Project name: 4OQV
Status: done
submitted: 2018-02-20 13:27:52, status changed: 2018-02-20 13:39:36
Settings
Chain sequence(s)
|
A: DERFYAEHLMPTLQGLLDPESAHRLAVRFTSSLGLLPRARFQDSDMMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVVFRLPEDQQAVINRYYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPGKAELRRLLTKVLQERDGLRRVVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTTNTTVSRPAGLQGALRSETGGLSGKPLRDLLSTQTIREMYALTQGRVPIIGVVGGVSSGQDALEKIRRAGASLVQLYTALTFWWGPPVVGKVKRELEALLKEQGFGGVTDDAIGADHR
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-3.5312
-
Maximal score value
-
1.5426
-
Average score
-
-0.8863
-
Total score value
-
-312.8702
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
34 |
D |
A |
-2.6271 |
|
35 |
E |
A |
-2.9759 |
|
36 |
R |
A |
-2.9100 |
|
37 |
F |
A |
-1.1908 |
|
38 |
Y |
A |
-1.1837 |
|
39 |
A |
A |
-1.7201 |
|
40 |
E |
A |
-2.4378 |
|
41 |
H |
A |
-1.5482 |
|
42 |
L |
A |
-0.2194 |
|
43 |
M |
A |
-0.0288 |
|
44 |
P |
A |
-0.5234 |
|
45 |
T |
A |
-0.1930 |
|
46 |
L |
A |
0.2687 |
|
47 |
Q |
A |
-0.3218 |
|
48 |
G |
A |
-0.0421 |
|
49 |
L |
A |
1.1273 |
|
50 |
L |
A |
0.2545 |
|
51 |
D |
A |
-0.9782 |
|
52 |
P |
A |
-0.7400 |
|
53 |
E |
A |
0.0000 |
|
54 |
S |
A |
-0.4111 |
|
55 |
A |
A |
-0.3992 |
|
56 |
H |
A |
-0.6882 |
|
57 |
R |
A |
-1.0420 |
|
58 |
L |
A |
-0.3983 |
|
59 |
A |
A |
-0.1084 |
|
60 |
V |
A |
0.0000 |
|
61 |
R |
A |
-0.9563 |
|
62 |
F |
A |
0.8101 |
|
63 |
T |
A |
0.0000 |
|
64 |
S |
A |
0.2019 |
|
65 |
L |
A |
1.5244 |
|
66 |
G |
A |
0.6625 |
|
67 |
L |
A |
1.5426 |
|
68 |
L |
A |
0.5933 |
|
69 |
P |
A |
-1.0499 |
|
70 |
R |
A |
-2.3147 |
|
71 |
A |
A |
-2.0671 |
|
72 |
R |
A |
-2.7828 |
|
73 |
F |
A |
-1.9173 |
|
74 |
Q |
A |
-2.1167 |
|
75 |
D |
A |
-2.1460 |
|
76 |
S |
A |
-1.9531 |
|
77 |
D |
A |
-2.6306 |
|
78 |
M |
A |
-1.9190 |
|
79 |
L |
A |
0.0000 |
|
80 |
E |
A |
-2.9730 |
|
81 |
V |
A |
0.0000 |
|
82 |
R |
A |
-2.6375 |
|
83 |
V |
A |
-1.2517 |
|
84 |
L |
A |
-0.6748 |
|
85 |
G |
A |
-1.0507 |
|
86 |
H |
A |
-1.8557 |
|
87 |
K |
A |
-2.8309 |
|
88 |
F |
A |
0.0000 |
|
89 |
R |
A |
-2.3671 |
|
90 |
N |
A |
0.0000 |
|
91 |
P |
A |
0.0000 |
|
92 |
V |
A |
0.0000 |
|
93 |
G |
A |
0.0000 |
|
94 |
I |
A |
0.0000 |
|
95 |
A |
A |
0.0000 |
|
96 |
A |
A |
-0.0930 |
|
97 |
G |
A |
0.0334 |
|
98 |
F |
A |
0.0000 |
|
99 |
D |
A |
0.0000 |
|
100 |
K |
A |
0.0000 |
|
101 |
H |
A |
0.0000 |
|
102 |
G |
A |
0.0000 |
|
103 |
E |
A |
-0.8108 |
|
104 |
A |
A |
0.0000 |
|
105 |
V |
A |
0.0000 |
|
106 |
D |
A |
-0.8985 |
|
107 |
G |
A |
-0.5265 |
|
108 |
L |
A |
0.0000 |
|
109 |
Y |
A |
0.0000 |
|
110 |
K |
A |
-1.4358 |
|
111 |
M |
A |
0.0000 |
|
112 |
G |
A |
-1.0364 |
|
113 |
F |
A |
0.0000 |
|
114 |
G |
A |
0.0000 |
|
115 |
F |
A |
0.0000 |
|
116 |
V |
A |
0.0000 |
|
117 |
E |
A |
0.0000 |
|
118 |
I |
A |
0.0000 |
|
119 |
G |
A |
0.0000 |
|
120 |
S |
A |
-0.0495 |
|
121 |
V |
A |
0.0000 |
|
122 |
T |
A |
0.0000 |
|
123 |
P |
A |
-1.4608 |
|
124 |
K |
A |
-2.2096 |
|
125 |
P |
A |
-1.5366 |
|
126 |
Q |
A |
-2.0166 |
|
127 |
E |
A |
-2.2331 |
|
128 |
G |
A |
-1.5658 |
|
129 |
N |
A |
-1.3247 |
|
130 |
P |
A |
-1.6054 |
|
131 |
R |
A |
-1.9995 |
|
132 |
P |
A |
-1.6175 |
|
133 |
R |
A |
0.0000 |
|
134 |
V |
A |
0.0000 |
|
135 |
F |
A |
0.0000 |
|
136 |
R |
A |
-1.0536 |
|
137 |
L |
A |
0.0000 |
|
138 |
P |
A |
-1.4939 |
|
139 |
E |
A |
-2.4637 |
|
140 |
D |
A |
-2.3570 |
|
141 |
Q |
A |
-1.8785 |
|
142 |
A |
A |
0.0000 |
|
143 |
V |
A |
0.0000 |
|
144 |
I |
A |
0.0000 |
|
145 |
N |
A |
-0.7607 |
|
146 |
R |
A |
-0.9222 |
|
147 |
Y |
A |
-0.7350 |
|
148 |
G |
A |
-0.6228 |
|
149 |
F |
A |
-0.2417 |
|
150 |
N |
A |
-0.9528 |
|
151 |
S |
A |
0.0000 |
|
152 |
H |
A |
-0.8137 |
|
153 |
G |
A |
0.0000 |
|
154 |
L |
A |
0.0000 |
|
155 |
S |
A |
-0.5753 |
|
156 |
V |
A |
-0.3438 |
|
157 |
V |
A |
0.0000 |
|
158 |
E |
A |
-1.2836 |
|
159 |
H |
A |
-1.9363 |
|
160 |
R |
A |
-1.6996 |
|
161 |
L |
A |
0.0000 |
|
162 |
R |
A |
-2.8803 |
|
163 |
A |
A |
-1.8923 |
|
164 |
R |
A |
-2.0961 |
|
165 |
Q |
A |
-2.5131 |
|
166 |
Q |
A |
-2.7913 |
|
167 |
K |
A |
-3.0363 |
|
168 |
Q |
A |
0.0000 |
|
169 |
A |
A |
-2.4960 |
|
170 |
K |
A |
-3.5312 |
|
171 |
L |
A |
-2.4656 |
|
172 |
T |
A |
-2.5284 |
|
173 |
E |
A |
-3.4001 |
|
174 |
D |
A |
-3.3068 |
|
175 |
G |
A |
0.0000 |
|
176 |
L |
A |
0.0000 |
|
177 |
P |
A |
0.0000 |
|
178 |
L |
A |
0.0000 |
|
179 |
G |
A |
0.0000 |
|
180 |
V |
A |
0.0000 |
|
181 |
N |
A |
0.0000 |
|
182 |
L |
A |
0.0000 |
|
183 |
G |
A |
0.0000 |
|
184 |
K |
A |
-1.7462 |
|
185 |
N |
A |
0.0000 |
|
186 |
K |
A |
-2.0166 |
|
187 |
T |
A |
-0.8446 |
|
188 |
S |
A |
-0.7782 |
|
189 |
V |
A |
0.4938 |
|
190 |
D |
A |
-1.1622 |
|
191 |
A |
A |
-1.1974 |
|
192 |
A |
A |
-1.6371 |
|
193 |
E |
A |
-1.8515 |
|
194 |
D |
A |
-1.6350 |
|
195 |
Y |
A |
0.0000 |
|
196 |
A |
A |
0.0000 |
|
197 |
E |
A |
-1.4394 |
|
198 |
G |
A |
0.0000 |
|
199 |
V |
A |
0.0000 |
|
200 |
R |
A |
-1.0369 |
|
201 |
V |
A |
-0.2864 |
|
202 |
L |
A |
0.0000 |
|
203 |
G |
A |
0.0000 |
|
204 |
P |
A |
-1.0189 |
|
205 |
L |
A |
-0.6173 |
|
206 |
A |
A |
-0.2943 |
|
207 |
D |
A |
-0.3431 |
|
208 |
Y |
A |
0.0000 |
|
209 |
L |
A |
0.0000 |
|
210 |
V |
A |
0.0000 |
|
211 |
V |
A |
0.0000 |
|
212 |
N |
A |
-0.3394 |
|
213 |
V |
A |
-0.0790 |
|
214 |
S |
A |
-0.4762 |
|
215 |
S |
A |
-0.8524 |
|
216 |
P |
A |
-0.4739 |
|
226 |
G |
A |
-2.2138 |
|
227 |
K |
A |
-3.1161 |
|
228 |
A |
A |
-2.4257 |
|
229 |
E |
A |
-3.2055 |
|
230 |
L |
A |
-2.4427 |
|
231 |
R |
A |
-3.0942 |
|
232 |
R |
A |
-3.2210 |
|
233 |
L |
A |
-2.0872 |
|
234 |
L |
A |
0.0000 |
|
235 |
T |
A |
-1.7508 |
|
236 |
K |
A |
-2.1576 |
|
237 |
V |
A |
0.0000 |
|
238 |
L |
A |
0.0000 |
|
239 |
Q |
A |
-2.3848 |
|
240 |
E |
A |
-2.2529 |
|
241 |
R |
A |
-2.7422 |
|
242 |
D |
A |
-3.5287 |
|
243 |
G |
A |
-2.7435 |
|
244 |
L |
A |
-2.6041 |
|
245 |
R |
A |
-3.0387 |
|
246 |
R |
A |
-2.7324 |
|
247 |
V |
A |
-0.1899 |
|
248 |
H |
A |
-1.5223 |
|
249 |
R |
A |
-2.6380 |
|
250 |
P |
A |
0.0000 |
|
251 |
A |
A |
-0.7498 |
|
252 |
V |
A |
0.0000 |
|
253 |
L |
A |
0.0000 |
|
254 |
V |
A |
0.0000 |
|
255 |
K |
A |
0.0000 |
|
256 |
I |
A |
0.0000 |
|
257 |
A |
A |
-0.3205 |
|
258 |
P |
A |
0.0000 |
|
259 |
D |
A |
-0.6245 |
|
260 |
L |
A |
0.0000 |
|
261 |
T |
A |
-1.2794 |
|
262 |
S |
A |
-1.8091 |
|
263 |
Q |
A |
-2.5174 |
|
264 |
D |
A |
-2.3801 |
|
265 |
K |
A |
-2.2158 |
|
266 |
E |
A |
-3.1023 |
|
267 |
D |
A |
-2.6276 |
|
268 |
I |
A |
0.0000 |
|
269 |
A |
A |
0.0000 |
|
270 |
S |
A |
-1.7193 |
|
271 |
V |
A |
0.0000 |
|
272 |
V |
A |
0.0000 |
|
273 |
K |
A |
-1.8191 |
|
274 |
E |
A |
-2.1393 |
|
275 |
L |
A |
-1.1403 |
|
276 |
G |
A |
-0.9560 |
|
277 |
I |
A |
0.0000 |
|
278 |
D |
A |
-0.8285 |
|
279 |
G |
A |
0.0000 |
|
280 |
L |
A |
0.0000 |
|
281 |
I |
A |
0.0000 |
|
282 |
V |
A |
0.0000 |
|
283 |
T |
A |
0.0000 |
|
284 |
N |
A |
-0.6026 |
|
285 |
T |
A |
-0.2084 |
|
286 |
T |
A |
0.0000 |
|
287 |
V |
A |
1.2916 |
|
288 |
S |
A |
0.3092 |
|
289 |
R |
A |
-0.6075 |
|
290 |
P |
A |
-0.3903 |
|
291 |
A |
A |
-0.5139 |
|
292 |
G |
A |
-1.0554 |
|
293 |
L |
A |
0.0000 |
|
294 |
Q |
A |
-2.1453 |
|
295 |
G |
A |
0.0000 |
|
296 |
A |
A |
-0.7780 |
|
297 |
L |
A |
-0.5519 |
|
298 |
R |
A |
-1.9938 |
|
299 |
S |
A |
-1.0916 |
|
300 |
E |
A |
-0.9471 |
|
301 |
T |
A |
-0.3855 |
|
302 |
G |
A |
-0.2961 |
|
303 |
G |
A |
0.0513 |
|
304 |
L |
A |
0.0000 |
|
305 |
S |
A |
-0.5820 |
|
306 |
G |
A |
0.0000 |
|
307 |
K |
A |
-2.3467 |
|
308 |
P |
A |
-1.5579 |
|
309 |
L |
A |
0.0000 |
|
310 |
R |
A |
-2.0970 |
|
311 |
D |
A |
-2.3629 |
|
312 |
L |
A |
-1.1625 |
|
313 |
S |
A |
0.0000 |
|
314 |
T |
A |
0.0000 |
|
315 |
Q |
A |
-2.2350 |
|
316 |
T |
A |
0.0000 |
|
317 |
I |
A |
0.0000 |
|
318 |
R |
A |
-1.9394 |
|
319 |
E |
A |
-2.2289 |
|
320 |
M |
A |
0.0000 |
|
321 |
Y |
A |
0.0000 |
|
322 |
A |
A |
-1.1527 |
|
323 |
L |
A |
-1.2638 |
|
324 |
T |
A |
0.0000 |
|
325 |
Q |
A |
-2.0063 |
|
326 |
G |
A |
-1.6701 |
|
327 |
R |
A |
-2.4248 |
|
328 |
V |
A |
0.0000 |
|
329 |
P |
A |
-0.5528 |
|
330 |
I |
A |
0.0000 |
|
331 |
I |
A |
0.0000 |
|
332 |
G |
A |
0.0000 |
|
333 |
V |
A |
-0.0461 |
|
334 |
G |
A |
0.0000 |
|
335 |
G |
A |
-1.2494 |
|
336 |
V |
A |
0.0000 |
|
337 |
S |
A |
-0.6439 |
|
338 |
S |
A |
-0.8645 |
|
339 |
G |
A |
0.0000 |
|
340 |
Q |
A |
-1.7308 |
|
341 |
D |
A |
0.0000 |
|
342 |
A |
A |
0.0000 |
|
343 |
L |
A |
0.0000 |
|
344 |
E |
A |
-2.7271 |
|
345 |
K |
A |
0.0000 |
|
346 |
I |
A |
0.0000 |
|
347 |
R |
A |
-1.8994 |
|
348 |
A |
A |
0.0000 |
|
349 |
G |
A |
0.0000 |
|
350 |
A |
A |
0.0000 |
|
351 |
S |
A |
0.0000 |
|
352 |
L |
A |
0.0000 |
|
353 |
V |
A |
0.0000 |
|
354 |
Q |
A |
0.0000 |
|
355 |
L |
A |
0.0000 |
|
356 |
Y |
A |
0.2278 |
|
357 |
T |
A |
0.0000 |
|
358 |
A |
A |
0.0000 |
|
359 |
L |
A |
0.0000 |
|
360 |
T |
A |
-0.0162 |
|
361 |
F |
A |
0.0000 |
|
362 |
W |
A |
-0.5273 |
|
363 |
G |
A |
0.0000 |
|
364 |
P |
A |
-0.6710 |
|
365 |
P |
A |
-1.2402 |
|
366 |
V |
A |
0.0000 |
|
367 |
V |
A |
0.0000 |
|
368 |
G |
A |
-1.4557 |
|
369 |
K |
A |
-1.3317 |
|
370 |
V |
A |
0.0000 |
|
371 |
K |
A |
0.0000 |
|
372 |
R |
A |
-2.3581 |
|
373 |
E |
A |
-1.6751 |
|
374 |
L |
A |
0.0000 |
|
375 |
E |
A |
-1.8452 |
|
376 |
A |
A |
-1.8801 |
|
377 |
L |
A |
-1.9560 |
|
378 |
L |
A |
0.0000 |
|
379 |
K |
A |
-2.9851 |
|
380 |
E |
A |
-3.0816 |
|
381 |
Q |
A |
-2.3545 |
|
382 |
G |
A |
-2.1731 |
|
383 |
F |
A |
-1.7469 |
|
384 |
G |
A |
-1.6003 |
|
385 |
G |
A |
0.0000 |
|
386 |
V |
A |
0.0000 |
|
387 |
T |
A |
-1.4782 |
|
388 |
D |
A |
-1.8957 |
|
389 |
A |
A |
0.0000 |
|
390 |
I |
A |
-0.8559 |
|
391 |
G |
A |
0.0000 |
|
392 |
A |
A |
-1.8395 |
|
393 |
D |
A |
-2.3139 |
|
394 |
H |
A |
-2.1045 |
|
395 |
R |
A |
-2.4441 |
|