Chain sequence(s) |
A: AMADLEQKVLEMEASTYDGVFIWKISDFPRKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLMLLDQNNREHVIDAFRPDVTSSSFQRPVNDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKAIVDLTGL C: AMADLEQKVLEMEASTYDGVFIWKISDFPRKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLMLLDQNNREHVIDAFRPDVTSSSFQRPVNDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKAIVDLTGL B: AMADLEQKVLEMEASTYDGVFIWKISDFPRKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLMLLDQNNREHVIDAFRPDVTSSSFQRPVNDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKAIVDLTGL D: PQQATDD |
Distance of aggregation | 10 Å |
Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
334 | A | A | -0.4573 | |
335 | M | A | -0.9094 | |
336 | A | A | -1.5154 | |
337 | D | A | -2.5817 | |
338 | L | A | 0.0000 | |
339 | E | A | -2.7378 | |
340 | Q | A | -2.7701 | |
341 | K | A | -2.4849 | |
342 | V | A | 0.0000 | |
343 | L | A | -1.1627 | |
344 | E | A | -1.6398 | |
345 | M | A | -1.4729 | |
346 | E | A | -1.8610 | |
347 | A | A | -0.7807 | |
348 | S | A | 0.0000 | |
349 | T | A | 0.0000 | |
350 | Y | A | -0.3470 | |
351 | D | A | -1.2562 | |
352 | G | A | 0.0000 | |
353 | V | A | 0.1961 | |
354 | F | A | 0.0000 | |
355 | I | A | -0.0322 | |
356 | W | A | 0.0000 | |
357 | K | A | -1.2156 | |
358 | I | A | 0.0000 | |
359 | S | A | -1.9404 | |
360 | D | A | -2.2685 | |
361 | F | A | 0.0000 | |
362 | P | A | -2.3551 | |
363 | R | A | -3.1758 | |
364 | K | A | -2.1928 | |
365 | R | A | 0.0000 | |
366 | Q | A | -2.3100 | |
367 | E | A | -2.2848 | |
368 | A | A | 0.0000 | |
369 | V | A | -0.4119 | |
370 | A | A | -0.7365 | |
371 | G | A | -0.9495 | |
372 | R | A | -1.7101 | |
373 | I | A | 0.0389 | |
374 | P | A | -0.4410 | |
375 | A | A | -0.2292 | |
376 | I | A | 0.8118 | |
377 | F | A | 0.6527 | |
378 | S | A | 0.0000 | |
379 | P | A | -0.2655 | |
380 | A | A | 0.0000 | |
381 | F | A | 0.0000 | |
382 | Y | A | -0.1676 | |
383 | T | A | 0.0000 | |
384 | S | A | -0.2275 | |
385 | R | A | -0.4429 | |
386 | Y | A | 0.1139 | |
387 | G | A | 0.0000 | |
388 | Y | A | 0.0000 | |
389 | K | A | -0.4057 | |
390 | M | A | 0.0000 | |
391 | C | A | 0.0000 | |
392 | L | A | 0.0000 | |
393 | R | A | -0.0424 | |
394 | I | A | 0.0000 | |
395 | Y | A | 0.0000 | |
396 | L | A | 0.0000 | |
397 | N | A | -0.6435 | |
398 | G | A | 0.0000 | |
399 | D | A | 0.0000 | |
400 | G | A | -1.1159 | |
401 | T | A | -0.5370 | |
402 | G | A | 0.0000 | |
403 | R | A | -1.3304 | |
404 | G | A | -0.9622 | |
405 | T | A | -0.5893 | |
406 | H | A | -0.5238 | |
407 | L | A | 0.0000 | |
408 | S | A | 0.0000 | |
409 | L | A | 0.0000 | |
410 | F | A | 0.0000 | |
411 | F | A | 0.0000 | |
412 | V | A | 0.0000 | |
413 | V | A | 0.0000 | |
414 | M | A | 0.0000 | |
415 | K | A | -1.7864 | |
416 | G | A | -0.9953 | |
417 | P | A | -0.5629 | |
418 | N | A | 0.0000 | |
419 | D | A | 0.0000 | |
420 | A | A | -1.0124 | |
421 | L | A | -0.4046 | |
422 | L | A | -0.5904 | |
423 | R | A | -1.9231 | |
424 | W | A | -1.1068 | |
425 | P | A | -0.9676 | |
426 | F | A | 0.0000 | |
427 | N | A | -2.0230 | |
428 | Q | A | 0.0000 | |
429 | K | A | -1.6594 | |
430 | V | A | 0.0000 | |
431 | T | A | -0.1200 | |
432 | L | A | 0.0000 | |
433 | M | A | 0.6780 | |
434 | L | A | 0.0000 | |
435 | L | A | 0.0000 | |
436 | D | A | 0.0000 | |
437 | Q | A | 0.0000 | |
438 | N | A | -3.1699 | |
439 | N | A | -3.4063 | |
440 | R | A | -3.8276 | |
441 | E | A | -3.2040 | |
442 | H | A | -1.5186 | |
443 | V | A | 0.1101 | |
444 | I | A | 1.3228 | |
445 | D | A | 0.0855 | |
446 | A | A | -0.3749 | |
447 | F | A | -1.3389 | |
448 | R | A | -2.3872 | |
449 | P | A | 0.0000 | |
450 | D | A | -1.1031 | |
451 | V | A | 0.2428 | |
452 | T | A | 0.1560 | |
453 | S | A | -0.2887 | |
454 | S | A | -0.4238 | |
455 | S | A | 0.0000 | |
456 | F | A | 0.0000 | |
457 | Q | A | -0.9371 | |
458 | R | A | -1.5272 | |
459 | P | A | 0.0000 | |
460 | V | A | 0.2539 | |
461 | N | A | -1.5019 | |
462 | D | A | -2.2242 | |
463 | M | A | -1.0530 | |
464 | N | A | -0.7095 | |
465 | I | A | -0.3918 | |
466 | A | A | 0.0000 | |
467 | S | A | 0.0000 | |
468 | G | A | 0.0000 | |
469 | C | A | 0.0000 | |
470 | P | A | 0.0000 | |
471 | L | A | 0.8029 | |
472 | F | A | 0.0000 | |
473 | C | A | 0.0000 | |
474 | P | A | -0.3527 | |
475 | V | A | -0.6431 | |
476 | S | A | -1.2104 | |
477 | K | A | -1.7122 | |
478 | M | A | 0.0000 | |
479 | E | A | -1.9065 | |
480 | A | A | -1.5968 | |
481 | K | A | -2.8957 | |
482 | N | A | -3.0083 | |
483 | S | A | -2.7529 | |
484 | Y | A | 0.0000 | |
485 | V | A | -2.3539 | |
486 | R | A | -3.7831 | |
487 | D | A | -3.5136 | |
488 | D | A | -3.5943 | |
489 | A | A | 0.0000 | |
490 | I | A | 0.0000 | |
491 | F | A | 0.0000 | |
492 | I | A | 0.0000 | |
493 | K | A | 0.0865 | |
494 | A | A | 0.0000 | |
495 | I | A | 0.2619 | |
496 | V | A | 0.0000 | |
497 | D | A | -0.9147 | |
498 | L | A | 0.1537 | |
499 | T | A | -0.0020 | |
500 | G | A | 0.1449 | |
501 | L | A | 1.1607 | |
334 | A | B | -0.5615 | |
335 | M | B | -0.5707 | |
336 | A | B | -1.3453 | |
337 | D | B | -2.3845 | |
338 | L | B | 0.0000 | |
339 | E | B | -2.2156 | |
340 | Q | B | -2.1564 | |
341 | K | B | -1.8026 | |
342 | V | B | 0.0000 | |
343 | L | B | -0.3771 | |
344 | E | B | -0.9089 | |
345 | M | B | -0.8087 | |
346 | E | B | -1.2129 | |
347 | A | B | -0.4191 | |
348 | S | B | 0.0000 | |
349 | T | B | 0.0000 | |
350 | Y | B | -0.3757 | |
351 | D | B | -1.3815 | |
352 | G | B | 0.0000 | |
353 | V | B | 0.1284 | |
354 | F | B | 0.0000 | |
355 | I | B | -0.0140 | |
356 | W | B | 0.0000 | |
357 | K | B | -1.1531 | |
358 | I | B | 0.0000 | |
359 | S | B | -2.0494 | |
360 | D | B | -2.6324 | |
361 | F | B | 0.0000 | |
362 | P | B | -2.4700 | |
363 | R | B | -3.2787 | |
364 | K | B | -2.3621 | |
365 | R | B | 0.0000 | |
366 | Q | B | -2.2451 | |
367 | E | B | -2.1613 | |
368 | A | B | 0.0000 | |
369 | V | B | -0.4093 | |
370 | A | B | -0.6825 | |
371 | G | B | -0.9854 | |
372 | R | B | -1.7891 | |
373 | I | B | -0.2076 | |
374 | P | B | -0.5154 | |
375 | A | B | 0.0240 | |
376 | I | B | 0.8042 | |
377 | F | B | 0.9379 | |
378 | S | B | 0.0000 | |
379 | P | B | -0.0416 | |
380 | A | B | 0.0000 | |
381 | F | B | 0.0000 | |
382 | Y | B | -0.1894 | |
383 | T | B | 0.0000 | |
384 | S | B | -0.3221 | |
385 | R | B | -0.4998 | |
386 | Y | B | 0.0927 | |
387 | G | B | 0.0000 | |
388 | Y | B | 0.0000 | |
389 | K | B | -0.4669 | |
390 | M | B | 0.0000 | |
391 | C | B | 0.0000 | |
392 | L | B | 0.0000 | |
393 | R | B | -0.0006 | |
394 | I | B | 0.0000 | |
395 | Y | B | 0.0000 | |
396 | L | B | 0.0000 | |
397 | N | B | -0.9041 | |
398 | G | B | 0.0000 | |
399 | D | B | -1.4854 | |
400 | G | B | -1.2296 | |
401 | T | B | -0.7697 | |
402 | G | B | 0.0000 | |
403 | R | B | -2.0701 | |
404 | G | B | -1.3048 | |
405 | T | B | -0.7968 | |
406 | H | B | -0.6102 | |
407 | L | B | 0.0000 | |
408 | S | B | 0.0000 | |
409 | L | B | 0.0000 | |
410 | F | B | 0.2447 | |
411 | F | B | 0.0000 | |
412 | V | B | 0.0000 | |
413 | V | B | 0.0000 | |
414 | M | B | 0.0000 | |
415 | K | B | -1.8293 | |
416 | G | B | 0.0000 | |
417 | P | B | -0.6169 | |
418 | N | B | 0.0000 | |
419 | D | B | 0.0000 | |
420 | A | B | -1.0982 | |
421 | L | B | -0.5014 | |
422 | L | B | -0.7677 | |
423 | R | B | -1.8277 | |
424 | W | B | -1.2205 | |
425 | P | B | -1.2091 | |
426 | F | B | 0.0000 | |
427 | N | B | -2.2020 | |
428 | Q | B | 0.0000 | |
429 | K | B | -1.6052 | |
430 | V | B | 0.0000 | |
431 | T | B | -0.1062 | |
432 | L | B | 0.0000 | |
433 | M | B | 0.6904 | |
434 | L | B | 0.0000 | |
435 | L | B | 0.0000 | |
436 | D | B | 0.0000 | |
437 | Q | B | 0.0000 | |
438 | N | B | -3.1540 | |
439 | N | B | -3.4189 | |
440 | R | B | -3.7920 | |
441 | E | B | -3.2135 | |
442 | H | B | -1.4738 | |
443 | V | B | 0.1545 | |
444 | I | B | 1.3629 | |
445 | D | B | 0.2867 | |
446 | A | B | -0.2789 | |
447 | F | B | -1.1616 | |
448 | R | B | -2.5170 | |
449 | P | B | 0.0000 | |
450 | D | B | -1.8517 | |
451 | V | B | -0.4602 | |
452 | T | B | -0.2455 | |
453 | S | B | -0.2595 | |
454 | S | B | -0.2586 | |
455 | S | B | 0.0000 | |
456 | F | B | 0.0000 | |
457 | Q | B | -1.0532 | |
458 | R | B | -1.5860 | |
459 | P | B | 0.0000 | |
460 | V | B | 0.2255 | |
461 | N | B | -1.3563 | |
462 | D | B | -2.2156 | |
463 | M | B | -0.6308 | |
464 | N | B | 0.1674 | |
465 | I | B | 1.8027 | |
466 | A | B | 0.8745 | |
467 | S | B | 0.1254 | |
468 | G | B | -0.2737 | |
469 | C | B | 0.0000 | |
470 | P | B | -0.0246 | |
471 | L | B | 0.6921 | |
472 | F | B | 0.0000 | |
473 | C | B | 0.0000 | |
474 | P | B | -0.2435 | |
475 | V | B | -0.5325 | |
476 | S | B | -1.0528 | |
477 | K | B | -1.4292 | |
478 | M | B | 0.0000 | |
479 | E | B | -1.7754 | |
480 | A | B | -1.5187 | |
481 | K | B | -2.7629 | |
482 | N | B | -2.8898 | |
483 | S | B | -2.6220 | |
484 | Y | B | 0.0000 | |
485 | V | B | -2.1907 | |
486 | R | B | -3.4763 | |
487 | D | B | -3.4700 | |
488 | D | B | -3.7183 | |
489 | A | B | 0.0000 | |
490 | I | B | 0.0000 | |
491 | F | B | 0.0000 | |
492 | I | B | 0.0000 | |
493 | K | B | 0.0902 | |
494 | A | B | 0.0000 | |
495 | I | B | 0.1966 | |
496 | V | B | 0.0000 | |
497 | D | B | -0.9638 | |
498 | L | B | 0.1124 | |
499 | T | B | 0.0058 | |
500 | G | B | 0.1369 | |
501 | L | B | 1.1642 | |
334 | A | C | -0.3942 | |
335 | M | C | -0.6806 | |
336 | A | C | -1.3474 | |
337 | D | C | -2.5976 | |
338 | L | C | 0.0000 | |
339 | E | C | -2.1278 | |
340 | Q | C | -2.3946 | |
341 | K | C | -2.1021 | |
342 | V | C | 0.0000 | |
343 | L | C | -0.5532 | |
344 | E | C | -0.9791 | |
345 | M | C | -0.9267 | |
346 | E | C | -1.1166 | |
347 | A | C | -0.3668 | |
348 | S | C | 0.0000 | |
349 | T | C | 0.0000 | |
350 | Y | C | -0.3370 | |
351 | D | C | -1.3378 | |
352 | G | C | 0.0000 | |
353 | V | C | 0.1750 | |
354 | F | C | 0.0000 | |
355 | I | C | -0.0037 | |
356 | W | C | 0.0000 | |
357 | K | C | -1.1780 | |
358 | I | C | 0.0000 | |
359 | S | C | -1.9728 | |
360 | D | C | -2.3441 | |
361 | F | C | 0.0000 | |
362 | P | C | -2.4295 | |
363 | R | C | -3.1955 | |
364 | K | C | -2.3432 | |
365 | R | C | -1.8156 | |
366 | Q | C | -2.3225 | |
367 | E | C | -2.3353 | |
368 | A | C | 0.0000 | |
369 | V | C | -0.3495 | |
370 | A | C | -0.7331 | |
371 | G | C | -1.1391 | |
372 | R | C | -1.9695 | |
373 | I | C | -0.5822 | |
374 | P | C | -0.7190 | |
375 | A | C | -0.0951 | |
376 | I | C | 0.7402 | |
377 | F | C | 0.9797 | |
378 | S | C | 0.0000 | |
379 | P | C | -0.0636 | |
380 | A | C | 0.0555 | |
381 | F | C | 0.0000 | |
382 | Y | C | -0.1466 | |
383 | T | C | 0.0000 | |
384 | S | C | -0.2538 | |
385 | R | C | -0.5831 | |
386 | Y | C | 0.1167 | |
387 | G | C | 0.0000 | |
388 | Y | C | 0.0000 | |
389 | K | C | -0.3873 | |
390 | M | C | 0.0000 | |
391 | C | C | 0.0000 | |
392 | L | C | 0.0000 | |
393 | R | C | 0.0179 | |
394 | I | C | 0.0000 | |
395 | Y | C | 0.0000 | |
396 | L | C | 0.0000 | |
397 | N | C | -0.9487 | |
398 | G | C | 0.0000 | |
399 | D | C | -1.4635 | |
400 | G | C | -1.2624 | |
401 | T | C | -0.8133 | |
402 | G | C | 0.0000 | |
403 | R | C | -2.2326 | |
404 | G | C | -1.3343 | |
405 | T | C | -0.8532 | |
406 | H | C | -0.6968 | |
407 | L | C | 0.0000 | |
408 | S | C | 0.0000 | |
409 | L | C | 0.0000 | |
410 | F | C | 0.2011 | |
411 | F | C | 0.0000 | |
412 | V | C | 0.0000 | |
413 | V | C | 0.0000 | |
414 | M | C | -0.8411 | |
415 | K | C | -1.7763 | |
416 | G | C | 0.0000 | |
417 | P | C | -0.5956 | |
418 | N | C | 0.0000 | |
419 | D | C | 0.0000 | |
420 | A | C | -1.0634 | |
421 | L | C | -0.4033 | |
422 | L | C | -0.7368 | |
423 | R | C | -1.9304 | |
424 | W | C | -1.1930 | |
425 | P | C | -1.2034 | |
426 | F | C | 0.0000 | |
427 | N | C | -2.2254 | |
428 | Q | C | 0.0000 | |
429 | K | C | -2.0579 | |
430 | V | C | 0.0000 | |
431 | T | C | -0.1970 | |
432 | L | C | 0.0000 | |
433 | M | C | 0.6656 | |
434 | L | C | 0.0000 | |
435 | L | C | 0.0000 | |
436 | D | C | 0.0000 | |
437 | Q | C | 0.0000 | |
438 | N | C | -3.1272 | |
439 | N | C | -3.2467 | |
440 | R | C | -3.8009 | |
441 | E | C | -3.2274 | |
442 | H | C | -1.5304 | |
443 | V | C | 0.1629 | |
444 | I | C | 1.3333 | |
445 | D | C | 0.2328 | |
446 | A | C | -0.3938 | |
447 | F | C | -1.2898 | |
448 | R | C | -2.6897 | |
449 | P | C | 0.0000 | |
450 | D | C | -1.7381 | |
451 | V | C | -0.4826 | |
452 | T | C | -0.2611 | |
453 | S | C | -0.2562 | |
454 | S | C | -0.2627 | |
455 | S | C | 0.0000 | |
456 | F | C | 0.0000 | |
457 | Q | C | -1.0412 | |
458 | R | C | -1.6750 | |
459 | P | C | 0.0000 | |
460 | V | C | 0.2021 | |
461 | N | C | -1.3709 | |
462 | D | C | -2.2008 | |
463 | M | C | -0.6612 | |
464 | N | C | 0.1634 | |
465 | I | C | 1.8131 | |
466 | A | C | 0.8752 | |
467 | S | C | 0.1680 | |
468 | G | C | -0.2912 | |
469 | C | C | 0.0000 | |
470 | P | C | -0.1172 | |
471 | L | C | 0.5797 | |
472 | F | C | 0.0000 | |
473 | C | C | 0.0000 | |
474 | P | C | -0.2987 | |
475 | V | C | -0.5533 | |
476 | S | C | -1.0922 | |
477 | K | C | -1.5354 | |
478 | M | C | 0.0000 | |
479 | E | C | -1.7837 | |
480 | A | C | -1.5043 | |
481 | K | C | -2.8110 | |
482 | N | C | -2.9153 | |
483 | S | C | -2.7850 | |
484 | Y | C | 0.0000 | |
485 | V | C | -2.3373 | |
486 | R | C | -3.7994 | |
487 | D | C | -3.5877 | |
488 | D | C | -3.7241 | |
489 | A | C | 0.0000 | |
490 | I | C | 0.0000 | |
491 | F | C | 0.0000 | |
492 | I | C | 0.0000 | |
493 | K | C | 0.0879 | |
494 | A | C | 0.0000 | |
495 | I | C | 0.2305 | |
496 | V | C | 0.0000 | |
497 | D | C | -1.0217 | |
498 | L | C | 0.1209 | |
499 | T | C | -0.0195 | |
500 | G | C | 0.1758 | |
501 | L | C | 1.1912 | |
204 | P | D | -1.3553 | |
205 | Q | D | -1.5936 | |
206 | Q | D | -1.6380 | |
207 | A | D | 0.0000 | |
208 | T | D | -1.6581 | |
209 | D | D | -2.5943 | |
210 | D | D | -2.4969 |