Project name: 10%_pd_6fxn
Status: done
submitted: 2018-08-14 19:32:34, status changed: 2018-08-14 19:43:52
Settings
Chain sequence(s)
|
A: SELTQDPAVSVALGQTVRVTCQGDSLRSYYASWYQQKPGQAPVLVIYGKNNRPSGIPDRFSGSSSGNTASLTITGAQAEDEADYYCSSRDSSGNHWVFGGGTELTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTVQLQQSGAEVKKPGSSVRVSCKASGGTFNNNAINWVRQAPGQGLEWMGGIIPMFGTAKYSQNFQGRVAITADESTGTASMELSSLRSEDTAVYYCARSRDLLLFPHHALSPWGRGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-3.1729
-
Maximal score value
-
2.6112
-
Average score
-
-0.7246
-
Total score value
-
-312.3167
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
2 |
S |
A |
-1.3907 |
|
3 |
E |
A |
-2.2158 |
|
4 |
L |
A |
-1.2955 |
|
5 |
T |
A |
-1.3804 |
|
6 |
Q |
A |
-1.3990 |
|
7 |
D |
A |
-2.3921 |
|
8 |
P |
A |
-1.7988 |
|
9 |
A |
A |
0.0000 |
|
10 |
V |
A |
-1.0493 |
|
11 |
S |
A |
-0.3602 |
|
12 |
V |
A |
0.0000 |
|
13 |
A |
A |
-0.0309 |
|
14 |
L |
A |
-0.2275 |
|
15 |
G |
A |
-0.9902 |
|
16 |
Q |
A |
-1.2984 |
|
17 |
T |
A |
-1.2214 |
|
18 |
V |
A |
0.0000 |
|
19 |
R |
A |
-1.8749 |
|
20 |
V |
A |
0.0000 |
|
21 |
T |
A |
-1.0889 |
|
22 |
C |
A |
0.0000 |
|
23 |
Q |
A |
-2.1585 |
|
24 |
G |
A |
-2.2499 |
|
25 |
D |
A |
-2.6143 |
|
26 |
S |
A |
0.0000 |
|
27 |
L |
A |
0.0000 |
|
28 |
R |
A |
-2.8156 |
|
29 |
S |
A |
-1.3045 |
|
30 |
Y |
A |
-0.3621 |
|
31 |
Y |
A |
-0.4629 |
|
32 |
A |
A |
0.0000 |
|
33 |
S |
A |
0.0000 |
|
34 |
W |
A |
0.0000 |
|
35 |
Y |
A |
0.0000 |
|
36 |
Q |
A |
0.0000 |
|
37 |
Q |
A |
0.0000 |
|
38 |
K |
A |
-1.6997 |
|
39 |
P |
A |
-1.3914 |
|
40 |
G |
A |
-1.3537 |
|
41 |
Q |
A |
-1.8651 |
|
42 |
A |
A |
-1.0782 |
|
43 |
P |
A |
0.0000 |
|
44 |
V |
A |
0.6647 |
|
45 |
L |
A |
0.0000 |
|
46 |
V |
A |
0.0000 |
|
47 |
I |
A |
0.0000 |
|
48 |
Y |
A |
-1.2701 |
|
49 |
G |
A |
0.0000 |
|
50 |
K |
A |
-2.6740 |
|
51 |
N |
A |
-2.4489 |
|
52 |
N |
A |
-2.4338 |
|
53 |
R |
A |
-2.1082 |
|
54 |
P |
A |
-0.8370 |
|
55 |
S |
A |
-0.7167 |
|
56 |
G |
A |
-0.8292 |
|
57 |
I |
A |
-0.8028 |
|
58 |
P |
A |
-1.3249 |
|
59 |
D |
A |
-2.1401 |
|
60 |
R |
A |
-1.2880 |
|
61 |
F |
A |
0.0000 |
|
62 |
S |
A |
-1.5654 |
|
63 |
G |
A |
-1.3987 |
|
64 |
S |
A |
-0.9168 |
|
65 |
S |
A |
-1.2961 |
|
66 |
S |
A |
-1.3062 |
|
67 |
G |
A |
-2.0970 |
|
68 |
N |
A |
-2.7267 |
|
69 |
T |
A |
-1.6845 |
|
70 |
A |
A |
0.0000 |
|
71 |
S |
A |
-0.7845 |
|
72 |
L |
A |
0.0000 |
|
73 |
T |
A |
-0.9179 |
|
74 |
I |
A |
0.0000 |
|
75 |
T |
A |
-1.2298 |
|
76 |
G |
A |
-0.9765 |
|
77 |
A |
A |
0.0000 |
|
78 |
Q |
A |
-1.4894 |
|
79 |
A |
A |
0.0000 |
|
80 |
E |
A |
-2.6459 |
|
81 |
D |
A |
0.0000 |
|
82 |
E |
A |
-2.0362 |
|
83 |
A |
A |
-1.7521 |
|
84 |
D |
A |
-1.7169 |
|
85 |
Y |
A |
0.0000 |
|
86 |
Y |
A |
0.0000 |
|
87 |
C |
A |
0.0000 |
|
88 |
S |
A |
-0.0570 |
|
89 |
S |
A |
0.0000 |
|
90 |
R |
A |
-0.5935 |
|
91 |
D |
A |
-1.0975 |
|
92 |
S |
A |
-1.2548 |
|
93 |
S |
A |
-0.6119 |
|
94 |
G |
A |
0.0000 |
|
95 |
N |
A |
-0.9263 |
|
96 |
H |
A |
-0.8349 |
|
97 |
W |
A |
0.0000 |
|
98 |
V |
A |
-0.4076 |
|
99 |
F |
A |
-0.3605 |
|
100 |
G |
A |
0.0000 |
|
101 |
G |
A |
-1.3489 |
|
102 |
G |
A |
-1.4948 |
|
103 |
T |
A |
0.0000 |
|
104 |
E |
A |
-2.5151 |
|
105 |
L |
A |
0.0000 |
|
106 |
T |
A |
-0.4889 |
|
107 |
V |
A |
0.0000 |
|
108 |
L |
A |
0.7154 |
|
109 |
G |
A |
-0.1088 |
|
110 |
Q |
A |
-0.5015 |
|
111 |
P |
A |
-1.0396 |
|
112 |
K |
A |
-2.2481 |
|
113 |
A |
A |
-1.3393 |
|
114 |
A |
A |
-0.7492 |
|
115 |
P |
A |
0.0000 |
|
116 |
S |
A |
-0.1785 |
|
117 |
V |
A |
0.0000 |
|
118 |
T |
A |
-0.2613 |
|
119 |
L |
A |
-0.2239 |
|
120 |
F |
A |
0.0000 |
|
121 |
P |
A |
-0.1690 |
|
122 |
P |
A |
0.0000 |
|
123 |
S |
A |
-1.2602 |
|
124 |
S |
A |
-1.7784 |
|
125 |
E |
A |
-2.7028 |
|
126 |
E |
A |
0.0000 |
|
127 |
L |
A |
-2.3095 |
|
128 |
Q |
A |
-2.5582 |
|
129 |
A |
A |
-2.1336 |
|
130 |
N |
A |
-2.8970 |
|
131 |
K |
A |
-3.0148 |
|
132 |
A |
A |
0.0000 |
|
133 |
T |
A |
0.0000 |
|
134 |
L |
A |
0.0000 |
|
135 |
V |
A |
0.0000 |
|
136 |
C |
A |
0.0000 |
|
137 |
L |
A |
0.0000 |
|
138 |
I |
A |
0.0000 |
|
139 |
S |
A |
0.0000 |
|
140 |
D |
A |
-1.2678 |
|
141 |
F |
A |
0.0000 |
|
142 |
Y |
A |
-1.2980 |
|
143 |
P |
A |
-1.1005 |
|
144 |
G |
A |
-0.8131 |
|
145 |
A |
A |
-0.3376 |
|
146 |
V |
A |
-0.1030 |
|
147 |
T |
A |
-0.0641 |
|
148 |
V |
A |
0.2723 |
|
149 |
A |
A |
-0.2005 |
|
150 |
W |
A |
0.0000 |
|
151 |
K |
A |
-0.9808 |
|
152 |
A |
A |
0.0000 |
|
153 |
D |
A |
-1.3377 |
|
154 |
S |
A |
-0.6794 |
|
155 |
S |
A |
-0.8343 |
|
156 |
P |
A |
-0.9061 |
|
157 |
V |
A |
-0.6234 |
|
158 |
K |
A |
-1.4676 |
|
159 |
A |
A |
-0.5339 |
|
160 |
G |
A |
-0.0608 |
|
161 |
V |
A |
0.5568 |
|
162 |
E |
A |
0.4171 |
|
163 |
T |
A |
0.3605 |
|
164 |
T |
A |
0.0969 |
|
165 |
T |
A |
-0.1368 |
|
166 |
P |
A |
-0.3937 |
|
167 |
S |
A |
-0.8079 |
|
168 |
K |
A |
-1.8195 |
|
169 |
Q |
A |
-1.4795 |
|
170 |
S |
A |
-1.4997 |
|
171 |
N |
A |
-2.1596 |
|
172 |
N |
A |
-2.3105 |
|
173 |
K |
A |
-2.1718 |
|
174 |
Y |
A |
-1.0908 |
|
175 |
A |
A |
0.0000 |
|
176 |
A |
A |
0.0000 |
|
177 |
S |
A |
0.0000 |
|
178 |
S |
A |
0.0000 |
|
179 |
Y |
A |
0.0000 |
|
180 |
L |
A |
1.4086 |
|
181 |
S |
A |
0.2536 |
|
182 |
L |
A |
-0.6338 |
|
183 |
T |
A |
-1.8924 |
|
184 |
P |
A |
-2.5327 |
|
185 |
E |
A |
-3.1729 |
|
186 |
Q |
A |
-2.5039 |
|
187 |
W |
A |
0.0000 |
|
188 |
K |
A |
-3.0698 |
|
189 |
S |
A |
0.0000 |
|
190 |
H |
A |
-2.3873 |
|
191 |
R |
A |
-2.5253 |
|
192 |
S |
A |
-1.5932 |
|
193 |
Y |
A |
0.0000 |
|
194 |
S |
A |
-0.9294 |
|
195 |
C |
A |
0.0000 |
|
196 |
Q |
A |
-0.9974 |
|
197 |
V |
A |
0.0000 |
|
198 |
T |
A |
-0.6344 |
|
199 |
H |
A |
0.0000 |
|
200 |
E |
A |
-2.3018 |
|
201 |
G |
A |
-1.4041 |
|
202 |
S |
A |
-0.7930 |
|
203 |
T |
A |
-0.6804 |
|
204 |
V |
A |
-0.5857 |
|
205 |
E |
A |
-1.9493 |
|
206 |
K |
A |
-1.4428 |
|
207 |
T |
A |
-0.9021 |
|
208 |
V |
A |
0.0000 |
|
209 |
A |
A |
-0.9862 |
|
210 |
P |
A |
-1.0716 |
|
2 |
V |
A |
1.0799 |
|
3 |
Q |
A |
-1.0107 |
|
4 |
L |
A |
-1.4239 |
|
5 |
Q |
A |
-2.1772 |
|
6 |
Q |
A |
-1.3732 |
|
7 |
S |
A |
-1.2402 |
|
8 |
G |
A |
-1.0081 |
|
9 |
A |
A |
0.0000 |
|
10 |
E |
A |
-1.2195 |
|
11 |
V |
A |
-0.7530 |
|
12 |
K |
A |
-1.5079 |
|
13 |
K |
A |
-2.3586 |
|
14 |
P |
A |
-1.9667 |
|
15 |
G |
A |
-1.5019 |
|
16 |
S |
A |
-1.2029 |
|
17 |
S |
A |
-1.3411 |
|
18 |
V |
A |
0.0000 |
|
19 |
R |
A |
-2.3642 |
|
20 |
V |
A |
0.0000 |
|
21 |
S |
A |
-1.1061 |
|
22 |
C |
A |
0.0000 |
|
23 |
K |
A |
-1.9294 |
|
24 |
A |
A |
0.0000 |
|
25 |
S |
A |
-0.9544 |
|
26 |
G |
A |
-0.7399 |
|
27 |
G |
A |
-1.2871 |
|
28 |
T |
A |
-1.6733 |
|
29 |
F |
A |
0.0000 |
|
30 |
N |
A |
-1.8778 |
|
31 |
N |
A |
-0.8697 |
|
32 |
N |
A |
0.0000 |
|
33 |
A |
A |
-0.0588 |
|
34 |
I |
A |
0.0000 |
|
35 |
N |
A |
0.0000 |
|
36 |
W |
A |
0.0000 |
|
37 |
V |
A |
0.0000 |
|
38 |
R |
A |
-0.4849 |
|
39 |
Q |
A |
-0.7562 |
|
40 |
A |
A |
-1.0267 |
|
41 |
P |
A |
-0.9127 |
|
42 |
G |
A |
-1.2383 |
|
43 |
Q |
A |
-1.8119 |
|
44 |
G |
A |
-1.3016 |
|
45 |
L |
A |
0.0000 |
|
46 |
E |
A |
-0.7096 |
|
47 |
W |
A |
0.0000 |
|
48 |
M |
A |
0.0000 |
|
49 |
G |
A |
0.0000 |
|
50 |
G |
A |
0.0000 |
|
51 |
I |
A |
0.3313 |
|
52 |
I |
A |
-0.0577 |
|
53 |
P |
A |
-0.6307 |
|
54 |
M |
A |
0.1838 |
|
55 |
F |
A |
1.5772 |
|
56 |
G |
A |
0.3354 |
|
57 |
T |
A |
-0.0286 |
|
58 |
A |
A |
-0.2030 |
|
59 |
K |
A |
-1.0734 |
|
60 |
Y |
A |
-0.5016 |
|
61 |
S |
A |
-1.2030 |
|
62 |
Q |
A |
-2.1461 |
|
63 |
N |
A |
-2.2114 |
|
64 |
F |
A |
0.0000 |
|
65 |
Q |
A |
-2.1003 |
|
66 |
G |
A |
-1.4731 |
|
67 |
R |
A |
-1.2124 |
|
68 |
V |
A |
-0.9838 |
|
69 |
A |
A |
-0.5910 |
|
70 |
I |
A |
0.0000 |
|
71 |
T |
A |
-0.5028 |
|
72 |
A |
A |
-1.3341 |
|
73 |
D |
A |
-2.7649 |
|
74 |
E |
A |
-2.8632 |
|
75 |
S |
A |
-1.6460 |
|
76 |
T |
A |
-1.4652 |
|
77 |
G |
A |
0.0000 |
|
78 |
T |
A |
-1.6931 |
|
79 |
A |
A |
0.0000 |
|
80 |
S |
A |
-1.0995 |
|
81 |
M |
A |
0.0000 |
|
82 |
E |
A |
-1.7565 |
|
83 |
L |
A |
0.0000 |
|
84 |
S |
A |
-1.1483 |
|
85 |
S |
A |
-1.0995 |
|
86 |
L |
A |
0.0000 |
|
87 |
R |
A |
-2.3793 |
|
88 |
S |
A |
-2.0771 |
|
89 |
E |
A |
-2.3544 |
|
90 |
D |
A |
0.0000 |
|
91 |
T |
A |
-0.8301 |
|
92 |
A |
A |
0.0000 |
|
93 |
V |
A |
0.0279 |
|
94 |
Y |
A |
0.0000 |
|
95 |
Y |
A |
0.0000 |
|
96 |
C |
A |
0.0000 |
|
97 |
A |
A |
0.0000 |
|
98 |
R |
A |
-0.4190 |
|
99 |
S |
A |
0.0000 |
|
100 |
R |
A |
-0.4139 |
|
101 |
D |
A |
0.6069 |
|
102 |
L |
A |
1.7631 |
|
103 |
L |
A |
2.6112 |
|
104 |
L |
A |
2.3699 |
|
105 |
F |
A |
1.3362 |
|
106 |
P |
A |
0.6260 |
|
107 |
H |
A |
-0.7698 |
|
108 |
H |
A |
-0.8071 |
|
109 |
A |
A |
0.0000 |
|
110 |
L |
A |
0.0000 |
|
111 |
S |
A |
-0.0952 |
|
112 |
P |
A |
0.1241 |
|
113 |
W |
A |
-0.3934 |
|
114 |
G |
A |
0.0000 |
|
115 |
R |
A |
-2.3159 |
|
116 |
G |
A |
0.0000 |
|
117 |
T |
A |
0.0000 |
|
118 |
M |
A |
-0.2363 |
|
119 |
V |
A |
0.0000 |
|
120 |
T |
A |
-0.6821 |
|
121 |
V |
A |
0.0000 |
|
122 |
S |
A |
-1.0804 |
|
123 |
S |
A |
-1.0197 |
|
124 |
A |
A |
-0.5791 |
|
125 |
S |
A |
-0.6696 |
|
126 |
T |
A |
-0.6478 |
|
127 |
K |
A |
-0.8846 |
|
128 |
G |
A |
-1.1034 |
|
129 |
P |
A |
0.0000 |
|
130 |
S |
A |
-0.3690 |
|
131 |
V |
A |
0.0000 |
|
132 |
F |
A |
0.0000 |
|
133 |
P |
A |
-1.1548 |
|
134 |
L |
A |
0.0000 |
|
135 |
A |
A |
-0.9136 |
|
136 |
P |
A |
0.0000 |
|
137 |
S |
A |
-0.9261 |
|
138 |
S |
A |
-1.2152 |
|
139 |
K |
A |
-2.0020 |
|
140 |
S |
A |
-1.4134 |
|
141 |
T |
A |
-0.8822 |
|
142 |
S |
A |
-0.9098 |
|
143 |
G |
A |
-0.8632 |
|
144 |
G |
A |
-1.1992 |
|
145 |
T |
A |
-0.9278 |
|
146 |
A |
A |
0.0000 |
|
147 |
A |
A |
-0.0691 |
|
148 |
L |
A |
0.0000 |
|
149 |
G |
A |
0.0000 |
|
150 |
C |
A |
0.0000 |
|
151 |
L |
A |
0.0000 |
|
152 |
V |
A |
0.0000 |
|
153 |
K |
A |
-0.2888 |
|
154 |
D |
A |
-0.3477 |
|
155 |
Y |
A |
0.0000 |
|
156 |
F |
A |
-0.1468 |
|
157 |
P |
A |
0.0000 |
|
158 |
E |
A |
-0.6284 |
|
159 |
P |
A |
-0.6863 |
|
160 |
V |
A |
-0.5183 |
|
161 |
T |
A |
-0.4712 |
|
162 |
V |
A |
0.0000 |
|
163 |
S |
A |
-0.4638 |
|
164 |
W |
A |
0.0000 |
|
165 |
N |
A |
-0.7949 |
|
166 |
S |
A |
-0.6732 |
|
167 |
G |
A |
-0.4308 |
|
168 |
A |
A |
-0.2074 |
|
169 |
L |
A |
-0.0610 |
|
170 |
T |
A |
-0.2126 |
|
171 |
S |
A |
-0.2850 |
|
172 |
G |
A |
-0.3673 |
|
173 |
V |
A |
0.0690 |
|
174 |
H |
A |
-0.1754 |
|
175 |
T |
A |
-0.0453 |
|
176 |
F |
A |
0.0000 |
|
177 |
P |
A |
-0.1434 |
|
178 |
A |
A |
0.2415 |
|
179 |
V |
A |
0.0000 |
|
180 |
L |
A |
1.3156 |
|
181 |
Q |
A |
0.3592 |
|
182 |
S |
A |
-0.0926 |
|
183 |
S |
A |
-0.1364 |
|
184 |
G |
A |
0.1738 |
|
185 |
L |
A |
0.2429 |
|
186 |
Y |
A |
0.4639 |
|
187 |
S |
A |
0.0000 |
|
188 |
L |
A |
0.0000 |
|
189 |
S |
A |
0.0000 |
|
190 |
S |
A |
0.0000 |
|
191 |
V |
A |
0.1419 |
|
192 |
V |
A |
0.0000 |
|
193 |
T |
A |
-0.2297 |
|
194 |
V |
A |
0.0000 |
|
195 |
P |
A |
-0.5970 |
|
196 |
S |
A |
-0.9399 |
|
197 |
S |
A |
-0.7845 |
|
198 |
S |
A |
-0.5501 |
|
199 |
L |
A |
-1.0101 |
|
200 |
G |
A |
-1.0586 |
|
201 |
T |
A |
-0.7413 |
|
202 |
Q |
A |
-1.3406 |
|
203 |
T |
A |
-1.2442 |
|
204 |
Y |
A |
0.0000 |
|
205 |
I |
A |
-1.3351 |
|
206 |
C |
A |
0.0000 |
|
207 |
N |
A |
0.0000 |
|
208 |
V |
A |
0.0000 |
|
209 |
N |
A |
-1.5606 |
|
210 |
H |
A |
0.0000 |
|
211 |
K |
A |
-2.2271 |
|
212 |
P |
A |
-1.4135 |
|
213 |
S |
A |
-1.5968 |
|
214 |
N |
A |
-2.2452 |
|
215 |
T |
A |
-1.8553 |
|
216 |
K |
A |
-2.6150 |
|
217 |
V |
A |
-1.8238 |
|
218 |
D |
A |
-2.7272 |
|
219 |
K |
A |
-2.2938 |
|
220 |
K |
A |
-2.6824 |
|
221 |
V |
A |
0.0000 |
|
222 |
E |
A |
-2.4663 |
|
223 |
P |
A |
-1.2308 |
|