Project name: 7f8a894efb0ce37

Chain sequence(s)	A: TLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEIYLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATC
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.3693
• Maximal score value: 0.9737
• Average score: -0.6476
• Total score value: -191.6887

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
28	T	A	-0.3269
29	L	A	-0.3699
30	P	A	-1.5710
31	K	A	-2.7573
32	R	A	-3.3693
33	V	A	0.0000
34	K	A	-1.6352
35	I	A	0.0000
36	V	A	0.0000
37	E	A	0.0000
38	V	A	0.0000
39	G	A	0.0000
40	P	A	0.0000
41	R	A	0.0000
42	D	A	-0.3478
43	G	A	0.0000
44	L	A	0.0000
45	Q	A	-0.6344
46	N	A	-0.9442
47	E	A	-1.2322
48	K	A	-2.0138
49	N	A	-1.2982
50	I	A	0.7709
51	V	A	0.0000
52	S	A	0.2657
53	T	A	-0.4808
54	P	A	-0.7159
55	V	A	-0.0612
56	K	A	0.0000
57	I	A	-1.0951
58	K	A	-1.3093
59	L	A	0.0000
60	I	A	0.0000
61	D	A	-1.4209
62	M	A	-1.3630
63	L	A	0.0000
64	S	A	0.0000
65	E	A	-2.1759
66	A	A	0.0000
67	G	A	-1.1584
68	L	A	0.0000
69	S	A	-0.6925
70	V	A	0.0000
71	I	A	0.0000
72	E	A	0.0000
73	T	A	0.0000
74	T	A	0.0000
75	S	A	0.0000
76	F	A	0.0000
77	V	A	0.0000
78	S	A	-0.6707
79	P	A	-0.8992
80	K	A	-1.3237
81	W	A	0.2348
82	V	A	-0.1209
83	P	A	-0.4517
84	Q	A	-0.4768
85	M	A	0.0000
86	G	A	-0.8739
87	D	A	-1.0265
88	H	A	-1.1384
89	T	A	-1.5368
90	E	A	-2.6232
91	V	A	0.0000
92	L	A	0.0000
93	K	A	-2.8866
94	G	A	-2.3172
95	I	A	0.0000
96	Q	A	-2.3658
97	K	A	-2.3681
98	F	A	-1.3088
99	P	A	-0.8534
100	G	A	-0.8335
101	I	A	-0.7635
102	N	A	-1.3961
103	Y	A	0.0000
104	P	A	0.0000
105	V	A	0.0000
106	L	A	0.0000
107	T	A	0.0000
108	P	A	0.0000
109	N	A	-1.1311
110	L	A	-1.3314
111	K	A	-2.2402
112	G	A	0.0000
113	F	A	0.0000
114	E	A	-2.1072
115	A	A	-1.0784
116	A	A	0.0000
117	V	A	-0.4120
118	A	A	-0.2185
119	A	A	0.0000
120	G	A	-0.7714
121	A	A	0.0000
122	K	A	-1.9474
123	E	A	0.0000
124	V	A	0.0000
125	V	A	0.0000
126	I	A	0.0000
127	F	A	0.6778
128	G	A	0.2725
129	A	A	0.0000
130	A	A	0.0000
131	S	A	0.0000
132	E	A	-2.0876
133	L	A	-1.3425
134	F	A	0.0000
135	T	A	0.0000
136	K	A	-2.7526
137	K	A	-2.5456
138	N	A	-1.5293
139	I	A	-0.6879
140	N	A	-2.1057
141	C	A	-2.1498
142	S	A	-2.1843
143	I	A	-1.9643
144	E	A	-3.2234
145	E	A	-3.3510
146	S	A	0.0000
147	F	A	0.0000
148	Q	A	-2.6784
149	R	A	-2.1876
150	F	A	0.0000
151	D	A	-1.5789
152	A	A	-1.2681
153	I	A	0.0000
154	L	A	0.0000
155	K	A	-2.2935
156	A	A	-1.6603
157	A	A	0.0000
158	Q	A	-2.3513
159	S	A	-1.5392
160	A	A	-1.3928
161	N	A	-1.9574
162	I	A	-1.3174
163	S	A	-0.8745
164	V	A	0.0000
165	R	A	0.0000
166	G	A	0.0000
167	Y	A	0.0000
168	V	A	0.0000
169	S	A	0.0846
170	C	A	0.0000
171	A	A	0.0000
172	L	A	0.0000
173	G	A	0.0000
174	C	A	0.0000
175	P	A	-0.0341
176	Y	A	-0.2866
177	E	A	-1.1036
178	G	A	-1.1690
179	K	A	-1.8494
180	I	A	0.0000
181	S	A	-1.0443
182	P	A	-1.1963
183	A	A	-1.1998
184	K	A	-1.1048
185	V	A	0.0000
186	A	A	0.0000
187	E	A	-2.6827
188	V	A	0.0000
189	T	A	0.0000
190	K	A	-2.1948
191	K	A	-2.0962
192	F	A	0.0000
193	Y	A	-0.3195
194	S	A	-0.4736
195	M	A	-0.6244
196	G	A	-0.7746
197	C	A	0.0000
198	Y	A	0.6390
199	E	A	0.0000
200	I	A	0.0000
201	Y	A	0.0000
202	L	A	0.0000
203	G	A	0.0000
204	D	A	0.0000
205	T	A	0.0645
206	I	A	0.0000
207	G	A	0.0000
208	V	A	0.6829
209	G	A	0.0000
210	T	A	-0.0305
211	P	A	-0.6922
212	G	A	-1.1930
213	I	A	-0.9645
214	M	A	0.0000
215	K	A	-2.2447
216	D	A	-2.4229
217	M	A	0.0000
218	L	A	0.0000
219	S	A	-1.3600
220	A	A	-1.5892
221	V	A	0.0000
222	M	A	-0.9439
223	Q	A	-1.9959
224	E	A	-2.7231
225	V	A	0.0000
226	P	A	-0.4325
227	L	A	0.2124
228	A	A	0.3583
229	A	A	0.0000
230	L	A	0.0000
231	A	A	0.0000
232	V	A	0.0000
233	H	A	0.0000
234	C	A	0.0000
235	H	A	0.0000
236	D	A	-0.3091
237	T	A	0.0494
238	Y	A	0.9737
239	G	A	-0.0723
240	Q	A	-0.1126
241	A	A	0.0000
242	L	A	0.1546
243	A	A	0.0979
244	N	A	0.0000
245	T	A	0.0000
246	L	A	0.4017
247	M	A	-0.2544
248	A	A	0.0000
249	L	A	0.0000
250	Q	A	-0.9123
251	M	A	-0.3238
252	G	A	-0.2007
253	V	A	0.0000
254	S	A	-0.9393
255	V	A	0.0000
256	V	A	0.0000
257	D	A	0.0000
258	S	A	0.0000
259	S	A	0.0000
260	V	A	0.0000
261	A	A	0.0000
262	G	A	0.0000
263	L	A	0.0000
264	G	A	0.0000
265	G	A	-0.7569
266	C	A	-0.3682
267	P	A	-0.3826
268	Y	A	0.0415
269	A	A	-0.4969
270	Q	A	-1.3694
271	G	A	-1.0271
272	A	A	-0.4960
273	S	A	-0.3646
274	G	A	0.0000
275	N	A	0.0000
276	L	A	0.0000
277	A	A	0.0000
278	T	A	0.0000
279	E	A	0.0000
280	D	A	0.0000
281	L	A	0.0000
282	V	A	0.0000
283	Y	A	0.7494
284	M	A	0.2692
285	L	A	0.0000
286	E	A	-1.7382
287	G	A	-0.7669
288	L	A	-0.3872
289	G	A	-1.5607
290	I	A	0.0000
291	H	A	-2.8613
292	T	A	-2.2208
293	G	A	-1.5827
294	V	A	0.0000
295	N	A	-1.7667
296	L	A	-1.3457
297	Q	A	-2.2258
298	K	A	-2.7842
299	L	A	0.0000
300	L	A	0.0000
301	E	A	-2.6363
302	A	A	0.0000
303	G	A	0.0000
304	N	A	-2.2641
305	F	A	-1.0702
306	I	A	0.0000
307	C	A	0.0000
308	Q	A	-2.2088
309	A	A	-0.8886
310	L	A	0.0000
311	N	A	-2.2453
312	R	A	-2.6576
313	K	A	-2.7360
314	T	A	-2.0016
315	S	A	-1.3005
316	S	A	0.0000
317	K	A	-2.1612
318	V	A	0.0000
319	A	A	0.0000
320	Q	A	-1.8241
321	A	A	-0.7906
322	T	A	-0.4256
323	C	A	0.3625