| Chain sequence(s) |
A: RKFFVGGNWKMNGRKQSLGELIGTLNAAKVPADTEVVCAPPTAYIDFARQKLDPKIAVAAQNCYKVTNGAFTGEISPGMIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKDWSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKSNVSDAVAQSTRIIYGGSVTGATCKELASQPDVDGFLVGGASLKPEFVDIINAKQ B: SRKFFVGGNWKMNGRKQSLGELIGTLNAAKVPADTEVVCAPPTAYIDFARQKLDPKIAVAAQNCYKVTNGAFTGEISPGMIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKDWSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKSNVSDAVAQSTRIIYGGSVTGATCKELASQPDVDGFLVGGASLKPEFVDIINAKQ |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 4 | R | A | -2.7184 | |
| 5 | K | A | -2.9765 | |
| 6 | F | A | 0.0000 | |
| 7 | F | A | 0.0000 | |
| 8 | V | A | 0.0000 | |
| 9 | G | A | 0.0000 | |
| 10 | G | A | 0.0000 | |
| 11 | N | A | 0.0000 | |
| 12 | W | A | 0.0000 | |
| 13 | K | A | -0.5390 | |
| 14 | M | A | 0.0000 | |
| 15 | N | A | -0.8357 | |
| 16 | G | A | -1.0341 | |
| 17 | R | A | -1.7175 | |
| 18 | K | A | -1.8976 | |
| 19 | Q | A | -2.2786 | |
| 20 | S | A | -1.7759 | |
| 21 | L | A | 0.0000 | |
| 22 | G | A | -2.1794 | |
| 23 | E | A | -2.7081 | |
| 24 | L | A | 0.0000 | |
| 25 | I | A | 0.0000 | |
| 26 | G | A | -1.5264 | |
| 27 | T | A | -1.0307 | |
| 28 | L | A | 0.0000 | |
| 29 | N | A | -1.5277 | |
| 30 | A | A | -0.6600 | |
| 31 | A | A | -1.0575 | |
| 32 | K | A | -1.6855 | |
| 33 | V | A | -1.0347 | |
| 34 | P | A | 0.0000 | |
| 35 | A | A | -1.3031 | |
| 36 | D | A | -2.7257 | |
| 37 | T | A | 0.0000 | |
| 38 | E | A | -1.3127 | |
| 39 | V | A | 0.0000 | |
| 40 | V | A | 0.0000 | |
| 41 | C | A | 0.0000 | |
| 42 | A | A | 0.0000 | |
| 43 | P | A | 0.0000 | |
| 44 | P | A | 0.0000 | |
| 45 | T | A | 0.0000 | |
| 46 | A | A | 0.0000 | |
| 47 | Y | A | 0.0000 | |
| 48 | I | A | 0.0000 | |
| 49 | D | A | -1.0882 | |
| 50 | F | A | 0.0000 | |
| 51 | A | A | 0.0000 | |
| 52 | R | A | -1.6757 | |
| 53 | Q | A | -2.3365 | |
| 54 | K | A | -2.5732 | |
| 55 | L | A | 0.0000 | |
| 56 | D | A | -1.7990 | |
| 57 | P | A | -1.4477 | |
| 58 | K | A | -1.4554 | |
| 59 | I | A | 0.0000 | |
| 60 | A | A | -0.5282 | |
| 61 | V | A | 0.0000 | |
| 62 | A | A | 0.0000 | |
| 63 | A | A | 0.0000 | |
| 64 | Q | A | 0.0000 | |
| 65 | N | A | 0.0000 | |
| 66 | C | A | 0.0000 | |
| 67 | Y | A | 0.0000 | |
| 68 | K | A | -0.4790 | |
| 69 | V | A | -0.0853 | |
| 70 | T | A | -0.4550 | |
| 71 | N | A | -0.9634 | |
| 72 | G | A | -0.5173 | |
| 73 | A | A | -0.2220 | |
| 74 | F | A | 0.3371 | |
| 75 | T | A | 0.0000 | |
| 76 | G | A | -0.1106 | |
| 77 | E | A | 0.0000 | |
| 78 | I | A | 0.0000 | |
| 79 | S | A | 0.0000 | |
| 80 | P | A | 0.0000 | |
| 81 | G | A | -0.8725 | |
| 82 | M | A | 0.0000 | |
| 83 | I | A | 0.0000 | |
| 84 | K | A | -1.6107 | |
| 85 | D | A | -1.5155 | |
| 86 | C | A | 0.0000 | |
| 87 | G | A | -1.1484 | |
| 88 | A | A | 0.0000 | |
| 89 | T | A | -0.5181 | |
| 90 | W | A | 0.0000 | |
| 91 | V | A | 0.0000 | |
| 92 | V | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | G | A | 0.0000 | |
| 95 | H | A | 0.0000 | |
| 96 | S | A | 0.0000 | |
| 97 | E | A | 0.0705 | |
| 98 | R | A | 0.0000 | |
| 99 | R | A | -0.4614 | |
| 100 | H | A | -0.1304 | |
| 101 | V | A | 0.9694 | |
| 102 | F | A | 0.4705 | |
| 103 | G | A | -0.3778 | |
| 104 | E | A | -0.7346 | |
| 105 | S | A | -1.3847 | |
| 106 | D | A | -2.5015 | |
| 107 | E | A | -2.4015 | |
| 108 | L | A | -1.3532 | |
| 109 | I | A | 0.0000 | |
| 110 | G | A | 0.0000 | |
| 111 | Q | A | -1.4585 | |
| 112 | K | A | 0.0000 | |
| 113 | V | A | 0.0000 | |
| 114 | A | A | -0.9076 | |
| 115 | H | A | -0.4597 | |
| 116 | A | A | 0.0000 | |
| 117 | L | A | -0.7973 | |
| 118 | A | A | -0.5298 | |
| 119 | E | A | -0.5478 | |
| 120 | G | A | -0.7103 | |
| 121 | L | A | 0.0000 | |
| 122 | G | A | 0.0000 | |
| 123 | V | A | 0.0000 | |
| 124 | I | A | 0.0000 | |
| 125 | A | A | 0.0000 | |
| 126 | C | A | 0.0000 | |
| 127 | I | A | 0.0000 | |
| 128 | G | A | 0.0000 | |
| 129 | E | A | 0.0000 | |
| 130 | K | A | -0.9150 | |
| 131 | L | A | -1.3652 | |
| 132 | D | A | -2.5999 | |
| 133 | E | A | -2.0984 | |
| 134 | R | A | -2.1393 | |
| 135 | E | A | -2.6745 | |
| 136 | A | A | -1.5414 | |
| 137 | G | A | -1.5934 | |
| 138 | I | A | -1.3600 | |
| 139 | T | A | -1.5103 | |
| 140 | E | A | -2.1601 | |
| 141 | K | A | -2.4428 | |
| 142 | V | A | -1.6858 | |
| 143 | V | A | 0.0000 | |
| 144 | F | A | -1.8371 | |
| 145 | E | A | -2.8742 | |
| 146 | Q | A | 0.0000 | |
| 147 | T | A | 0.0000 | |
| 148 | K | A | -2.8037 | |
| 149 | V | A | -2.3129 | |
| 150 | I | A | 0.0000 | |
| 151 | A | A | -1.9951 | |
| 152 | D | A | -2.6742 | |
| 153 | N | A | -2.3103 | |
| 154 | V | A | 0.0000 | |
| 155 | K | A | -2.8714 | |
| 156 | D | A | -2.8221 | |
| 157 | W | A | 0.0000 | |
| 158 | S | A | -1.5941 | |
| 159 | K | A | -1.7552 | |
| 160 | V | A | 0.0000 | |
| 161 | V | A | 0.0000 | |
| 162 | L | A | 0.0000 | |
| 163 | A | A | 0.0000 | |
| 164 | Y | A | 0.0000 | |
| 165 | E | A | 0.0000 | |
| 166 | P | A | 0.0000 | |
| 167 | V | A | 0.4307 | |
| 168 | W | A | 0.0000 | |
| 169 | A | A | 0.2838 | |
| 170 | I | A | 1.4742 | |
| 171 | G | A | 0.1765 | |
| 172 | T | A | -0.1784 | |
| 173 | G | A | -0.7976 | |
| 174 | K | A | -1.0637 | |
| 175 | T | A | -0.5068 | |
| 176 | A | A | -0.4257 | |
| 177 | T | A | -1.1302 | |
| 178 | P | A | -1.4843 | |
| 179 | Q | A | -2.1561 | |
| 180 | Q | A | -1.8830 | |
| 181 | A | A | 0.0000 | |
| 182 | Q | A | -2.4321 | |
| 183 | E | A | -3.3471 | |
| 184 | V | A | 0.0000 | |
| 185 | H | A | 0.0000 | |
| 186 | E | A | -3.2344 | |
| 187 | K | A | -2.9176 | |
| 188 | L | A | 0.0000 | |
| 189 | R | A | 0.0000 | |
| 190 | G | A | -2.1440 | |
| 191 | W | A | -1.4843 | |
| 192 | L | A | 0.0000 | |
| 193 | K | A | -2.8952 | |
| 194 | S | A | -1.7378 | |
| 195 | N | A | -1.8621 | |
| 196 | V | A | -1.0424 | |
| 197 | S | A | -1.4991 | |
| 198 | D | A | -2.7069 | |
| 199 | A | A | -1.3350 | |
| 200 | V | A | -1.3732 | |
| 201 | A | A | 0.0000 | |
| 202 | Q | A | -2.3242 | |
| 203 | S | A | -1.8643 | |
| 204 | T | A | 0.0000 | |
| 205 | R | A | -1.2639 | |
| 206 | I | A | 0.0000 | |
| 207 | I | A | 0.0000 | |
| 208 | Y | A | 0.0000 | |
| 209 | G | A | -0.1475 | |
| 210 | G | A | 0.1462 | |
| 211 | S | A | -0.0557 | |
| 212 | V | A | 0.0000 | |
| 213 | T | A | -0.8803 | |
| 214 | G | A | -1.1894 | |
| 215 | A | A | -0.8614 | |
| 216 | T | A | -1.0193 | |
| 217 | C | A | 0.0000 | |
| 218 | K | A | -3.2554 | |
| 219 | E | A | -2.7487 | |
| 220 | L | A | 0.0000 | |
| 221 | A | A | 0.0000 | |
| 222 | S | A | -1.5793 | |
| 223 | Q | A | -1.6476 | |
| 224 | P | A | -0.9981 | |
| 225 | D | A | -1.5386 | |
| 226 | V | A | 0.0000 | |
| 227 | D | A | 0.0000 | |
| 228 | G | A | 0.0000 | |
| 229 | F | A | 0.0000 | |
| 230 | L | A | 0.0000 | |
| 231 | V | A | 0.0000 | |
| 232 | G | A | -0.4425 | |
| 233 | G | A | -0.9897 | |
| 234 | A | A | -1.2791 | |
| 235 | S | A | 0.0000 | |
| 236 | L | A | -1.2256 | |
| 237 | K | A | -2.4558 | |
| 238 | P | A | -1.7417 | |
| 239 | E | A | -2.2264 | |
| 240 | F | A | 0.0000 | |
| 241 | V | A | -1.4292 | |
| 242 | D | A | -2.6937 | |
| 243 | I | A | 0.0000 | |
| 244 | I | A | 0.0000 | |
| 245 | N | A | -2.1525 | |
| 246 | A | A | 0.0000 | |
| 247 | K | A | -3.0167 | |
| 248 | Q | A | -2.6063 | |
| 3 | S | B | -1.0695 | |
| 4 | R | B | -1.8895 | |
| 5 | K | B | -2.3611 | |
| 6 | F | B | 0.0000 | |
| 7 | F | B | 0.0000 | |
| 8 | V | B | 0.0000 | |
| 9 | G | B | 0.0000 | |
| 10 | G | B | 0.0000 | |
| 11 | N | B | 0.0000 | |
| 12 | W | B | 0.0000 | |
| 13 | K | B | -0.4396 | |
| 14 | M | B | 0.0000 | |
| 15 | N | B | -0.6825 | |
| 16 | G | B | -1.0954 | |
| 17 | R | B | -1.6433 | |
| 18 | K | B | -1.7590 | |
| 19 | Q | B | -2.2273 | |
| 20 | S | B | -1.6961 | |
| 21 | L | B | 0.0000 | |
| 22 | G | B | -2.1110 | |
| 23 | E | B | -2.6260 | |
| 24 | L | B | 0.0000 | |
| 25 | I | B | 0.0000 | |
| 26 | G | B | -1.5189 | |
| 27 | T | B | -0.9943 | |
| 28 | L | B | 0.0000 | |
| 29 | N | B | -1.5952 | |
| 30 | A | B | -0.7131 | |
| 31 | A | B | -1.0295 | |
| 32 | K | B | -1.5541 | |
| 33 | V | B | -0.9939 | |
| 34 | P | B | -1.3376 | |
| 35 | A | B | -1.1511 | |
| 36 | D | B | -2.5857 | |
| 37 | T | B | -1.6643 | |
| 38 | E | B | -1.2001 | |
| 39 | V | B | 0.0000 | |
| 40 | V | B | 0.0000 | |
| 41 | C | B | 0.0000 | |
| 42 | A | B | 0.0000 | |
| 43 | P | B | 0.0000 | |
| 44 | P | B | 0.0000 | |
| 45 | T | B | 0.0000 | |
| 46 | A | B | 0.0000 | |
| 47 | Y | B | 0.0000 | |
| 48 | I | B | 0.0000 | |
| 49 | D | B | -1.0937 | |
| 50 | F | B | -1.0608 | |
| 51 | A | B | 0.0000 | |
| 52 | R | B | -1.6595 | |
| 53 | Q | B | -2.3007 | |
| 54 | K | B | -2.5330 | |
| 55 | L | B | 0.0000 | |
| 56 | D | B | -1.9541 | |
| 57 | P | B | -1.6116 | |
| 58 | K | B | -1.6016 | |
| 59 | I | B | 0.0000 | |
| 60 | A | B | -0.6028 | |
| 61 | V | B | 0.0000 | |
| 62 | A | B | 0.0000 | |
| 63 | A | B | 0.0000 | |
| 64 | Q | B | 0.0000 | |
| 65 | N | B | -0.2002 | |
| 66 | C | B | 0.0000 | |
| 67 | Y | B | 0.0000 | |
| 68 | K | B | -0.4976 | |
| 69 | V | B | -0.1428 | |
| 70 | T | B | -0.6097 | |
| 71 | N | B | -1.3193 | |
| 72 | G | B | -0.6829 | |
| 73 | A | B | -0.2142 | |
| 74 | F | B | 0.2128 | |
| 75 | T | B | 0.0000 | |
| 76 | G | B | -0.1154 | |
| 77 | E | B | -0.4100 | |
| 78 | I | B | 0.0000 | |
| 79 | S | B | 0.0000 | |
| 80 | P | B | 0.0000 | |
| 81 | G | B | -0.8886 | |
| 82 | M | B | 0.0000 | |
| 83 | I | B | 0.0000 | |
| 84 | K | B | -1.5935 | |
| 85 | D | B | -1.4120 | |
| 86 | C | B | 0.0000 | |
| 87 | G | B | -1.1186 | |
| 88 | A | B | 0.0000 | |
| 89 | T | B | -0.6055 | |
| 90 | W | B | 0.0000 | |
| 91 | V | B | 0.0000 | |
| 92 | V | B | 0.0000 | |
| 93 | L | B | 0.0000 | |
| 94 | G | B | 0.0000 | |
| 95 | H | B | 0.0000 | |
| 96 | S | B | -0.0802 | |
| 97 | E | B | 0.1640 | |
| 98 | R | B | 0.0000 | |
| 99 | R | B | -0.4819 | |
| 100 | H | B | -0.0487 | |
| 101 | V | B | 1.2135 | |
| 102 | F | B | 0.6046 | |
| 103 | G | B | -0.3734 | |
| 104 | E | B | -0.8360 | |
| 105 | S | B | -1.6525 | |
| 106 | D | B | -2.8623 | |
| 107 | E | B | -2.5650 | |
| 108 | L | B | -1.4906 | |
| 109 | I | B | 0.0000 | |
| 110 | G | B | 0.0000 | |
| 111 | Q | B | -1.2673 | |
| 112 | K | B | 0.0000 | |
| 113 | V | B | 0.0000 | |
| 114 | A | B | -0.7611 | |
| 115 | H | B | -0.3993 | |
| 116 | A | B | 0.0000 | |
| 117 | L | B | -0.7743 | |
| 118 | A | B | -0.6254 | |
| 119 | E | B | -0.5665 | |
| 120 | G | B | -0.7160 | |
| 121 | L | B | 0.0000 | |
| 122 | G | B | 0.0000 | |
| 123 | V | B | 0.0000 | |
| 124 | I | B | 0.0000 | |
| 125 | A | B | 0.0000 | |
| 126 | C | B | 0.0000 | |
| 127 | I | B | 0.0000 | |
| 128 | G | B | 0.0000 | |
| 129 | E | B | 0.0000 | |
| 130 | K | B | -1.0862 | |
| 131 | L | B | -1.5571 | |
| 132 | D | B | -2.5810 | |
| 133 | E | B | -2.1437 | |
| 134 | R | B | -1.9472 | |
| 135 | E | B | -2.6496 | |
| 136 | A | B | -1.5081 | |
| 137 | G | B | -1.5570 | |
| 138 | I | B | -1.3406 | |
| 139 | T | B | 0.0000 | |
| 140 | E | B | -2.1530 | |
| 141 | K | B | -2.4255 | |
| 142 | V | B | -1.6586 | |
| 143 | V | B | 0.0000 | |
| 144 | F | B | -1.6869 | |
| 145 | E | B | -2.7143 | |
| 146 | Q | B | -1.9417 | |
| 147 | T | B | 0.0000 | |
| 148 | K | B | -2.1617 | |
| 149 | V | B | -1.9328 | |
| 150 | I | B | 0.0000 | |
| 151 | A | B | -1.6570 | |
| 152 | D | B | -2.1484 | |
| 153 | N | B | -1.8054 | |
| 154 | V | B | 0.0000 | |
| 155 | K | B | -2.9349 | |
| 156 | D | B | -2.7728 | |
| 157 | W | B | -1.4142 | |
| 158 | S | B | -1.2932 | |
| 159 | K | B | -1.4648 | |
| 160 | V | B | 0.0000 | |
| 161 | V | B | 0.0000 | |
| 162 | L | B | 0.0000 | |
| 163 | A | B | 0.0000 | |
| 164 | Y | B | 0.0000 | |
| 165 | E | B | 0.0000 | |
| 166 | P | B | 0.0000 | |
| 167 | V | B | -0.0143 | |
| 168 | W | B | 0.0000 | |
| 169 | A | B | -0.0964 | |
| 170 | I | B | 0.6614 | |
| 171 | G | B | -0.1798 | |
| 172 | T | B | -0.4101 | |
| 173 | G | B | -0.8840 | |
| 174 | K | B | -1.0997 | |
| 175 | T | B | -0.5999 | |
| 176 | A | B | -0.4398 | |
| 177 | T | B | -1.0546 | |
| 178 | P | B | -1.7604 | |
| 179 | Q | B | -2.2498 | |
| 180 | Q | B | -2.0546 | |
| 181 | A | B | 0.0000 | |
| 182 | Q | B | -2.4496 | |
| 183 | E | B | -3.3389 | |
| 184 | V | B | 0.0000 | |
| 185 | H | B | 0.0000 | |
| 186 | E | B | -3.1508 | |
| 187 | K | B | -2.7234 | |
| 188 | L | B | 0.0000 | |
| 189 | R | B | 0.0000 | |
| 190 | G | B | -2.1081 | |
| 191 | W | B | -1.5318 | |
| 192 | L | B | 0.0000 | |
| 193 | K | B | -2.9739 | |
| 194 | S | B | -1.8315 | |
| 195 | N | B | -1.9066 | |
| 196 | V | B | -1.1177 | |
| 197 | S | B | -1.6942 | |
| 198 | D | B | -2.8203 | |
| 199 | A | B | -1.3878 | |
| 200 | V | B | -1.3539 | |
| 201 | A | B | 0.0000 | |
| 202 | Q | B | -2.1630 | |
| 203 | S | B | -1.4048 | |
| 204 | T | B | 0.0000 | |
| 205 | R | B | -0.8452 | |
| 206 | I | B | 0.0000 | |
| 207 | I | B | 0.0000 | |
| 208 | Y | B | 0.0000 | |
| 209 | G | B | 0.0035 | |
| 210 | G | B | 0.0000 | |
| 211 | S | B | -0.1168 | |
| 212 | V | B | 0.0000 | |
| 213 | T | B | -0.7124 | |
| 214 | G | B | -1.0267 | |
| 215 | A | B | -0.8417 | |
| 216 | T | B | -1.0380 | |
| 217 | C | B | 0.0000 | |
| 218 | K | B | -3.3932 | |
| 219 | E | B | -2.9241 | |
| 220 | L | B | 0.0000 | |
| 221 | A | B | 0.0000 | |
| 222 | S | B | -1.7479 | |
| 223 | Q | B | -1.7491 | |
| 224 | P | B | -1.0235 | |
| 225 | D | B | -1.6063 | |
| 226 | V | B | 0.0000 | |
| 227 | D | B | 0.0000 | |
| 228 | G | B | 0.0000 | |
| 229 | F | B | 0.0000 | |
| 230 | L | B | 0.0000 | |
| 231 | V | B | 0.0000 | |
| 232 | G | B | -0.3835 | |
| 233 | G | B | -0.7800 | |
| 234 | A | B | -0.8936 | |
| 235 | S | B | 0.0000 | |
| 236 | L | B | -0.6933 | |
| 237 | K | B | -1.7977 | |
| 238 | P | B | -1.2469 | |
| 239 | E | B | -1.4354 | |
| 240 | F | B | 0.0000 | |
| 241 | V | B | -1.1919 | |
| 242 | D | B | -2.5662 | |
| 243 | I | B | 0.0000 | |
| 244 | I | B | 0.0000 | |
| 245 | N | B | -2.3409 | |
| 246 | A | B | 0.0000 | |
| 247 | K | B | -3.4155 | |
| 248 | Q | B | -2.7728 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine