Project name: 7f2a06fd4bd6d3e

Chain sequence(s)	A: ETNNECSIKVLCRFRPLNQAEILRGDKFIPIFQGDDSVVIGAGKPYVFDRVFPPNTTQEQVCHACAMQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHIYSMDENLEFHIKVSYFEIYLDKIRDLLDVTKTNLSVHEDKNRVPFVKGCTERFVSSPEEILDVIDEGKSNRHVAVTNMNEHSSRSHSIFLINIKQENMETEQKLSGKLYLVDLAGSEKV
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.5863
• Maximal score value: 2.5521
• Average score: -0.7681
• Total score value: -182.8187

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	E	A	-2.2898
3	T	A	-2.0566
4	N	A	-2.6779
5	N	A	-2.8223
6	E	A	-2.4250
7	C	A	-0.4096
8	S	A	0.5547
9	I	A	1.6032
10	K	A	0.0892
11	V	A	1.3217
12	L	A	0.2353
13	C	A	0.4585
14	R	A	-0.3289
15	F	A	-0.3491
16	R	A	-1.0616
17	P	A	-0.6256
18	L	A	-0.0739
19	N	A	-0.9008
20	Q	A	-0.8107
21	A	A	-0.3342
22	E	A	-0.4829
23	I	A	0.9960
24	L	A	0.9151
25	R	A	-1.3733
26	G	A	-0.8416
27	D	A	-0.9985
28	K	A	-1.1320
29	F	A	1.0932
30	I	A	2.1823
31	P	A	1.8456
32	I	A	2.1239
33	F	A	0.4902
34	Q	A	-1.1506
35	G	A	-1.8636
36	D	A	-2.6605
37	D	A	-1.6899
38	S	A	-0.2636
39	V	A	0.0000
40	V	A	0.8791
41	I	A	1.1496
42	G	A	0.2467
43	A	A	-0.5269
44	G	A	-0.9530
45	K	A	-1.5068
46	P	A	-0.1786
47	Y	A	0.9218
48	V	A	1.2103
49	F	A	0.3613
50	D	A	-1.3402
51	R	A	-1.4162
52	V	A	0.0000
53	F	A	0.0000
54	P	A	-0.6331
55	P	A	-0.9265
56	N	A	-1.5273
57	T	A	-1.1601
58	T	A	-0.9728
59	Q	A	0.0000
60	E	A	-1.3857
61	Q	A	-1.7264
62	V	A	0.0000
63	C	A	0.0000
64	H	A	-1.4575
65	A	A	-1.0789
66	C	A	-0.5478
67	A	A	0.0000
68	M	A	-0.7839
69	Q	A	-1.0459
70	I	A	-0.4124
71	V	A	0.0000
72	K	A	-1.1315
73	D	A	-0.7265
74	V	A	0.0000
75	L	A	0.0000
76	A	A	-0.0749
77	G	A	-0.3305
78	Y	A	0.3720
79	N	A	-0.8839
80	G	A	-0.5514
81	T	A	0.6793
82	I	A	1.6163
83	F	A	2.5521
84	A	A	1.5966
85	Y	A	1.5116
86	G	A	-0.3158
87	Q	A	-1.6296
88	T	A	-1.2584
89	S	A	-0.9411
90	S	A	-0.8295
91	G	A	-0.8653
92	K	A	-0.3992
93	T	A	-0.8547
94	H	A	-1.5323
95	T	A	-0.7565
96	M	A	0.0000
97	E	A	-1.0634
98	G	A	-1.5683
99	K	A	-2.1809
100	L	A	-1.5387
101	H	A	-1.9734
102	D	A	-1.6614
103	P	A	-1.4136
104	Q	A	-1.6233
105	L	A	-1.1430
106	M	A	-1.3995
107	G	A	0.0000
108	I	A	0.0000
109	I	A	0.0000
110	P	A	0.0000
111	R	A	-1.2225
112	I	A	0.0000
113	A	A	0.0000
114	R	A	-2.8078
115	D	A	-1.8878
116	I	A	0.0000
117	F	A	0.0000
118	N	A	-1.5427
119	H	A	-0.8168
120	I	A	-0.2280
121	Y	A	0.4138
122	S	A	-0.3505
123	M	A	-0.9038
124	D	A	-2.6837
125	E	A	-3.0092
126	N	A	-2.8056
127	L	A	-2.9003
128	E	A	-2.8561
129	F	A	-1.5990
130	H	A	-1.3398
131	I	A	0.0000
132	K	A	-0.6569
133	V	A	0.0000
134	S	A	0.0000
135	Y	A	0.0000
136	F	A	0.0000
137	E	A	0.0000
138	I	A	-0.4944
139	Y	A	-0.3248
140	L	A	0.2185
141	D	A	-1.8387
142	K	A	-2.3066
143	I	A	0.0000
144	R	A	-1.2898
145	D	A	0.0000
146	L	A	0.0000
147	L	A	0.0000
148	D	A	-1.1111
149	V	A	-0.4988
150	T	A	-0.6324
151	K	A	-1.4124
152	T	A	-1.4838
153	N	A	-2.0681
154	L	A	-1.0959
155	S	A	-0.3636
156	V	A	0.5499
157	H	A	-1.4093
158	E	A	-3.2781
159	D	A	-3.3287
160	K	A	-3.5512
161	N	A	-3.3073
162	R	A	-3.5863
163	V	A	-1.5763
164	P	A	-1.3471
165	F	A	-0.4418
166	V	A	-0.2181
167	K	A	-1.3275
168	G	A	-1.1683
169	C	A	-1.1861
170	T	A	-1.5393
171	E	A	-1.7645
172	R	A	-0.7220
173	F	A	0.6804
174	V	A	0.0000
175	S	A	-0.5265
176	S	A	-1.3274
177	P	A	0.0000
178	E	A	-3.2214
179	E	A	-2.3779
180	I	A	0.0000
181	L	A	0.0000
182	D	A	-3.0685
183	V	A	0.0000
184	I	A	0.0000
185	D	A	-2.0475
186	E	A	-1.8938
187	G	A	0.0000
188	K	A	-1.9261
189	S	A	-1.2042
190	N	A	-0.7910
191	R	A	0.0000
192	H	A	-0.5955
193	V	A	0.9933
194	A	A	0.5767
195	V	A	-0.1547
196	T	A	-0.6383
197	N	A	-1.8536
198	M	A	-1.5207
199	N	A	-2.3564
200	E	A	-2.6059
201	H	A	0.0000
202	S	A	-1.4486
203	S	A	-1.5570
204	R	A	-1.1110
205	S	A	0.0000
206	H	A	-0.0271
207	S	A	-0.0165
208	I	A	0.0000
209	F	A	0.0000
210	L	A	0.0000
211	I	A	0.0000
212	N	A	0.0000
213	I	A	0.0000
214	K	A	-1.9697
215	Q	A	0.0000
216	E	A	-3.4154
217	N	A	-3.1742
218	M	A	-2.1684
219	E	A	-2.6470
220	T	A	-2.4344
221	E	A	-3.4198
222	Q	A	-3.2956
223	K	A	-3.2681
224	L	A	-1.0895
225	S	A	-0.9835
226	G	A	0.0000
227	K	A	-0.9017
228	L	A	0.0000
229	Y	A	0.3046
230	L	A	0.0000
231	V	A	1.1390
232	D	A	0.5852
233	L	A	0.5845
234	A	A	-0.3930
235	G	A	-1.0750
236	S	A	-0.9155
237	E	A	-1.6872
238	K	A	-1.3833
239	V	A	0.7526