Project name: 8b498a7d0517a0f
Status: done
submitted: 2018-10-12 16:08:53, status changed: 2018-10-12 16:22:24
Settings
Chain sequence(s)
|
A: MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKEPPSSGEPPKSGDRSGYSSPGEPGTPGSRSRTPSLPTPPEREPKKVAVVREPPKSPESAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTEPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-3.8983
-
Maximal score value
-
2.0967
-
Average score
-
-1.0299
-
Total score value
-
-454.1959
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
1 |
M |
A |
0.4399 |
|
2 |
A |
A |
0.0000 |
|
3 |
E |
A |
-1.0033 |
|
4 |
P |
A |
0.0000 |
|
5 |
R |
A |
-1.6014 |
|
6 |
Q |
A |
-1.6079 |
|
7 |
E |
A |
-1.1034 |
|
8 |
F |
A |
-0.7879 |
|
9 |
E |
A |
0.0000 |
|
10 |
V |
A |
-0.7236 |
|
11 |
M |
A |
-1.1047 |
|
12 |
E |
A |
-2.4266 |
|
13 |
D |
A |
-2.3601 |
|
14 |
H |
A |
-1.3182 |
|
15 |
A |
A |
-0.5354 |
|
16 |
G |
A |
-0.0843 |
|
17 |
T |
A |
0.3387 |
|
18 |
Y |
A |
0.7157 |
|
19 |
G |
A |
0.4871 |
|
20 |
L |
A |
1.3934 |
|
21 |
G |
A |
0.1350 |
|
22 |
D |
A |
-1.3666 |
|
23 |
R |
A |
-3.1233 |
|
24 |
K |
A |
-3.8983 |
|
25 |
D |
A |
-3.5937 |
|
26 |
Q |
A |
-3.0024 |
|
27 |
G |
A |
-2.0195 |
|
28 |
G |
A |
-2.0587 |
|
29 |
Y |
A |
-1.0528 |
|
30 |
T |
A |
-0.6868 |
|
31 |
M |
A |
0.3931 |
|
32 |
H |
A |
-0.8035 |
|
33 |
Q |
A |
-1.3166 |
|
34 |
D |
A |
-2.9416 |
|
35 |
Q |
A |
-2.7994 |
|
36 |
E |
A |
-2.9587 |
|
37 |
G |
A |
-2.1002 |
|
38 |
D |
A |
-3.2445 |
|
39 |
T |
A |
-2.2880 |
|
40 |
D |
A |
-2.0597 |
|
41 |
A |
A |
-0.7898 |
|
42 |
G |
A |
0.0000 |
|
43 |
L |
A |
-0.9924 |
|
44 |
K |
A |
-1.7232 |
|
45 |
E |
A |
-1.5102 |
|
46 |
S |
A |
-1.1045 |
|
47 |
P |
A |
0.0000 |
|
48 |
L |
A |
0.0000 |
|
49 |
Q |
A |
-1.5655 |
|
50 |
T |
A |
-1.1419 |
|
51 |
P |
A |
-1.3206 |
|
52 |
T |
A |
-1.9164 |
|
53 |
E |
A |
-3.4544 |
|
54 |
D |
A |
-3.4487 |
|
55 |
G |
A |
-3.2012 |
|
56 |
S |
A |
-2.6397 |
|
57 |
E |
A |
-3.1330 |
|
58 |
E |
A |
-3.3240 |
|
59 |
P |
A |
-2.2177 |
|
60 |
G |
A |
-2.1098 |
|
61 |
S |
A |
-2.7055 |
|
62 |
E |
A |
-2.7830 |
|
63 |
T |
A |
-2.1314 |
|
64 |
S |
A |
-1.9340 |
|
65 |
D |
A |
-3.1087 |
|
66 |
A |
A |
-2.3399 |
|
67 |
K |
A |
-3.4021 |
|
68 |
S |
A |
-2.4665 |
|
69 |
T |
A |
0.0000 |
|
70 |
P |
A |
0.0000 |
|
71 |
T |
A |
-1.1343 |
|
72 |
A |
A |
-0.8252 |
|
73 |
E |
A |
-1.8603 |
|
74 |
D |
A |
-1.1395 |
|
75 |
V |
A |
0.7000 |
|
76 |
T |
A |
-0.3054 |
|
77 |
A |
A |
0.0000 |
|
78 |
P |
A |
0.0000 |
|
79 |
L |
A |
1.0326 |
|
80 |
V |
A |
0.0000 |
|
81 |
D |
A |
-1.1630 |
|
82 |
E |
A |
-2.1217 |
|
83 |
G |
A |
-1.6154 |
|
84 |
A |
A |
-1.0583 |
|
85 |
P |
A |
-0.9921 |
|
86 |
G |
A |
-1.3891 |
|
87 |
K |
A |
-2.0617 |
|
88 |
Q |
A |
-2.0139 |
|
89 |
A |
A |
0.0000 |
|
90 |
A |
A |
-0.9055 |
|
91 |
A |
A |
-0.8910 |
|
92 |
Q |
A |
-1.1865 |
|
93 |
P |
A |
-1.1689 |
|
94 |
H |
A |
-2.1925 |
|
95 |
T |
A |
-2.1874 |
|
96 |
E |
A |
-2.6288 |
|
97 |
I |
A |
-2.0677 |
|
98 |
P |
A |
-1.8828 |
|
99 |
E |
A |
-3.0591 |
|
100 |
G |
A |
0.0000 |
|
101 |
T |
A |
-2.8082 |
|
102 |
T |
A |
-1.7353 |
|
103 |
A |
A |
-1.5970 |
|
104 |
E |
A |
-1.9382 |
|
105 |
E |
A |
-1.0958 |
|
106 |
A |
A |
-0.9891 |
|
107 |
G |
A |
0.0000 |
|
108 |
I |
A |
0.3727 |
|
109 |
G |
A |
-0.7799 |
|
110 |
D |
A |
-1.4427 |
|
111 |
T |
A |
-0.9417 |
|
112 |
P |
A |
-0.5735 |
|
113 |
S |
A |
-0.2319 |
|
114 |
L |
A |
0.4474 |
|
115 |
E |
A |
-1.1860 |
|
116 |
D |
A |
-2.1933 |
|
117 |
E |
A |
-2.0342 |
|
118 |
A |
A |
-1.1706 |
|
119 |
A |
A |
-0.4926 |
|
120 |
G |
A |
-0.9212 |
|
121 |
H |
A |
-1.2858 |
|
122 |
V |
A |
-0.7653 |
|
123 |
T |
A |
-0.8446 |
|
124 |
Q |
A |
-1.0256 |
|
125 |
A |
A |
0.0000 |
|
126 |
R |
A |
-2.0268 |
|
127 |
M |
A |
-1.4385 |
|
128 |
V |
A |
-1.5291 |
|
129 |
S |
A |
-2.1919 |
|
130 |
K |
A |
-2.9347 |
|
131 |
S |
A |
-2.2070 |
|
132 |
K |
A |
-3.2441 |
|
133 |
D |
A |
-3.1377 |
|
134 |
G |
A |
-1.7206 |
|
135 |
T |
A |
-1.2828 |
|
136 |
G |
A |
-1.8989 |
|
137 |
S |
A |
-2.1201 |
|
138 |
D |
A |
-3.4957 |
|
139 |
D |
A |
-3.8142 |
|
140 |
K |
A |
-3.2998 |
|
141 |
K |
A |
0.0000 |
|
142 |
A |
A |
-1.7813 |
|
143 |
K |
A |
-2.2989 |
|
144 |
G |
A |
-1.5383 |
|
145 |
A |
A |
-1.6583 |
|
146 |
D |
A |
-2.6410 |
|
147 |
G |
A |
-2.0253 |
|
148 |
K |
A |
-2.0228 |
|
149 |
T |
A |
-1.7053 |
|
150 |
K |
A |
-1.2503 |
|
151 |
I |
A |
-0.2962 |
|
152 |
A |
A |
-0.3711 |
|
153 |
T |
A |
-0.8357 |
|
154 |
P |
A |
-1.4025 |
|
155 |
R |
A |
-2.2351 |
|
156 |
G |
A |
-1.5510 |
|
157 |
A |
A |
-0.8191 |
|
158 |
A |
A |
-0.8700 |
|
159 |
P |
A |
-0.7574 |
|
160 |
P |
A |
-1.0800 |
|
161 |
G |
A |
-1.1075 |
|
162 |
Q |
A |
-1.8449 |
|
163 |
K |
A |
-2.4177 |
|
164 |
G |
A |
-1.9335 |
|
165 |
Q |
A |
-1.9114 |
|
166 |
A |
A |
-1.1188 |
|
167 |
N |
A |
0.0000 |
|
168 |
A |
A |
-0.6285 |
|
169 |
T |
A |
0.0000 |
|
170 |
R |
A |
-1.1246 |
|
171 |
I |
A |
0.0000 |
|
172 |
P |
A |
-0.6067 |
|
173 |
A |
A |
0.0000 |
|
174 |
K |
A |
-1.0088 |
|
175 |
T |
A |
-0.7585 |
|
176 |
P |
A |
-0.9396 |
|
177 |
P |
A |
-1.5252 |
|
178 |
A |
A |
-1.5756 |
|
179 |
P |
A |
-1.9636 |
|
180 |
K |
A |
-3.1416 |
|
181 |
E |
A |
-3.0332 |
|
182 |
P |
A |
-1.7537 |
|
183 |
P |
A |
-0.7665 |
|
184 |
S |
A |
-0.3721 |
|
185 |
S |
A |
-0.4713 |
|
186 |
G |
A |
-0.5654 |
|
187 |
E |
A |
-0.6370 |
|
188 |
P |
A |
0.0000 |
|
189 |
P |
A |
-0.8786 |
|
190 |
K |
A |
-1.0911 |
|
191 |
S |
A |
-1.1448 |
|
192 |
G |
A |
-1.5882 |
|
193 |
D |
A |
-2.0144 |
|
194 |
R |
A |
-2.4055 |
|
195 |
S |
A |
-1.6945 |
|
196 |
G |
A |
-1.5883 |
|
197 |
Y |
A |
-1.4092 |
|
198 |
S |
A |
0.0000 |
|
199 |
S |
A |
-1.1334 |
|
200 |
P |
A |
-1.2832 |
|
201 |
G |
A |
-1.2405 |
|
202 |
E |
A |
-1.5079 |
|
203 |
P |
A |
-1.0625 |
|
204 |
G |
A |
-0.8630 |
|
205 |
T |
A |
-0.6508 |
|
206 |
P |
A |
-1.1971 |
|
207 |
G |
A |
-0.9666 |
|
208 |
S |
A |
-1.0875 |
|
209 |
R |
A |
-0.8575 |
|
210 |
S |
A |
0.0000 |
|
211 |
R |
A |
-0.7766 |
|
212 |
T |
A |
0.0000 |
|
213 |
P |
A |
0.0000 |
|
214 |
S |
A |
0.0000 |
|
215 |
L |
A |
-0.1017 |
|
216 |
P |
A |
-0.3783 |
|
217 |
T |
A |
-0.6493 |
|
218 |
P |
A |
-1.1716 |
|
219 |
P |
A |
-1.5000 |
|
220 |
E |
A |
-3.1134 |
|
221 |
R |
A |
-2.8699 |
|
222 |
E |
A |
-3.3104 |
|
223 |
P |
A |
-2.6126 |
|
224 |
K |
A |
-3.2138 |
|
225 |
K |
A |
-2.9671 |
|
226 |
V |
A |
-0.7264 |
|
227 |
A |
A |
0.2763 |
|
228 |
V |
A |
0.0075 |
|
229 |
V |
A |
-0.2587 |
|
230 |
R |
A |
-1.8978 |
|
231 |
E |
A |
-2.1232 |
|
232 |
P |
A |
-1.9785 |
|
233 |
P |
A |
-1.6313 |
|
234 |
K |
A |
-1.7152 |
|
235 |
S |
A |
-1.1501 |
|
236 |
P |
A |
-1.3638 |
|
237 |
E |
A |
-2.1801 |
|
238 |
S |
A |
-1.7688 |
|
239 |
A |
A |
-1.5187 |
|
240 |
K |
A |
-2.5658 |
|
241 |
S |
A |
-1.6893 |
|
242 |
R |
A |
-0.8381 |
|
243 |
L |
A |
-0.1057 |
|
244 |
Q |
A |
-0.6100 |
|
245 |
T |
A |
-0.3507 |
|
246 |
A |
A |
-0.2108 |
|
247 |
P |
A |
-0.3952 |
|
248 |
V |
A |
0.4076 |
|
249 |
P |
A |
-0.5205 |
|
250 |
M |
A |
0.0000 |
|
251 |
P |
A |
-1.4597 |
|
252 |
D |
A |
-2.5748 |
|
253 |
L |
A |
-1.8397 |
|
254 |
K |
A |
-2.1515 |
|
255 |
N |
A |
-1.9620 |
|
256 |
V |
A |
-1.5941 |
|
257 |
K |
A |
-2.0252 |
|
258 |
S |
A |
-1.0182 |
|
259 |
K |
A |
-2.0877 |
|
260 |
I |
A |
0.0000 |
|
261 |
G |
A |
-2.5370 |
|
262 |
S |
A |
-1.8400 |
|
263 |
T |
A |
-1.8249 |
|
264 |
E |
A |
-2.7654 |
|
265 |
N |
A |
-2.6240 |
|
266 |
L |
A |
0.0000 |
|
267 |
K |
A |
-1.5176 |
|
268 |
H |
A |
-1.8646 |
|
269 |
Q |
A |
-2.0410 |
|
270 |
P |
A |
-1.4637 |
|
271 |
G |
A |
-0.9131 |
|
272 |
G |
A |
-0.8442 |
|
273 |
G |
A |
-0.7914 |
|
274 |
K |
A |
-0.8995 |
|
275 |
V |
A |
1.3329 |
|
276 |
Q |
A |
0.3508 |
|
277 |
I |
A |
1.8701 |
|
278 |
I |
A |
1.7198 |
|
279 |
N |
A |
-0.8647 |
|
280 |
K |
A |
-2.1091 |
|
281 |
K |
A |
-2.3734 |
|
282 |
L |
A |
-0.7774 |
|
283 |
D |
A |
-1.7671 |
|
284 |
L |
A |
-1.6185 |
|
285 |
S |
A |
-1.3733 |
|
286 |
N |
A |
-1.0765 |
|
287 |
V |
A |
0.2238 |
|
288 |
Q |
A |
-1.1342 |
|
289 |
S |
A |
-1.1297 |
|
290 |
K |
A |
-1.5929 |
|
291 |
C |
A |
-1.6751 |
|
292 |
G |
A |
-1.7131 |
|
293 |
S |
A |
-1.5763 |
|
294 |
K |
A |
-2.0521 |
|
295 |
D |
A |
-2.8108 |
|
296 |
N |
A |
-2.2581 |
|
297 |
I |
A |
-1.6387 |
|
298 |
K |
A |
-1.8218 |
|
299 |
H |
A |
0.0000 |
|
300 |
V |
A |
0.0000 |
|
301 |
P |
A |
0.0000 |
|
302 |
G |
A |
-0.7326 |
|
303 |
G |
A |
-0.7594 |
|
304 |
G |
A |
-0.2991 |
|
305 |
S |
A |
0.5993 |
|
306 |
V |
A |
1.5320 |
|
307 |
Q |
A |
0.5991 |
|
308 |
I |
A |
1.6058 |
|
309 |
V |
A |
2.0967 |
|
310 |
Y |
A |
0.6585 |
|
311 |
K |
A |
0.0009 |
|
312 |
P |
A |
-0.8639 |
|
313 |
V |
A |
0.0000 |
|
314 |
D |
A |
0.0000 |
|
315 |
L |
A |
0.0000 |
|
316 |
S |
A |
-0.7244 |
|
317 |
K |
A |
0.1994 |
|
318 |
V |
A |
0.8161 |
|
319 |
T |
A |
0.5577 |
|
320 |
S |
A |
0.7512 |
|
321 |
K |
A |
0.3948 |
|
322 |
C |
A |
0.3462 |
|
323 |
G |
A |
-0.4524 |
|
324 |
S |
A |
-0.7801 |
|
325 |
L |
A |
0.4259 |
|
326 |
G |
A |
0.0000 |
|
327 |
N |
A |
0.0000 |
|
328 |
I |
A |
0.8710 |
|
329 |
H |
A |
-0.3412 |
|
330 |
H |
A |
-1.0730 |
|
331 |
K |
A |
-0.7294 |
|
332 |
P |
A |
0.0000 |
|
333 |
G |
A |
0.0000 |
|
334 |
G |
A |
-0.4869 |
|
335 |
G |
A |
-0.7350 |
|
336 |
Q |
A |
-0.9660 |
|
337 |
V |
A |
0.4186 |
|
338 |
E |
A |
-1.1684 |
|
339 |
V |
A |
-0.5451 |
|
340 |
K |
A |
-2.2373 |
|
341 |
S |
A |
-1.9391 |
|
342 |
E |
A |
-2.0495 |
|
343 |
K |
A |
-1.7676 |
|
344 |
L |
A |
-0.2980 |
|
345 |
D |
A |
-0.4862 |
|
346 |
F |
A |
0.3269 |
|
347 |
K |
A |
-1.5207 |
|
348 |
D |
A |
-2.0149 |
|
349 |
R |
A |
-1.2838 |
|
350 |
V |
A |
-0.0528 |
|
351 |
Q |
A |
-0.8947 |
|
352 |
S |
A |
-0.6982 |
|
353 |
K |
A |
-0.4771 |
|
354 |
I |
A |
1.2974 |
|
355 |
G |
A |
0.1879 |
|
356 |
S |
A |
0.3292 |
|
357 |
L |
A |
1.0438 |
|
358 |
D |
A |
-0.4557 |
|
359 |
N |
A |
-0.8269 |
|
360 |
I |
A |
-0.7138 |
|
361 |
T |
A |
-0.7654 |
|
362 |
H |
A |
-1.0824 |
|
363 |
V |
A |
-0.7451 |
|
364 |
P |
A |
-0.9537 |
|
365 |
G |
A |
-1.2153 |
|
366 |
G |
A |
-0.7785 |
|
367 |
G |
A |
-0.9847 |
|
368 |
N |
A |
0.0000 |
|
369 |
K |
A |
-0.8777 |
|
370 |
K |
A |
0.0000 |
|
371 |
I |
A |
0.0000 |
|
372 |
E |
A |
0.0599 |
|
373 |
T |
A |
-0.2602 |
|
374 |
H |
A |
-0.2346 |
|
375 |
K |
A |
-0.7019 |
|
376 |
L |
A |
-0.0590 |
|
377 |
T |
A |
-0.5372 |
|
378 |
F |
A |
-0.8067 |
|
379 |
R |
A |
-1.1867 |
|
380 |
E |
A |
-1.6787 |
|
381 |
N |
A |
-1.3342 |
|
382 |
A |
A |
0.0000 |
|
383 |
K |
A |
-1.1733 |
|
384 |
A |
A |
-0.9298 |
|
385 |
K |
A |
-0.9690 |
|
386 |
T |
A |
-1.1124 |
|
387 |
D |
A |
-1.2246 |
|
388 |
H |
A |
-1.2422 |
|
389 |
G |
A |
0.0000 |
|
390 |
A |
A |
-0.7177 |
|
391 |
E |
A |
-0.8965 |
|
392 |
I |
A |
0.6059 |
|
393 |
V |
A |
1.5180 |
|
394 |
Y |
A |
0.0968 |
|
395 |
K |
A |
-1.2310 |
|
396 |
S |
A |
-0.9231 |
|
397 |
P |
A |
-1.0271 |
|
398 |
V |
A |
0.0000 |
|
399 |
V |
A |
-0.6537 |
|
400 |
S |
A |
-0.5358 |
|
401 |
G |
A |
0.0000 |
|
402 |
D |
A |
-1.4800 |
|
403 |
T |
A |
-1.6502 |
|
404 |
E |
A |
-2.4831 |
|
405 |
P |
A |
-1.8810 |
|
406 |
R |
A |
-2.2160 |
|
407 |
H |
A |
-1.6390 |
|
408 |
L |
A |
-0.9166 |
|
409 |
S |
A |
-0.3289 |
|
410 |
N |
A |
-0.3558 |
|
411 |
V |
A |
1.4149 |
|
412 |
S |
A |
0.4791 |
|
413 |
S |
A |
0.1148 |
|
414 |
T |
A |
0.0000 |
|
415 |
G |
A |
-0.7127 |
|
416 |
S |
A |
-0.3277 |
|
417 |
I |
A |
0.0000 |
|
418 |
D |
A |
-0.0249 |
|
419 |
M |
A |
0.0000 |
|
420 |
V |
A |
0.0702 |
|
421 |
D |
A |
-0.4850 |
|
422 |
S |
A |
-0.9816 |
|
423 |
P |
A |
-0.8048 |
|
424 |
Q |
A |
-0.7490 |
|
425 |
L |
A |
0.1814 |
|
426 |
A |
A |
0.2304 |
|
427 |
T |
A |
0.5462 |
|
428 |
L |
A |
1.2622 |
|
429 |
A |
A |
0.0626 |
|
430 |
D |
A |
-0.6715 |
|
431 |
E |
A |
-1.5271 |
|
432 |
V |
A |
0.1224 |
|
433 |
S |
A |
-0.0240 |
|
434 |
A |
A |
0.1843 |
|
435 |
S |
A |
0.0931 |
|
436 |
L |
A |
0.7265 |
|
437 |
A |
A |
-0.3521 |
|
438 |
K |
A |
-1.8309 |
|
439 |
Q |
A |
-1.2430 |
|
440 |
G |
A |
-0.1445 |
|
441 |
L |
A |
1.3285 |
|