Project name: 8697fa86e91288a

Chain sequence(s)	A: MKNVGFIVTKSEIGGAQTWVNEISNLIKEECNIFLITSEEGWLTHKDVFAGVFVIPGIKKYFDFLTLFKLRKILKENNISTLIASSANAGVYARLVRLLVDFKCIYVSHGWSCLKSIFCIVEKYLSLLTDVIWCVSKNDEKKAIENIGIKEPKIITVSNSVPQMPRCKQLQYKVLFVGRLTHPKRPELLANVISKKPQYSLHIVGSLKKQFSECENIHFLGEVNNFYNYHEYDLFSLISDSEGLPMSGLEAHTAAIPLLLSDVGGCFELIEGNGLLVENTEDDIGYKLDKIFDDYENYREQAIRASGKFVIENYASAYKSIILG
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.9143
• Maximal score value: 2.4986
• Average score: -0.6563
• Total score value: -212.6403

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	0.0404
2	K	A	-0.7875
3	N	A	-0.9573
4	V	A	0.0000
5	G	A	0.0000
6	F	A	0.0000
7	I	A	0.0000
8	V	A	0.0000
9	T	A	0.0000
10	K	A	-2.5416
11	S	A	0.0000
12	E	A	-2.2705
13	I	A	-1.1932
14	G	A	-1.0517
15	G	A	-0.9953
16	A	A	-0.6828
17	Q	A	0.0000
18	T	A	-0.5373
19	W	A	0.0000
20	V	A	0.0000
21	N	A	-0.4658
22	E	A	-0.6964
23	I	A	0.0000
24	S	A	0.0000
25	N	A	-1.2972
26	L	A	-1.3206
27	I	A	0.0000
28	K	A	-2.7946
29	E	A	-3.2488
30	E	A	-3.0508
31	C	A	0.0000
32	N	A	-1.3646
33	I	A	0.0000
34	F	A	0.2773
35	L	A	0.0000
36	I	A	0.0000
37	T	A	0.0000
38	S	A	0.0000
39	E	A	-1.9757
40	E	A	-2.5413
41	G	A	-2.0844
42	W	A	-1.4441
43	L	A	0.0000
44	T	A	-1.6532
45	H	A	-1.9096
46	K	A	-1.7919
47	D	A	-2.1385
48	V	A	-1.5600
49	F	A	0.0000
50	A	A	-0.4040
51	G	A	0.0944
52	V	A	0.3665
53	F	A	0.5380
54	V	A	0.3072
55	I	A	0.0000
56	P	A	-1.1376
57	G	A	-0.6132
58	I	A	0.0000
59	K	A	-1.9686
60	K	A	-1.7481
61	Y	A	-0.0217
62	F	A	0.8947
63	D	A	0.7604
64	F	A	2.4986
65	L	A	2.1825
66	T	A	0.0000
67	L	A	0.0000
68	F	A	0.4470
69	K	A	-0.8044
70	L	A	0.0000
71	R	A	-1.9248
72	K	A	-2.9986
73	I	A	0.0000
74	L	A	0.0000
75	K	A	-3.9143
76	E	A	-3.6351
77	N	A	-2.5690
78	N	A	-2.8957
79	I	A	0.0000
80	S	A	-1.3171
81	T	A	0.0000
82	L	A	0.0000
83	I	A	0.0000
84	A	A	0.0000
85	S	A	0.0000
86	S	A	-0.4099
87	A	A	0.0539
88	N	A	-0.4333
89	A	A	0.0000
90	G	A	0.0000
91	V	A	0.0000
92	Y	A	0.0000
93	A	A	0.0000
94	R	A	0.0000
95	L	A	0.8768
96	V	A	0.0000
97	R	A	0.0742
98	L	A	1.4484
99	L	A	0.5530
100	V	A	0.0000
101	D	A	-1.8810
102	F	A	0.0000
103	K	A	-1.0464
104	C	A	0.0000
105	I	A	0.0000
106	Y	A	0.0000
107	V	A	0.0000
108	S	A	0.0000
109	H	A	-0.4484
110	G	A	-0.4834
111	W	A	0.0000
112	S	A	0.2724
113	C	A	0.8038
114	L	A	1.1739
121	K	A	-0.3808
122	S	A	0.5503
123	I	A	2.0851
124	F	A	1.6240
125	C	A	1.2222
126	I	A	2.2641
127	V	A	2.0754
128	E	A	0.0000
129	K	A	1.0060
130	Y	A	2.1685
131	L	A	1.6412
132	S	A	0.0000
133	L	A	1.6922
134	L	A	1.4263
135	T	A	0.0000
136	D	A	-0.6992
137	V	A	0.0000
138	I	A	0.0000
139	W	A	0.0000
140	C	A	0.0000
141	V	A	0.0000
142	S	A	0.0000
143	K	A	-2.3848
144	N	A	-1.9853
145	D	A	0.0000
146	E	A	-2.4272
147	K	A	-3.3158
148	K	A	-3.0151
149	A	A	0.0000
150	I	A	-2.5039
151	E	A	-3.1686
152	N	A	-2.6130
153	I	A	0.0000
154	G	A	-1.5663
155	I	A	0.0000
156	K	A	-2.6678
157	E	A	-2.7012
158	P	A	-1.6597
159	K	A	-1.1277
160	I	A	-0.6133
161	I	A	0.6251
162	T	A	-0.2475
163	V	A	0.2030
164	S	A	-0.1602
165	N	A	0.0000
166	S	A	0.0000
167	V	A	0.0000
168	P	A	-0.9962
169	Q	A	-1.3093
170	M	A	-0.3492
171	P	A	-0.6376
172	R	A	-0.6835
173	C	A	-0.3176
176	K	A	-2.1306
177	Q	A	-2.1484
178	L	A	-1.3728
179	Q	A	-1.8243
180	Y	A	-0.9525
181	K	A	-0.9074
182	V	A	0.0000
183	L	A	0.0000
184	F	A	0.0000
185	V	A	-0.2028
186	G	A	-0.8948
187	R	A	-1.7847
188	L	A	0.0000
189	T	A	-0.9776
190	H	A	-1.6681
191	P	A	-1.5170
192	K	A	-1.5331
193	R	A	-1.3233
194	P	A	0.0000
195	E	A	-1.0931
196	L	A	0.0000
197	L	A	0.0000
198	A	A	0.0000
199	N	A	-2.0130
200	V	A	0.0000
201	I	A	0.0000
202	S	A	-1.9935
203	K	A	-2.2612
204	K	A	-1.7439
205	P	A	-1.6731
206	Q	A	-1.7457
207	Y	A	0.0000
208	S	A	-1.1499
209	L	A	0.0000
210	H	A	-0.1485
211	I	A	0.0000
212	V	A	0.0000
213	G	A	-0.9484
220	S	A	0.2832
221	L	A	0.6094
222	K	A	-0.9219
223	K	A	-2.5092
224	Q	A	-2.4769
225	F	A	0.0000
226	S	A	-2.5251
227	E	A	-2.8367
228	C	A	-2.5498
229	E	A	-2.4402
230	N	A	0.0000
231	I	A	0.0000
232	H	A	-0.7906
233	F	A	0.0889
234	L	A	0.4784
235	G	A	-0.3906
236	E	A	-1.7270
237	V	A	-0.7571
238	N	A	-1.7401
239	N	A	-1.5757
240	F	A	0.0000
241	Y	A	0.1160
242	N	A	-0.6364
243	Y	A	0.0000
244	H	A	-1.1993
245	E	A	-2.1550
246	Y	A	0.0000
247	D	A	0.0000
248	L	A	0.0000
249	F	A	0.0000
250	S	A	0.0000
251	L	A	0.0000
252	I	A	0.0000
253	S	A	0.0000
254	D	A	-1.9174
255	S	A	-1.0474
256	E	A	-0.9840
257	G	A	-0.5151
258	L	A	0.0000
259	P	A	0.0000
260	M	A	-0.0773
261	S	A	0.0285
262	G	A	0.0000
263	L	A	0.0000
264	E	A	-0.1528
265	A	A	0.0000
266	H	A	0.0000
267	T	A	0.0000
268	A	A	0.0000
269	A	A	0.0000
270	I	A	0.0000
271	P	A	0.0000
272	L	A	0.0000
273	L	A	0.0000
274	L	A	0.0000
275	S	A	0.0000
276	D	A	-2.0763
277	V	A	-1.1143
278	G	A	-0.8945
279	G	A	0.0000
280	C	A	0.0000
281	F	A	-0.0736
282	E	A	-0.5423
283	L	A	0.0000
284	I	A	-0.4984
285	E	A	-1.7071
286	G	A	-1.6658
287	N	A	0.0000
288	G	A	0.0000
289	L	A	-0.2099
290	L	A	-0.6095
291	V	A	0.0000
292	E	A	-3.0165
293	N	A	-2.3159
294	T	A	-2.1984
295	E	A	-3.1068
296	D	A	-2.8046
297	D	A	-1.8939
298	I	A	0.0000
299	G	A	-1.3663
300	Y	A	-0.1845
301	K	A	-0.8483
302	L	A	0.0000
303	D	A	-1.5870
304	K	A	-1.8624
305	I	A	0.0000
306	F	A	0.0000
307	D	A	-3.2758
308	D	A	-3.3053
309	Y	A	0.0000
310	E	A	-3.5214
311	N	A	-3.0305
312	Y	A	0.0000
313	R	A	-2.0315
314	E	A	-2.7247
315	Q	A	-2.0948
316	A	A	0.0000
317	I	A	0.0210
318	R	A	-1.8517
319	A	A	-1.4675
320	S	A	0.0000
321	G	A	-1.5517
322	K	A	-1.9753
323	F	A	0.0000
324	V	A	-1.5123
325	I	A	0.0000
326	E	A	-2.5027
327	N	A	-2.3386
328	Y	A	-1.2018
329	A	A	-1.0651
330	S	A	-0.8800
331	A	A	-0.5097
332	Y	A	0.0000
333	K	A	-0.8481
334	S	A	-0.6006
335	I	A	0.0000
336	I	A	0.0000
337	L	A	-0.6303
338	G	A	-0.5434