Project name: 5%_ag_2osl
Status: done
submitted: 2018-08-15 12:22:44, status changed: 2018-08-15 12:35:42
Settings
Chain sequence(s)
|
A: QIVLSQSPAILSASPGEKVTMTCRASSSVSYIHWFQQKPGSSPKPWIYATSNLASGVPVRFSGSGSGTSYSLTISRVEAEDAATYYCQQWTSNPPTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECQVQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGRGLEWIGAIYPGNGDTSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCARSTYYGGDWYFNVWGAGTTVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-3.7866
-
Maximal score value
-
1.7119
-
Average score
-
-0.6378
-
Total score value
-
-277.4256
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
1 |
Q |
A |
-0.9800 |
|
2 |
I |
A |
0.0592 |
|
3 |
V |
A |
1.1206 |
|
4 |
L |
A |
0.0000 |
|
5 |
S |
A |
-0.6745 |
|
6 |
Q |
A |
-0.8008 |
|
7 |
S |
A |
-0.4371 |
|
8 |
P |
A |
0.2532 |
|
9 |
A |
A |
0.5293 |
|
10 |
I |
A |
1.6286 |
|
11 |
L |
A |
0.8525 |
|
12 |
S |
A |
-0.1523 |
|
13 |
A |
A |
0.0000 |
|
14 |
S |
A |
-1.6204 |
|
15 |
P |
A |
-1.9163 |
|
16 |
G |
A |
-2.2457 |
|
17 |
E |
A |
-2.7614 |
|
18 |
K |
A |
-2.7808 |
|
19 |
V |
A |
-1.1542 |
|
20 |
T |
A |
-0.4425 |
|
21 |
M |
A |
0.0000 |
|
22 |
T |
A |
-0.7506 |
|
23 |
C |
A |
0.0000 |
|
24 |
R |
A |
-1.9394 |
|
25 |
A |
A |
0.0000 |
|
26 |
S |
A |
-0.2477 |
|
27 |
S |
A |
-0.4826 |
|
28 |
S |
A |
-0.6783 |
|
29 |
V |
A |
0.0000 |
|
30 |
S |
A |
-0.2815 |
|
31 |
Y |
A |
0.0990 |
|
32 |
I |
A |
0.0000 |
|
33 |
H |
A |
0.0000 |
|
34 |
W |
A |
0.0000 |
|
35 |
F |
A |
0.0000 |
|
36 |
Q |
A |
0.0000 |
|
37 |
Q |
A |
-0.8586 |
|
38 |
K |
A |
-1.2477 |
|
39 |
P |
A |
-0.9980 |
|
40 |
G |
A |
-0.6679 |
|
41 |
S |
A |
-0.7074 |
|
42 |
S |
A |
-0.5940 |
|
43 |
P |
A |
0.0000 |
|
44 |
K |
A |
-1.2644 |
|
45 |
P |
A |
0.0000 |
|
46 |
W |
A |
-0.4138 |
|
47 |
I |
A |
0.0000 |
|
48 |
Y |
A |
-0.0200 |
|
49 |
A |
A |
-0.1700 |
|
50 |
T |
A |
-0.3135 |
|
51 |
S |
A |
-0.5857 |
|
52 |
N |
A |
-0.7246 |
|
53 |
L |
A |
0.1101 |
|
54 |
A |
A |
0.0000 |
|
55 |
S |
A |
-0.5427 |
|
56 |
G |
A |
-0.3045 |
|
57 |
V |
A |
0.0000 |
|
58 |
P |
A |
0.6407 |
|
59 |
V |
A |
1.2619 |
|
60 |
R |
A |
-0.3775 |
|
61 |
F |
A |
0.0000 |
|
62 |
S |
A |
-0.0688 |
|
63 |
G |
A |
0.0000 |
|
64 |
S |
A |
-0.5764 |
|
65 |
G |
A |
-0.7798 |
|
66 |
S |
A |
-0.7287 |
|
67 |
G |
A |
-0.7735 |
|
68 |
T |
A |
-1.0532 |
|
69 |
S |
A |
-1.3006 |
|
70 |
Y |
A |
0.0000 |
|
71 |
S |
A |
-0.6351 |
|
72 |
L |
A |
0.0000 |
|
73 |
T |
A |
-0.7053 |
|
74 |
I |
A |
0.0000 |
|
75 |
S |
A |
-1.9756 |
|
76 |
R |
A |
-2.9806 |
|
77 |
V |
A |
0.0000 |
|
78 |
E |
A |
-2.6565 |
|
79 |
A |
A |
0.0000 |
|
80 |
E |
A |
-2.3762 |
|
81 |
D |
A |
0.0000 |
|
82 |
A |
A |
-1.5234 |
|
83 |
A |
A |
0.0000 |
|
84 |
T |
A |
-0.4681 |
|
85 |
Y |
A |
0.0000 |
|
86 |
Y |
A |
0.0000 |
|
87 |
C |
A |
0.0000 |
|
88 |
Q |
A |
0.0000 |
|
89 |
Q |
A |
0.0000 |
|
90 |
W |
A |
0.0000 |
|
91 |
T |
A |
-0.3237 |
|
92 |
S |
A |
-0.9542 |
|
93 |
N |
A |
-1.6358 |
|
94 |
P |
A |
0.0000 |
|
95 |
P |
A |
0.0000 |
|
96 |
T |
A |
0.0000 |
|
97 |
F |
A |
0.2112 |
|
98 |
G |
A |
-0.2328 |
|
99 |
G |
A |
-0.8071 |
|
100 |
G |
A |
-0.4395 |
|
101 |
T |
A |
0.0000 |
|
102 |
K |
A |
-0.5663 |
|
103 |
L |
A |
0.0000 |
|
104 |
E |
A |
-0.8446 |
|
105 |
I |
A |
0.0000 |
|
106 |
K |
A |
-1.0325 |
|
107 |
R |
A |
-0.7743 |
|
108 |
T |
A |
0.2533 |
|
109 |
V |
A |
1.0458 |
|
110 |
A |
A |
0.3065 |
|
111 |
A |
A |
-0.0857 |
|
112 |
P |
A |
0.0000 |
|
113 |
S |
A |
-0.2313 |
|
114 |
V |
A |
0.0000 |
|
115 |
F |
A |
-0.0673 |
|
116 |
I |
A |
0.0000 |
|
117 |
F |
A |
0.0000 |
|
118 |
P |
A |
-0.4685 |
|
119 |
P |
A |
0.0000 |
|
120 |
S |
A |
-1.3281 |
|
121 |
D |
A |
-2.5465 |
|
122 |
E |
A |
-2.2195 |
|
123 |
Q |
A |
0.0000 |
|
124 |
L |
A |
-1.4168 |
|
125 |
K |
A |
-1.7995 |
|
126 |
S |
A |
-1.2013 |
|
127 |
G |
A |
-1.1316 |
|
128 |
T |
A |
-0.9743 |
|
129 |
A |
A |
0.0000 |
|
130 |
S |
A |
0.0000 |
|
131 |
V |
A |
0.0000 |
|
132 |
V |
A |
0.0000 |
|
133 |
C |
A |
0.0000 |
|
134 |
L |
A |
0.0000 |
|
135 |
L |
A |
0.0000 |
|
136 |
N |
A |
0.0000 |
|
137 |
N |
A |
-0.9832 |
|
138 |
F |
A |
0.0000 |
|
139 |
Y |
A |
0.0000 |
|
140 |
P |
A |
0.0000 |
|
141 |
R |
A |
-3.0336 |
|
142 |
E |
A |
-3.3037 |
|
143 |
A |
A |
-2.4359 |
|
144 |
K |
A |
-2.4277 |
|
145 |
V |
A |
-1.3393 |
|
146 |
Q |
A |
-0.7287 |
|
147 |
W |
A |
0.0000 |
|
148 |
K |
A |
-0.6450 |
|
149 |
V |
A |
0.0000 |
|
150 |
D |
A |
-1.8477 |
|
151 |
N |
A |
-1.3571 |
|
152 |
A |
A |
-0.2469 |
|
153 |
L |
A |
0.7318 |
|
154 |
Q |
A |
-0.2254 |
|
155 |
S |
A |
-0.7284 |
|
156 |
G |
A |
-1.2849 |
|
157 |
N |
A |
-1.4504 |
|
158 |
S |
A |
-1.1255 |
|
159 |
Q |
A |
-1.7071 |
|
160 |
E |
A |
-1.6596 |
|
161 |
S |
A |
-0.8336 |
|
162 |
V |
A |
-0.8172 |
|
163 |
T |
A |
-1.0416 |
|
164 |
E |
A |
-2.0490 |
|
165 |
Q |
A |
-1.9891 |
|
166 |
D |
A |
-1.8554 |
|
167 |
S |
A |
-2.2248 |
|
168 |
K |
A |
-2.5717 |
|
169 |
D |
A |
-1.7496 |
|
170 |
S |
A |
0.0000 |
|
171 |
T |
A |
0.0000 |
|
172 |
Y |
A |
0.0000 |
|
173 |
S |
A |
0.0000 |
|
174 |
L |
A |
0.0000 |
|
175 |
S |
A |
0.0000 |
|
176 |
S |
A |
0.0000 |
|
177 |
T |
A |
-0.1318 |
|
178 |
L |
A |
0.6361 |
|
179 |
T |
A |
-0.0243 |
|
180 |
L |
A |
-0.4977 |
|
181 |
S |
A |
-1.1127 |
|
182 |
K |
A |
-1.9454 |
|
183 |
A |
A |
-1.8648 |
|
184 |
D |
A |
-2.7869 |
|
185 |
Y |
A |
0.0000 |
|
186 |
E |
A |
-3.7866 |
|
187 |
K |
A |
-3.6977 |
|
188 |
H |
A |
-3.1143 |
|
189 |
K |
A |
-3.3425 |
|
190 |
V |
A |
0.0000 |
|
191 |
Y |
A |
0.0000 |
|
192 |
A |
A |
0.0000 |
|
193 |
C |
A |
0.0000 |
|
194 |
E |
A |
-0.8038 |
|
195 |
V |
A |
0.0000 |
|
196 |
T |
A |
-1.2038 |
|
197 |
H |
A |
0.0000 |
|
198 |
Q |
A |
-1.5126 |
|
199 |
G |
A |
-0.2089 |
|
200 |
L |
A |
-0.2087 |
|
201 |
S |
A |
-0.4971 |
|
202 |
S |
A |
-0.4577 |
|
203 |
P |
A |
-0.3938 |
|
204 |
V |
A |
-0.0145 |
|
205 |
T |
A |
-0.3804 |
|
206 |
K |
A |
-0.5684 |
|
207 |
S |
A |
-0.6402 |
|
208 |
F |
A |
-1.1320 |
|
209 |
N |
A |
-2.1589 |
|
210 |
R |
A |
-2.7743 |
|
211 |
G |
A |
-2.4130 |
|
212 |
E |
A |
-2.6050 |
|
1 |
Q |
A |
-0.8699 |
|
2 |
V |
A |
0.2422 |
|
3 |
Q |
A |
-0.9830 |
|
4 |
L |
A |
0.0000 |
|
5 |
Q |
A |
-1.9026 |
|
6 |
Q |
A |
-1.1187 |
|
7 |
P |
A |
-0.8397 |
|
8 |
G |
A |
-0.9439 |
|
9 |
A |
A |
-0.6960 |
|
10 |
E |
A |
-0.7971 |
|
11 |
L |
A |
-0.1937 |
|
12 |
V |
A |
0.0000 |
|
13 |
K |
A |
-1.8578 |
|
14 |
P |
A |
-1.2883 |
|
15 |
G |
A |
-1.1806 |
|
16 |
A |
A |
-0.9768 |
|
17 |
S |
A |
-1.0651 |
|
18 |
V |
A |
-0.9319 |
|
19 |
K |
A |
-1.4452 |
|
20 |
M |
A |
0.0000 |
|
21 |
S |
A |
-0.8339 |
|
22 |
C |
A |
0.0000 |
|
23 |
K |
A |
-1.7222 |
|
24 |
A |
A |
0.0000 |
|
25 |
S |
A |
-0.8821 |
|
26 |
G |
A |
-0.4448 |
|
27 |
Y |
A |
-0.0299 |
|
28 |
T |
A |
0.0447 |
|
29 |
F |
A |
0.0000 |
|
30 |
T |
A |
-0.6979 |
|
31 |
S |
A |
0.0135 |
|
32 |
Y |
A |
0.4127 |
|
33 |
N |
A |
-0.1993 |
|
34 |
M |
A |
0.0000 |
|
35 |
H |
A |
0.0000 |
|
36 |
W |
A |
0.0000 |
|
37 |
V |
A |
0.0000 |
|
38 |
K |
A |
-0.5059 |
|
39 |
Q |
A |
-0.6869 |
|
40 |
T |
A |
-1.1028 |
|
41 |
P |
A |
-1.0191 |
|
42 |
G |
A |
-1.5186 |
|
43 |
R |
A |
-2.3797 |
|
44 |
G |
A |
-1.3942 |
|
45 |
L |
A |
0.0000 |
|
46 |
E |
A |
-1.0848 |
|
47 |
W |
A |
0.0000 |
|
48 |
I |
A |
0.0000 |
|
49 |
G |
A |
0.0000 |
|
50 |
A |
A |
0.0000 |
|
51 |
I |
A |
0.0000 |
|
52 |
Y |
A |
-0.7189 |
|
53 |
P |
A |
0.0000 |
|
54 |
G |
A |
-1.3813 |
|
55 |
N |
A |
-2.0748 |
|
56 |
G |
A |
-2.1617 |
|
57 |
D |
A |
-2.4085 |
|
58 |
T |
A |
-1.1321 |
|
59 |
S |
A |
-0.8309 |
|
60 |
Y |
A |
-0.9827 |
|
61 |
N |
A |
0.0000 |
|
62 |
Q |
A |
-2.8058 |
|
63 |
K |
A |
-2.9112 |
|
64 |
F |
A |
0.0000 |
|
65 |
K |
A |
-2.8865 |
|
66 |
G |
A |
-1.9332 |
|
67 |
K |
A |
-1.6974 |
|
68 |
A |
A |
0.0000 |
|
69 |
T |
A |
-0.8982 |
|
70 |
L |
A |
0.0000 |
|
71 |
T |
A |
-0.5338 |
|
72 |
A |
A |
-1.0965 |
|
73 |
D |
A |
-1.9416 |
|
74 |
K |
A |
-2.3726 |
|
75 |
S |
A |
-1.3622 |
|
76 |
S |
A |
-1.2629 |
|
77 |
S |
A |
-1.3292 |
|
78 |
T |
A |
0.0000 |
|
79 |
A |
A |
0.0000 |
|
80 |
Y |
A |
-0.5443 |
|
81 |
M |
A |
0.0000 |
|
82 |
Q |
A |
-1.3092 |
|
83 |
L |
A |
0.0000 |
|
84 |
S |
A |
-0.8621 |
|
85 |
S |
A |
-0.8622 |
|
86 |
L |
A |
0.0000 |
|
87 |
T |
A |
-1.2282 |
|
88 |
S |
A |
-1.4148 |
|
89 |
E |
A |
-1.9670 |
|
90 |
D |
A |
0.0000 |
|
91 |
S |
A |
-0.6411 |
|
92 |
A |
A |
0.0000 |
|
93 |
V |
A |
0.3372 |
|
94 |
Y |
A |
0.0000 |
|
95 |
Y |
A |
0.0000 |
|
96 |
C |
A |
0.0000 |
|
97 |
A |
A |
0.0000 |
|
98 |
R |
A |
0.0000 |
|
99 |
S |
A |
0.0000 |
|
100 |
T |
A |
0.0000 |
|
101 |
Y |
A |
1.7119 |
|
102 |
Y |
A |
1.6293 |
|
103 |
G |
A |
0.3853 |
|
104 |
G |
A |
0.0777 |
|
105 |
D |
A |
0.4688 |
|
106 |
W |
A |
0.9818 |
|
107 |
Y |
A |
0.0000 |
|
108 |
F |
A |
0.0000 |
|
109 |
N |
A |
-0.4973 |
|
110 |
V |
A |
0.0000 |
|
111 |
W |
A |
-0.3617 |
|
112 |
G |
A |
0.0000 |
|
113 |
A |
A |
-0.4406 |
|
114 |
G |
A |
-0.3454 |
|
115 |
T |
A |
0.0000 |
|
116 |
T |
A |
-0.1517 |
|
117 |
V |
A |
0.0000 |
|
118 |
T |
A |
-0.3001 |
|
119 |
V |
A |
0.0000 |
|
120 |
S |
A |
-0.5774 |
|
121 |
A |
A |
-0.5800 |
|
122 |
A |
A |
-0.3898 |
|
123 |
S |
A |
-0.5226 |
|
124 |
T |
A |
-0.7877 |
|
125 |
K |
A |
-1.1260 |
|
126 |
G |
A |
-1.3097 |
|
127 |
P |
A |
-0.5442 |
|
128 |
S |
A |
-0.3743 |
|
129 |
V |
A |
0.0000 |
|
130 |
F |
A |
-0.6355 |
|
131 |
P |
A |
-1.0779 |
|
132 |
L |
A |
0.0000 |
|
133 |
A |
A |
-1.0492 |
|
134 |
P |
A |
0.0000 |
|
135 |
S |
A |
-1.1599 |
|
136 |
S |
A |
-1.0970 |
|
137 |
K |
A |
-1.2791 |
|
138 |
S |
A |
-0.8168 |
|
139 |
T |
A |
-0.7327 |
|
140 |
S |
A |
-0.7070 |
|
141 |
G |
A |
-0.7709 |
|
142 |
G |
A |
-0.7601 |
|
143 |
T |
A |
-0.5251 |
|
144 |
A |
A |
-0.3737 |
|
145 |
A |
A |
0.0000 |
|
146 |
L |
A |
0.0000 |
|
147 |
G |
A |
0.0000 |
|
148 |
C |
A |
0.0000 |
|
149 |
L |
A |
0.0000 |
|
150 |
V |
A |
0.0000 |
|
151 |
K |
A |
0.0000 |
|
152 |
D |
A |
-0.4968 |
|
153 |
Y |
A |
0.0000 |
|
154 |
F |
A |
-0.1481 |
|
155 |
P |
A |
0.0000 |
|
156 |
E |
A |
-0.5284 |
|
157 |
P |
A |
-0.7497 |
|
158 |
V |
A |
-0.3640 |
|
159 |
T |
A |
-0.5424 |
|
160 |
V |
A |
-0.1684 |
|
161 |
S |
A |
-0.3977 |
|
162 |
W |
A |
0.0000 |
|
163 |
N |
A |
-0.9154 |
|
164 |
S |
A |
-0.7275 |
|
165 |
G |
A |
-0.6179 |
|
166 |
A |
A |
-0.2672 |
|
167 |
L |
A |
-0.0896 |
|
168 |
T |
A |
-0.2255 |
|
169 |
S |
A |
-0.2840 |
|
170 |
G |
A |
-0.3435 |
|
171 |
V |
A |
0.1365 |
|
172 |
H |
A |
-0.1198 |
|
173 |
T |
A |
-0.0044 |
|
174 |
F |
A |
0.0000 |
|
175 |
P |
A |
-0.3376 |
|
176 |
A |
A |
0.2908 |
|
177 |
V |
A |
0.5889 |
|
178 |
L |
A |
1.3493 |
|
179 |
Q |
A |
0.2532 |
|
180 |
S |
A |
-0.0551 |
|
181 |
S |
A |
-0.2531 |
|
182 |
G |
A |
-0.0380 |
|
183 |
L |
A |
0.1786 |
|
184 |
Y |
A |
0.5149 |
|
185 |
S |
A |
0.0000 |
|
186 |
L |
A |
0.0000 |
|
187 |
S |
A |
0.0000 |
|
188 |
S |
A |
0.0000 |
|
189 |
V |
A |
0.0000 |
|
190 |
V |
A |
0.0000 |
|
191 |
T |
A |
-0.1503 |
|
192 |
V |
A |
0.0000 |
|
193 |
P |
A |
-0.4904 |
|
194 |
S |
A |
-0.5596 |
|
195 |
S |
A |
-0.6285 |
|
196 |
S |
A |
-0.6408 |
|
197 |
L |
A |
-0.8509 |
|
198 |
G |
A |
-0.7591 |
|
199 |
T |
A |
-0.8544 |
|
200 |
Q |
A |
-1.3222 |
|
201 |
T |
A |
-1.2639 |
|
202 |
Y |
A |
0.0000 |
|
203 |
I |
A |
-1.4148 |
|
204 |
C |
A |
0.0000 |
|
205 |
N |
A |
-1.7348 |
|
206 |
V |
A |
0.0000 |
|
207 |
N |
A |
-1.8857 |
|
208 |
H |
A |
0.0000 |
|
209 |
K |
A |
-2.8010 |
|
210 |
P |
A |
-1.5729 |
|
211 |
S |
A |
-1.8040 |
|
212 |
N |
A |
-2.5488 |
|
213 |
T |
A |
-2.0648 |
|
214 |
K |
A |
-2.7341 |
|
215 |
V |
A |
-1.6681 |
|
216 |
D |
A |
-2.6367 |
|
217 |
K |
A |
-2.2791 |
|
218 |
K |
A |
-2.6162 |
|
219 |
V |
A |
0.0000 |
|
220 |
E |
A |
-2.5762 |
|
221 |
P |
A |
-1.8930 |
|
222 |
K |
A |
-1.9376 |
|
223 |
S |
A |
-1.2247 |
|