
248	H	A	-1.5720
249	L	A	0.0479
250	L	A	0.4177
251	P	A	-0.3824
252	K	A	-0.3813
253	I	A	0.3594
254	R	A	-2.1012
255	D	A	-2.5792
256	S	A	-1.5266
257	A	A	-1.3000
258	G	A	-1.1150
259	Q	A	-1.4747
260	K	A	-2.4354
261	G	A	-1.4780
262	T	A	-0.6861
263	G	A	0.0000
264	K	A	-0.3866
265	W	A	0.6500
266	T	A	0.0000
267	A	A	0.0000
268	I	A	0.7007
269	S	A	0.0000
270	A	A	0.0000
271	L	A	0.7936
272	E	A	-0.9840
273	Y	A	-0.7857
274	G	A	-0.4200
275	V	A	0.0000
276	P	A	0.1633
277	V	A	0.0000
278	T	A	-0.0519
279	L	A	0.0000
280	I	A	0.0000
281	G	A	0.0000
282	E	A	-0.2009
283	A	A	0.0000
284	V	A	0.0000
285	F	A	1.1930
286	A	A	0.5632
287	R	A	-0.4959
288	C	A	0.1388
289	L	A	1.1296
290	S	A	-0.8239
291	S	A	-1.2795
292	L	A	-1.0539
293	K	A	-2.4604
294	D	A	-2.8668
295	E	A	-2.8292
296	R	A	-1.8748
297	I	A	-1.0204
298	Q	A	-2.4486
299	A	A	-2.0707
300	S	A	-1.8531
301	K	A	-2.5387
302	K	A	-2.3319
303	L	A	-0.9507
304	K	A	-2.0029
305	G	A	-1.1984
306	P	A	-0.6285
309	F	A	0.4075
310	Q	A	-0.9430
311	F	A	-1.7333
312	D	A	-2.6197
313	G	A	-2.9811
314	D	A	-3.6980
315	K	A	-3.8489
316	K	A	-3.2499
317	S	A	-2.2871
318	F	A	0.0000
319	L	A	-1.5085
320	E	A	-1.3105
321	D	A	0.0000
322	I	A	0.0000
323	R	A	-0.5801
324	K	A	-1.0855
325	A	A	0.0000
326	L	A	0.0000
327	Y	A	0.0000
328	A	A	0.0000
329	S	A	0.0000
330	K	A	0.0000
331	I	A	0.0000
332	I	A	0.0000
333	S	A	0.0000
334	Y	A	0.0000
335	A	A	0.0000
336	Q	A	0.0000
337	G	A	0.0000
338	F	A	0.0000
339	M	A	-0.6090
340	L	A	0.0000
341	L	A	0.0000
342	R	A	-1.8277
343	Q	A	-1.4621
344	A	A	0.0000
345	A	A	-1.2441
346	T	A	-1.4174
347	E	A	-1.9939
348	F	A	-0.8300
349	G	A	-0.9271
350	W	A	0.0000
351	T	A	-0.5139
352	L	A	0.0000
353	N	A	-0.5587
354	Y	A	-0.7413
355	G	A	-1.4472
356	G	A	0.0000
357	I	A	0.0000
358	A	A	0.0000
359	L	A	0.0000
360	M	A	0.0000
361	W	A	0.0000
362	R	A	-0.6614
363	G	A	-0.8178
364	G	A	-0.5181
365	C	A	0.0000
366	I	A	0.4574
367	I	A	0.0000
368	R	A	-0.8262
369	S	A	0.0000
370	V	A	-0.2971
371	F	A	0.0000
372	L	A	0.0000
373	G	A	-0.9221
374	K	A	-1.5241
375	I	A	0.0000
376	K	A	-2.2163
377	D	A	-3.0611
378	A	A	0.0000
379	F	A	0.0000
380	D	A	-3.7800
381	R	A	-3.6699
382	N	A	-3.4035
383	P	A	-2.8898
384	E	A	-2.9328
385	L	A	-2.0074
386	Q	A	-1.8613
387	N	A	-0.7683
388	L	A	0.0000
389	L	A	0.0000
390	L	A	-0.1521
391	D	A	0.0000
392	D	A	-1.9218
393	F	A	-1.1230
394	F	A	0.0000
395	K	A	-2.1049
396	S	A	-1.8933
397	A	A	-1.6946
398	V	A	0.0000
399	E	A	-3.0100
400	N	A	-2.7509
401	C	A	0.0000
402	Q	A	-2.4258
403	D	A	-3.0743
404	S	A	0.0000
405	W	A	0.0000
406	R	A	-2.0821
407	R	A	-2.2307
408	A	A	0.0000
409	V	A	-0.3577
410	S	A	-0.6211
411	T	A	-0.4130
412	G	A	0.0000
413	V	A	0.7461
414	Q	A	-0.3697
415	A	A	-0.2946
416	G	A	-0.6098
417	I	A	0.0000
418	P	A	-0.0757
419	M	A	0.0000
420	P	A	-0.1473
421	C	A	0.0000
422	F	A	0.0000
423	T	A	0.0228
424	T	A	-0.1637
425	A	A	0.0000
426	L	A	-0.0550
427	S	A	-0.1163
428	F	A	-0.1152
429	Y	A	0.0000
430	D	A	-0.5586
431	G	A	-0.3865
432	Y	A	-0.3890
433	R	A	-1.4854
434	H	A	-1.3257
435	E	A	-1.5070
436	M	A	0.4692
437	L	A	1.3058
438	P	A	1.2236
439	A	A	1.1369
440	S	A	1.0971
441	L	A	1.4761
442	I	A	0.8814
443	Q	A	-0.6544
444	A	A	-0.0551
445	Q	A	-0.2175
446	R	A	-1.2496
447	D	A	0.0000
448	Y	A	0.7144
449	F	A	1.4267
450	G	A	-0.0845
451	A	A	-0.5486
452	H	A	-1.0518
453	T	A	-0.7171
454	Y	A	-0.1048
455	E	A	-0.7540
456	L	A	0.4322
457	L	A	0.8779
458	A	A	-0.1884
459	K	A	-1.4802
460	P	A	-1.0683
461	G	A	-1.0342
462	Q	A	-0.9281
463	F	A	0.6943
464	I	A	0.3494
465	H	A	-0.3551
466	T	A	-0.5131
467	N	A	-0.9424
468	W	A	0.3336
469	T	A	0.0013