Project name: CdeC

Chain sequence(s)	A: MQDYKKNKRRMMNQPMSTMNEEEVYTDEINSEDMRGFKKSHHHNGCNTDNKCECHDECNPCNPCNPCKPNPCNPCKPNPCDDKCECHDKCKCDCEPCEMDSDECFENKCGPECCNPISPRNFSVSNAVPFAIEANRIFDTMQFQTFTDATGPNGEPLTFETEVVEVFGSIPSAGQASVTIEKICLSNDGIVIDTGMTTLEDFDLDPLGDIVGRNCETTFEFAVCGERNAECCRQGKGKSVAYKQRGLTVAVRNLVLELRGRCGCTEFVALAFPAVRAGGGCKRRVDYVEFTFNTLSAPICLPADGRAVTLRQEYQTNLTVDCIGKSILKLECNECCEPFYELIIPNDIDLVLCLQETVSTLISEQIVVLASPNPIQPRLVDTFSKVCDFSQCGPNHGSGKPSCHR
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.4861
• Maximal score value: 2.6573
• Average score: -0.6365
• Total score value: -257.7643

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	-0.3385
2	Q	A	-1.6532
3	D	A	-2.2049
4	Y	A	-1.3001
5	K	A	-1.6494
6	K	A	-2.5437
7	N	A	0.0000
8	K	A	-2.8546
9	R	A	-3.2700
10	R	A	-3.0504
11	M	A	-1.2522
12	M	A	-0.4759
13	N	A	-0.6184
14	Q	A	-1.2989
15	P	A	-0.7266
16	M	A	0.3468
17	S	A	-0.5921
18	T	A	-0.7736
19	M	A	-1.0677
20	N	A	-2.2706
21	E	A	-3.3990
22	E	A	-3.1934
23	E	A	-3.1251
24	V	A	-0.8613
25	Y	A	0.0000
26	T	A	-1.4827
27	D	A	-2.4086
28	E	A	-3.0580
29	I	A	-1.0689
30	N	A	-2.6263
31	S	A	-1.3526
32	E	A	-2.0208
33	D	A	-2.2815
34	M	A	-1.2350
35	R	A	-2.0851
36	G	A	-1.8683
37	F	A	-0.8511
38	K	A	-2.0174
39	K	A	-2.4665
40	S	A	-1.8461
41	H	A	-1.7634
42	H	A	-2.3165
43	H	A	-2.1419
44	N	A	-2.4143
45	G	A	-1.6073
46	C	A	-1.7377
47	N	A	-2.4189
48	T	A	-2.1338
49	D	A	-3.0883
50	N	A	-3.1745
51	K	A	-2.6524
52	C	A	-1.5669
53	E	A	-2.4241
54	C	A	-0.9181
55	H	A	-1.9152
56	D	A	-2.4637
57	E	A	-3.0508
58	C	A	0.0000
59	N	A	-1.9335
60	P	A	-1.1084
61	C	A	-0.9100
62	N	A	-1.5884
63	P	A	0.0000
64	C	A	-0.9929
65	N	A	-1.0058
66	P	A	-0.5433
67	C	A	-0.2778
68	K	A	-0.7358
69	P	A	-1.4834
70	N	A	-2.1466
71	P	A	-2.2274
72	C	A	-1.8905
73	N	A	-1.2799
74	P	A	-0.6904
75	C	A	-0.0726
76	K	A	-1.4640
77	P	A	-0.9649
78	N	A	-1.4357
79	P	A	0.0000
80	C	A	-1.2316
81	D	A	-2.6105
82	D	A	-3.1695
83	K	A	-2.6297
84	C	A	-1.6038
85	E	A	-2.3786
86	C	A	-2.0931
87	H	A	-2.5622
88	D	A	-3.4861
89	K	A	-3.0352
90	C	A	-1.9260
91	K	A	-2.2289
92	C	A	0.0000
93	D	A	-2.9025
94	C	A	-2.1148
95	E	A	-1.9029
96	P	A	-0.4978
97	C	A	-0.6187
98	E	A	-1.5954
99	M	A	-1.1310
100	D	A	-2.9723
101	S	A	-2.6819
102	D	A	-3.0603
103	E	A	-2.7493
104	C	A	-1.9698
105	F	A	-1.0926
106	E	A	-2.4907
107	N	A	-2.6015
108	K	A	-2.0988
109	C	A	-1.2697
110	G	A	-0.8494
111	P	A	0.1254
112	E	A	-0.6193
113	C	A	0.1045
114	C	A	0.1423
115	N	A	-0.2977
116	P	A	0.9154
117	I	A	1.8391
118	S	A	0.0000
119	P	A	0.0396
120	R	A	0.0000
121	N	A	0.1868
122	F	A	0.9614
123	S	A	0.9990
124	V	A	0.8400
125	S	A	0.0683
126	N	A	-1.2952
127	A	A	-0.5390
128	V	A	0.9889
129	P	A	1.4016
130	F	A	2.6346
131	A	A	1.4807
132	I	A	1.6763
133	E	A	-0.0233
134	A	A	-0.9068
135	N	A	-1.7521
136	R	A	-2.2154
137	I	A	-0.4343
138	F	A	1.2604
139	D	A	0.6884
140	T	A	0.4989
141	M	A	0.8462
142	Q	A	-0.1118
143	F	A	1.0087
144	Q	A	-0.4093
145	T	A	-0.0715
146	F	A	0.0000
147	T	A	-0.3309
148	D	A	-0.8857
149	A	A	-0.4542
150	T	A	-0.4254
151	G	A	-0.8770
152	P	A	-0.7222
153	N	A	-0.5684
154	G	A	-0.4249
155	E	A	-0.1876
156	P	A	-0.0312
157	L	A	0.0000
158	T	A	0.0000
159	F	A	0.0000
160	E	A	-1.4023
161	T	A	-1.1522
162	E	A	-1.9438
163	V	A	-0.6306
164	V	A	0.0000
165	E	A	-0.7962
166	V	A	-0.4393
167	F	A	-0.0770
168	G	A	-0.0159
169	S	A	0.4218
170	I	A	1.5920
171	P	A	0.4989
172	S	A	0.0231
173	A	A	-0.2794
174	G	A	-1.0808
175	Q	A	-1.3817
176	A	A	-0.3609
177	S	A	0.0000
178	V	A	0.3720
179	T	A	0.0657
180	I	A	0.0000
181	E	A	0.0000
182	K	A	0.0000
183	I	A	0.0000
184	C	A	0.1407
185	L	A	0.0000
186	S	A	-0.4576
187	N	A	0.0000
188	D	A	-1.5258
189	G	A	-0.4528
190	I	A	0.5103
191	V	A	0.3629
192	I	A	0.0000
193	D	A	0.0000
194	T	A	0.0000
195	G	A	0.0000
196	M	A	-0.1474
197	T	A	-0.2715
198	T	A	0.1198
199	L	A	0.9957
200	E	A	0.4812
201	D	A	0.9014
202	F	A	0.0000
203	D	A	0.0000
204	L	A	0.4304
205	D	A	0.0000
206	P	A	0.1227
207	L	A	0.3219
208	G	A	-0.4082
209	D	A	-1.1067
210	I	A	0.0000
211	V	A	0.8838
212	G	A	-0.7632
213	R	A	-1.7875
214	N	A	-1.8917
215	C	A	-0.9695
216	E	A	-0.7263
217	T	A	-0.2451
218	T	A	0.7577
219	F	A	1.9114
220	E	A	2.0046
221	F	A	2.6573
222	A	A	1.8517
223	V	A	2.3286
224	C	A	1.4139
225	G	A	0.0000
226	E	A	-1.3092
227	R	A	-1.7038
228	N	A	0.0000
229	A	A	-0.3963
230	E	A	0.0000
231	C	A	0.0000
232	C	A	0.0000
233	R	A	-0.5819
234	Q	A	0.0000
235	G	A	-1.3624
236	K	A	0.0000
237	G	A	-0.8197
238	K	A	-1.9303
239	S	A	0.0000
240	V	A	0.0000
241	A	A	0.0000
242	Y	A	0.0000
243	K	A	0.0000
244	Q	A	0.0000
245	R	A	-2.4278
246	G	A	-1.8479
247	L	A	-1.1569
248	T	A	0.0000
249	V	A	0.0000
250	A	A	0.0000
251	V	A	0.0000
252	R	A	0.0000
253	N	A	0.1583
254	L	A	1.6308
255	V	A	2.5676
256	L	A	2.1667
257	E	A	0.2386
258	L	A	-0.2624
259	R	A	-0.7801
260	G	A	-0.9072
261	R	A	-1.5578
262	C	A	-0.4229
263	G	A	-0.5053
264	C	A	-1.1664
265	T	A	-1.5604
266	E	A	-2.0244
267	F	A	0.0000
268	V	A	0.8289
269	A	A	0.8071
270	L	A	0.0000
271	A	A	0.0198
272	F	A	0.0000
273	P	A	0.0000
274	A	A	-0.8627
275	V	A	-0.9765
276	R	A	-1.9681
277	A	A	-1.1743
278	G	A	-0.4527
279	G	A	0.0000
280	G	A	0.0000
281	C	A	0.0000
282	K	A	-0.8534
283	R	A	-1.8141
284	R	A	-2.1470
285	V	A	-1.1205
286	D	A	-0.2675
287	Y	A	0.5707
288	V	A	0.0000
289	E	A	0.2983
290	F	A	0.4243
291	T	A	0.0375
292	F	A	0.0667
293	N	A	-0.0294
294	T	A	0.3494
295	L	A	0.8728
296	S	A	0.3958
297	A	A	0.4484
298	P	A	0.6520
299	I	A	1.4453
300	C	A	1.2707
301	L	A	0.8913
302	P	A	-0.1487
303	A	A	-0.8756
304	D	A	-1.8596
305	G	A	-1.3376
306	R	A	-0.7892
307	A	A	-0.1876
308	V	A	0.1807
309	T	A	0.1205
310	L	A	0.0000
311	R	A	0.0000
312	Q	A	-1.0166
313	E	A	-1.4352
314	Y	A	-0.6712
315	Q	A	-1.2190
316	T	A	0.0000
317	N	A	0.0000
318	L	A	0.0000
319	T	A	0.0000
320	V	A	0.0621
321	D	A	0.0378
322	C	A	0.0000
323	I	A	-0.3639
324	G	A	-1.3379
325	K	A	-1.7766
326	S	A	-0.6577
327	I	A	0.2833
328	L	A	0.7074
329	K	A	0.2205
330	L	A	-0.5213
331	E	A	-2.1430
332	C	A	-2.0652
333	N	A	-3.0174
334	E	A	-2.9937
335	C	A	-1.4763
336	C	A	-1.6383
337	E	A	-2.8033
338	P	A	-1.1035
339	F	A	0.3107
340	Y	A	0.8550
341	E	A	0.5852
342	L	A	0.0000
343	I	A	0.0000
344	I	A	0.0000
345	P	A	-0.5996
346	N	A	-0.8922
347	D	A	-1.1793
348	I	A	0.0200
349	D	A	0.0000
350	L	A	0.0000
351	V	A	0.1175
352	L	A	0.0000
353	C	A	0.7586
354	L	A	1.2253
355	Q	A	-0.0144
356	E	A	-1.0679
357	T	A	-0.1913
358	V	A	0.5449
359	S	A	0.3253
360	T	A	0.3449
361	L	A	0.7519
362	I	A	0.3201
363	S	A	-0.7150
364	E	A	-1.7520
365	Q	A	0.0000
366	I	A	0.8263
367	V	A	0.6538
368	V	A	0.0000
369	L	A	0.1221
370	A	A	0.0000
371	S	A	0.0000
372	P	A	-0.9346
373	N	A	-1.7286
374	P	A	-1.5870
375	I	A	0.0000
376	Q	A	0.0000
377	P	A	-1.5859
378	R	A	-1.8665
379	L	A	-0.0057
380	V	A	1.4326
381	D	A	0.2865
382	T	A	0.4762
383	F	A	2.0864
384	S	A	1.0637
385	K	A	0.7002
386	V	A	1.4150
387	C	A	0.4277
388	D	A	-1.5154
389	F	A	-0.6581
390	S	A	-0.7809
391	Q	A	-0.5301
392	C	A	-0.5225
393	G	A	-1.3127
394	P	A	0.0000
395	N	A	-2.4380
396	H	A	-2.1103
397	G	A	-1.7547
398	S	A	-1.5122
399	G	A	-1.8988
400	K	A	-2.5683
401	P	A	-1.6093
402	S	A	-1.2434
403	C	A	-1.2981
404	H	A	-2.0540
405	R	A	-2.4570