| Chain sequence(s) |
A: DKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELSYKDSTLIMQLLRDNLTLWT Q: RSKAKALFDNR B: DKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLW |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 2 | D | A | -3.0112 | |
| 3 | K | A | -3.3755 | |
| 4 | N | A | -2.8491 | |
| 5 | E | A | -2.7541 | |
| 6 | L | A | -1.9832 | |
| 7 | V | A | 0.0000 | |
| 8 | Q | A | -1.7714 | |
| 9 | K | A | -1.9672 | |
| 10 | A | A | 0.0000 | |
| 11 | K | A | -1.9909 | |
| 12 | L | A | 0.0000 | |
| 13 | A | A | 0.0000 | |
| 14 | E | A | -2.6483 | |
| 15 | Q | A | -2.3231 | |
| 16 | A | A | 0.0000 | |
| 17 | E | A | -3.0139 | |
| 18 | R | A | -2.2995 | |
| 19 | Y | A | -2.0198 | |
| 20 | D | A | -2.4249 | |
| 21 | D | A | -1.9017 | |
| 22 | M | A | 0.0000 | |
| 23 | A | A | 0.0000 | |
| 24 | A | A | -0.7463 | |
| 25 | C | A | 0.0000 | |
| 26 | M | A | 0.0000 | |
| 27 | K | A | -1.2164 | |
| 28 | S | A | -1.5383 | |
| 29 | V | A | 0.0000 | |
| 30 | T | A | 0.0000 | |
| 31 | E | A | -2.6101 | |
| 32 | Q | A | -2.4597 | |
| 33 | G | A | -1.8560 | |
| 34 | A | A | -1.5143 | |
| 35 | E | A | -2.4208 | |
| 36 | L | A | 0.0000 | |
| 37 | S | A | -1.9044 | |
| 38 | N | A | -2.6614 | |
| 39 | E | A | -2.6903 | |
| 40 | E | A | 0.0000 | |
| 41 | R | A | -1.8703 | |
| 42 | N | A | -1.8977 | |
| 43 | L | A | 0.0000 | |
| 44 | L | A | 0.0000 | |
| 45 | S | A | -0.7682 | |
| 46 | V | A | -0.3612 | |
| 47 | A | A | 0.0000 | |
| 48 | Y | A | 0.0000 | |
| 49 | K | A | -1.1486 | |
| 50 | N | A | -1.5245 | |
| 51 | V | A | 0.0000 | |
| 52 | V | A | 0.0000 | |
| 53 | G | A | -0.9087 | |
| 54 | A | A | -0.8994 | |
| 55 | R | A | -1.3742 | |
| 56 | R | A | -1.3159 | |
| 57 | S | A | -1.2723 | |
| 58 | S | A | 0.0000 | |
| 59 | W | A | 0.0000 | |
| 60 | R | A | -1.9347 | |
| 61 | V | A | -0.9937 | |
| 62 | V | A | 0.0000 | |
| 63 | S | A | 0.0000 | |
| 64 | S | A | -1.2626 | |
| 65 | I | A | -1.6562 | |
| 66 | E | A | 0.0000 | |
| 67 | Q | A | -2.7335 | |
| 68 | K | A | -2.7371 | |
| 69 | T | A | 0.0000 | |
| 70 | E | A | -3.2634 | |
| 72 | A | A | -2.4330 | |
| 73 | E | A | -3.6995 | |
| 74 | K | A | -3.7521 | |
| 75 | K | A | -3.5058 | |
| 76 | Q | A | -3.8662 | |
| 77 | Q | A | -3.8930 | |
| 78 | M | A | -3.0972 | |
| 79 | A | A | 0.0000 | |
| 80 | R | A | -3.9333 | |
| 81 | E | A | -3.7396 | |
| 82 | Y | A | 0.0000 | |
| 83 | R | A | -2.6902 | |
| 84 | E | A | -3.2203 | |
| 85 | K | A | -2.8905 | |
| 86 | I | A | 0.0000 | |
| 87 | E | A | 0.0000 | |
| 88 | T | A | -1.8325 | |
| 89 | E | A | -2.0829 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -1.9813 | |
| 92 | D | A | -2.7636 | |
| 93 | I | A | 0.0000 | |
| 94 | C | A | 0.0000 | |
| 95 | N | A | -2.2601 | |
| 96 | D | A | -1.8446 | |
| 97 | V | A | 0.0000 | |
| 98 | L | A | 0.0000 | |
| 99 | S | A | -1.7169 | |
| 100 | L | A | 0.0000 | |
| 101 | L | A | 0.0000 | |
| 102 | E | A | -2.7296 | |
| 103 | K | A | -2.7809 | |
| 104 | F | A | -2.0521 | |
| 105 | L | A | 0.0000 | |
| 106 | I | A | -1.1570 | |
| 107 | P | A | -1.3322 | |
| 108 | N | A | -1.6207 | |
| 109 | A | A | 0.0000 | |
| 110 | S | A | -1.3399 | |
| 111 | Q | A | -1.6333 | |
| 112 | A | A | -1.5531 | |
| 113 | E | A | -1.3049 | |
| 114 | S | A | 0.0000 | |
| 115 | K | A | -1.1185 | |
| 116 | V | A | 0.0000 | |
| 117 | F | A | 0.0000 | |
| 118 | Y | A | 0.0000 | |
| 119 | L | A | 0.0000 | |
| 120 | K | A | 0.0000 | |
| 121 | M | A | 0.0000 | |
| 122 | K | A | -0.7944 | |
| 123 | G | A | 0.0000 | |
| 124 | D | A | 0.0000 | |
| 125 | Y | A | 0.0000 | |
| 126 | Y | A | -0.7301 | |
| 127 | R | A | 0.0000 | |
| 128 | Y | A | 0.0000 | |
| 129 | L | A | 0.0000 | |
| 130 | A | A | 0.0000 | |
| 131 | E | A | -0.7061 | |
| 132 | V | A | 0.0000 | |
| 133 | A | A | 0.0000 | |
| 134 | A | A | -1.5654 | |
| 135 | G | A | -2.3925 | |
| 136 | D | A | -3.4971 | |
| 137 | D | A | -3.6077 | |
| 138 | K | A | -3.1465 | |
| 139 | K | A | -3.6277 | |
| 140 | G | A | -2.7093 | |
| 141 | I | A | -2.1478 | |
| 142 | V | A | 0.0000 | |
| 143 | D | A | -3.0768 | |
| 144 | Q | A | -2.3487 | |
| 145 | S | A | 0.0000 | |
| 146 | Q | A | -1.9531 | |
| 147 | Q | A | -2.6036 | |
| 148 | A | A | 0.0000 | |
| 149 | Y | A | 0.0000 | |
| 150 | Q | A | -1.7924 | |
| 151 | E | A | -2.3874 | |
| 152 | A | A | 0.0000 | |
| 153 | F | A | -1.8552 | |
| 154 | E | A | -2.8125 | |
| 155 | I | A | -2.3930 | |
| 156 | S | A | 0.0000 | |
| 157 | K | A | -3.7009 | |
| 158 | K | A | -3.7513 | |
| 159 | E | A | -3.5399 | |
| 160 | M | A | 0.0000 | |
| 161 | Q | A | -2.3999 | |
| 162 | P | A | -1.4404 | |
| 163 | T | A | -0.1765 | |
| 164 | H | A | -0.6937 | |
| 165 | P | A | -0.6895 | |
| 166 | I | A | -0.3290 | |
| 167 | R | A | -0.8261 | |
| 168 | L | A | 0.0000 | |
| 169 | G | A | 0.0000 | |
| 170 | L | A | 0.0000 | |
| 171 | A | A | 0.0000 | |
| 172 | L | A | 0.0000 | |
| 173 | N | A | 0.0000 | |
| 174 | F | A | 0.0000 | |
| 175 | S | A | 0.0000 | |
| 176 | V | A | 0.0000 | |
| 177 | F | A | 0.0000 | |
| 178 | Y | A | -0.7082 | |
| 179 | Y | A | -1.0250 | |
| 180 | E | A | -1.4277 | |
| 181 | I | A | 0.0000 | |
| 182 | L | A | -0.2772 | |
| 183 | N | A | -1.5672 | |
| 184 | S | A | -1.4648 | |
| 185 | P | A | -1.5914 | |
| 186 | E | A | -2.4857 | |
| 187 | K | A | -2.1251 | |
| 188 | A | A | 0.0000 | |
| 189 | C | A | -1.2572 | |
| 190 | S | A | -1.2145 | |
| 191 | L | A | 0.0000 | |
| 192 | A | A | 0.0000 | |
| 193 | K | A | -1.4544 | |
| 194 | T | A | -0.7845 | |
| 195 | A | A | 0.0000 | |
| 196 | F | A | -0.6710 | |
| 197 | D | A | -0.8709 | |
| 198 | E | A | -0.8777 | |
| 199 | A | A | 0.0000 | |
| 200 | I | A | 0.8604 | |
| 201 | A | A | 0.1271 | |
| 202 | E | A | -0.5928 | |
| 203 | L | A | 1.3100 | |
| 210 | S | A | -0.6473 | |
| 211 | Y | A | 0.1223 | |
| 212 | K | A | -1.8158 | |
| 213 | D | A | -2.0227 | |
| 214 | S | A | 0.0000 | |
| 215 | T | A | -0.5148 | |
| 216 | L | A | -0.4519 | |
| 217 | I | A | 0.0000 | |
| 218 | M | A | -0.7679 | |
| 219 | Q | A | -1.3928 | |
| 220 | L | A | -1.0645 | |
| 221 | L | A | 0.0000 | |
| 222 | R | A | -1.5903 | |
| 223 | D | A | -1.5281 | |
| 224 | N | A | 0.0000 | |
| 225 | L | A | 0.0000 | |
| 226 | T | A | -0.0618 | |
| 227 | L | A | 0.6966 | |
| 228 | W | A | 0.1798 | |
| 229 | T | A | 0.0948 | |
| 2 | D | B | -3.0176 | |
| 3 | K | B | -2.8624 | |
| 4 | N | B | -2.7020 | |
| 5 | E | B | -2.5704 | |
| 6 | L | B | -1.7814 | |
| 7 | V | B | -1.6933 | |
| 8 | Q | B | -1.8724 | |
| 9 | K | B | -1.5688 | |
| 10 | A | B | 0.0000 | |
| 11 | K | B | -1.8801 | |
| 12 | L | B | 0.0000 | |
| 13 | A | B | 0.0000 | |
| 14 | E | B | -2.6061 | |
| 15 | Q | B | -2.2194 | |
| 16 | A | B | 0.0000 | |
| 17 | E | B | -2.9340 | |
| 18 | R | B | -2.1396 | |
| 19 | Y | B | -1.9507 | |
| 20 | D | B | -2.3333 | |
| 21 | D | B | -1.6762 | |
| 22 | M | B | 0.0000 | |
| 23 | A | B | 0.0000 | |
| 24 | A | B | -0.7392 | |
| 25 | C | B | 0.0000 | |
| 26 | M | B | 0.0000 | |
| 27 | K | B | -1.2300 | |
| 28 | S | B | -1.6073 | |
| 29 | V | B | 0.0000 | |
| 30 | T | B | 0.0000 | |
| 31 | E | B | -2.8443 | |
| 32 | Q | B | -2.6471 | |
| 33 | G | B | -1.7897 | |
| 34 | A | B | -1.2155 | |
| 35 | E | B | -1.4723 | |
| 36 | L | B | 0.0000 | |
| 37 | S | B | -1.6221 | |
| 38 | N | B | -2.4697 | |
| 39 | E | B | -2.6513 | |
| 40 | E | B | 0.0000 | |
| 41 | R | B | -1.7729 | |
| 42 | N | B | -1.9590 | |
| 43 | L | B | 0.0000 | |
| 44 | L | B | 0.0000 | |
| 45 | S | B | 0.0000 | |
| 46 | V | B | 0.0000 | |
| 47 | A | B | 0.0000 | |
| 48 | Y | B | 0.0000 | |
| 49 | K | B | -1.0157 | |
| 50 | N | B | -1.3894 | |
| 51 | V | B | 0.0000 | |
| 52 | V | B | 0.0000 | |
| 53 | G | B | -0.7035 | |
| 54 | A | B | -0.8418 | |
| 55 | R | B | -1.2795 | |
| 56 | R | B | -1.1586 | |
| 57 | S | B | -1.1316 | |
| 58 | S | B | 0.0000 | |
| 59 | W | B | -1.3873 | |
| 60 | R | B | -1.5213 | |
| 61 | V | B | -0.9190 | |
| 62 | V | B | 0.0000 | |
| 63 | S | B | -1.5562 | |
| 64 | S | B | -1.4180 | |
| 65 | I | B | 0.0000 | |
| 66 | E | B | -2.9059 | |
| 67 | Q | B | -2.9567 | |
| 68 | K | B | -3.1597 | |
| 69 | T | B | 0.0000 | |
| 70 | E | B | -3.6127 | |
| 71 | G | B | -2.5919 | |
| 72 | A | B | -2.9625 | |
| 73 | E | B | -3.7345 | |
| 74 | K | B | -3.4667 | |
| 75 | K | B | -3.4930 | |
| 76 | Q | B | -3.6033 | |
| 77 | Q | B | -3.1712 | |
| 78 | M | B | -2.5467 | |
| 79 | A | B | 0.0000 | |
| 80 | R | B | -2.8541 | |
| 81 | E | B | -2.9356 | |
| 82 | Y | B | 0.0000 | |
| 83 | R | B | -2.5297 | |
| 84 | E | B | -3.1456 | |
| 85 | K | B | -2.7697 | |
| 86 | I | B | 0.0000 | |
| 87 | E | B | 0.0000 | |
| 88 | T | B | -1.8294 | |
| 89 | E | B | -2.0005 | |
| 90 | L | B | 0.0000 | |
| 91 | R | B | -1.9936 | |
| 92 | D | B | -2.8356 | |
| 93 | I | B | -1.7673 | |
| 94 | C | B | 0.0000 | |
| 95 | N | B | -2.4998 | |
| 96 | D | B | -2.2824 | |
| 97 | V | B | 0.0000 | |
| 98 | L | B | 0.0000 | |
| 99 | S | B | -1.8485 | |
| 100 | L | B | 0.0000 | |
| 101 | L | B | 0.0000 | |
| 102 | E | B | -2.7738 | |
| 103 | K | B | -2.8259 | |
| 104 | F | B | -1.9169 | |
| 105 | L | B | 0.0000 | |
| 106 | I | B | -1.2824 | |
| 107 | P | B | -1.3787 | |
| 108 | N | B | -1.5253 | |
| 109 | A | B | 0.0000 | |
| 110 | S | B | -1.3835 | |
| 111 | Q | B | -1.9313 | |
| 112 | A | B | -2.0147 | |
| 113 | E | B | -2.1970 | |
| 114 | S | B | -1.7032 | |
| 115 | K | B | -1.5349 | |
| 116 | V | B | 0.0000 | |
| 117 | F | B | 0.0000 | |
| 118 | Y | B | 0.0000 | |
| 119 | L | B | 0.0000 | |
| 120 | K | B | 0.0000 | |
| 121 | M | B | 0.0000 | |
| 122 | K | B | -0.8046 | |
| 123 | G | B | 0.0000 | |
| 124 | D | B | 0.0000 | |
| 125 | Y | B | 0.0000 | |
| 126 | Y | B | -0.6019 | |
| 127 | R | B | 0.0000 | |
| 128 | Y | B | 0.0000 | |
| 129 | L | B | 0.0000 | |
| 130 | A | B | 0.0000 | |
| 131 | E | B | -0.5397 | |
| 132 | V | B | 0.0000 | |
| 133 | A | B | 0.0000 | |
| 134 | A | B | -1.4893 | |
| 135 | G | B | -2.3545 | |
| 136 | D | B | -3.4665 | |
| 137 | D | B | -3.5036 | |
| 138 | K | B | -3.0973 | |
| 139 | K | B | -3.2934 | |
| 140 | G | B | -2.5182 | |
| 141 | I | B | -1.8938 | |
| 142 | V | B | -1.4622 | |
| 143 | D | B | -2.1138 | |
| 144 | Q | B | -2.1613 | |
| 145 | S | B | 0.0000 | |
| 146 | Q | B | -1.6383 | |
| 147 | Q | B | -2.4809 | |
| 148 | A | B | 0.0000 | |
| 149 | Y | B | 0.0000 | |
| 150 | Q | B | -2.3278 | |
| 151 | E | B | -2.8325 | |
| 152 | A | B | 0.0000 | |
| 153 | F | B | -2.2872 | |
| 154 | E | B | -3.3551 | |
| 155 | I | B | -2.9382 | |
| 156 | S | B | 0.0000 | |
| 157 | K | B | -3.7004 | |
| 158 | K | B | -3.8812 | |
| 159 | E | B | -3.7652 | |
| 160 | M | B | 0.0000 | |
| 161 | Q | B | -2.4133 | |
| 162 | P | B | -1.5706 | |
| 163 | T | B | 0.0000 | |
| 164 | H | B | -0.8633 | |
| 165 | P | B | -0.8066 | |
| 166 | I | B | -0.4056 | |
| 167 | R | B | -1.1695 | |
| 168 | L | B | 0.0000 | |
| 169 | G | B | 0.0000 | |
| 170 | L | B | 0.0000 | |
| 171 | A | B | 0.0000 | |
| 172 | L | B | 0.0000 | |
| 173 | N | B | 0.0000 | |
| 174 | F | B | 0.0000 | |
| 175 | S | B | 0.0000 | |
| 176 | V | B | 0.0000 | |
| 177 | F | B | 0.0000 | |
| 178 | Y | B | -0.8848 | |
| 179 | Y | B | -1.2570 | |
| 180 | E | B | -1.4300 | |
| 181 | I | B | -0.4415 | |
| 182 | L | B | -0.3839 | |
| 183 | N | B | -1.7316 | |
| 184 | S | B | -1.6162 | |
| 185 | P | B | -1.7946 | |
| 186 | E | B | -2.7053 | |
| 187 | K | B | -2.6999 | |
| 188 | A | B | 0.0000 | |
| 189 | C | B | -1.3195 | |
| 190 | S | B | -1.4418 | |
| 191 | L | B | -0.9183 | |
| 192 | A | B | 0.0000 | |
| 193 | K | B | -1.5408 | |
| 194 | T | B | -0.7170 | |
| 195 | A | B | 0.0000 | |
| 196 | F | B | 0.0000 | |
| 197 | D | B | -1.2786 | |
| 198 | E | B | -1.0097 | |
| 199 | A | B | 0.0000 | |
| 200 | I | B | 0.2396 | |
| 201 | A | B | -0.4859 | |
| 202 | E | B | -1.4232 | |
| 203 | L | B | -0.2844 | |
| 204 | D | B | -1.5657 | |
| 205 | T | B | -1.1304 | |
| 206 | L | B | -1.2905 | |
| 207 | S | B | -1.6402 | |
| 208 | E | B | -2.6195 | |
| 209 | E | B | -2.8224 | |
| 210 | S | B | -1.5796 | |
| 211 | Y | B | -0.8541 | |
| 212 | K | B | -1.9820 | |
| 213 | D | B | -2.1215 | |
| 214 | S | B | 0.0000 | |
| 215 | T | B | -0.4113 | |
| 216 | L | B | -0.9425 | |
| 217 | I | B | 0.0000 | |
| 218 | M | B | 0.0000 | |
| 219 | Q | B | -2.0172 | |
| 220 | L | B | -1.3199 | |
| 221 | L | B | 0.0000 | |
| 222 | R | B | -3.0798 | |
| 223 | D | B | -2.5087 | |
| 224 | N | B | 0.0000 | |
| 225 | L | B | -1.0669 | |
| 226 | T | B | -0.6620 | |
| 227 | L | B | -0.0942 | |
| 228 | W | B | -0.0309 | |
| 343 | R | Q | -2.4974 | |
| 344 | S | Q | -1.6431 | |
| 345 | K | Q | -1.9633 | |
| 347 | A | Q | -0.1573 | |
| 365 | K | Q | -1.3176 | |
| 366 | A | Q | -0.5694 | |
| 367 | L | Q | 0.1070 | |
| 369 | F | Q | -0.6339 | |
| 370 | D | Q | -2.2015 | |
| 371 | N | Q | -1.9917 | |
| 372 | R | Q | -2.6794 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine