Project name: 9c49b25efef52f

Chain sequence(s)	A: LPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRHNPHEVQPAYATRYAITVWYFDADERARAKVKYLKGVRVEL
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.4948
• Maximal score value: 1.6513
• Average score: -0.9392
• Total score value: -210.3901

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
188	L	A	1.2146
189	P	A	0.4368
190	A	A	-0.0032
191	L	A	-0.0218
192	K	A	-0.5943
193	L	A	0.0484
194	A	A	0.0000
195	L	A	-0.1951
196	E	A	-1.3392
197	Y	A	-0.1751
198	I	A	0.0000
199	V	A	-0.8068
200	P	A	-1.0919
201	C	A	-0.9251
202	M	A	0.0000
203	N	A	-2.0099
204	K	A	-2.4084
205	H	A	-1.6740
206	G	A	0.0000
207	I	A	0.0000
208	C	A	0.0000
209	V	A	-0.0543
210	V	A	0.0000
211	D	A	-2.2912
212	D	A	-2.5333
213	F	A	-0.9314
214	L	A	-0.9132
215	G	A	-2.2020
216	K	A	-3.4948
217	E	A	-3.2616
218	T	A	-2.1779
219	G	A	0.0000
220	Q	A	-3.3271
221	Q	A	-3.3464
222	I	A	0.0000
223	G	A	-2.6104
224	D	A	-3.0475
225	E	A	-2.5222
226	V	A	0.0000
227	R	A	-2.8028
228	A	A	-2.2179
229	L	A	-2.0287
230	H	A	-2.4324
231	D	A	-2.7242
232	T	A	-1.8820
233	G	A	-2.3446
234	K	A	-2.5213
235	F	A	0.0000
236	T	A	-1.4589
237	D	A	-2.3701
238	G	A	0.0000
239	Q	A	-0.5645
240	L	A	0.0589
241	V	A	1.2881
242	S	A	-0.4216
243	Q	A	-2.0217
244	K	A	-2.8349
245	S	A	-2.3271
246	D	A	-2.7835
247	S	A	-2.4338
248	S	A	-1.9566
249	K	A	-2.9445
250	D	A	-1.9817
251	I	A	-0.2788
252	R	A	-0.9284
253	G	A	0.0000
254	D	A	-0.7434
255	K	A	-1.1526
256	I	A	-0.1896
257	T	A	-0.0624
258	W	A	-0.1148
259	I	A	0.0000
260	E	A	-2.8751
261	G	A	-2.5332
262	K	A	-3.0148
263	E	A	-2.3148
264	P	A	-1.5059
265	G	A	-1.7076
266	C	A	0.0000
267	E	A	-2.7720
268	T	A	0.0000
269	I	A	0.0000
270	G	A	-1.5985
271	L	A	-0.0684
272	L	A	0.0000
273	M	A	0.0000
274	S	A	-0.3969
275	S	A	-0.5788
276	M	A	0.0000
277	D	A	-1.4807
278	D	A	-2.0917
279	L	A	0.0000
280	I	A	0.0000
281	R	A	-3.1313
282	H	A	-1.6702
283	C	A	0.0000
284	N	A	-2.6721
285	G	A	-2.1890
286	K	A	-2.2270
287	L	A	0.0000
288	G	A	-1.4487
289	S	A	-1.0898
290	Y	A	-1.5837
291	K	A	-2.9518
292	I	A	0.0000
293	N	A	-2.4427
294	G	A	-1.4977
295	R	A	-1.1485
296	T	A	-1.1067
297	K	A	-1.9469
298	A	A	0.0000
299	M	A	-0.0322
300	V	A	0.0000
301	A	A	0.0000
302	C	A	0.0000
303	Y	A	0.0000
304	P	A	-0.7194
305	G	A	-0.2747
306	N	A	-1.0586
307	G	A	-0.5560
308	T	A	0.0000
309	G	A	0.1540
310	Y	A	0.7260
311	V	A	0.8675
312	R	A	-1.2182
313	H	A	-0.8765
314	V	A	-1.2680
315	D	A	-1.0641
316	N	A	0.0000
317	P	A	-1.6971
318	N	A	-1.8404
319	G	A	-1.8854
320	D	A	-1.8297
321	G	A	0.0000
322	R	A	-0.9774
323	C	A	0.0000
324	V	A	0.0000
325	T	A	0.0000
326	C	A	0.0000
327	I	A	0.2354
328	Y	A	0.0000
329	Y	A	0.0000
330	L	A	0.0000
331	N	A	0.0000
332	K	A	-2.9794
333	D	A	-2.8349
334	W	A	0.0000
335	D	A	-1.4935
336	A	A	-0.7590
337	K	A	-1.0728
338	V	A	0.9603
339	S	A	0.6728
340	G	A	0.0000
341	G	A	0.0000
342	I	A	-0.9060
343	L	A	0.0000
344	R	A	-0.8924
345	I	A	0.0000
346	F	A	-1.0893
347	P	A	-1.8818
348	E	A	-3.1337
349	G	A	-2.3634
350	K	A	-2.3338
351	A	A	-1.2700
352	Q	A	-1.1452
353	F	A	0.3145
354	A	A	-0.0486
355	D	A	-1.0156
356	I	A	0.0000
357	E	A	-1.3335
358	P	A	0.0000
359	K	A	-2.0254
360	F	A	-2.0882
361	D	A	0.0000
362	R	A	-1.3193
363	L	A	0.0000
364	L	A	0.0000
365	F	A	0.0000
366	F	A	0.0000
367	W	A	-0.7545
368	S	A	0.0000
369	D	A	-1.9791
370	R	A	-3.0719
371	H	A	-2.6354
372	N	A	0.0000
373	P	A	-1.3956
374	H	A	0.0000
375	E	A	-0.7929
376	V	A	0.0000
377	Q	A	-0.3094
378	P	A	0.0131
379	A	A	0.0000
380	Y	A	1.0269
381	A	A	0.4396
382	T	A	-0.0537
383	R	A	0.0000
384	Y	A	0.0000
385	A	A	0.0000
386	I	A	0.0000
387	T	A	0.0000
388	V	A	0.0000
389	W	A	0.0000
390	Y	A	0.0000
391	F	A	-1.3189
392	D	A	0.0000
393	A	A	-2.4613
394	D	A	-3.1538
395	E	A	-2.9122
396	R	A	-3.2431
397	A	A	-2.6242
398	R	A	-3.0680
399	A	A	0.0000
400	K	A	-1.3822
401	V	A	0.3180
402	K	A	-0.9486
403	Y	A	0.9409
404	L	A	1.6513
408	K	A	-1.6695
409	G	A	-0.8368
410	V	A	0.9741
411	R	A	-0.8712
412	V	A	0.3423
413	E	A	-0.6108
414	L	A	0.8284