Project name: Mohammad Arabpour
Status: done
submitted: 2018-06-18 12:02:33, status changed: 2018-06-18 12:14:17
Settings
Chain sequence(s)
|
A: MDDKLYRADSRPPDEIKQSGGLMPRGQSEYFDRGTQMNINLYDHARGTQTGFVRHDDGYVSTSISLRSAHLVGQTILSGHSTYYIYVIATAPNMFNVNDVLGAYSPHPDEQEVSALGGIPYSQIYGWYRVHFGVLDEQLHRNRGYRDRYYSNLDIAPAADGYGLAGFPPEHRAWREEPWIHHAPPGCGNAPRSSGSFNKDQQSAFYEILNMPNLNEAQRNGFIQSLKDDPSQSTNVLGEAKKLNESQAPKPEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKGGGSGAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAEGDYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPEAAAKEAAAKEAAAKEAAAKDYKDDDDKGGGSG
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-4.7268
-
Maximal score value
-
1.8583
-
Average score
-
-0.9937
-
Total score value
-
-439.2314
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
1 |
M |
A |
-1.0070 |
|
2 |
D |
A |
-2.8919 |
|
3 |
D |
A |
-2.6093 |
|
4 |
K |
A |
-1.1497 |
|
5 |
L |
A |
0.0000 |
|
6 |
Y |
A |
0.3873 |
|
7 |
R |
A |
0.0000 |
|
8 |
A |
A |
0.0000 |
|
9 |
D |
A |
0.0000 |
|
10 |
S |
A |
-0.1912 |
|
11 |
R |
A |
-0.8402 |
|
12 |
P |
A |
-1.5044 |
|
13 |
P |
A |
-2.1407 |
|
14 |
D |
A |
-3.4792 |
|
15 |
E |
A |
-3.3548 |
|
16 |
I |
A |
0.0000 |
|
17 |
K |
A |
-3.4568 |
|
18 |
Q |
A |
-3.1311 |
|
19 |
S |
A |
-2.0708 |
|
20 |
G |
A |
-1.4794 |
|
21 |
G |
A |
0.0000 |
|
22 |
L |
A |
0.0000 |
|
23 |
M |
A |
0.0000 |
|
24 |
P |
A |
0.0000 |
|
25 |
R |
A |
-2.4833 |
|
26 |
G |
A |
-1.8172 |
|
27 |
Q |
A |
-1.2647 |
|
28 |
S |
A |
-1.3106 |
|
29 |
E |
A |
-1.2521 |
|
30 |
Y |
A |
-0.3401 |
|
31 |
F |
A |
0.1338 |
|
32 |
D |
A |
-0.8317 |
|
33 |
R |
A |
-0.6349 |
|
34 |
G |
A |
-0.5803 |
|
35 |
T |
A |
-0.7629 |
|
36 |
Q |
A |
-0.8425 |
|
37 |
M |
A |
-1.2996 |
|
38 |
N |
A |
-1.9398 |
|
39 |
I |
A |
0.0000 |
|
40 |
N |
A |
-0.9729 |
|
41 |
L |
A |
0.0000 |
|
42 |
Y |
A |
-0.5826 |
|
43 |
D |
A |
-1.3639 |
|
44 |
H |
A |
0.0000 |
|
45 |
A |
A |
0.0000 |
|
46 |
R |
A |
-1.5330 |
|
47 |
G |
A |
-1.0755 |
|
48 |
T |
A |
-0.5091 |
|
49 |
Q |
A |
-0.6204 |
|
50 |
T |
A |
-0.0815 |
|
51 |
G |
A |
-0.0904 |
|
52 |
F |
A |
0.0381 |
|
53 |
V |
A |
0.0000 |
|
54 |
R |
A |
0.0000 |
|
55 |
H |
A |
0.0000 |
|
56 |
D |
A |
-1.8310 |
|
57 |
D |
A |
-1.9462 |
|
58 |
G |
A |
0.0000 |
|
59 |
Y |
A |
0.0000 |
|
60 |
V |
A |
0.0000 |
|
61 |
S |
A |
0.0000 |
|
62 |
T |
A |
0.0000 |
|
63 |
S |
A |
0.0000 |
|
64 |
I |
A |
0.4829 |
|
65 |
S |
A |
0.2635 |
|
66 |
L |
A |
0.1136 |
|
67 |
R |
A |
-0.4754 |
|
68 |
S |
A |
-0.0094 |
|
69 |
A |
A |
0.0000 |
|
70 |
H |
A |
0.4870 |
|
71 |
L |
A |
1.1676 |
|
72 |
V |
A |
0.6726 |
|
73 |
G |
A |
0.0000 |
|
74 |
Q |
A |
0.4065 |
|
75 |
T |
A |
0.2334 |
|
76 |
I |
A |
0.3875 |
|
77 |
L |
A |
0.0000 |
|
78 |
S |
A |
-0.3422 |
|
79 |
G |
A |
-0.5193 |
|
80 |
H |
A |
-0.4751 |
|
81 |
S |
A |
0.2547 |
|
82 |
T |
A |
0.0525 |
|
83 |
Y |
A |
0.0000 |
|
84 |
Y |
A |
-0.2490 |
|
85 |
I |
A |
0.0000 |
|
86 |
Y |
A |
0.0000 |
|
87 |
V |
A |
0.0000 |
|
88 |
I |
A |
0.0000 |
|
89 |
A |
A |
0.0000 |
|
90 |
T |
A |
0.0000 |
|
91 |
A |
A |
0.0000 |
|
92 |
P |
A |
-0.7144 |
|
93 |
N |
A |
-0.4707 |
|
94 |
M |
A |
0.0000 |
|
95 |
F |
A |
0.0000 |
|
96 |
N |
A |
-1.0277 |
|
97 |
V |
A |
0.0000 |
|
98 |
N |
A |
-1.9134 |
|
99 |
D |
A |
-1.8681 |
|
100 |
V |
A |
0.0000 |
|
101 |
L |
A |
0.0000 |
|
102 |
G |
A |
-0.7204 |
|
103 |
A |
A |
-0.2196 |
|
104 |
Y |
A |
-0.3890 |
|
105 |
S |
A |
0.0000 |
|
106 |
P |
A |
-0.9576 |
|
107 |
H |
A |
-1.5919 |
|
108 |
P |
A |
-2.0326 |
|
109 |
D |
A |
-2.7305 |
|
110 |
E |
A |
-2.1025 |
|
111 |
Q |
A |
-2.2469 |
|
112 |
E |
A |
0.0000 |
|
113 |
V |
A |
0.0000 |
|
114 |
S |
A |
0.0000 |
|
115 |
A |
A |
0.0000 |
|
116 |
L |
A |
0.0000 |
|
117 |
G |
A |
0.0000 |
|
118 |
G |
A |
0.0000 |
|
119 |
I |
A |
0.0000 |
|
120 |
P |
A |
-0.1779 |
|
121 |
Y |
A |
-0.5833 |
|
122 |
S |
A |
-0.4103 |
|
123 |
Q |
A |
0.0000 |
|
124 |
I |
A |
0.0000 |
|
125 |
Y |
A |
-0.3819 |
|
126 |
G |
A |
0.0000 |
|
127 |
W |
A |
0.0000 |
|
128 |
Y |
A |
-1.1181 |
|
129 |
R |
A |
-0.9843 |
|
130 |
V |
A |
0.0000 |
|
131 |
H |
A |
0.6881 |
|
132 |
F |
A |
1.8583 |
|
133 |
G |
A |
1.2521 |
|
134 |
V |
A |
1.6354 |
|
135 |
L |
A |
0.0000 |
|
136 |
D |
A |
-1.3726 |
|
137 |
E |
A |
-2.3426 |
|
138 |
Q |
A |
-2.3782 |
|
139 |
L |
A |
-1.3989 |
|
140 |
H |
A |
-1.9065 |
|
141 |
R |
A |
-2.3882 |
|
142 |
N |
A |
0.0000 |
|
143 |
R |
A |
-2.2868 |
|
144 |
G |
A |
-1.3544 |
|
145 |
Y |
A |
-0.9698 |
|
146 |
R |
A |
-1.0817 |
|
147 |
D |
A |
-1.7098 |
|
148 |
R |
A |
-2.3244 |
|
149 |
Y |
A |
-0.9273 |
|
150 |
Y |
A |
0.0000 |
|
151 |
S |
A |
-2.1002 |
|
152 |
N |
A |
-1.9106 |
|
153 |
L |
A |
-1.2567 |
|
154 |
D |
A |
-2.0833 |
|
155 |
I |
A |
-0.8092 |
|
156 |
A |
A |
0.0000 |
|
157 |
P |
A |
-0.9387 |
|
158 |
A |
A |
-0.8504 |
|
159 |
A |
A |
-0.7828 |
|
160 |
D |
A |
-1.0812 |
|
161 |
G |
A |
0.0000 |
|
162 |
Y |
A |
-0.4684 |
|
163 |
G |
A |
-0.3280 |
|
164 |
L |
A |
0.0000 |
|
165 |
A |
A |
0.0000 |
|
166 |
G |
A |
0.0000 |
|
167 |
F |
A |
0.0000 |
|
168 |
P |
A |
-1.0583 |
|
169 |
P |
A |
-1.4675 |
|
170 |
E |
A |
-2.8563 |
|
171 |
H |
A |
-2.3029 |
|
172 |
R |
A |
-3.0456 |
|
173 |
A |
A |
0.0000 |
|
174 |
W |
A |
0.0000 |
|
175 |
R |
A |
-2.6149 |
|
176 |
E |
A |
-2.3942 |
|
177 |
E |
A |
-2.4951 |
|
178 |
P |
A |
-1.3078 |
|
179 |
W |
A |
0.0000 |
|
180 |
I |
A |
-1.1857 |
|
181 |
H |
A |
-1.3374 |
|
182 |
H |
A |
-0.9720 |
|
183 |
A |
A |
-0.5879 |
|
184 |
P |
A |
-0.2937 |
|
185 |
P |
A |
-0.6141 |
|
186 |
G |
A |
-0.9832 |
|
187 |
C |
A |
0.0000 |
|
188 |
G |
A |
0.0000 |
|
189 |
N |
A |
-2.1115 |
|
190 |
A |
A |
-1.2726 |
|
191 |
P |
A |
-0.8587 |
|
192 |
R |
A |
-0.9774 |
|
193 |
S |
A |
-1.2242 |
|
194 |
S |
A |
-0.6534 |
|
195 |
G |
A |
-0.6092 |
|
196 |
S |
A |
0.0522 |
|
197 |
F |
A |
0.6507 |
|
198 |
N |
A |
-1.4210 |
|
199 |
K |
A |
-2.1509 |
|
200 |
D |
A |
0.0000 |
|
201 |
Q |
A |
-1.5525 |
|
202 |
Q |
A |
0.0000 |
|
203 |
S |
A |
-0.8929 |
|
204 |
A |
A |
-0.8712 |
|
205 |
F |
A |
-0.2472 |
|
206 |
Y |
A |
0.0000 |
|
207 |
E |
A |
-0.6977 |
|
208 |
I |
A |
-0.3531 |
|
209 |
L |
A |
0.0882 |
|
210 |
N |
A |
0.0000 |
|
211 |
M |
A |
0.0000 |
|
212 |
P |
A |
0.0000 |
|
213 |
N |
A |
-0.7144 |
|
214 |
L |
A |
-0.3254 |
|
215 |
N |
A |
0.0000 |
|
216 |
E |
A |
-1.0417 |
|
217 |
A |
A |
-0.5533 |
|
218 |
Q |
A |
-0.0682 |
|
219 |
R |
A |
-0.0962 |
|
220 |
N |
A |
-0.4735 |
|
221 |
G |
A |
0.4127 |
|
222 |
F |
A |
1.7458 |
|
223 |
I |
A |
1.4480 |
|
224 |
Q |
A |
0.2036 |
|
225 |
S |
A |
0.0065 |
|
226 |
L |
A |
0.0671 |
|
227 |
K |
A |
-1.5272 |
|
228 |
D |
A |
-1.7730 |
|
229 |
D |
A |
-2.3544 |
|
230 |
P |
A |
-2.0360 |
|
231 |
S |
A |
-2.0052 |
|
232 |
Q |
A |
-2.2512 |
|
233 |
S |
A |
-1.2523 |
|
234 |
T |
A |
-0.5948 |
|
235 |
N |
A |
-1.4360 |
|
236 |
V |
A |
-0.4954 |
|
237 |
L |
A |
0.4767 |
|
238 |
G |
A |
-0.9661 |
|
239 |
E |
A |
-2.1269 |
|
240 |
A |
A |
-1.8536 |
|
241 |
K |
A |
-2.6060 |
|
242 |
K |
A |
-2.7299 |
|
243 |
L |
A |
-1.3672 |
|
244 |
N |
A |
-2.7069 |
|
245 |
E |
A |
-2.7390 |
|
246 |
S |
A |
-2.0763 |
|
247 |
Q |
A |
-2.8298 |
|
248 |
A |
A |
-1.7182 |
|
249 |
P |
A |
-1.6698 |
|
250 |
K |
A |
-2.7077 |
|
251 |
P |
A |
-2.6478 |
|
252 |
E |
A |
-2.7980 |
|
253 |
A |
A |
-1.7215 |
|
254 |
A |
A |
-1.3644 |
|
255 |
A |
A |
-1.8099 |
|
256 |
K |
A |
-2.8374 |
|
257 |
E |
A |
-3.1265 |
|
258 |
A |
A |
-2.1848 |
|
259 |
A |
A |
-2.1526 |
|
260 |
A |
A |
-1.8357 |
|
261 |
K |
A |
-3.0220 |
|
262 |
E |
A |
-2.8191 |
|
263 |
A |
A |
-1.4939 |
|
264 |
A |
A |
-1.2447 |
|
265 |
A |
A |
-2.0603 |
|
266 |
K |
A |
-2.7479 |
|
267 |
E |
A |
-2.6694 |
|
268 |
A |
A |
-1.8612 |
|
269 |
A |
A |
-2.3865 |
|
270 |
A |
A |
-2.5095 |
|
271 |
K |
A |
-2.4740 |
|
272 |
E |
A |
-2.6129 |
|
273 |
A |
A |
-2.3661 |
|
274 |
A |
A |
0.0000 |
|
275 |
A |
A |
-1.6134 |
|
276 |
K |
A |
-1.9196 |
|
277 |
E |
A |
-1.5543 |
|
278 |
A |
A |
-0.8338 |
|
279 |
A |
A |
-0.9356 |
|
280 |
A |
A |
-1.0032 |
|
281 |
K |
A |
0.0000 |
|
282 |
G |
A |
-1.0705 |
|
283 |
G |
A |
-1.0375 |
|
284 |
G |
A |
-1.2638 |
|
285 |
S |
A |
-1.0738 |
|
286 |
G |
A |
-1.3516 |
|
287 |
A |
A |
-1.5520 |
|
288 |
E |
A |
-2.5222 |
|
289 |
A |
A |
-1.3996 |
|
290 |
G |
A |
-1.1190 |
|
291 |
I |
A |
-0.2907 |
|
292 |
T |
A |
-0.4239 |
|
293 |
G |
A |
-0.5477 |
|
294 |
T |
A |
-0.5691 |
|
295 |
W |
A |
0.0000 |
|
296 |
Y |
A |
-0.2730 |
|
297 |
N |
A |
-0.7827 |
|
298 |
Q |
A |
-1.8862 |
|
299 |
L |
A |
-0.5704 |
|
300 |
G |
A |
-0.6931 |
|
301 |
S |
A |
0.0000 |
|
302 |
T |
A |
0.0000 |
|
303 |
F |
A |
0.0000 |
|
304 |
I |
A |
0.0000 |
|
305 |
V |
A |
0.0000 |
|
306 |
T |
A |
0.0000 |
|
307 |
A |
A |
0.0000 |
|
308 |
G |
A |
-1.8755 |
|
309 |
A |
A |
-2.0053 |
|
310 |
D |
A |
-2.5603 |
|
311 |
G |
A |
-1.8725 |
|
312 |
A |
A |
-1.0855 |
|
313 |
L |
A |
0.0000 |
|
314 |
T |
A |
-0.2493 |
|
315 |
G |
A |
0.0000 |
|
316 |
T |
A |
-0.2277 |
|
317 |
Y |
A |
0.0000 |
|
318 |
E |
A |
-0.3669 |
|
319 |
S |
A |
0.0000 |
|
320 |
A |
A |
-0.7243 |
|
321 |
V |
A |
0.0000 |
|
322 |
G |
A |
-1.2640 |
|
323 |
N |
A |
-2.3041 |
|
324 |
A |
A |
-1.9332 |
|
325 |
E |
A |
-2.7940 |
|
326 |
G |
A |
-2.3089 |
|
327 |
D |
A |
-1.9690 |
|
328 |
Y |
A |
-0.5879 |
|
329 |
V |
A |
0.7849 |
|
330 |
L |
A |
0.3914 |
|
331 |
T |
A |
0.1610 |
|
332 |
G |
A |
-0.2977 |
|
333 |
R |
A |
-0.8142 |
|
334 |
Y |
A |
0.0000 |
|
335 |
D |
A |
-1.3521 |
|
336 |
S |
A |
-0.7460 |
|
337 |
A |
A |
-0.6983 |
|
338 |
P |
A |
-0.6694 |
|
339 |
A |
A |
-1.1790 |
|
340 |
T |
A |
-1.3250 |
|
341 |
D |
A |
-2.3197 |
|
342 |
G |
A |
-1.9515 |
|
343 |
S |
A |
-1.4297 |
|
344 |
G |
A |
-0.8560 |
|
345 |
T |
A |
0.0000 |
|
346 |
A |
A |
0.0000 |
|
347 |
L |
A |
0.0000 |
|
348 |
G |
A |
-0.8549 |
|
349 |
W |
A |
0.0000 |
|
350 |
T |
A |
-0.0257 |
|
351 |
V |
A |
0.0000 |
|
352 |
A |
A |
0.2335 |
|
353 |
W |
A |
-0.6226 |
|
354 |
K |
A |
-1.8936 |
|
355 |
N |
A |
-2.1970 |
|
356 |
N |
A |
-1.7986 |
|
357 |
Y |
A |
-0.5477 |
|
358 |
R |
A |
-2.2258 |
|
359 |
N |
A |
0.0000 |
|
360 |
A |
A |
-1.3252 |
|
361 |
H |
A |
-1.5055 |
|
362 |
S |
A |
0.0000 |
|
363 |
A |
A |
0.0000 |
|
364 |
T |
A |
0.0000 |
|
365 |
T |
A |
0.0000 |
|
366 |
W |
A |
0.0000 |
|
367 |
S |
A |
-0.9579 |
|
368 |
G |
A |
0.0000 |
|
369 |
Q |
A |
-0.6438 |
|
370 |
Y |
A |
0.0226 |
|
371 |
V |
A |
0.0974 |
|
372 |
G |
A |
-1.0231 |
|
373 |
G |
A |
-1.4972 |
|
374 |
A |
A |
-1.9129 |
|
375 |
E |
A |
-2.5421 |
|
376 |
A |
A |
-1.7353 |
|
377 |
R |
A |
-1.2208 |
|
378 |
I |
A |
0.0000 |
|
379 |
N |
A |
-1.6112 |
|
380 |
T |
A |
0.0000 |
|
381 |
Q |
A |
-1.9910 |
|
382 |
W |
A |
0.0000 |
|
383 |
L |
A |
0.3634 |
|
384 |
L |
A |
0.0000 |
|
385 |
T |
A |
0.0257 |
|
386 |
S |
A |
-0.5798 |
|
387 |
G |
A |
-1.0824 |
|
388 |
T |
A |
-1.0574 |
|
389 |
T |
A |
-1.0954 |
|
390 |
E |
A |
-2.3241 |
|
391 |
A |
A |
-1.3374 |
|
392 |
N |
A |
-1.5312 |
|
393 |
A |
A |
0.0000 |
|
394 |
W |
A |
-1.1659 |
|
395 |
K |
A |
-1.7765 |
|
396 |
S |
A |
0.0000 |
|
397 |
T |
A |
0.2872 |
|
398 |
L |
A |
1.0594 |
|
399 |
V |
A |
0.1817 |
|
400 |
G |
A |
-0.8962 |
|
401 |
H |
A |
-1.8847 |
|
402 |
D |
A |
-1.8859 |
|
403 |
T |
A |
-1.1922 |
|
404 |
F |
A |
-0.2530 |
|
405 |
T |
A |
-0.7678 |
|
406 |
K |
A |
-1.6704 |
|
407 |
V |
A |
-1.3576 |
|
408 |
K |
A |
-2.6240 |
|
409 |
P |
A |
-1.9277 |
|
410 |
E |
A |
-2.2644 |
|
411 |
A |
A |
-1.2076 |
|
412 |
A |
A |
-0.8910 |
|
413 |
A |
A |
-1.6386 |
|
414 |
K |
A |
-2.5120 |
|
415 |
E |
A |
-2.5675 |
|
416 |
A |
A |
-1.7200 |
|
417 |
A |
A |
-1.5012 |
|
418 |
A |
A |
-1.9165 |
|
419 |
K |
A |
-2.7359 |
|
420 |
E |
A |
-3.2658 |
|
421 |
A |
A |
-2.3091 |
|
422 |
A |
A |
-2.1996 |
|
423 |
A |
A |
-2.3989 |
|
424 |
K |
A |
-3.2310 |
|
425 |
E |
A |
-2.9274 |
|
426 |
A |
A |
-1.5432 |
|
427 |
A |
A |
-1.4786 |
|
428 |
A |
A |
-1.7884 |
|
429 |
K |
A |
-2.1990 |
|
430 |
D |
A |
-2.7709 |
|
431 |
Y |
A |
-1.9803 |
|
432 |
K |
A |
-3.3018 |
|
433 |
D |
A |
-4.3669 |
|
434 |
D |
A |
-4.7268 |
|
435 |
D |
A |
-4.7111 |
|
436 |
D |
A |
-4.2847 |
|
437 |
K |
A |
-3.8420 |
|
438 |
G |
A |
-3.7781 |
|
439 |
G |
A |
-2.6686 |
|
440 |
G |
A |
-1.7919 |
|
441 |
S |
A |
-1.1630 |
|
442 |
G |
A |
-1.9423 |
|