Project name: CotCB

Chain sequence(s)	A: MWIYQKTIQHPVNIKTCDPRMAKFLITQFGGPNGELAASLRYLSQRYTMPTGNMRALLTDIGTEELAHVELICTMVYQLTSDASPEELKAAGLGSNYAQNGYGIYPTDSNGVPFDVRPIAVMSNPVTDLHEDMAAEQKALATYYQLINLTDDVDVIDVLKFLGQREIIHYQRFGEALMDAYELEESQKMF
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -2.6335
• Maximal score value: 2.8645
• Average score: -0.3358
• Total score value: -63.8111

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	1.7290
2	W	A	2.2908
3	I	A	2.8645
4	Y	A	1.5098
5	Q	A	-0.9212
6	K	A	-1.9685
7	T	A	-1.0279
8	I	A	-0.4781
9	Q	A	-0.8162
10	H	A	-0.5985
11	P	A	-0.5795
12	V	A	0.0000
13	N	A	-1.4781
14	I	A	-0.9800
15	K	A	-1.7414
16	T	A	-1.3840
17	C	A	-0.7543
18	D	A	-1.1305
19	P	A	0.0000
20	R	A	-0.9957
21	M	A	-0.4149
22	A	A	0.0000
23	K	A	-0.5382
24	F	A	-0.0140
25	L	A	0.0000
26	I	A	0.0000
27	T	A	-0.0860
28	Q	A	0.0000
29	F	A	0.0000
30	G	A	0.0000
31	G	A	0.0000
32	P	A	-0.6475
33	N	A	-0.7383
34	G	A	0.0000
35	E	A	0.0000
36	L	A	0.4783
37	A	A	0.0000
38	A	A	0.0000
39	S	A	0.0000
40	L	A	1.2384
41	R	A	0.0000
42	Y	A	0.0000
43	L	A	0.6088
44	S	A	0.8279
45	Q	A	0.0000
46	R	A	0.1579
47	Y	A	1.0314
48	T	A	0.3223
49	M	A	0.0000
50	P	A	-0.7010
51	T	A	-0.9400
52	G	A	-1.3848
53	N	A	-1.8659
54	M	A	0.0000
55	R	A	-1.2090
56	A	A	-1.0811
57	L	A	-0.9237
58	L	A	0.0000
59	T	A	-0.6344
60	D	A	-1.1557
61	I	A	0.0000
62	G	A	0.0000
63	T	A	0.2949
64	E	A	-0.5381
65	E	A	0.0000
66	L	A	0.9179
67	A	A	0.1871
68	H	A	0.0000
69	V	A	0.3100
70	E	A	-0.2488
71	L	A	0.0000
72	I	A	0.0000
73	C	A	0.4904
74	T	A	0.2614
75	M	A	0.0000
76	V	A	0.0000
77	Y	A	1.2769
78	Q	A	-0.1097
79	L	A	0.0000
80	T	A	0.0000
81	S	A	-0.3726
82	D	A	-1.6050
83	A	A	-1.0946
84	S	A	-1.3394
85	P	A	-1.5419
86	E	A	-2.0985
87	E	A	-2.3073
88	L	A	-1.2259
89	K	A	0.0000
90	A	A	-1.0085
91	A	A	-0.7922
92	G	A	-0.8070
93	L	A	-0.5440
94	G	A	-0.7200
95	S	A	-0.8310
96	N	A	0.0000
97	Y	A	0.0226
98	A	A	-0.7029
99	Q	A	-1.4273
100	N	A	-0.9163
101	G	A	-0.0969
102	Y	A	1.0988
103	G	A	1.1347
104	I	A	1.3201
105	Y	A	0.9785
106	P	A	0.4592
107	T	A	0.0000
108	D	A	0.0000
109	S	A	-0.3825
110	N	A	-0.8670
111	G	A	-0.1096
112	V	A	0.8669
113	P	A	0.2532
114	F	A	-0.1903
115	D	A	-1.2438
116	V	A	0.0540
117	R	A	-1.5487
118	P	A	-0.7956
119	I	A	0.0000
120	A	A	0.3278
121	V	A	0.5794
122	M	A	0.1847
123	S	A	-0.4878
124	N	A	-0.6776
125	P	A	-0.3719
126	V	A	0.0000
127	T	A	-0.3680
128	D	A	0.0000
129	L	A	0.0000
130	H	A	-1.0899
131	E	A	-0.7120
132	D	A	0.0000
133	M	A	-0.5121
134	A	A	-0.6386
135	A	A	-0.6566
136	E	A	0.0000
137	Q	A	-0.6610
138	K	A	-0.8999
139	A	A	0.0000
140	L	A	0.0125
141	A	A	-0.0957
142	T	A	-0.1980
143	Y	A	0.0000
144	Y	A	0.6572
145	Q	A	-0.1757
146	L	A	0.0000
147	I	A	-0.1863
148	N	A	-0.7496
149	L	A	0.3074
150	T	A	0.0000
151	D	A	-1.3479
152	D	A	0.0000
153	V	A	0.5966
154	D	A	-0.8193
155	V	A	0.0000
156	I	A	-0.2046
157	D	A	-1.5438
158	V	A	0.0000
159	L	A	0.0000
160	K	A	-1.8742
161	F	A	-1.2226
162	L	A	0.0000
163	G	A	-0.5946
164	Q	A	-0.9212
165	R	A	-0.5264
166	E	A	0.0000
167	I	A	0.7193
168	I	A	0.2969
169	H	A	0.0000
170	Y	A	-0.1688
171	Q	A	-1.2730
172	R	A	-1.3418
173	F	A	0.0000
174	G	A	-1.6441
175	E	A	-2.6335
176	A	A	0.0000
177	L	A	0.0000
178	M	A	-1.6580
179	D	A	-2.4206
180	A	A	-0.7646
181	Y	A	-0.9355
182	E	A	-2.2516
183	L	A	-1.1443
184	E	A	-2.0765
185	E	A	-2.0261
186	S	A	-1.3855
187	Q	A	-1.2292
188	K	A	-0.5894
189	M	A	1.2740
190	F	A	1.9790