Project name: 2V40

Chain sequence(s)	A: GGNRVTVVLGAQWGDEGKGKVVDLLAQDADIVVCRCQGGNNAGHHTVVVDSVEYDFHLLPSGIINPNVVTAFIGNGVVIHLPGLFEEAEKNVQKGKGLEGWEKRLIISDRAHIVFDFHQAADGIQEQQKKGIGPVYSSKAARRSGLLRMCDLVSDFDGFSERRFKVLANQYKSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHGPPKKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLLKYAHMINGFTALALTKLDILDMMFTEIKVGVAYKLDGEIIPHIPANQEVLNKVVEVQYKTLLPGWNTDISNARAFKELPVVNAQNYVRRFIEDELQQIPVKWIGVGKSRESMIQLF
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.3489
• Maximal score value: 2.2504
• Average score: -0.7607
• Total score value: -318.7211

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
26	G	A	-1.4197
27	G	A	-2.0503
28	N	A	-2.0392
29	R	A	-2.7688
30	V	A	0.0000
31	T	A	0.0000
32	V	A	0.0000
33	V	A	0.0000
34	L	A	0.0000
35	G	A	0.0000
36	A	A	0.0000
37	Q	A	0.0000
38	W	A	0.0000
39	G	A	-0.4192
40	D	A	-0.9591
41	E	A	0.0000
42	G	A	-0.9609
43	K	A	-0.7778
44	G	A	-0.6516
45	K	A	-1.1579
46	V	A	0.0000
47	V	A	0.0000
48	D	A	-1.1068
49	L	A	-1.1248
50	L	A	-0.7644
51	A	A	0.0000
52	Q	A	-2.3848
53	D	A	-2.9599
54	A	A	0.0000
55	D	A	-2.4002
56	I	A	0.0000
57	V	A	0.0000
58	C	A	0.0000
59	R	A	0.0000
60	C	A	0.0000
61	Q	A	-0.2988
62	G	A	0.0000
63	G	A	-0.6775
64	N	A	-1.1336
65	N	A	-1.9910
66	A	A	-1.3266
67	G	A	-1.0756
68	H	A	-1.0173
69	T	A	-0.4933
70	V	A	0.4798
71	V	A	1.2459
72	V	A	0.6117
73	D	A	-1.0995
74	S	A	-0.4298
75	V	A	-0.6455
76	E	A	-1.2926
77	Y	A	0.0000
78	D	A	-1.3610
79	F	A	0.0000
80	H	A	-1.1663
81	L	A	0.0000
82	L	A	0.0000
83	P	A	0.0000
84	S	A	-0.3128
85	G	A	0.0000
86	I	A	0.0000
87	I	A	-0.0600
88	N	A	-1.3078
89	P	A	-1.4742
90	N	A	-2.1386
91	V	A	0.0000
92	T	A	-1.0543
93	A	A	0.0000
94	F	A	0.0000
95	I	A	0.0000
96	G	A	0.0000
97	N	A	-0.9025
98	G	A	0.0000
99	V	A	0.0000
100	V	A	0.0000
101	I	A	0.0000
102	H	A	0.0000
103	L	A	0.0000
104	P	A	-0.9909
105	G	A	-1.1926
106	L	A	0.0000
107	F	A	0.0000
108	E	A	-2.6450
109	E	A	0.0000
110	A	A	0.0000
111	E	A	-2.7810
112	K	A	-2.9898
113	N	A	0.0000
114	V	A	-1.9520
115	Q	A	-2.3080
116	K	A	-2.3496
117	G	A	-2.1544
118	K	A	-2.4115
119	G	A	-1.5824
120	L	A	0.0000
121	E	A	-2.7158
122	G	A	-2.1166
123	W	A	0.0000
124	E	A	-2.4252
125	K	A	-2.5806
126	R	A	-1.8076
127	L	A	0.0000
128	I	A	0.0000
129	I	A	0.0000
130	S	A	0.0000
131	D	A	-1.6840
132	R	A	-1.7874
133	A	A	0.0000
134	H	A	0.0000
135	I	A	0.0000
136	V	A	0.0000
137	F	A	0.0000
138	D	A	-1.5895
139	F	A	0.0000
140	H	A	0.0000
141	Q	A	-1.4121
142	A	A	-1.1856
143	A	A	0.0000
144	D	A	-2.0855
145	G	A	-2.0421
146	I	A	-1.6324
147	Q	A	-2.4382
148	E	A	-3.3259
149	Q	A	-2.7878
150	Q	A	-2.5599
163	K	A	-2.7162
164	K	A	-2.2036
165	G	A	0.0000
166	I	A	-0.7770
167	G	A	-0.7128
168	P	A	0.0000
169	V	A	0.0000
170	Y	A	0.0000
171	S	A	-0.7084
172	S	A	0.0000
173	K	A	-1.5849
174	A	A	-0.9690
175	A	A	-1.1315
176	R	A	-2.1379
177	S	A	-1.2429
178	G	A	0.0000
179	L	A	0.0000
180	R	A	-1.3370
181	M	A	0.0000
182	C	A	-1.3142
183	D	A	-1.3865
184	L	A	0.0000
185	V	A	-1.2449
186	S	A	-1.3827
187	D	A	-2.4130
188	F	A	-2.1050
189	D	A	-3.0371
190	G	A	-2.6076
191	F	A	0.0000
192	S	A	-2.4112
193	E	A	-2.6470
194	R	A	-1.8843
195	F	A	0.0000
196	K	A	-1.5078
197	V	A	-0.0728
198	L	A	0.0000
199	A	A	0.0000
200	N	A	-1.1572
201	Q	A	-0.8805
202	Y	A	0.0000
203	K	A	-1.1218
204	S	A	-0.2312
205	I	A	1.2797
206	Y	A	0.1931
207	P	A	-0.2370
208	T	A	-0.4162
209	L	A	0.0000
210	E	A	-2.3304
211	I	A	-2.1461
212	D	A	-2.8926
213	I	A	-2.3910
214	E	A	-2.9643
215	G	A	-2.4052
216	E	A	0.0000
217	L	A	0.0000
218	Q	A	-3.0824
219	K	A	-2.9386
220	L	A	0.0000
221	K	A	-2.5148
222	G	A	-2.4212
223	Y	A	-2.1979
224	M	A	0.0000
225	E	A	-3.3428
226	K	A	-3.2814
227	I	A	0.0000
228	K	A	-2.6734
229	P	A	-2.0914
230	M	A	0.0000
231	V	A	-1.4761
232	R	A	-1.7874
233	D	A	-1.2529
234	G	A	0.0000
235	V	A	0.7344
236	Y	A	1.1163
237	F	A	0.3431
238	L	A	0.0000
239	Y	A	0.2422
240	E	A	-1.2654
241	A	A	0.0000
242	L	A	0.0000
243	H	A	-2.1721
244	G	A	-1.5503
245	P	A	-1.1475
246	P	A	-1.3703
247	K	A	-1.8715
248	K	A	-1.8747
249	I	A	0.0000
250	L	A	0.0000
251	V	A	0.0000
252	E	A	0.0000
253	G	A	-0.1891
254	A	A	-0.4797
255	N	A	-0.7021
256	A	A	0.0000
257	A	A	0.0000
258	L	A	0.0000
259	L	A	0.5392
260	D	A	0.0000
261	I	A	0.2995
262	D	A	-0.9111
263	F	A	0.4287
264	G	A	0.5977
265	T	A	0.0000
266	Y	A	1.1899
267	P	A	0.6342
268	F	A	1.5116
269	V	A	0.8822
270	T	A	0.1722
271	S	A	0.0575
272	S	A	0.0000
273	N	A	-0.4536
274	C	A	0.0000
275	T	A	0.0000
276	V	A	0.0140
277	G	A	-0.3284
278	G	A	0.0000
279	V	A	0.0000
280	C	A	-0.2117
281	T	A	-0.2558
282	G	A	0.0000
283	L	A	0.0000
284	G	A	0.2849
285	M	A	0.0000
286	P	A	-0.5197
287	P	A	-1.0649
288	Q	A	-1.7915
289	N	A	0.0000
290	V	A	-1.1651
291	G	A	-1.4223
292	E	A	-1.3080
293	V	A	0.0000
294	Y	A	0.0000
295	G	A	0.0000
296	V	A	0.0000
297	V	A	0.0000
298	K	A	0.0000
299	A	A	0.0000
300	Y	A	0.0000
301	T	A	0.0000
302	T	A	0.0000
303	R	A	0.0000
304	V	A	1.2105
305	G	A	1.3284
306	I	A	2.2504
307	G	A	0.9658
308	A	A	0.0000
309	F	A	0.0000
310	P	A	-1.0292
311	T	A	0.0000
312	E	A	-1.2292
313	Q	A	-2.0256
314	D	A	-2.9943
315	N	A	-2.7406
316	E	A	-2.8685
317	I	A	-1.5668
318	G	A	0.0000
319	E	A	-3.0766
320	L	A	-1.2516
321	L	A	0.0000
322	Q	A	0.0000
323	T	A	-1.4238
324	R	A	-1.3042
325	G	A	0.0000
326	R	A	-1.8852
327	E	A	0.0000
328	F	A	-0.8934
329	G	A	-0.2038
330	V	A	0.9357
331	T	A	0.3841
332	T	A	-0.4951
333	G	A	-1.1138
334	R	A	-2.2699
335	K	A	-2.6097
336	R	A	-1.4398
337	R	A	-1.0593
338	C	A	0.0000
339	G	A	0.0000
340	W	A	0.0000
341	L	A	0.0000
342	D	A	0.0000
343	L	A	0.0000
344	V	A	-0.0561
345	L	A	0.0000
346	L	A	0.0000
347	K	A	-0.7442
348	Y	A	0.1971
349	A	A	0.0000
350	H	A	-0.0092
351	M	A	0.8732
352	I	A	0.7156
353	N	A	0.0000
354	G	A	-0.1867
355	F	A	0.0000
356	T	A	-0.6131
357	A	A	0.0000
358	L	A	0.0000
359	A	A	0.0000
360	L	A	0.0000
361	T	A	0.0000
362	K	A	-0.8805
363	L	A	0.0000
364	D	A	-1.0577
365	I	A	0.0000
366	L	A	0.0000
367	D	A	0.0000
368	M	A	-0.0511
369	F	A	0.0000
370	T	A	-1.1405
371	E	A	-2.2020
372	I	A	0.0000
373	K	A	-1.2244
374	V	A	0.0000
375	G	A	0.0000
376	V	A	0.3033
377	A	A	0.2989
378	Y	A	0.0000
379	K	A	-1.4964
380	L	A	-1.8984
381	D	A	-2.7948
382	G	A	-2.1015
383	E	A	-1.9106
384	I	A	0.2729
385	I	A	0.0211
386	P	A	-0.3258
387	H	A	-0.6595
388	I	A	-0.1923
389	P	A	0.0000
390	A	A	-0.5404
391	N	A	-1.4010
392	Q	A	-1.6139
393	E	A	-2.7993
394	V	A	-1.6430
395	L	A	0.0000
396	N	A	-2.9749
397	K	A	-3.2271
398	V	A	-2.3556
399	E	A	-2.6679
400	V	A	-0.6474
401	Q	A	-0.2300
402	Y	A	-0.2673
403	K	A	-0.7514
404	T	A	-1.1396
405	L	A	0.0000
406	P	A	-1.2511
407	G	A	-1.1875
408	W	A	0.0000
409	N	A	-1.6941
410	T	A	-1.4304
411	D	A	-2.2288
412	I	A	0.0000
413	S	A	-1.7607
414	N	A	-2.3975
415	A	A	0.0000
416	R	A	-2.3125
417	A	A	-1.7019
418	F	A	-1.2238
419	K	A	-2.2990
420	E	A	-2.7093
421	L	A	0.0000
422	P	A	-0.5176
423	V	A	0.8779
424	N	A	-0.3906
425	A	A	0.0000
426	Q	A	-0.6622
427	N	A	-1.0193
428	Y	A	0.0000
429	V	A	0.0000
430	R	A	-2.3446
431	F	A	-1.7201
432	I	A	0.0000
433	E	A	-2.4504
434	D	A	-3.2337
435	E	A	-2.4818
436	L	A	0.0000
437	Q	A	-2.5018
438	I	A	0.0000
439	P	A	-0.7594
440	V	A	0.0000
441	K	A	0.0874
442	W	A	0.0000
443	I	A	0.0000
444	G	A	0.0000
445	V	A	0.0000
446	G	A	-1.9669
447	K	A	-2.6751
448	S	A	-2.5406
449	R	A	-3.2919
450	E	A	-3.3489
451	S	A	0.0000
452	M	A	0.0000
453	I	A	0.0000
454	Q	A	-0.5842
455	L	A	0.5047
456	F	A	1.7251