Chain sequence(s) |
A: TPVAKNGQLSIKGTQLVNRDGKAVQLKGISSHGLQWYGEYVNKDSLKWLRDDWGITVFRAAMYTADGGYIDNPSVKNKVKEAVEAAKELGIYVIIDWHILNDGNPNQNKEKAKEFFKEMSSLYGNTPNVIYEIANEPNGDVNWKRDIKPYAEEVISVIRKNDPDNIIIVGTGTWSQDVNDAADDQLKDANVMYALHFYAGTHGQFLRDKANYALSKGAPIFVTEWGTSDASGNGGVFLDQSREWLKYLDSKTISWVNWNLSDKQESSSALKPGASKTGGWRLSDLSASGTFVRENILG |
Distance of aggregation | 10 Å |
Dynamic mode | No |
Mutated residues | RA52T, DA99G, NA266S |
Energy difference between WT (input) and mutated protein (by FoldX) | -0.29823 kcal/mol
Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive. |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
34 | T | A | -0.5882 | |
35 | P | A | -0.7870 | |
36 | V | A | -0.8872 | |
37 | A | A | -0.8996 | |
38 | K | A | -2.0117 | |
39 | N | A | 0.0000 | |
40 | G | A | -1.3951 | |
41 | Q | A | -1.9639 | |
42 | L | A | 0.0000 | |
43 | S | A | -1.5325 | |
44 | I | A | -1.1730 | |
45 | K | A | -2.3121 | |
46 | G | A | -1.5128 | |
47 | T | A | -1.4397 | |
48 | Q | A | -1.9090 | |
49 | L | A | 0.0000 | |
50 | V | A | 0.0000 | |
51 | N | A | 0.0000 | |
52 | T | A | -1.9680 | mutated: RA52T |
53 | D | A | -2.8133 | |
54 | G | A | -2.3567 | |
55 | K | A | -2.6511 | |
56 | A | A | -1.4756 | |
57 | V | A | -0.5682 | |
58 | Q | A | -0.9649 | |
59 | L | A | 0.0000 | |
60 | K | A | -0.1708 | |
61 | G | A | 0.0000 | |
62 | I | A | 0.0000 | |
63 | S | A | 0.0000 | |
64 | S | A | 0.0000 | |
65 | H | A | 0.0000 | |
66 | G | A | 0.0000 | |
67 | L | A | 0.0000 | |
68 | Q | A | -0.2901 | |
69 | W | A | 0.7186 | |
70 | Y | A | -0.1465 | |
71 | G | A | 0.0000 | |
72 | E | A | -1.9411 | |
73 | Y | A | 0.0000 | |
74 | V | A | 0.0000 | |
75 | N | A | -2.4536 | |
76 | K | A | -2.9857 | |
77 | D | A | -2.8466 | |
78 | S | A | 0.0000 | |
79 | L | A | 0.0000 | |
80 | K | A | -2.6761 | |
81 | W | A | -1.6918 | |
82 | L | A | 0.0000 | |
83 | R | A | -1.7595 | |
84 | D | A | -2.0304 | |
85 | D | A | -1.1117 | |
86 | W | A | 0.0000 | |
87 | G | A | -0.8945 | |
88 | I | A | 0.0000 | |
89 | T | A | -0.2551 | |
90 | V | A | 0.0000 | |
91 | F | A | 0.0000 | |
92 | R | A | 0.0000 | |
93 | A | A | 0.0000 | |
94 | A | A | 0.0000 | |
95 | M | A | 0.0000 | |
96 | Y | A | 0.0000 | |
97 | T | A | 0.0000 | |
98 | A | A | -0.9143 | |
99 | G | A | -1.1113 | mutated: DA99G |
100 | G | A | -1.1716 | |
101 | G | A | 0.0000 | |
102 | Y | A | -1.1431 | |
103 | I | A | -1.0385 | |
104 | D | A | -2.3177 | |
105 | N | A | -2.2633 | |
106 | P | A | -1.4545 | |
107 | S | A | -1.3163 | |
108 | V | A | -1.3087 | |
109 | K | A | -1.6571 | |
110 | N | A | -2.0760 | |
111 | K | A | -2.0804 | |
112 | V | A | 0.0000 | |
113 | K | A | -2.0295 | |
114 | E | A | -2.7434 | |
115 | A | A | 0.0000 | |
116 | V | A | 0.0000 | |
117 | E | A | -3.3781 | |
118 | A | A | 0.0000 | |
119 | A | A | 0.0000 | |
120 | K | A | -2.4212 | |
121 | E | A | -3.0389 | |
122 | L | A | 0.0000 | |
123 | G | A | -1.2115 | |
124 | I | A | 0.0000 | |
125 | Y | A | 0.0000 | |
126 | V | A | 0.0000 | |
127 | I | A | 0.0000 | |
128 | I | A | 0.0000 | |
129 | D | A | 0.0000 | |
130 | W | A | 0.0000 | |
131 | H | A | 0.0000 | |
132 | I | A | 0.0000 | |
133 | L | A | -0.5017 | |
134 | N | A | -1.4542 | |
135 | D | A | -1.3326 | |
136 | G | A | -1.3039 | |
137 | N | A | -1.7514 | |
138 | P | A | 0.0000 | |
139 | N | A | -1.6930 | |
140 | Q | A | -2.0573 | |
141 | N | A | 0.0000 | |
142 | K | A | -2.5361 | |
143 | E | A | -3.4472 | |
144 | K | A | -3.1322 | |
145 | A | A | 0.0000 | |
146 | K | A | -2.8999 | |
147 | E | A | -3.5758 | |
148 | F | A | 0.0000 | |
149 | F | A | 0.0000 | |
150 | K | A | -2.7819 | |
151 | E | A | -1.9732 | |
152 | M | A | 0.0000 | |
153 | S | A | 0.0000 | |
154 | S | A | -0.9780 | |
155 | L | A | 0.3211 | |
156 | Y | A | 0.0000 | |
157 | G | A | -1.3836 | |
158 | N | A | -1.4776 | |
159 | T | A | 0.0000 | |
160 | P | A | -1.1937 | |
161 | N | A | 0.0000 | |
162 | V | A | 0.0000 | |
163 | I | A | 0.0000 | |
164 | Y | A | 0.0000 | |
165 | E | A | 0.0000 | |
166 | I | A | 0.0000 | |
167 | A | A | 0.0000 | |
168 | N | A | 0.0000 | |
169 | E | A | 0.0000 | |
170 | P | A | 0.0000 | |
171 | N | A | -0.9914 | |
172 | G | A | -1.6640 | |
173 | D | A | -2.3156 | |
174 | V | A | 0.0000 | |
175 | N | A | -2.4777 | |
176 | W | A | 0.0000 | |
177 | K | A | -3.3605 | |
178 | R | A | -3.0370 | |
179 | D | A | -2.2888 | |
180 | I | A | 0.0000 | |
181 | K | A | -1.7433 | |
182 | P | A | -1.4638 | |
183 | Y | A | 0.0000 | |
184 | A | A | 0.0000 | |
185 | E | A | -1.4832 | |
186 | E | A | -1.4324 | |
187 | V | A | 0.0000 | |
188 | I | A | 0.0000 | |
189 | S | A | -1.2546 | |
190 | V | A | -1.6509 | |
191 | I | A | 0.0000 | |
192 | R | A | -1.8877 | |
193 | K | A | -2.3284 | |
194 | N | A | -2.2156 | |
195 | D | A | 0.0000 | |
196 | P | A | -1.9811 | |
197 | D | A | -2.3877 | |
198 | N | A | 0.0000 | |
199 | I | A | 0.0000 | |
200 | I | A | 0.0000 | |
201 | I | A | 0.0000 | |
202 | V | A | 0.0000 | |
203 | G | A | 0.0000 | |
204 | T | A | 0.0000 | |
205 | G | A | 0.0000 | |
206 | T | A | -0.2647 | |
207 | W | A | 0.5863 | |
208 | S | A | 0.0000 | |
209 | Q | A | -0.2565 | |
210 | D | A | -0.6711 | |
211 | V | A | 0.0000 | |
212 | N | A | -1.8378 | |
213 | D | A | -2.1221 | |
214 | A | A | 0.0000 | |
215 | A | A | 0.0000 | |
216 | D | A | -2.8109 | |
217 | D | A | -2.1711 | |
218 | Q | A | -2.0019 | |
219 | L | A | -1.4268 | |
220 | K | A | -1.9929 | |
221 | D | A | -1.5062 | |
222 | A | A | -1.0849 | |
223 | N | A | 0.0000 | |
224 | V | A | 0.0000 | |
225 | M | A | 0.0000 | |
226 | Y | A | 0.0000 | |
227 | A | A | 0.0000 | |
228 | L | A | 0.0000 | |
229 | H | A | 0.0000 | |
230 | F | A | 0.0000 | |
231 | Y | A | 0.0000 | |
232 | A | A | 0.0000 | |
233 | G | A | -0.4957 | |
234 | T | A | -0.4144 | |
235 | H | A | -0.2416 | |
236 | G | A | -0.6022 | |
237 | Q | A | -0.9591 | |
238 | F | A | 0.5658 | |
239 | L | A | 0.0000 | |
240 | R | A | 0.0000 | |
241 | D | A | -1.7320 | |
242 | K | A | -1.2760 | |
243 | A | A | 0.0000 | |
244 | N | A | -1.6858 | |
245 | Y | A | -1.2556 | |
246 | A | A | 0.0000 | |
247 | L | A | -1.1592 | |
248 | S | A | -0.9737 | |
249 | K | A | -1.9181 | |
250 | G | A | -1.3732 | |
251 | A | A | 0.0000 | |
252 | P | A | 0.0000 | |
253 | I | A | 0.0000 | |
254 | F | A | 0.0000 | |
255 | V | A | 0.0000 | |
256 | T | A | 0.0000 | |
257 | E | A | 0.0000 | |
258 | W | A | 0.0000 | |
259 | G | A | 0.0000 | |
260 | T | A | 0.0000 | |
261 | S | A | 0.0000 | |
262 | D | A | -0.6138 | |
263 | A | A | -0.3155 | |
264 | S | A | -0.4796 | |
265 | G | A | 0.0000 | |
266 | S | A | -0.7240 | mutated: NA266S |
267 | G | A | -0.6751 | |
268 | G | A | -0.1452 | |
269 | V | A | 0.4166 | |
270 | F | A | 0.2151 | |
271 | L | A | 0.0463 | |
272 | D | A | -1.9662 | |
273 | Q | A | -1.9959 | |
274 | S | A | 0.0000 | |
275 | R | A | -2.6033 | |
276 | E | A | -2.9095 | |
277 | W | A | 0.0000 | |
278 | L | A | 0.0000 | |
279 | K | A | -3.2411 | |
280 | Y | A | -2.0851 | |
281 | L | A | 0.0000 | |
282 | D | A | -2.9326 | |
283 | S | A | -2.1692 | |
284 | K | A | -2.5740 | |
285 | T | A | -1.8463 | |
286 | I | A | 0.0000 | |
287 | S | A | 0.0000 | |
288 | W | A | 0.0000 | |
289 | V | A | 0.0000 | |
290 | N | A | 0.0000 | |
291 | W | A | 0.0000 | |
292 | N | A | 0.0000 | |
293 | L | A | 0.0000 | |
294 | S | A | 0.0000 | |
295 | D | A | -1.6432 | |
296 | K | A | -1.4487 | |
297 | Q | A | -1.9085 | |
298 | E | A | -1.3774 | |
299 | S | A | -0.8027 | |
300 | S | A | 0.0000 | |
301 | S | A | 0.0000 | |
302 | A | A | 0.0000 | |
303 | L | A | 0.0000 | |
304 | K | A | -2.0411 | |
305 | P | A | -1.6673 | |
306 | G | A | -1.2473 | |
307 | A | A | 0.0000 | |
308 | S | A | -1.4775 | |
309 | K | A | -2.0184 | |
310 | T | A | -1.8639 | |
311 | G | A | 0.0000 | |
312 | G | A | -1.2316 | |
313 | W | A | 0.0000 | |
314 | R | A | -1.3554 | |
315 | L | A | 0.4212 | |
316 | S | A | -0.3767 | |
317 | D | A | -1.0869 | |
318 | L | A | 0.0000 | |
319 | S | A | -0.3589 | |
320 | A | A | 0.0804 | |
321 | S | A | 0.0000 | |
322 | G | A | 0.0000 | |
323 | T | A | -0.3961 | |
324 | F | A | 0.0000 | |
325 | V | A | 0.0000 | |
326 | R | A | -0.9712 | |
327 | E | A | -1.6573 | |
328 | N | A | -0.9938 | |
329 | I | A | -0.1807 | |
330 | L | A | 0.4392 | |
331 | G | A | -0.2422 |