| Chain sequence(s) |
A: SELTQDPAVSVALGQTVRVTCQGDSLRSYYASWYQQKPGQAPVLVIYGKNNRPSGIPDRFSGSSSGNTASLTITGAQAEDEADYYCSSRDSSGNHWVFGGGTELTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPT B: VQLQQSGAEVKKPGSSVRVSCKASGGTFNNNAINWVRQAPGQGLEWMGGIIPMFGTAKYSQNFQGRVAITADESTGTASMELSSLRSEDTAVYYCARSRDLLLFPHHALSPWGRGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 2 | S | A | -1.6446 | |
| 3 | E | A | -2.5392 | |
| 4 | L | A | 0.0000 | |
| 5 | T | A | -1.3195 | |
| 6 | Q | A | -0.8565 | |
| 7 | D | A | -1.2475 | |
| 8 | P | A | -1.0773 | |
| 9 | A | A | -0.9418 | |
| 10 | V | A | -0.6364 | |
| 11 | S | A | -0.0704 | |
| 12 | V | A | 0.0000 | |
| 13 | A | A | 0.0396 | |
| 14 | L | A | -0.1031 | |
| 15 | G | A | -0.9050 | |
| 16 | Q | A | -1.3001 | |
| 17 | T | A | -1.1915 | |
| 18 | V | A | 0.0000 | |
| 19 | R | A | -1.9041 | |
| 20 | V | A | 0.0000 | |
| 21 | T | A | -0.9339 | |
| 22 | C | A | 0.0000 | |
| 23 | Q | A | -2.1338 | |
| 24 | G | A | 0.0000 | |
| 25 | D | A | -3.1031 | |
| 26 | S | A | 0.0000 | |
| 27 | L | A | 0.0000 | |
| 28 | R | A | -2.6195 | |
| 29 | S | A | -1.2746 | |
| 30 | Y | A | -0.0085 | |
| 31 | Y | A | 0.5432 | |
| 32 | A | A | 0.3163 | |
| 33 | S | A | 0.0000 | |
| 34 | W | A | 0.0000 | |
| 35 | Y | A | 0.0000 | |
| 36 | Q | A | 0.0000 | |
| 37 | Q | A | 0.0000 | |
| 38 | K | A | -1.5980 | |
| 39 | P | A | -1.4582 | |
| 40 | G | A | -1.3642 | |
| 41 | Q | A | -1.8649 | |
| 42 | A | A | -1.1039 | |
| 43 | P | A | 0.0000 | |
| 44 | V | A | 0.6410 | |
| 45 | L | A | 0.4927 | |
| 46 | V | A | 0.0000 | |
| 47 | I | A | 0.0000 | |
| 48 | Y | A | -0.8575 | |
| 49 | G | A | -1.1834 | |
| 50 | K | A | -2.2756 | |
| 51 | N | A | -2.5104 | |
| 52 | N | A | -2.2238 | |
| 53 | R | A | -1.8537 | |
| 54 | P | A | -0.7033 | |
| 55 | S | A | -0.7992 | |
| 56 | G | A | -0.7588 | |
| 57 | I | A | -0.4988 | |
| 58 | P | A | -1.2035 | |
| 59 | D | A | -2.1389 | |
| 60 | R | A | -1.2215 | |
| 61 | F | A | 0.0000 | |
| 62 | S | A | -1.5815 | |
| 63 | G | A | -1.3571 | |
| 64 | S | A | -0.9697 | |
| 65 | S | A | -1.0405 | |
| 66 | S | A | -0.9157 | |
| 67 | G | A | -1.7590 | |
| 68 | N | A | -2.1975 | |
| 69 | T | A | -1.5065 | |
| 70 | A | A | 0.0000 | |
| 71 | S | A | -0.7600 | |
| 72 | L | A | 0.0000 | |
| 73 | T | A | -0.8785 | |
| 74 | I | A | 0.0000 | |
| 75 | T | A | -1.1900 | |
| 76 | G | A | -0.8856 | |
| 77 | A | A | 0.0000 | |
| 78 | Q | A | -1.1819 | |
| 79 | A | A | -1.3012 | |
| 80 | E | A | -2.3361 | |
| 81 | D | A | 0.0000 | |
| 82 | E | A | -1.3148 | |
| 83 | A | A | 0.0000 | |
| 84 | D | A | -2.1466 | |
| 85 | Y | A | 0.0000 | |
| 86 | Y | A | 0.0000 | |
| 87 | C | A | 0.0000 | |
| 88 | S | A | 0.0000 | |
| 89 | S | A | 0.0000 | |
| 90 | R | A | -0.6201 | |
| 91 | D | A | -1.4191 | |
| 92 | S | A | -1.5247 | |
| 93 | S | A | -0.8392 | |
| 94 | G | A | -0.5949 | |
| 95 | N | A | -1.0217 | |
| 96 | H | A | -0.8944 | |
| 97 | W | A | 0.0000 | |
| 98 | V | A | -0.9179 | |
| 99 | F | A | 0.0000 | |
| 100 | G | A | 0.0000 | |
| 101 | G | A | -1.1973 | |
| 102 | G | A | -1.3711 | |
| 103 | T | A | 0.0000 | |
| 104 | E | A | -2.2181 | |
| 105 | L | A | 0.0000 | |
| 106 | T | A | -0.2354 | |
| 107 | V | A | 0.0000 | |
| 108 | L | A | 0.9270 | |
| 109 | G | A | -0.0690 | |
| 110 | Q | A | -0.4522 | |
| 111 | P | A | -1.0414 | |
| 112 | K | A | -2.2690 | |
| 113 | A | A | -1.3294 | |
| 114 | A | A | -0.7792 | |
| 115 | P | A | -0.6046 | |
| 116 | S | A | -0.3885 | |
| 117 | V | A | 0.0000 | |
| 118 | T | A | -0.4270 | |
| 119 | L | A | 0.0000 | |
| 120 | F | A | 0.0000 | |
| 121 | P | A | -0.1608 | |
| 122 | P | A | -0.4597 | |
| 123 | S | A | 0.0000 | |
| 124 | S | A | -1.3357 | |
| 125 | E | A | -2.0108 | |
| 126 | E | A | 0.0000 | |
| 127 | L | A | -2.1901 | |
| 128 | Q | A | -2.2815 | |
| 129 | A | A | -1.9294 | |
| 130 | N | A | -2.8064 | |
| 131 | K | A | -2.8346 | |
| 132 | A | A | 0.0000 | |
| 133 | T | A | 0.0000 | |
| 134 | L | A | 0.0000 | |
| 135 | V | A | 0.0000 | |
| 136 | C | A | 0.0000 | |
| 137 | L | A | 0.0000 | |
| 138 | I | A | 0.0000 | |
| 139 | S | A | -0.7181 | |
| 140 | D | A | -1.5141 | |
| 141 | F | A | 0.0000 | |
| 142 | Y | A | -1.0952 | |
| 143 | P | A | -0.8629 | |
| 144 | G | A | -0.5901 | |
| 145 | A | A | -0.2876 | |
| 146 | V | A | -0.0843 | |
| 147 | T | A | -0.1120 | |
| 148 | V | A | 0.2648 | |
| 149 | A | A | -0.4194 | |
| 150 | W | A | 0.0000 | |
| 151 | K | A | -1.2246 | |
| 152 | A | A | -1.1556 | |
| 153 | D | A | -1.8449 | |
| 154 | S | A | -1.0818 | |
| 155 | S | A | -0.6819 | |
| 156 | P | A | -0.8076 | |
| 157 | V | A | -0.6922 | |
| 158 | K | A | -1.6809 | |
| 159 | A | A | -0.9060 | |
| 160 | G | A | -0.8077 | |
| 161 | V | A | -0.6684 | |
| 162 | E | A | -0.9110 | |
| 163 | T | A | -0.2283 | |
| 164 | T | A | -0.0781 | |
| 165 | T | A | -0.1294 | |
| 166 | P | A | -0.1955 | |
| 167 | S | A | -0.5100 | |
| 168 | K | A | -1.0954 | |
| 169 | Q | A | -1.1777 | |
| 170 | S | A | -1.3727 | |
| 171 | N | A | -1.8455 | |
| 172 | N | A | 0.0000 | |
| 173 | K | A | -1.3615 | |
| 174 | Y | A | -0.6939 | |
| 175 | A | A | 0.0000 | |
| 176 | A | A | 0.0000 | |
| 177 | S | A | 0.0000 | |
| 178 | S | A | 0.0000 | |
| 179 | Y | A | 0.0000 | |
| 180 | L | A | 0.0000 | |
| 181 | S | A | -0.6516 | |
| 182 | L | A | -1.0637 | |
| 183 | T | A | -1.9002 | |
| 184 | P | A | 0.0000 | |
| 185 | E | A | -3.3065 | |
| 186 | Q | A | -2.4141 | |
| 187 | W | A | 0.0000 | |
| 188 | K | A | -3.1067 | |
| 189 | S | A | -2.3563 | |
| 190 | H | A | -2.4360 | |
| 191 | R | A | -2.5923 | |
| 192 | S | A | -1.6939 | |
| 193 | Y | A | 0.0000 | |
| 194 | S | A | 0.0000 | |
| 195 | C | A | 0.0000 | |
| 196 | Q | A | -0.8039 | |
| 197 | V | A | 0.0000 | |
| 198 | T | A | -0.5399 | |
| 199 | H | A | 0.0000 | |
| 200 | E | A | -2.3145 | |
| 201 | G | A | -1.4659 | |
| 202 | S | A | -0.8688 | |
| 203 | T | A | -0.5121 | |
| 204 | V | A | -0.3006 | |
| 205 | E | A | -1.6568 | |
| 206 | K | A | -1.5582 | |
| 207 | T | A | -1.0542 | |
| 208 | V | A | 0.0000 | |
| 209 | A | A | -0.9742 | |
| 210 | P | A | -1.2900 | |
| 2 | V | B | 1.0461 | |
| 3 | Q | B | -1.0560 | |
| 4 | L | B | 0.0000 | |
| 5 | Q | B | -1.8154 | |
| 6 | Q | B | -1.4920 | |
| 7 | S | B | -1.0565 | |
| 8 | G | B | -0.8467 | |
| 9 | A | B | -0.5909 | |
| 10 | E | B | -0.8897 | |
| 11 | V | B | -0.6548 | |
| 12 | K | B | -1.5658 | |
| 13 | K | B | -2.4410 | |
| 14 | P | B | -1.9846 | |
| 15 | G | B | -1.6175 | |
| 16 | S | B | -1.3158 | |
| 17 | S | B | -1.5567 | |
| 18 | V | B | 0.0000 | |
| 19 | R | B | -2.4930 | |
| 20 | V | B | 0.0000 | |
| 21 | S | B | -1.0371 | |
| 22 | C | B | 0.0000 | |
| 23 | K | B | -1.2864 | |
| 24 | A | B | -0.9550 | |
| 25 | S | B | -0.7986 | |
| 26 | G | B | -0.8605 | |
| 27 | G | B | -0.9678 | |
| 28 | T | B | -0.9939 | |
| 29 | F | B | 0.0000 | |
| 30 | N | B | -0.4783 | |
| 31 | N | B | -0.8841 | |
| 32 | N | B | -0.8959 | |
| 33 | A | B | -0.2575 | |
| 34 | I | B | 0.0000 | |
| 35 | N | B | 0.0000 | |
| 36 | W | B | 0.0000 | |
| 37 | V | B | 0.0000 | |
| 38 | R | B | -0.7846 | |
| 39 | Q | B | -0.8981 | |
| 40 | A | B | -1.2014 | |
| 41 | P | B | -1.1265 | |
| 42 | G | B | -1.2465 | |
| 43 | Q | B | -1.8822 | |
| 44 | G | B | -1.5369 | |
| 45 | L | B | 0.0000 | |
| 46 | E | B | -1.3323 | |
| 47 | W | B | 0.0000 | |
| 48 | M | B | 0.0000 | |
| 49 | G | B | 0.0000 | |
| 50 | G | B | -0.1965 | |
| 51 | I | B | 0.4370 | |
| 52 | I | B | 0.9122 | |
| 53 | P | B | 0.6093 | |
| 54 | M | B | 1.4000 | |
| 55 | F | B | 2.1638 | |
| 56 | G | B | 0.7626 | |
| 57 | T | B | 0.1567 | |
| 58 | A | B | -0.1763 | |
| 59 | K | B | -1.4835 | |
| 60 | Y | B | -1.4170 | |
| 61 | S | B | -1.5739 | |
| 62 | Q | B | -2.4405 | |
| 63 | N | B | -2.2864 | |
| 64 | F | B | 0.0000 | |
| 65 | Q | B | -2.4632 | |
| 66 | G | B | -1.5501 | |
| 67 | R | B | -1.6136 | |
| 68 | V | B | 0.0000 | |
| 69 | A | B | -1.1471 | |
| 70 | I | B | 0.0000 | |
| 71 | T | B | -0.2614 | |
| 72 | A | B | -0.3163 | |
| 73 | D | B | -0.9517 | |
| 74 | E | B | -1.0097 | |
| 75 | S | B | -0.7916 | |
| 76 | T | B | -0.7216 | |
| 77 | G | B | 0.0000 | |
| 78 | T | B | -0.7767 | |
| 79 | A | B | 0.0000 | |
| 80 | S | B | 0.0000 | |
| 81 | M | B | 0.0000 | |
| 82 | E | B | -2.1797 | |
| 83 | L | B | 0.0000 | |
| 84 | S | B | -1.2982 | |
| 85 | S | B | -1.1737 | |
| 86 | L | B | 0.0000 | |
| 87 | R | B | -2.9769 | |
| 88 | S | B | -2.2881 | |
| 89 | E | B | -2.5202 | |
| 90 | D | B | 0.0000 | |
| 91 | T | B | -1.0391 | |
| 92 | A | B | 0.0000 | |
| 93 | V | B | -0.0104 | |
| 94 | Y | B | 0.0000 | |
| 95 | Y | B | 0.0000 | |
| 96 | C | B | 0.0000 | |
| 97 | A | B | 0.0000 | |
| 98 | R | B | -0.5420 | |
| 99 | S | B | 0.0000 | |
| 100 | R | B | -1.3881 | |
| 101 | D | B | -1.2150 | |
| 102 | L | B | 0.3587 | |
| 103 | L | B | 1.8578 | |
| 104 | L | B | 1.7918 | |
| 105 | F | B | 0.6790 | |
| 106 | P | B | 0.5649 | |
| 107 | H | B | -0.6253 | |
| 108 | H | B | -0.8255 | |
| 109 | A | B | 0.0000 | |
| 110 | L | B | 0.0000 | |
| 111 | S | B | -0.3849 | |
| 112 | P | B | -0.0477 | |
| 113 | W | B | 0.0000 | |
| 114 | G | B | 0.0000 | |
| 115 | R | B | -2.5194 | |
| 116 | G | B | -1.2446 | |
| 117 | T | B | 0.0000 | |
| 118 | M | B | -0.1086 | |
| 119 | V | B | 0.0000 | |
| 120 | T | B | -0.7950 | |
| 121 | V | B | 0.0000 | |
| 122 | S | B | -1.1614 | |
| 123 | S | B | -1.2149 | |
| 124 | A | B | -0.6552 | |
| 125 | S | B | -0.6790 | |
| 126 | T | B | -0.6910 | |
| 127 | K | B | -1.1181 | |
| 128 | G | B | -1.2701 | |
| 129 | P | B | -0.5908 | |
| 130 | S | B | -0.2175 | |
| 131 | V | B | 0.0000 | |
| 132 | F | B | -0.6487 | |
| 133 | P | B | -1.0609 | |
| 134 | L | B | 0.0000 | |
| 135 | A | B | -0.9246 | |
| 136 | P | B | -0.9818 | |
| 137 | S | B | -0.7905 | |
| 138 | S | B | -1.2148 | |
| 139 | K | B | -2.1707 | |
| 140 | S | B | -1.4794 | |
| 141 | T | B | -1.0209 | |
| 142 | S | B | -0.9820 | |
| 143 | G | B | -1.1971 | |
| 144 | G | B | -0.9555 | |
| 145 | T | B | -0.8461 | |
| 146 | A | B | 0.0000 | |
| 147 | A | B | -0.3652 | |
| 148 | L | B | 0.0000 | |
| 149 | G | B | 0.0000 | |
| 150 | C | B | 0.0000 | |
| 151 | L | B | 0.0000 | |
| 152 | V | B | 0.0000 | |
| 153 | K | B | 0.0000 | |
| 154 | D | B | -0.4817 | |
| 155 | Y | B | 0.0000 | |
| 156 | F | B | -0.1920 | |
| 157 | P | B | 0.0000 | |
| 158 | E | B | -0.4927 | |
| 159 | P | B | -0.6390 | |
| 160 | V | B | -0.4419 | |
| 161 | T | B | -0.6166 | |
| 162 | V | B | -0.0961 | |
| 163 | S | B | -0.4584 | |
| 164 | W | B | 0.0000 | |
| 165 | N | B | -0.8191 | |
| 166 | S | B | -0.7387 | |
| 167 | G | B | -0.4241 | |
| 168 | A | B | -0.1794 | |
| 169 | L | B | 0.0068 | |
| 170 | T | B | -0.2234 | |
| 171 | S | B | -0.3563 | |
| 172 | G | B | -0.5434 | |
| 173 | V | B | -0.2093 | |
| 174 | H | B | -0.5595 | |
| 175 | T | B | -0.2356 | |
| 176 | F | B | 0.0000 | |
| 177 | P | B | -0.1226 | |
| 178 | A | B | 0.2246 | |
| 179 | V | B | 0.0000 | |
| 180 | L | B | 0.9057 | |
| 181 | Q | B | -0.0561 | |
| 182 | S | B | -0.3120 | |
| 183 | S | B | -0.3320 | |
| 184 | G | B | -0.1796 | |
| 185 | L | B | 0.0087 | |
| 186 | Y | B | 0.4144 | |
| 187 | S | B | 0.0000 | |
| 188 | L | B | 0.0000 | |
| 189 | S | B | 0.0000 | |
| 190 | S | B | 0.0000 | |
| 191 | V | B | 0.0000 | |
| 192 | V | B | 0.0000 | |
| 193 | T | B | -0.3329 | |
| 194 | V | B | 0.0000 | |
| 195 | P | B | -0.6046 | |
| 196 | S | B | -1.0301 | |
| 197 | S | B | -0.7689 | |
| 198 | S | B | -0.7966 | |
| 199 | L | B | 0.0000 | |
| 200 | G | B | -1.3952 | |
| 201 | T | B | -1.1111 | |
| 202 | Q | B | -1.6130 | |
| 203 | T | B | -1.3616 | |
| 204 | Y | B | 0.0000 | |
| 205 | I | B | -1.4910 | |
| 206 | C | B | 0.0000 | |
| 207 | N | B | 0.0000 | |
| 208 | V | B | 0.0000 | |
| 209 | N | B | -2.0594 | |
| 210 | H | B | 0.0000 | |
| 211 | K | B | -2.4190 | |
| 212 | P | B | -1.4424 | |
| 213 | S | B | -1.6820 | |
| 214 | N | B | -2.4185 | |
| 215 | T | B | -2.0471 | |
| 216 | K | B | -2.7157 | |
| 217 | V | B | -1.5776 | |
| 218 | D | B | -2.6572 | |
| 219 | K | B | -2.2759 | |
| 220 | K | B | -2.7033 | |
| 221 | V | B | 0.0000 | |
| 222 | E | B | -2.6406 | |
| 223 | P | B | -1.7410 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine