Project name: 90a509f5e2492ef
Status: done
submitted: 2018-04-12 18:09:43, status changed: 2018-04-16 01:01:53
Settings
Chain sequence(s)
|
A: NWYNDTYPLSPPQRTPAGIRYRIAVIADLDTESRAQEENTWFSYLKKGYLTLSDSGDKVAVEWDKDHGVLESHLAEKGRGMELSDLIVFNGKLYSVDDRTGVVYQIEGSKAVPWVILSDGDGTVEKGFKAEWLAVKDERLYVGGLGKEWTTTTGDVVNENPEWVKVVGYKGSVDHENWVSNYNALRAAAGIQPPGYLIHESACWSDTLQRWFFLPCRASQERYSEKDDERKGANLLLSASPDFGDIAVSHVGAVVPTHGFSSFKFIPNTDDQIIVALKSEEDSGRVASYIMAFTLDGRFLLPETKIGSVKYEGIEFI
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-4.0353
-
Maximal score value
-
2.0816
-
Average score
-
-0.8091
-
Total score value
-
-256.4716
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
15 |
N |
A |
-0.9019 |
|
16 |
W |
A |
0.1677 |
|
17 |
Y |
A |
-0.7555 |
|
18 |
N |
A |
-1.1985 |
|
19 |
D |
A |
-1.8447 |
|
20 |
T |
A |
-0.6784 |
|
21 |
Y |
A |
0.3044 |
|
22 |
P |
A |
0.0000 |
|
23 |
L |
A |
0.2412 |
|
24 |
S |
A |
0.0701 |
|
25 |
P |
A |
-0.4972 |
|
26 |
P |
A |
-0.9762 |
|
27 |
Q |
A |
-1.5243 |
|
28 |
R |
A |
-2.3220 |
|
29 |
T |
A |
-1.3522 |
|
30 |
P |
A |
-0.8859 |
|
31 |
A |
A |
-0.8580 |
|
32 |
G |
A |
0.0000 |
|
33 |
I |
A |
-1.3525 |
|
34 |
R |
A |
-1.0528 |
|
35 |
Y |
A |
0.0000 |
|
36 |
R |
A |
-0.6063 |
|
37 |
I |
A |
0.0000 |
|
38 |
A |
A |
0.0000 |
|
39 |
V |
A |
0.0000 |
|
40 |
I |
A |
0.0000 |
|
41 |
A |
A |
0.0000 |
|
42 |
D |
A |
0.0000 |
|
43 |
L |
A |
-1.0219 |
|
44 |
D |
A |
-1.6563 |
|
45 |
T |
A |
-1.8569 |
|
46 |
E |
A |
-2.6412 |
|
47 |
S |
A |
0.0000 |
|
48 |
R |
A |
-3.8865 |
|
49 |
A |
A |
-3.2584 |
|
50 |
Q |
A |
-3.0780 |
|
51 |
E |
A |
-4.0008 |
|
52 |
E |
A |
-4.0353 |
|
53 |
N |
A |
-3.4190 |
|
54 |
T |
A |
0.0000 |
|
55 |
W |
A |
0.0000 |
|
56 |
F |
A |
-1.0857 |
|
57 |
S |
A |
0.0000 |
|
58 |
Y |
A |
-0.1767 |
|
59 |
L |
A |
0.0000 |
|
60 |
K |
A |
-1.4075 |
|
61 |
K |
A |
-1.8007 |
|
62 |
G |
A |
0.0000 |
|
63 |
Y |
A |
-0.6874 |
|
64 |
L |
A |
0.0000 |
|
65 |
T |
A |
-0.9192 |
|
66 |
L |
A |
-1.1413 |
|
67 |
S |
A |
-1.8253 |
|
68 |
D |
A |
-2.5823 |
|
69 |
S |
A |
-2.0042 |
|
70 |
G |
A |
-2.0772 |
|
71 |
D |
A |
-2.9580 |
|
72 |
K |
A |
-2.2877 |
|
73 |
V |
A |
0.0000 |
|
74 |
A |
A |
-0.4961 |
|
75 |
V |
A |
-0.4510 |
|
76 |
E |
A |
-1.9106 |
|
77 |
W |
A |
-1.9244 |
|
78 |
D |
A |
-2.8607 |
|
79 |
K |
A |
-3.4084 |
|
80 |
D |
A |
-3.2662 |
|
81 |
H |
A |
-2.1823 |
|
82 |
G |
A |
-0.9417 |
|
83 |
V |
A |
-0.0774 |
|
84 |
L |
A |
0.0000 |
|
85 |
E |
A |
-1.9125 |
|
86 |
S |
A |
-1.5756 |
|
87 |
H |
A |
-2.1323 |
|
88 |
L |
A |
-0.5776 |
|
89 |
A |
A |
-1.3150 |
|
90 |
E |
A |
-1.7531 |
|
91 |
K |
A |
-2.4708 |
|
92 |
G |
A |
-2.0660 |
|
93 |
R |
A |
-2.2556 |
|
94 |
G |
A |
0.0000 |
|
95 |
M |
A |
0.0000 |
|
96 |
E |
A |
0.0000 |
|
97 |
L |
A |
0.0000 |
|
98 |
S |
A |
0.0000 |
|
99 |
D |
A |
0.0000 |
|
100 |
L |
A |
0.0000 |
|
101 |
I |
A |
0.0000 |
|
102 |
V |
A |
0.0000 |
|
103 |
F |
A |
0.0000 |
|
104 |
N |
A |
-1.2368 |
|
105 |
G |
A |
-0.7849 |
|
106 |
K |
A |
-1.2429 |
|
107 |
L |
A |
0.0000 |
|
108 |
Y |
A |
0.0000 |
|
109 |
S |
A |
0.0000 |
|
110 |
V |
A |
0.0000 |
|
111 |
D |
A |
0.0000 |
|
112 |
D |
A |
0.0000 |
|
113 |
R |
A |
-1.3459 |
|
114 |
T |
A |
0.0000 |
|
115 |
G |
A |
0.0000 |
|
116 |
V |
A |
0.0000 |
|
117 |
V |
A |
0.0000 |
|
118 |
Y |
A |
0.0000 |
|
119 |
Q |
A |
-0.8132 |
|
120 |
I |
A |
0.0000 |
|
121 |
E |
A |
-2.7190 |
|
122 |
G |
A |
-1.9320 |
|
123 |
S |
A |
-1.7468 |
|
124 |
K |
A |
-2.6333 |
|
125 |
A |
A |
-1.3002 |
|
126 |
V |
A |
-0.2203 |
|
127 |
P |
A |
0.5660 |
|
128 |
W |
A |
0.5698 |
|
129 |
V |
A |
0.0000 |
|
130 |
I |
A |
2.0816 |
|
131 |
L |
A |
0.0000 |
|
132 |
S |
A |
-0.8212 |
|
133 |
D |
A |
-1.2843 |
|
134 |
G |
A |
0.0000 |
|
135 |
D |
A |
-2.0518 |
|
136 |
G |
A |
-1.4913 |
|
137 |
T |
A |
-1.0147 |
|
138 |
V |
A |
-1.3653 |
|
139 |
E |
A |
-2.3845 |
|
140 |
K |
A |
-2.5802 |
|
141 |
G |
A |
-1.1173 |
|
142 |
F |
A |
0.0000 |
|
143 |
K |
A |
-0.9222 |
|
144 |
A |
A |
0.0000 |
|
145 |
E |
A |
0.0000 |
|
146 |
W |
A |
0.0000 |
|
147 |
L |
A |
0.0000 |
|
148 |
A |
A |
0.0000 |
|
149 |
V |
A |
-1.0423 |
|
150 |
K |
A |
-2.2557 |
|
151 |
D |
A |
-3.0867 |
|
152 |
E |
A |
-2.8491 |
|
153 |
R |
A |
-2.3955 |
|
154 |
L |
A |
0.0000 |
|
155 |
Y |
A |
0.0000 |
|
156 |
V |
A |
0.0000 |
|
157 |
G |
A |
0.0000 |
|
158 |
G |
A |
0.0000 |
|
159 |
L |
A |
0.0158 |
|
160 |
G |
A |
0.0000 |
|
161 |
K |
A |
0.0000 |
|
162 |
E |
A |
0.1028 |
|
163 |
W |
A |
0.8333 |
|
164 |
T |
A |
0.4742 |
|
165 |
T |
A |
0.0600 |
|
166 |
T |
A |
-0.9820 |
|
167 |
T |
A |
-1.2629 |
|
168 |
G |
A |
0.0000 |
|
169 |
D |
A |
-0.2966 |
|
170 |
V |
A |
1.7876 |
|
171 |
V |
A |
2.0039 |
|
172 |
N |
A |
0.3710 |
|
173 |
E |
A |
-0.8103 |
|
174 |
N |
A |
-0.8721 |
|
175 |
P |
A |
0.0000 |
|
176 |
E |
A |
0.0000 |
|
177 |
W |
A |
-1.1302 |
|
178 |
V |
A |
0.0000 |
|
179 |
K |
A |
0.0000 |
|
180 |
V |
A |
0.0000 |
|
181 |
V |
A |
0.0000 |
|
182 |
G |
A |
-1.4911 |
|
183 |
Y |
A |
-1.0715 |
|
184 |
K |
A |
-1.6706 |
|
185 |
G |
A |
-0.7337 |
|
186 |
S |
A |
-0.7736 |
|
187 |
V |
A |
-0.4162 |
|
188 |
D |
A |
-1.9312 |
|
189 |
H |
A |
-1.9368 |
|
190 |
E |
A |
-1.9056 |
|
191 |
N |
A |
-1.9152 |
|
192 |
W |
A |
0.0000 |
|
193 |
V |
A |
-0.6415 |
|
194 |
S |
A |
-0.5977 |
|
195 |
N |
A |
-0.9149 |
|
196 |
Y |
A |
0.0000 |
|
197 |
N |
A |
-0.9388 |
|
198 |
A |
A |
-0.6631 |
|
199 |
L |
A |
0.0000 |
|
200 |
R |
A |
-0.7950 |
|
201 |
A |
A |
-0.6982 |
|
202 |
A |
A |
-0.3995 |
|
203 |
A |
A |
-0.3102 |
|
204 |
G |
A |
-0.8633 |
|
205 |
I |
A |
0.0000 |
|
206 |
Q |
A |
-2.1047 |
|
207 |
P |
A |
-1.8951 |
|
208 |
P |
A |
-2.1849 |
|
209 |
G |
A |
0.0000 |
|
210 |
Y |
A |
0.0000 |
|
211 |
L |
A |
0.0000 |
|
212 |
I |
A |
0.0000 |
|
213 |
H |
A |
0.0000 |
|
214 |
E |
A |
-0.2565 |
|
215 |
S |
A |
0.0000 |
|
216 |
A |
A |
0.0000 |
|
217 |
C |
A |
0.0000 |
|
218 |
W |
A |
-0.7985 |
|
219 |
S |
A |
0.0000 |
|
220 |
D |
A |
-2.6428 |
|
221 |
T |
A |
-1.6557 |
|
222 |
L |
A |
-1.1327 |
|
223 |
Q |
A |
-1.7751 |
|
224 |
R |
A |
-1.4183 |
|
225 |
W |
A |
0.0000 |
|
226 |
F |
A |
0.0000 |
|
227 |
F |
A |
0.0000 |
|
228 |
L |
A |
0.0000 |
|
229 |
P |
A |
0.0000 |
|
230 |
C |
A |
0.0000 |
|
231 |
R |
A |
-0.7973 |
|
232 |
A |
A |
-0.9642 |
|
233 |
S |
A |
0.0000 |
|
234 |
Q |
A |
-2.8478 |
|
235 |
E |
A |
-3.5513 |
|
236 |
R |
A |
-3.2392 |
|
237 |
Y |
A |
-2.1494 |
|
238 |
S |
A |
-2.6272 |
|
239 |
E |
A |
-3.4370 |
|
240 |
K |
A |
-3.5919 |
|
241 |
D |
A |
-3.5668 |
|
242 |
D |
A |
0.0000 |
|
243 |
E |
A |
-3.2049 |
|
244 |
R |
A |
-3.0531 |
|
245 |
K |
A |
-2.0262 |
|
246 |
G |
A |
0.0000 |
|
247 |
A |
A |
0.0000 |
|
248 |
N |
A |
0.1147 |
|
249 |
L |
A |
0.0000 |
|
250 |
L |
A |
0.0000 |
|
251 |
L |
A |
0.0000 |
|
252 |
S |
A |
-0.2090 |
|
253 |
A |
A |
0.0000 |
|
254 |
S |
A |
-1.5417 |
|
255 |
P |
A |
-1.6632 |
|
256 |
D |
A |
-2.3406 |
|
257 |
F |
A |
0.0000 |
|
258 |
G |
A |
-1.8637 |
|
259 |
D |
A |
-2.1584 |
|
260 |
I |
A |
-0.7418 |
|
261 |
A |
A |
0.0094 |
|
262 |
V |
A |
0.3012 |
|
263 |
S |
A |
-0.6380 |
|
264 |
H |
A |
-1.1262 |
|
265 |
V |
A |
0.0000 |
|
266 |
G |
A |
-0.6378 |
|
267 |
A |
A |
0.6808 |
|
268 |
V |
A |
1.5497 |
|
269 |
V |
A |
0.9541 |
|
270 |
P |
A |
-0.4470 |
|
271 |
T |
A |
0.0000 |
|
272 |
H |
A |
0.0000 |
|
273 |
G |
A |
0.0000 |
|
274 |
F |
A |
0.0000 |
|
275 |
S |
A |
0.0000 |
|
276 |
S |
A |
0.0000 |
|
277 |
F |
A |
0.0000 |
|
278 |
K |
A |
0.0000 |
|
279 |
F |
A |
0.0000 |
|
280 |
I |
A |
0.0000 |
|
281 |
P |
A |
-1.0129 |
|
282 |
N |
A |
-1.9878 |
|
283 |
T |
A |
0.0000 |
|
284 |
D |
A |
-2.8053 |
|
285 |
D |
A |
-2.0551 |
|
286 |
Q |
A |
-2.1848 |
|
287 |
I |
A |
0.0000 |
|
288 |
I |
A |
0.0000 |
|
289 |
V |
A |
0.0000 |
|
290 |
A |
A |
0.0000 |
|
291 |
L |
A |
0.0000 |
|
292 |
K |
A |
0.0000 |
|
293 |
S |
A |
0.0000 |
|
294 |
E |
A |
-1.2021 |
|
295 |
E |
A |
-1.9344 |
|
296 |
D |
A |
0.0000 |
|
297 |
S |
A |
-1.4707 |
|
298 |
G |
A |
-1.7018 |
|
299 |
R |
A |
-2.2178 |
|
300 |
V |
A |
-1.0490 |
|
301 |
A |
A |
0.0000 |
|
302 |
S |
A |
0.0000 |
|
303 |
Y |
A |
0.0000 |
|
304 |
I |
A |
0.0000 |
|
305 |
M |
A |
0.0000 |
|
306 |
A |
A |
0.0000 |
|
307 |
F |
A |
0.0000 |
|
308 |
T |
A |
0.0000 |
|
309 |
L |
A |
-1.4057 |
|
310 |
D |
A |
-2.5266 |
|
311 |
G |
A |
-1.9185 |
|
312 |
R |
A |
-2.2784 |
|
313 |
F |
A |
-1.0043 |
|
314 |
L |
A |
0.0000 |
|
315 |
L |
A |
-0.6155 |
|
316 |
P |
A |
-0.9059 |
|
317 |
E |
A |
-1.1938 |
|
318 |
T |
A |
-1.2632 |
|
319 |
K |
A |
-1.9854 |
|
320 |
I |
A |
0.0000 |
|
321 |
G |
A |
-0.5928 |
|
322 |
S |
A |
-0.7200 |
|
323 |
V |
A |
-0.2846 |
|
324 |
K |
A |
-0.2761 |
|
325 |
Y |
A |
0.0000 |
|
326 |
E |
A |
0.0000 |
|
327 |
G |
A |
0.0000 |
|
328 |
I |
A |
0.0000 |
|
329 |
E |
A |
0.0000 |
|
330 |
F |
A |
0.0000 |
|
331 |
I |
A |
0.0000 |
|