Project name: 4LIK

Chain sequence(s)	A: METFDPTELPELLKLYYRRRLFPYSSQYYRRWLNYGGVIKNYFQHREFSSFTLKDDIYIRYQSFNNQSDLEKEMQKMNPYKIDIGAVYSHRPNQHNTVKLGAFQAQEKELVFDIIDMTDYDDVRRCCSSADICPKCWTLMTMAIRIIDRALKEDFGFKHRLWVYSGRRGVHCWVCDESVRKLSSSAVRSGIVEYLSLVKGGQDVKKKVHLIIHHPPFIRKSINIIKKYFEEYALVNQDILENKESWDKILALVPETIHDELQQSFQKSHNSLQRWEHLKKVALEWEIMLQYCFPRLLDDINVSKGINHLLKSPFSVHPKTGRISVPIDLQKVDQFDPFTVPTISFICRELDATRRDYKKTSLAPYVKVFEEHFLENLDKSRK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.3845
• Maximal score value: 1.6478
• Average score: -1.0428
• Total score value: -384.8085

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	-0.2302
2	E	A	-1.7001
3	T	A	-1.4597
4	F	A	0.0000
5	D	A	-2.6052
6	P	A	-1.7805
7	T	A	-1.5246
8	E	A	-1.9366
9	L	A	0.0000
10	P	A	-1.7274
11	E	A	-2.4170
12	L	A	0.0000
13	L	A	0.0000
14	K	A	-2.5074
15	L	A	-1.8944
16	Y	A	0.0000
17	Y	A	0.0000
18	R	A	-3.1140
19	R	A	-2.6210
20	L	A	0.0000
21	F	A	0.0000
22	P	A	0.0000
23	Y	A	0.0000
24	S	A	-0.8711
25	Q	A	-1.1541
26	Y	A	0.0000
27	Y	A	-1.2199
28	R	A	-2.5698
29	W	A	0.0000
30	L	A	0.0000
31	N	A	-1.1300
32	Y	A	0.0000
33	G	A	-1.2765
34	G	A	-0.5427
35	V	A	0.7172
36	I	A	0.2907
37	K	A	-1.3402
38	N	A	-1.6699
39	Y	A	0.0000
40	F	A	0.0000
41	Q	A	-1.9822
42	H	A	-2.0374
43	R	A	0.0000
44	E	A	0.0000
45	F	A	0.0000
46	S	A	0.0000
47	F	A	0.0000
48	T	A	0.0000
49	L	A	-0.8118
50	K	A	-2.4565
51	D	A	-2.7683
52	D	A	-2.1123
53	I	A	0.3725
54	Y	A	0.9448
55	I	A	0.8338
56	R	A	-0.3134
57	Y	A	-1.1305
58	Q	A	-1.1402
59	S	A	-1.6573
60	F	A	0.0000
61	N	A	-2.1966
62	N	A	-1.7475
63	Q	A	-1.7490
64	S	A	-1.7458
65	D	A	-2.2747
66	L	A	0.0000
67	E	A	-2.4825
68	K	A	-3.2152
69	E	A	-2.4600
70	M	A	0.0000
71	Q	A	-2.7952
72	K	A	-2.8211
73	M	A	-1.5575
74	N	A	-1.6712
75	P	A	0.0000
76	Y	A	-0.5095
77	K	A	-0.7496
78	I	A	0.0000
79	D	A	-0.6195
80	I	A	0.0000
81	G	A	0.0000
82	A	A	0.0000
83	V	A	0.0000
84	Y	A	0.0000
85	S	A	-1.3561
86	H	A	-2.1560
87	R	A	-3.1072
88	P	A	0.0000
89	N	A	-2.8112
90	Q	A	-2.8147
91	H	A	-2.3549
92	N	A	-1.9150
93	T	A	-1.3053
94	V	A	-1.3821
95	K	A	-1.1191
96	L	A	0.3126
97	G	A	-0.2516
98	A	A	-0.4962
99	F	A	-1.2152
100	Q	A	-1.5209
101	A	A	-1.5187
102	Q	A	-2.0295
103	E	A	0.0000
104	K	A	0.0000
105	E	A	0.0000
106	L	A	0.0000
107	V	A	0.0000
108	F	A	0.0000
109	D	A	-0.8964
110	I	A	0.0000
111	D	A	-1.4385
112	M	A	0.0000
113	T	A	-2.0996
114	D	A	-3.1590
115	Y	A	0.0000
116	D	A	-3.4919
117	D	A	-3.6385
118	V	A	0.0000
119	R	A	0.0000
120	R	A	-1.8271
121	C	A	-1.0043
122	C	A	-1.0526
123	S	A	-1.1651
124	S	A	-1.6876
125	A	A	-1.2182
126	D	A	-1.8851
127	I	A	0.0000
128	C	A	-0.6151
129	P	A	-0.6080
130	K	A	-0.9731
131	C	A	0.0000
132	W	A	0.0000
133	T	A	-0.7072
134	L	A	0.0000
135	M	A	0.0000
136	T	A	0.0000
137	M	A	0.0000
138	A	A	0.0000
139	I	A	0.0000
140	R	A	-1.0802
141	I	A	0.0000
142	I	A	0.0000
143	D	A	0.0000
144	R	A	-1.5945
145	A	A	0.0000
146	L	A	0.0000
147	K	A	-2.6436
148	E	A	-2.8865
149	D	A	-1.7770
150	F	A	-0.8996
151	G	A	-1.5612
152	F	A	-1.6255
153	K	A	-2.3856
154	H	A	0.0000
155	R	A	-0.7685
156	L	A	0.0000
157	W	A	0.0000
158	V	A	0.0000
159	Y	A	0.0000
160	S	A	0.0000
161	G	A	0.0000
162	R	A	-1.2525
163	R	A	-1.0186
164	G	A	0.0000
165	V	A	0.0000
166	H	A	0.0000
167	C	A	0.0000
168	W	A	0.0000
169	V	A	0.0000
170	C	A	0.0000
171	D	A	-1.2412
172	E	A	-1.4417
173	S	A	-1.0271
174	V	A	0.0000
175	R	A	0.0000
176	K	A	-1.9355
177	L	A	-0.5617
178	S	A	-0.3514
179	S	A	-0.3495
180	A	A	0.3118
181	V	A	0.5438
182	R	A	0.0000
183	S	A	-0.5923
184	G	A	-0.4953
185	I	A	0.0000
186	V	A	0.0000
187	E	A	-1.7173
188	Y	A	-0.5204
189	L	A	0.0000
190	S	A	-0.8188
191	L	A	-0.2866
192	V	A	-0.8202
193	K	A	-2.1284
194	G	A	-2.0303
195	G	A	-2.3960
196	Q	A	-3.3569
197	D	A	-2.7157
198	V	A	-2.1862
199	K	A	-2.7354
200	K	A	-1.7643
201	K	A	0.0000
202	V	A	0.0000
203	H	A	-0.3906
204	L	A	1.3895
208	I	A	1.6478
209	H	A	0.1238
210	P	A	-0.6977
211	F	A	0.0000
212	I	A	-0.4179
213	R	A	-1.5820
214	K	A	-1.8778
215	S	A	0.0000
216	I	A	0.0000
217	N	A	-1.9628
218	I	A	-1.5462
219	I	A	0.0000
220	K	A	-2.3271
221	K	A	-2.6597
222	Y	A	-1.8600
223	F	A	0.0000
224	E	A	-2.0501
225	E	A	-2.2240
226	Y	A	0.0000
227	A	A	0.0000
228	L	A	0.0000
229	V	A	0.0437
230	N	A	-0.8403
231	Q	A	0.0000
232	D	A	-1.3102
233	I	A	0.0000
234	L	A	0.0000
235	E	A	-2.8114
236	N	A	-3.5109
237	K	A	-4.2595
238	E	A	-3.9519
239	S	A	0.0000
240	W	A	-3.0772
241	D	A	-3.7790
242	K	A	-3.5633
243	I	A	0.0000
244	L	A	0.0000
245	A	A	-1.7710
246	L	A	0.0000
247	V	A	0.0000
248	P	A	-1.0375
249	E	A	-1.9291
250	T	A	-1.4896
251	I	A	-1.5592
252	H	A	-2.7258
253	D	A	-3.4554
254	E	A	-3.4369
255	L	A	0.0000
256	Q	A	-4.0142
257	Q	A	-3.7719
258	S	A	-3.1897
259	F	A	0.0000
260	Q	A	-3.5934
261	K	A	-3.1530
262	S	A	-2.3552
263	H	A	-2.4080
264	N	A	-2.0450
265	S	A	0.0000
266	L	A	-1.1106
267	Q	A	-1.9176
268	R	A	0.0000
269	W	A	0.0000
270	E	A	-2.9328
271	H	A	-2.4607
272	L	A	0.0000
273	K	A	-2.6996
274	K	A	-2.5286
275	V	A	-0.6801
276	A	A	-0.3648
292	L	A	0.2605
293	E	A	-0.5417
294	W	A	-0.0968
295	E	A	0.1113
296	I	A	0.0000
297	M	A	0.0000
298	L	A	0.0000
299	Q	A	0.0000
300	Y	A	0.0000
301	C	A	0.0000
302	F	A	0.0000
303	P	A	0.0000
304	R	A	0.0000
305	L	A	0.0000
306	D	A	-2.5287
307	I	A	-1.2864
308	N	A	-1.8288
309	V	A	0.0000
310	S	A	0.0000
311	K	A	-1.5959
312	G	A	-1.0092
313	I	A	-1.2507
314	N	A	-1.7194
315	H	A	-1.2125
316	L	A	-0.4547
317	L	A	0.0000
318	K	A	-0.6505
319	S	A	0.0000
320	P	A	0.0000
321	F	A	0.0000
322	S	A	0.0000
323	V	A	0.0000
324	H	A	-0.9685
325	P	A	-1.2835
326	K	A	-2.1952
327	T	A	-1.5307
328	G	A	0.0000
329	R	A	-0.4523
330	I	A	0.0000
331	S	A	0.0000
332	V	A	0.0000
333	P	A	0.0000
334	I	A	0.0000
335	D	A	-1.4524
336	L	A	-1.2428
337	Q	A	-2.2398
338	K	A	-2.9965
339	V	A	0.0000
340	D	A	-3.1714
341	Q	A	-2.8128
342	F	A	-1.7188
343	D	A	-1.1136
344	P	A	0.0000
345	F	A	0.0626
346	T	A	-0.1004
347	V	A	0.0000
348	P	A	0.0000
349	T	A	0.0000
350	I	A	0.0000
351	S	A	-1.0067
352	F	A	-0.4774
353	I	A	0.0000
354	C	A	0.0000
355	R	A	-2.4285
356	E	A	-2.0291
357	L	A	0.0000
358	D	A	-2.8096
359	A	A	-2.0808
380	T	A	-2.2818
381	R	A	-3.2121
382	D	A	-2.3389
383	Y	A	-1.3392
384	K	A	-2.2829
385	K	A	-2.6474
386	T	A	0.0000
387	S	A	-0.4869
388	L	A	0.0000
389	A	A	-1.0447
390	P	A	-1.1225
391	Y	A	-0.3996
392	V	A	-0.9577
393	K	A	-1.8619
394	V	A	-1.0333
395	F	A	0.0000
396	E	A	-2.1087
397	H	A	-2.3835
398	F	A	-1.8138
399	L	A	0.0000
400	E	A	-3.7114
401	N	A	-3.5697
402	L	A	0.0000
403	D	A	-4.3845
404	K	A	-4.2188
405	S	A	-3.3142
406	R	A	-3.1363
407	K	A	-3.4261