| Chain sequence(s) |
A: EEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPITNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYDCRVEHWGLDEPLLKHWEFD C: NPVVHFFKNIVTPRTPPPSQ B: GDTRPRFLQQDKYECHFFNGTERVRFLHRDIYNQEEDLRFDSDVGEYRAVTELGRPDAEYWNSQKDFLEDRRAAVDTYCRHNYGVGESFTVQRRVEPKVTVYPARTQTLQHHNLLVCSVNGFYPGSIEVRWFRNSQEEKAGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRA |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 3 | E | A | -2.9829 | |
| 4 | E | A | -2.9841 | |
| 5 | H | A | -1.7462 | |
| 6 | V | A | -0.8212 | |
| 7 | I | A | 0.0000 | |
| 8 | I | A | 0.1199 | |
| 9 | Q | A | 0.0000 | |
| 10 | A | A | 0.0000 | |
| 11 | E | A | 0.0000 | |
| 12 | F | A | 0.0000 | |
| 13 | Y | A | 0.0000 | |
| 14 | L | A | 0.0000 | |
| 15 | N | A | -1.4774 | |
| 16 | P | A | -1.2219 | |
| 17 | D | A | -1.5674 | |
| 18 | Q | A | -1.8176 | |
| 19 | S | A | -1.0240 | |
| 20 | G | A | -0.6043 | |
| 21 | E | A | 0.0000 | |
| 22 | F | A | 0.0000 | |
| 23 | M | A | 0.0000 | |
| 24 | F | A | 0.0000 | |
| 25 | D | A | 0.0000 | |
| 26 | F | A | 0.0000 | |
| 27 | D | A | -1.1161 | |
| 28 | G | A | -0.9166 | |
| 29 | D | A | 0.0000 | |
| 30 | E | A | 0.0000 | |
| 31 | I | A | 0.0000 | |
| 32 | F | A | 0.0000 | |
| 33 | H | A | -0.1341 | |
| 34 | V | A | 0.0000 | |
| 35 | D | A | -1.6010 | |
| 36 | M | A | -1.3960 | |
| 37 | A | A | -1.5049 | |
| 38 | K | A | -2.9969 | |
| 39 | K | A | -3.7206 | |
| 40 | E | A | -3.5128 | |
| 41 | T | A | -1.7395 | |
| 42 | V | A | -0.4398 | |
| 43 | W | A | -0.7325 | |
| 44 | R | A | -0.6728 | |
| 45 | L | A | -1.3125 | |
| 46 | E | A | -2.3880 | |
| 47 | E | A | -2.1784 | |
| 48 | F | A | 0.0000 | |
| 49 | G | A | -1.2245 | |
| 50 | R | A | -1.6384 | |
| 51 | F | A | 0.6848 | |
| 52 | A | A | 0.0000 | |
| 53 | S | A | 0.0102 | |
| 54 | F | A | 0.0000 | |
| 55 | E | A | -2.7105 | |
| 56 | A | A | 0.0000 | |
| 57 | Q | A | -2.3897 | |
| 58 | G | A | -1.1742 | |
| 59 | A | A | 0.0000 | |
| 60 | L | A | -0.8918 | |
| 61 | A | A | 0.1568 | |
| 62 | N | A | 0.0000 | |
| 63 | I | A | 0.0000 | |
| 64 | A | A | -0.2443 | |
| 65 | V | A | -0.4048 | |
| 66 | D | A | 0.0000 | |
| 67 | K | A | -1.5086 | |
| 68 | A | A | -1.1121 | |
| 69 | N | A | 0.0000 | |
| 70 | L | A | 0.0000 | |
| 71 | E | A | -1.9506 | |
| 72 | I | A | -1.2678 | |
| 73 | M | A | 0.0000 | |
| 74 | T | A | 0.0000 | |
| 75 | K | A | -2.2778 | |
| 76 | R | A | -1.6203 | |
| 77 | S | A | -1.1795 | |
| 78 | N | A | -1.4730 | |
| 79 | Y | A | -0.2967 | |
| 80 | T | A | -0.2398 | |
| 81 | P | A | -0.3774 | |
| 82 | I | A | 0.0000 | |
| 83 | T | A | -0.4428 | |
| 84 | N | A | -0.6447 | |
| 85 | V | A | -0.4232 | |
| 86 | P | A | -0.9353 | |
| 87 | P | A | 0.0000 | |
| 88 | E | A | -1.9662 | |
| 89 | V | A | 0.0000 | |
| 90 | T | A | -0.4354 | |
| 91 | V | A | -0.0168 | |
| 92 | L | A | 0.1323 | |
| 93 | T | A | 0.0992 | |
| 94 | N | A | -0.2453 | |
| 95 | S | A | -0.5486 | |
| 96 | P | A | -0.5128 | |
| 97 | V | A | -1.2975 | |
| 98 | E | A | -2.4537 | |
| 99 | L | A | -1.3289 | |
| 100 | R | A | -2.6037 | |
| 101 | E | A | -2.9243 | |
| 102 | P | A | -1.4488 | |
| 103 | N | A | 0.0000 | |
| 104 | V | A | 0.2885 | |
| 105 | L | A | 0.0000 | |
| 106 | I | A | 0.0000 | |
| 107 | C | A | 0.0000 | |
| 108 | F | A | -0.0535 | |
| 109 | I | A | 0.0000 | |
| 110 | D | A | 0.0000 | |
| 111 | K | A | -1.5424 | |
| 112 | F | A | 0.0000 | |
| 113 | T | A | 0.0000 | |
| 114 | P | A | 0.0000 | |
| 115 | P | A | 0.0000 | |
| 116 | V | A | 0.0559 | |
| 117 | V | A | -0.3814 | |
| 118 | N | A | -1.4296 | |
| 119 | V | A | -0.8916 | |
| 120 | T | A | -0.7294 | |
| 121 | W | A | 0.0000 | |
| 122 | L | A | 0.0000 | |
| 123 | R | A | -2.0221 | |
| 124 | N | A | -2.5785 | |
| 125 | G | A | -2.0912 | |
| 126 | K | A | -2.5957 | |
| 127 | P | A | -1.5561 | |
| 128 | V | A | -0.7291 | |
| 129 | T | A | -0.1283 | |
| 130 | T | A | -0.1892 | |
| 131 | G | A | -0.3227 | |
| 132 | V | A | -0.2017 | |
| 133 | S | A | -0.9885 | |
| 134 | E | A | -1.6981 | |
| 135 | T | A | 0.0000 | |
| 136 | V | A | -0.1555 | |
| 137 | F | A | 0.1252 | |
| 138 | L | A | 0.0000 | |
| 139 | P | A | 0.0000 | |
| 140 | R | A | -1.6622 | |
| 141 | E | A | -2.3756 | |
| 142 | D | A | -2.2629 | |
| 143 | H | A | 0.0000 | |
| 144 | L | A | 0.0000 | |
| 145 | F | A | 0.0000 | |
| 146 | R | A | -0.5915 | |
| 147 | K | A | 0.0000 | |
| 148 | F | A | 0.0000 | |
| 149 | H | A | 0.0000 | |
| 150 | Y | A | 0.0000 | |
| 151 | L | A | 0.0000 | |
| 152 | P | A | -0.0006 | |
| 153 | F | A | 0.0000 | |
| 154 | L | A | -0.5397 | |
| 155 | P | A | 0.0000 | |
| 156 | S | A | -1.4203 | |
| 157 | T | A | -1.5076 | |
| 158 | E | A | -2.1995 | |
| 159 | D | A | -1.6203 | |
| 160 | V | A | -1.2309 | |
| 161 | Y | A | 0.0000 | |
| 162 | D | A | -1.5210 | |
| 163 | C | A | 0.0000 | |
| 164 | R | A | -1.3300 | |
| 165 | V | A | 0.0000 | |
| 166 | E | A | -1.6834 | |
| 167 | H | A | 0.0000 | |
| 168 | W | A | -0.9629 | |
| 169 | G | A | -0.8292 | |
| 170 | L | A | -1.4137 | |
| 171 | D | A | -2.6101 | |
| 172 | E | A | -2.6144 | |
| 173 | P | A | -1.6157 | |
| 174 | L | A | -0.8602 | |
| 175 | L | A | -0.5041 | |
| 176 | K | A | -1.1003 | |
| 177 | H | A | -1.4423 | |
| 178 | W | A | -1.1697 | |
| 179 | E | A | -2.1766 | |
| 180 | F | A | -1.8729 | |
| 181 | D | A | -2.7297 | |
| 1 | G | B | -1.0152 | |
| 2 | D | B | -1.4967 | |
| 3 | T | B | -1.4282 | |
| 4 | R | B | -2.3057 | |
| 5 | P | B | -1.1782 | |
| 6 | R | B | 0.0000 | |
| 7 | F | B | -0.4424 | |
| 8 | L | B | 0.0000 | |
| 9 | Q | B | 0.0000 | |
| 10 | Q | B | 0.0000 | |
| 11 | D | B | 0.0000 | |
| 12 | K | B | 0.0000 | |
| 13 | Y | B | 0.0000 | |
| 14 | E | B | 0.0000 | |
| 15 | C | B | 0.0000 | |
| 16 | H | B | -1.2438 | |
| 17 | F | B | 0.0000 | |
| 18 | F | B | -2.8170 | |
| 19 | N | B | -2.9641 | |
| 20 | G | B | -2.2135 | |
| 21 | T | B | -2.5376 | |
| 22 | E | B | -3.1639 | |
| 23 | R | B | -3.2819 | |
| 24 | V | B | -2.3267 | |
| 25 | R | B | -1.4865 | |
| 26 | F | B | 0.0000 | |
| 27 | L | B | 0.0000 | |
| 28 | H | B | 0.0000 | |
| 29 | R | B | -0.7166 | |
| 30 | D | B | -0.7407 | |
| 31 | I | B | 0.0000 | |
| 32 | Y | B | 0.0000 | |
| 33 | N | B | 0.0000 | |
| 34 | Q | B | -1.5576 | |
| 35 | E | B | -2.1624 | |
| 36 | E | B | -1.2778 | |
| 37 | D | B | 0.0000 | |
| 38 | L | B | 0.0000 | |
| 39 | R | B | -0.9054 | |
| 40 | F | B | 0.0000 | |
| 41 | D | B | 0.0000 | |
| 42 | S | B | -1.1036 | |
| 43 | D | B | -1.4578 | |
| 44 | V | B | 0.0359 | |
| 45 | G | B | -1.1159 | |
| 46 | E | B | -2.0482 | |
| 47 | Y | B | 0.0000 | |
| 48 | R | B | -2.3092 | |
| 49 | A | B | -1.9215 | |
| 50 | V | B | -0.7572 | |
| 51 | T | B | -1.4314 | |
| 52 | E | B | -2.1947 | |
| 53 | L | B | -1.4333 | |
| 54 | G | B | 0.0000 | |
| 55 | R | B | -3.0342 | |
| 56 | P | B | -1.9699 | |
| 57 | D | B | 0.0000 | |
| 58 | A | B | 0.0000 | |
| 59 | E | B | -2.5752 | |
| 60 | Y | B | -0.7550 | |
| 61 | W | B | -1.2083 | |
| 62 | N | B | -2.0428 | |
| 63 | S | B | -1.4384 | |
| 64 | Q | B | -2.0745 | |
| 65 | K | B | -3.4732 | |
| 66 | D | B | -3.8239 | |
| 67 | F | B | -2.7072 | |
| 68 | L | B | 0.0000 | |
| 69 | E | B | -4.3794 | |
| 70 | D | B | -3.6829 | |
| 71 | R | B | 0.0000 | |
| 72 | R | B | -3.1436 | |
| 73 | A | B | -2.1487 | |
| 74 | A | B | 0.0000 | |
| 75 | V | B | -1.6468 | |
| 76 | D | B | -2.2206 | |
| 77 | T | B | -1.6794 | |
| 78 | Y | B | 0.0000 | |
| 79 | C | B | 0.0000 | |
| 80 | R | B | -1.9878 | |
| 81 | H | B | -1.5750 | |
| 82 | N | B | 0.0000 | |
| 83 | Y | B | 0.0000 | |
| 84 | G | B | -1.0940 | |
| 85 | V | B | -0.1649 | |
| 86 | G | B | 0.0000 | |
| 87 | E | B | -1.2728 | |
| 88 | S | B | -0.6792 | |
| 89 | F | B | 0.0000 | |
| 90 | T | B | 0.0000 | |
| 91 | V | B | -1.3502 | |
| 92 | Q | B | -1.8561 | |
| 93 | R | B | -1.5676 | |
| 94 | R | B | -2.1652 | |
| 95 | V | B | -1.4176 | |
| 96 | E | B | -2.4562 | |
| 97 | P | B | 0.0000 | |
| 98 | K | B | -1.9534 | |
| 99 | V | B | -0.6323 | |
| 100 | T | B | -0.2234 | |
| 101 | V | B | 0.0618 | |
| 102 | Y | B | -0.1479 | |
| 103 | P | B | -0.5368 | |
| 104 | A | B | -1.2652 | |
| 105 | R | B | -2.3659 | |
| 106 | T | B | -1.5085 | |
| 107 | Q | B | -0.9263 | |
| 108 | T | B | -0.0264 | |
| 109 | L | B | 0.4195 | |
| 110 | Q | B | -1.1929 | |
| 111 | H | B | -1.4875 | |
| 112 | H | B | -1.4901 | |
| 113 | N | B | -1.2479 | |
| 114 | L | B | -0.9802 | |
| 115 | L | B | 0.0000 | |
| 116 | V | B | 0.0000 | |
| 117 | C | B | 0.0000 | |
| 118 | S | B | 0.0000 | |
| 119 | V | B | 0.0000 | |
| 120 | N | B | 0.0000 | |
| 121 | G | B | -0.9471 | |
| 122 | F | B | 0.0000 | |
| 123 | Y | B | 0.0000 | |
| 124 | P | B | -0.9103 | |
| 125 | G | B | -0.3003 | |
| 126 | S | B | -0.5048 | |
| 127 | I | B | -0.8664 | |
| 128 | E | B | -2.4261 | |
| 129 | V | B | -1.4356 | |
| 130 | R | B | -1.9902 | |
| 131 | W | B | 0.0000 | |
| 132 | F | B | -2.2196 | |
| 133 | R | B | -2.4776 | |
| 134 | N | B | -2.4181 | |
| 135 | S | B | -1.7749 | |
| 136 | Q | B | -2.5487 | |
| 137 | E | B | -2.5908 | |
| 138 | E | B | -2.5802 | |
| 139 | K | B | -2.2481 | |
| 140 | A | B | -1.0221 | |
| 141 | G | B | -0.6283 | |
| 142 | V | B | 0.3171 | |
| 143 | V | B | 1.5312 | |
| 144 | S | B | 1.0085 | |
| 145 | T | B | 0.5172 | |
| 146 | G | B | 0.4658 | |
| 147 | L | B | 0.9178 | |
| 148 | I | B | 0.5185 | |
| 149 | Q | B | -0.3406 | |
| 150 | N | B | 0.0000 | |
| 151 | G | B | -0.6021 | |
| 152 | D | B | -0.4860 | |
| 153 | W | B | 0.0000 | |
| 154 | T | B | -0.5947 | |
| 155 | F | B | 0.0000 | |
| 156 | Q | B | 0.0000 | |
| 157 | T | B | 0.0000 | |
| 158 | L | B | 0.7363 | |
| 159 | V | B | 0.0000 | |
| 160 | M | B | 0.6173 | |
| 161 | L | B | 0.0000 | |
| 162 | E | B | -1.5821 | |
| 163 | T | B | 0.0000 | |
| 164 | V | B | -1.1652 | |
| 165 | P | B | -1.4241 | |
| 166 | R | B | -1.9111 | |
| 167 | S | B | -1.4667 | |
| 168 | G | B | -1.4151 | |
| 169 | E | B | -1.5396 | |
| 170 | V | B | -1.6567 | |
| 171 | Y | B | 0.0000 | |
| 172 | T | B | -1.6816 | |
| 173 | C | B | 0.0000 | |
| 174 | Q | B | -1.3878 | |
| 175 | V | B | 0.0000 | |
| 176 | E | B | -2.6841 | |
| 177 | H | B | 0.0000 | |
| 178 | P | B | -1.1918 | |
| 179 | S | B | -1.2278 | |
| 180 | V | B | -0.7133 | |
| 181 | T | B | -0.3069 | |
| 182 | S | B | -0.5330 | |
| 183 | P | B | -1.0329 | |
| 184 | L | B | -0.5777 | |
| 185 | T | B | -0.5585 | |
| 186 | V | B | -0.5806 | |
| 187 | E | B | -2.1131 | |
| 188 | W | B | -1.3565 | |
| 189 | R | B | -2.1067 | |
| 190 | A | B | -1.4452 | |
| 86 | N | C | -0.5908 | |
| 87 | P | C | 0.3974 | |
| 88 | V | C | 1.9949 | |
| 89 | V | C | 2.3032 | |
| 90 | H | C | 0.7858 | |
| 91 | F | C | 0.7462 | |
| 92 | F | C | 0.0000 | |
| 93 | K | C | -1.2038 | |
| 94 | N | C | -0.3746 | |
| 95 | I | C | 0.0000 | |
| 96 | V | C | 1.3983 | |
| 97 | T | C | 0.0000 | |
| 98 | P | C | -0.4084 | |
| 99 | R | C | -1.7261 | |
| 100 | T | C | 0.0000 | |
| 101 | P | C | -0.6567 | |
| 102 | P | C | -0.8302 | |
| 103 | P | C | -0.8134 | |
| 104 | S | C | -1.0122 | |
| 105 | Q | C | -1.3954 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine