Project name: AG_6fxn

Chain sequence(s)	A: SELTQDPAVSVALGQTVRVTCQGDSLRSYYASWYQQKPGQAPVLVIYGKNNRPSGIPDRFSGSSSGNTASLTITGAQAEDEADYYCSSRDSSGNHWVFGGGTELTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTVQLQQSGAEVKKPGSSVRVSCKASGGTFNNNAINWVRQAPGQGLEWMGGIIPMFGTAKYSQNFQGRVAITADESTGTASMELSSLRSEDTAVYYCARSRDLLLFPHHALSPWGRGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.1262
• Maximal score value: 2.4447
• Average score: -0.7061
• Total score value: -304.3454

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	S	A	-1.6843
3	E	A	-2.4611
4	L	A	0.0000
5	T	A	-1.4890
6	Q	A	-1.4040
7	D	A	-2.3083
8	P	A	-1.6706
9	A	A	0.0000
10	V	A	-1.0153
11	S	A	-0.2918
12	V	A	0.0000
13	A	A	0.1192
14	L	A	0.0810
15	G	A	-0.7931
16	Q	A	-1.1537
17	T	A	-1.1663
18	V	A	0.0000
19	R	A	-1.8945
20	V	A	0.0000
21	T	A	-1.1232
22	C	A	0.0000
23	Q	A	-2.0389
24	G	A	0.0000
25	D	A	-3.1262
26	S	A	0.0000
27	L	A	0.0000
28	R	A	-2.8051
29	S	A	-1.5170
30	Y	A	-1.0113
31	Y	A	-0.8299
32	A	A	0.0000
33	S	A	0.0000
34	W	A	0.0000
35	Y	A	0.0000
36	Q	A	-0.3522
37	Q	A	0.0000
38	K	A	-1.3260
39	P	A	-1.2223
40	G	A	-1.0002
41	Q	A	-1.1113
42	A	A	-0.7541
43	P	A	0.0000
44	V	A	0.6181
45	L	A	0.0000
46	V	A	0.0000
47	I	A	0.0000
48	Y	A	-1.2901
49	G	A	0.0000
50	K	A	-2.7597
51	N	A	-2.7249
52	N	A	-2.3865
53	R	A	-2.3229
54	P	A	-0.9214
55	S	A	-0.7323
56	G	A	-0.8453
57	I	A	-0.8206
58	P	A	-1.3061
59	D	A	-2.1858
60	R	A	-1.4163
61	F	A	0.0000
62	S	A	-1.6272
63	G	A	-1.5250
64	S	A	-1.1978
65	S	A	-1.2627
66	S	A	-1.0676
67	G	A	-1.7579
68	N	A	-2.0260
69	T	A	-1.3830
70	A	A	0.0000
71	S	A	0.0000
72	L	A	0.0000
73	T	A	-0.9025
74	I	A	0.0000
75	T	A	-1.2036
76	G	A	-0.8950
77	A	A	0.0000
78	Q	A	-1.1956
79	A	A	0.0000
80	E	A	-1.9497
81	D	A	0.0000
82	E	A	-1.7857
83	A	A	0.0000
84	D	A	-1.7157
85	Y	A	0.0000
86	Y	A	0.0000
87	C	A	0.0000
88	S	A	-0.2578
89	S	A	0.0000
90	R	A	0.0000
91	D	A	-1.4430
92	S	A	-1.5743
93	S	A	-0.8439
94	G	A	-0.9147
95	N	A	-1.3211
96	H	A	-0.9867
97	W	A	0.0000
98	V	A	-0.4553
99	F	A	-0.4003
100	G	A	0.0000
101	G	A	-1.3440
102	G	A	-1.4350
103	T	A	0.0000
104	E	A	-2.1434
105	L	A	0.0000
106	T	A	-0.4019
107	V	A	0.0000
108	L	A	0.8470
109	G	A	-0.0299
110	Q	A	0.0000
111	P	A	-0.9485
112	K	A	-2.2104
113	A	A	-1.3414
114	A	A	-0.7762
115	P	A	-0.2430
116	S	A	-0.5009
117	V	A	0.0000
118	T	A	-0.4886
119	L	A	0.0000
120	F	A	0.0000
121	P	A	-0.0528
122	P	A	0.0000
123	S	A	-0.9666
124	S	A	-1.4002
125	E	A	-1.9595
126	E	A	0.0000
127	L	A	-1.9285
128	Q	A	-2.2244
129	A	A	-1.8217
130	N	A	-2.5830
131	K	A	-2.4606
132	A	A	0.0000
133	T	A	0.0000
134	L	A	0.0000
135	V	A	0.0000
136	C	A	0.0000
137	L	A	0.0000
138	I	A	0.0000
139	S	A	-0.5778
140	D	A	-1.1773
141	F	A	0.0000
142	Y	A	-1.2188
143	P	A	-1.0568
144	G	A	-0.9241
145	A	A	-0.3066
146	V	A	-0.0632
147	T	A	-0.0766
148	V	A	0.0741
149	A	A	-0.2123
150	W	A	0.0000
151	K	A	-0.8698
152	A	A	0.0000
153	D	A	-1.3988
154	S	A	-0.9491
155	S	A	-0.8576
156	P	A	-0.9339
157	V	A	-0.6466
158	K	A	-1.4402
159	A	A	-0.4747
160	G	A	0.1081
161	V	A	0.5374
162	E	A	0.3302
163	T	A	0.3076
164	T	A	0.1054
165	T	A	-0.1215
166	P	A	-0.2829
167	S	A	-0.5930
168	K	A	-1.2914
169	Q	A	-1.0585
170	S	A	-0.9731
171	N	A	-1.3663
172	N	A	-1.6078
173	K	A	-1.6614
174	Y	A	-0.7871
175	A	A	0.0000
176	A	A	0.0000
177	S	A	0.0000
178	S	A	0.0000
179	Y	A	0.0000
180	L	A	1.3662
181	S	A	0.3711
182	L	A	-0.4634
183	T	A	-1.7265
184	P	A	-2.3214
185	E	A	-3.0868
186	Q	A	-2.1962
187	W	A	0.0000
188	K	A	-3.0701
189	S	A	0.0000
190	H	A	-2.3376
191	R	A	-2.5491
192	S	A	-1.5974
193	Y	A	0.0000
194	S	A	-0.9884
195	C	A	0.0000
196	Q	A	-1.2261
197	V	A	0.0000
198	T	A	-0.7016
199	H	A	0.0000
200	E	A	-2.3378
201	G	A	-1.3959
202	S	A	-0.9095
203	T	A	-0.7983
204	V	A	-0.9360
205	E	A	-2.3257
206	K	A	-2.0767
207	T	A	-1.2121
208	V	A	0.0000
209	A	A	-0.9657
210	P	A	-1.0408
2	V	A	1.0729
3	Q	A	-1.0488
4	L	A	0.0000
5	Q	A	-2.0379
6	Q	A	-1.3379
7	S	A	-1.3062
8	G	A	-1.2802
9	A	A	0.0000
10	E	A	-1.2907
11	V	A	-0.7828
12	K	A	-1.6695
13	K	A	-2.4099
14	P	A	-2.0419
15	G	A	-1.5477
16	S	A	-1.2517
17	S	A	-1.2234
18	V	A	0.0000
19	R	A	-2.3133
20	V	A	0.0000
21	S	A	-1.0962
22	C	A	0.0000
23	K	A	-1.6449
24	A	A	0.0000
25	S	A	-0.8401
26	G	A	-0.6320
27	G	A	-1.1930
28	T	A	-1.1530
29	F	A	0.0000
30	N	A	-1.6390
31	N	A	-0.6163
32	N	A	-0.6189
33	A	A	-0.0935
34	I	A	0.0000
35	N	A	0.0000
36	W	A	0.0000
37	V	A	0.0000
38	R	A	-0.5562
39	Q	A	-0.7765
40	A	A	-1.0415
41	P	A	-0.9228
42	G	A	-1.2965
43	Q	A	-1.7964
44	G	A	-1.2933
45	L	A	0.0000
46	E	A	-0.7561
47	W	A	0.0000
48	M	A	0.0000
49	G	A	0.0000
50	G	A	0.0000
51	I	A	0.2546
52	I	A	0.1432
53	P	A	-0.4853
54	M	A	0.4532
55	F	A	1.3641
56	G	A	0.2017
57	T	A	-0.0936
58	A	A	-0.3114
59	K	A	-1.1785
60	Y	A	-0.7048
61	S	A	-1.2891
62	Q	A	-2.2069
63	N	A	-2.2677
64	F	A	0.0000
65	Q	A	-2.1211
66	G	A	-1.5078
67	R	A	-1.1868
68	V	A	-0.9046
69	A	A	-0.6089
70	I	A	0.0000
71	T	A	-0.4772
72	A	A	-1.2038
73	D	A	-2.6757
74	E	A	-2.8128
75	S	A	-1.6537
76	T	A	-1.4630
77	G	A	0.0000
78	T	A	-1.5703
79	A	A	0.0000
80	S	A	-1.0748
81	M	A	0.0000
82	E	A	-1.6272
83	L	A	0.0000
84	S	A	-1.1860
85	S	A	-1.2268
86	L	A	0.0000
87	R	A	-2.8582
88	S	A	-2.2607
89	E	A	-2.5226
90	D	A	0.0000
91	T	A	-0.9092
92	A	A	0.0000
93	V	A	0.0366
94	Y	A	0.0000
95	Y	A	0.0000
96	C	A	0.0000
97	A	A	0.0000
98	R	A	-0.3880
99	S	A	0.0000
100	R	A	-0.4066
101	D	A	0.7654
102	L	A	1.4324
103	L	A	2.4447
104	L	A	2.2548
105	F	A	1.3142
106	P	A	0.6685
107	H	A	-0.5985
108	H	A	-0.5548
109	A	A	0.0000
110	L	A	0.0000
111	S	A	-0.0467
112	P	A	0.0912
113	W	A	-0.4532
114	G	A	0.0000
115	R	A	-2.2111
116	G	A	-1.1242
117	T	A	0.0000
118	M	A	-0.2400
119	V	A	0.0000
120	T	A	-0.7366
121	V	A	0.0000
122	S	A	-1.0268
123	S	A	-0.9201
124	A	A	-0.6119
125	S	A	-0.6984
126	T	A	-0.7091
127	K	A	-0.9840
128	G	A	-1.3453
129	P	A	-0.5878
130	S	A	-0.2597
131	V	A	0.0000
132	F	A	0.0000
133	P	A	-1.0460
134	L	A	0.0000
135	A	A	-0.9733
136	P	A	-0.8636
137	S	A	-0.9391
138	S	A	-1.2515
139	K	A	-2.0096
140	S	A	-1.4378
141	T	A	-0.8805
142	S	A	-0.8773
143	G	A	-0.8671
144	G	A	-1.1919
145	T	A	-0.9139
146	A	A	0.0000
147	A	A	-0.1093
148	L	A	0.0000
149	G	A	0.0000
150	C	A	0.0000
151	L	A	0.0000
152	V	A	0.0000
153	K	A	0.0000
154	D	A	-0.3639
155	Y	A	0.0000
156	F	A	0.0000
157	P	A	0.0000
158	E	A	-0.8873
159	P	A	-1.0183
160	V	A	0.0000
161	T	A	-0.5916
162	V	A	-0.2718
163	S	A	-0.3440
164	W	A	0.0000
165	N	A	-0.8073
166	S	A	-0.6245
167	G	A	-0.3566
168	A	A	-0.1885
169	L	A	0.0474
170	T	A	-0.1478
171	S	A	-0.2772
172	G	A	-0.3539
173	V	A	0.1116
174	H	A	-0.1578
175	T	A	-0.0404
176	F	A	0.0000
177	P	A	-0.1347
178	A	A	0.2241
179	V	A	0.0000
180	L	A	1.2032
181	Q	A	0.2801
182	S	A	-0.1735
183	S	A	-0.2761
184	G	A	-0.1485
185	L	A	0.0943
186	Y	A	0.3252
187	S	A	0.0000
188	L	A	0.0000
189	S	A	0.0000
190	S	A	0.0000
191	V	A	0.1702
192	V	A	0.0000
193	T	A	-0.2033
194	V	A	0.0000
195	P	A	-0.6614
196	S	A	-0.9631
197	S	A	-0.8657
198	S	A	-0.6423
199	L	A	-1.0961
200	G	A	-1.1095
201	T	A	-0.8520
202	Q	A	-1.5714
203	T	A	-1.3386
204	Y	A	0.0000
205	I	A	-1.2840
206	C	A	0.0000
207	N	A	0.0000
208	V	A	0.0000
209	N	A	-1.7311
210	H	A	0.0000
211	K	A	-2.9230
212	P	A	-1.7958
213	S	A	-1.8785
214	N	A	-2.4921
215	T	A	-2.0613
216	K	A	-2.5007
217	V	A	-1.3177
218	D	A	-2.4941
219	K	A	-2.1811
220	K	A	-2.6644
221	V	A	0.0000
222	E	A	-2.5678
223	P	A	-1.2409