Project name: 10%_ap_6fxn
Status: done
submitted: 2018-08-14 19:32:04, status changed: 2018-08-14 19:43:47
Settings
Chain sequence(s)
|
A: SELTQDPAVSVALGQTVRVTCQGDSLRSYYASWYQQKPGQAPVLVIYGKNNRPSGIPDRFSGSSSGNTASLTITGAQAEDEADYYCSSRDSSGNHWVFGGGTELTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTVQLQQSGAEVKKPGSSVRVSCKASGGTFNNNAINWVRQAPGQGLEWMGGIIPMFGTAKYSQNFQGRVAITADESTGTASMELSSLRSEDTAVYYCARSRDLLLFPHHALSPWGRGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-3.4679
-
Maximal score value
-
2.5814
-
Average score
-
-0.7175
-
Total score value
-
-309.2448
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
2 |
S |
A |
-1.6800 |
|
3 |
E |
A |
-2.3547 |
|
4 |
L |
A |
0.0000 |
|
5 |
T |
A |
-1.5122 |
|
6 |
Q |
A |
-1.6052 |
|
7 |
D |
A |
-2.3341 |
|
8 |
P |
A |
-1.8096 |
|
9 |
A |
A |
0.0000 |
|
10 |
V |
A |
-0.7853 |
|
11 |
S |
A |
-0.1393 |
|
12 |
V |
A |
-0.1533 |
|
13 |
A |
A |
0.1613 |
|
14 |
L |
A |
-0.1346 |
|
15 |
G |
A |
-0.9014 |
|
16 |
Q |
A |
-1.2914 |
|
17 |
T |
A |
-1.2594 |
|
18 |
V |
A |
0.0000 |
|
19 |
R |
A |
-1.8571 |
|
20 |
V |
A |
0.0000 |
|
21 |
T |
A |
-1.0645 |
|
22 |
C |
A |
0.0000 |
|
23 |
Q |
A |
-2.1982 |
|
24 |
G |
A |
0.0000 |
|
25 |
D |
A |
-3.4679 |
|
26 |
S |
A |
0.0000 |
|
27 |
L |
A |
0.0000 |
|
28 |
R |
A |
-3.1079 |
|
29 |
S |
A |
-1.6297 |
|
30 |
Y |
A |
-0.9490 |
|
31 |
Y |
A |
-0.7241 |
|
32 |
A |
A |
0.0000 |
|
33 |
S |
A |
0.0000 |
|
34 |
W |
A |
0.0000 |
|
35 |
Y |
A |
0.0000 |
|
36 |
Q |
A |
0.0000 |
|
37 |
Q |
A |
0.0000 |
|
38 |
K |
A |
-1.4917 |
|
39 |
P |
A |
-1.4214 |
|
40 |
G |
A |
-1.1842 |
|
41 |
Q |
A |
-1.4991 |
|
42 |
A |
A |
-0.9627 |
|
43 |
P |
A |
0.0000 |
|
44 |
V |
A |
0.4798 |
|
45 |
L |
A |
0.0000 |
|
46 |
V |
A |
0.0000 |
|
47 |
I |
A |
0.0000 |
|
48 |
Y |
A |
-0.9857 |
|
49 |
G |
A |
0.0000 |
|
50 |
K |
A |
-2.5193 |
|
51 |
N |
A |
-2.1609 |
|
52 |
N |
A |
-1.9323 |
|
53 |
R |
A |
-1.7776 |
|
54 |
P |
A |
-0.6351 |
|
55 |
S |
A |
-0.6082 |
|
56 |
G |
A |
-0.7936 |
|
57 |
I |
A |
-0.7250 |
|
58 |
P |
A |
-1.2722 |
|
59 |
D |
A |
-2.1808 |
|
60 |
R |
A |
-1.5091 |
|
61 |
F |
A |
0.0000 |
|
62 |
S |
A |
-1.5124 |
|
63 |
G |
A |
-1.2796 |
|
64 |
S |
A |
-1.1310 |
|
65 |
S |
A |
-1.3423 |
|
66 |
S |
A |
-1.2345 |
|
67 |
G |
A |
-2.2146 |
|
68 |
N |
A |
-2.9439 |
|
69 |
T |
A |
-1.7990 |
|
70 |
A |
A |
0.0000 |
|
71 |
S |
A |
0.0000 |
|
72 |
L |
A |
0.0000 |
|
73 |
T |
A |
-1.0185 |
|
74 |
I |
A |
0.0000 |
|
75 |
T |
A |
-1.3841 |
|
76 |
G |
A |
-1.0601 |
|
77 |
A |
A |
0.0000 |
|
78 |
Q |
A |
-1.2373 |
|
79 |
A |
A |
0.0000 |
|
80 |
E |
A |
-2.0667 |
|
81 |
D |
A |
0.0000 |
|
82 |
E |
A |
-1.6434 |
|
83 |
A |
A |
-1.6987 |
|
84 |
D |
A |
-1.8265 |
|
85 |
Y |
A |
0.0000 |
|
86 |
Y |
A |
0.0000 |
|
87 |
C |
A |
0.0000 |
|
88 |
S |
A |
-0.2638 |
|
89 |
S |
A |
0.0000 |
|
90 |
R |
A |
0.0000 |
|
91 |
D |
A |
-1.6192 |
|
92 |
S |
A |
-1.5310 |
|
93 |
S |
A |
-0.9951 |
|
94 |
G |
A |
-1.0904 |
|
95 |
N |
A |
-1.5320 |
|
96 |
H |
A |
-1.0766 |
|
97 |
W |
A |
0.0000 |
|
98 |
V |
A |
-0.6426 |
|
99 |
F |
A |
-0.4830 |
|
100 |
G |
A |
0.0000 |
|
101 |
G |
A |
-1.5276 |
|
102 |
G |
A |
0.0000 |
|
103 |
T |
A |
0.0000 |
|
104 |
E |
A |
-2.5756 |
|
105 |
L |
A |
0.0000 |
|
106 |
T |
A |
-0.6105 |
|
107 |
V |
A |
0.0000 |
|
108 |
L |
A |
0.8107 |
|
109 |
G |
A |
-0.0206 |
|
110 |
Q |
A |
0.0000 |
|
111 |
P |
A |
-1.0525 |
|
112 |
K |
A |
-2.2278 |
|
113 |
A |
A |
-1.3286 |
|
114 |
A |
A |
-0.7042 |
|
115 |
P |
A |
-0.1847 |
|
116 |
S |
A |
-0.4413 |
|
117 |
V |
A |
0.0000 |
|
118 |
T |
A |
-0.5198 |
|
119 |
L |
A |
0.0000 |
|
120 |
F |
A |
-0.0697 |
|
121 |
P |
A |
-0.0959 |
|
122 |
P |
A |
0.0000 |
|
123 |
S |
A |
-0.9922 |
|
124 |
S |
A |
-1.3854 |
|
125 |
E |
A |
-2.1595 |
|
126 |
E |
A |
0.0000 |
|
127 |
L |
A |
-1.8551 |
|
128 |
Q |
A |
-2.3475 |
|
129 |
A |
A |
-1.9695 |
|
130 |
N |
A |
-2.7987 |
|
131 |
K |
A |
-2.9350 |
|
132 |
A |
A |
0.0000 |
|
133 |
T |
A |
0.0000 |
|
134 |
L |
A |
0.0000 |
|
135 |
V |
A |
0.0000 |
|
136 |
C |
A |
0.0000 |
|
137 |
L |
A |
0.0000 |
|
138 |
I |
A |
0.0000 |
|
139 |
S |
A |
-0.5875 |
|
140 |
D |
A |
-1.3924 |
|
141 |
F |
A |
0.0000 |
|
142 |
Y |
A |
-1.2614 |
|
143 |
P |
A |
-1.0489 |
|
144 |
G |
A |
-0.8349 |
|
145 |
A |
A |
-0.2643 |
|
146 |
V |
A |
-0.0508 |
|
147 |
T |
A |
0.1545 |
|
148 |
V |
A |
0.2481 |
|
149 |
A |
A |
-0.4495 |
|
150 |
W |
A |
0.0000 |
|
151 |
K |
A |
-1.0353 |
|
152 |
A |
A |
0.0000 |
|
153 |
D |
A |
-1.4643 |
|
154 |
S |
A |
-0.9731 |
|
155 |
S |
A |
-0.6652 |
|
156 |
P |
A |
-0.9077 |
|
157 |
V |
A |
-0.7672 |
|
158 |
K |
A |
-1.5422 |
|
159 |
A |
A |
-0.7046 |
|
160 |
G |
A |
-0.4072 |
|
161 |
V |
A |
-0.0248 |
|
162 |
E |
A |
-0.0614 |
|
163 |
T |
A |
0.2258 |
|
164 |
T |
A |
0.0242 |
|
165 |
T |
A |
-0.1678 |
|
166 |
P |
A |
-0.3281 |
|
167 |
S |
A |
-0.7105 |
|
168 |
K |
A |
-1.5579 |
|
169 |
Q |
A |
-1.4969 |
|
170 |
S |
A |
-1.3778 |
|
171 |
N |
A |
-2.0668 |
|
172 |
N |
A |
0.0000 |
|
173 |
K |
A |
-1.8304 |
|
174 |
Y |
A |
-1.0253 |
|
175 |
A |
A |
0.0000 |
|
176 |
A |
A |
0.0000 |
|
177 |
S |
A |
0.0000 |
|
178 |
S |
A |
0.0000 |
|
179 |
Y |
A |
0.0000 |
|
180 |
L |
A |
0.9283 |
|
181 |
S |
A |
0.0914 |
|
182 |
L |
A |
-0.5350 |
|
183 |
T |
A |
-1.6290 |
|
184 |
P |
A |
0.0000 |
|
185 |
E |
A |
-2.9145 |
|
186 |
Q |
A |
-2.3432 |
|
187 |
W |
A |
-1.9213 |
|
188 |
K |
A |
-2.9676 |
|
189 |
S |
A |
0.0000 |
|
190 |
H |
A |
-2.3491 |
|
191 |
R |
A |
-2.6928 |
|
192 |
S |
A |
-1.6211 |
|
193 |
Y |
A |
0.0000 |
|
194 |
S |
A |
0.0000 |
|
195 |
C |
A |
0.0000 |
|
196 |
Q |
A |
-0.7277 |
|
197 |
V |
A |
0.0000 |
|
198 |
T |
A |
-0.3769 |
|
199 |
H |
A |
0.0000 |
|
200 |
E |
A |
-2.2338 |
|
201 |
G |
A |
-1.4692 |
|
202 |
S |
A |
-0.7509 |
|
203 |
T |
A |
-0.2030 |
|
204 |
V |
A |
0.2465 |
|
205 |
E |
A |
-1.3455 |
|
206 |
K |
A |
-1.6858 |
|
207 |
T |
A |
-1.0748 |
|
208 |
V |
A |
0.0000 |
|
209 |
A |
A |
-0.9659 |
|
210 |
P |
A |
-1.0846 |
|
2 |
V |
A |
0.8374 |
|
3 |
Q |
A |
-1.1090 |
|
4 |
L |
A |
0.0000 |
|
5 |
Q |
A |
-2.1820 |
|
6 |
Q |
A |
-1.5357 |
|
7 |
S |
A |
-1.3031 |
|
8 |
G |
A |
-1.2201 |
|
9 |
A |
A |
0.0000 |
|
10 |
E |
A |
-1.7706 |
|
11 |
V |
A |
-0.9373 |
|
12 |
K |
A |
-1.6180 |
|
13 |
K |
A |
-2.3392 |
|
14 |
P |
A |
-2.0729 |
|
15 |
G |
A |
-1.4489 |
|
16 |
S |
A |
-1.1727 |
|
17 |
S |
A |
-1.2395 |
|
18 |
V |
A |
0.0000 |
|
19 |
R |
A |
-2.3725 |
|
20 |
V |
A |
0.0000 |
|
21 |
S |
A |
-1.2826 |
|
22 |
C |
A |
0.0000 |
|
23 |
K |
A |
-2.1616 |
|
24 |
A |
A |
0.0000 |
|
25 |
S |
A |
-0.8387 |
|
26 |
G |
A |
-0.6134 |
|
27 |
G |
A |
-1.0366 |
|
28 |
T |
A |
-1.1347 |
|
29 |
F |
A |
0.0000 |
|
30 |
N |
A |
-1.9505 |
|
31 |
N |
A |
-1.1513 |
|
32 |
N |
A |
-0.8829 |
|
33 |
A |
A |
-0.1020 |
|
34 |
I |
A |
0.0000 |
|
35 |
N |
A |
0.0000 |
|
36 |
W |
A |
0.0000 |
|
37 |
V |
A |
0.0000 |
|
38 |
R |
A |
0.0000 |
|
39 |
Q |
A |
-0.6479 |
|
40 |
A |
A |
-1.0103 |
|
41 |
P |
A |
-1.0456 |
|
42 |
G |
A |
-1.2668 |
|
43 |
Q |
A |
-1.7879 |
|
44 |
G |
A |
-1.2687 |
|
45 |
L |
A |
0.0000 |
|
46 |
E |
A |
-0.8376 |
|
47 |
W |
A |
0.0000 |
|
48 |
M |
A |
0.0000 |
|
49 |
G |
A |
0.0000 |
|
50 |
G |
A |
0.0000 |
|
51 |
I |
A |
0.7566 |
|
52 |
I |
A |
0.9384 |
|
53 |
P |
A |
0.1558 |
|
54 |
M |
A |
0.8739 |
|
55 |
F |
A |
2.0898 |
|
56 |
G |
A |
0.6727 |
|
57 |
T |
A |
0.2051 |
|
58 |
A |
A |
0.1384 |
|
59 |
K |
A |
-0.7772 |
|
60 |
Y |
A |
-0.6703 |
|
61 |
S |
A |
-1.3548 |
|
62 |
Q |
A |
-2.2956 |
|
63 |
N |
A |
-2.3034 |
|
64 |
F |
A |
0.0000 |
|
65 |
Q |
A |
-2.2718 |
|
66 |
G |
A |
-1.5890 |
|
67 |
R |
A |
-1.3191 |
|
68 |
V |
A |
0.0000 |
|
69 |
A |
A |
-0.5962 |
|
70 |
I |
A |
-0.2515 |
|
71 |
T |
A |
-0.6008 |
|
72 |
A |
A |
-1.2732 |
|
73 |
D |
A |
-2.7282 |
|
74 |
E |
A |
-2.7948 |
|
75 |
S |
A |
-1.6822 |
|
76 |
T |
A |
-1.4949 |
|
77 |
G |
A |
0.0000 |
|
78 |
T |
A |
-1.8063 |
|
79 |
A |
A |
0.0000 |
|
80 |
S |
A |
0.0000 |
|
81 |
M |
A |
0.0000 |
|
82 |
E |
A |
-1.7207 |
|
83 |
L |
A |
0.0000 |
|
84 |
S |
A |
-1.1023 |
|
85 |
S |
A |
-1.0831 |
|
86 |
L |
A |
0.0000 |
|
87 |
R |
A |
-2.7016 |
|
88 |
S |
A |
-2.2107 |
|
89 |
E |
A |
-2.4897 |
|
90 |
D |
A |
0.0000 |
|
91 |
T |
A |
-0.9070 |
|
92 |
A |
A |
0.0000 |
|
93 |
V |
A |
0.1823 |
|
94 |
Y |
A |
0.0000 |
|
95 |
Y |
A |
0.0000 |
|
96 |
C |
A |
0.0000 |
|
97 |
A |
A |
0.0000 |
|
98 |
R |
A |
-0.6917 |
|
99 |
S |
A |
0.0000 |
|
100 |
R |
A |
-0.7390 |
|
101 |
D |
A |
0.2981 |
|
102 |
L |
A |
1.1413 |
|
103 |
L |
A |
2.4610 |
|
104 |
L |
A |
2.5814 |
|
105 |
F |
A |
1.8540 |
|
106 |
P |
A |
0.8748 |
|
107 |
H |
A |
-0.4856 |
|
108 |
H |
A |
-0.6423 |
|
109 |
A |
A |
0.0000 |
|
110 |
L |
A |
0.0000 |
|
111 |
S |
A |
-0.3762 |
|
112 |
P |
A |
-0.2090 |
|
113 |
W |
A |
-0.6779 |
|
114 |
G |
A |
-1.6545 |
|
115 |
R |
A |
-2.3804 |
|
116 |
G |
A |
-1.2184 |
|
117 |
T |
A |
0.0000 |
|
118 |
M |
A |
-0.1041 |
|
119 |
V |
A |
0.0000 |
|
120 |
T |
A |
-0.6969 |
|
121 |
V |
A |
0.0000 |
|
122 |
S |
A |
-1.1053 |
|
123 |
S |
A |
-1.0149 |
|
124 |
A |
A |
-0.6235 |
|
125 |
S |
A |
-0.6508 |
|
126 |
T |
A |
-0.7436 |
|
127 |
K |
A |
-1.0639 |
|
128 |
G |
A |
-1.2687 |
|
129 |
P |
A |
-0.6875 |
|
130 |
S |
A |
-0.6456 |
|
131 |
V |
A |
0.0000 |
|
132 |
F |
A |
-0.8167 |
|
133 |
P |
A |
-1.2148 |
|
134 |
L |
A |
0.0000 |
|
135 |
A |
A |
-0.9448 |
|
136 |
P |
A |
0.0000 |
|
137 |
S |
A |
-0.8857 |
|
138 |
S |
A |
-1.1605 |
|
139 |
K |
A |
-2.1217 |
|
140 |
S |
A |
-1.4316 |
|
141 |
T |
A |
-0.8867 |
|
142 |
S |
A |
-0.8646 |
|
143 |
G |
A |
-0.8786 |
|
144 |
G |
A |
-1.1278 |
|
145 |
T |
A |
-1.0007 |
|
146 |
A |
A |
0.0000 |
|
147 |
A |
A |
-0.3608 |
|
148 |
L |
A |
0.0000 |
|
149 |
G |
A |
0.0000 |
|
150 |
C |
A |
0.0000 |
|
151 |
L |
A |
0.0000 |
|
152 |
V |
A |
0.0000 |
|
153 |
K |
A |
0.0000 |
|
154 |
D |
A |
-0.5877 |
|
155 |
Y |
A |
0.0000 |
|
156 |
F |
A |
0.0000 |
|
157 |
P |
A |
0.0000 |
|
158 |
E |
A |
-0.4872 |
|
159 |
P |
A |
-0.6321 |
|
160 |
V |
A |
-0.4744 |
|
161 |
T |
A |
-0.4090 |
|
162 |
V |
A |
-0.2495 |
|
163 |
S |
A |
-0.4469 |
|
164 |
W |
A |
0.0000 |
|
165 |
N |
A |
-0.8466 |
|
166 |
S |
A |
-0.6949 |
|
167 |
G |
A |
-0.5156 |
|
168 |
A |
A |
-0.2599 |
|
169 |
L |
A |
-0.0321 |
|
170 |
T |
A |
-0.2220 |
|
171 |
S |
A |
-0.3284 |
|
172 |
G |
A |
-0.4215 |
|
173 |
V |
A |
0.0229 |
|
174 |
H |
A |
-0.3432 |
|
175 |
T |
A |
-0.1147 |
|
176 |
F |
A |
0.0000 |
|
177 |
P |
A |
-0.2485 |
|
178 |
A |
A |
0.1776 |
|
179 |
V |
A |
0.0000 |
|
180 |
L |
A |
0.9486 |
|
181 |
Q |
A |
0.1200 |
|
182 |
S |
A |
-0.2377 |
|
183 |
S |
A |
-0.3085 |
|
184 |
G |
A |
-0.1774 |
|
185 |
L |
A |
0.0001 |
|
186 |
Y |
A |
0.2321 |
|
187 |
S |
A |
0.0000 |
|
188 |
L |
A |
0.0000 |
|
189 |
S |
A |
0.0000 |
|
190 |
S |
A |
0.0000 |
|
191 |
V |
A |
0.1260 |
|
192 |
V |
A |
0.0000 |
|
193 |
T |
A |
-0.3420 |
|
194 |
V |
A |
0.0000 |
|
195 |
P |
A |
-0.9394 |
|
196 |
S |
A |
-1.1495 |
|
197 |
S |
A |
-0.9119 |
|
198 |
S |
A |
-0.9686 |
|
199 |
L |
A |
0.0000 |
|
200 |
G |
A |
-1.4939 |
|
201 |
T |
A |
-1.1315 |
|
202 |
Q |
A |
-1.6734 |
|
203 |
T |
A |
-1.3928 |
|
204 |
Y |
A |
0.0000 |
|
205 |
I |
A |
-1.4068 |
|
206 |
C |
A |
0.0000 |
|
207 |
N |
A |
-1.5977 |
|
208 |
V |
A |
0.0000 |
|
209 |
N |
A |
-1.6448 |
|
210 |
H |
A |
0.0000 |
|
211 |
K |
A |
-2.4069 |
|
212 |
P |
A |
0.0000 |
|
213 |
S |
A |
-1.8305 |
|
214 |
N |
A |
-2.3805 |
|
215 |
T |
A |
-1.8913 |
|
216 |
K |
A |
-2.4979 |
|
217 |
V |
A |
-1.5640 |
|
218 |
D |
A |
-2.6041 |
|
219 |
K |
A |
-2.0993 |
|
220 |
K |
A |
-2.6125 |
|
221 |
V |
A |
0.0000 |
|
222 |
E |
A |
-2.5504 |
|
223 |
P |
A |
-1.4947 |
|