Project name: acohen@caltech.edu

Status: done

submitted: 2018-06-21 21:34:15, status changed: 2018-06-21 21:44:27
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Chain sequence(s) H: RLSQSGGQMKKPGESMRLSCRASGYEFLNCPINWIRLAPGRRPEWMGWLKPRGGAVNYARKFQGRVTMTRDVYSDTAFLELRSLTSDDDTAVYFCTRGKYCTARDYYNWDFEHWGRGAPVTVSSASTKGPSVFPLAPSSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK
L: VLTQSPATLSLSPGETAIISCRTSQSGSLAWYQQRPGQAPRLVIYSGSTRAAGIPDRFSGSRWGADYNLSISNLESGDFGVYYCQQYEFFGQGTKVQVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
Distance of aggregation 10 Å
Dynamic mode No
Show buried residues

Minimal score value
-3.7633
Maximal score value
1.3762
Average score
-0.7577
Total score value
-324.3147

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
3 R H -2.5539
4 L H 0.0000
5 S H -1.7800
6 Q H 0.0000
7 S H -1.2217
8 G H -1.1450
9 G H -0.8136
10 Q H -0.7246
11 M H -0.3185
12 K H -1.2430
13 K H -2.2414
14 P H -1.8468
15 G H -1.6200
16 E H -1.7390
17 S H -1.7951
18 M H 0.0000
19 R H -2.2274
20 L H 0.0000
21 S H -1.0187
22 C H 0.0000
23 R H -2.4922
24 A H 0.0000
25 S H -1.7410
26 G H -1.2207
27 Y H -1.1743
28 E H -1.8377
29 F H 0.0000
30 L H -1.1111
31 N H -1.4976
32 C H 0.0000
33 P H 0.0000
34 I H 0.0000
35 N H 0.0000
36 W H 0.0000
37 I H 0.0000
38 R H 0.0000
39 L H 0.0000
40 A H -1.2262
41 P H -1.1332
42 G H -1.8435
43 R H -2.7226
44 R H -1.9681
45 P H 0.0000
46 E H -0.8067
47 W H -0.0933
48 M H 0.0000
49 G H 0.0000
50 W H -0.1132
51 L H 0.0000
52 K H -1.2625
52A P H 0.0000
53 R H -2.1621
54 G H -1.3734
55 G H -1.0602
56 A H -0.6447
57 V H -0.0019
58 N H -1.0172
59 Y H -1.2648
60 A H -1.8978
61 R H -3.1647
62 K H -3.0268
63 F H 0.0000
64 Q H -2.6549
65 G H -1.7801
66 R H -1.6457
67 V H 0.0000
68 T H -0.7488
69 M H 0.0000
70 T H -0.4707
71 R H -1.3028
72 D H -1.1322
73 V H -0.0371
74 Y H 0.9508
75 S H -0.2990
76 D H -1.0719
77 T H 0.0000
78 A H 0.0000
79 F H -0.8897
80 L H 0.0000
81 E H -1.5938
82 L H 0.0000
82A R H -1.7803
82B S H -1.3057
82C L H 0.0000
83 T H -1.5459
84 S H -1.5076
85 D H -1.9425
86 D H 0.0000
87 T H -0.6030
88 A H 0.0000
89 V H -0.0033
90 Y H 0.0000
91 F H 0.0000
92 C H 0.0000
93 T H 0.0000
94 R H -0.5090
95 G H 0.0000
96 K H -0.4134
97 Y H 0.2096
98 C H -0.4282
99 T H -1.0879
99A A H -1.5985
99B R H -2.6005
99C D H -2.0973
99D Y H -0.1750
100 Y H 1.1968
101 N H 0.0000
102 W H 0.5498
103 D H -0.1635
104 F H 0.0000
105 E H -1.2068
106 H H -1.5069
107 W H -1.1590
108 G H 0.0000
109 R H -2.4258
110 G H 0.0000
111 A H 0.0000
112 P H -0.5381
113 V H 0.0000
114 T H -0.6058
115 V H 0.0000
116 S H -1.0820
117 S H -0.9599
118 A H -0.6350
119 S H -0.6966
120 T H -0.6275
121 K H -1.1460
122 G H -1.3723
123 P H 0.0000
124 S H -0.4034
125 V H 0.0000
126 F H -0.7266
127 P H -1.2357
128 L H 0.0000
129 A H -0.9900
130 P H 0.0000
131 S H -0.7333
132 S H -0.6730
137 G H -0.7949
138 G H -0.9035
139 T H -0.6228
140 A H 0.0000
141 A H 0.0000
142 L H 0.0000
143 G H 0.0000
144 C H 0.0000
145 L H 0.0000
146 V H 0.0000
147 K H 0.0000
148 D H -0.4058
149 Y H 0.0000
150 F H 0.0000
151 P H -0.6935
152 E H -0.9403
153 P H -1.0889
154 V H -0.9300
155 T H -0.7668
156 V H -0.4208
157 S H -0.4395
158 W H 0.0000
159 N H -0.8470
160 S H -0.6615
161 G H -0.4239
162 A H -0.2014
163 L H 0.0158
164 T H -0.1401
165 S H -0.3701
166 G H -0.3744
167 V H 0.2179
168 H H 0.0000
169 T H 0.0479
170 F H 0.0000
171 P H -0.4366
172 A H 0.1414
173 V H 0.4400
174 L H 1.0517
175 Q H 0.2115
176 S H -0.0460
177 S H -0.2019
178 G H 0.0473
179 L H 0.0484
180 Y H 0.3585
181 S H 0.0000
182 L H 0.0000
183 S H 0.0000
184 S H 0.0000
185 V H 0.0000
186 V H 0.0000
187 T H -0.1675
188 V H 0.0000
189 P H -0.6981
190 S H -0.7918
191 S H -0.7240
192 S H -0.8005
193 L H -0.9943
194 G H -1.0132
195 T H -0.8331
196 Q H -1.4781
197 T H -1.2642
198 Y H 0.0000
199 I H -1.3612
200 C H 0.0000
201 N H -1.6184
202 V H 0.0000
203 N H -2.3175
204 H H 0.0000
205 K H -2.9362
206 P H -1.7373
207 S H -1.8572
208 N H -2.6643
209 T H -2.1576
210 K H -2.8730
211 V H -1.8897
212 D H -2.6841
213 K H -2.2750
214 R H -2.6832
215 V H 0.0000
216 E H -2.7423
217 P H -1.8383
218 K H -2.0808
3 V L 1.3762
4 L L 0.0000
5 T L -0.5585
6 Q L 0.0000
7 S L -0.4972
8 P L -0.1259
9 A L -0.3753
10 T L -0.4322
11 L L 0.0346
12 S L -0.2380
13 L L -0.1549
14 S L -0.7828
15 P L -1.4386
16 G L -1.7361
17 E L -1.7216
18 T L -0.6345
19 A L 0.0000
20 I L 1.3556
21 I L 0.0000
22 S L -0.7067
23 C L 0.0000
24 R L -2.2412
25 T L 0.0000
26 S L -0.9326
27 Q L -1.3112
28 S L -1.0693
29 G L -0.6166
30 S L -0.3142
31 L L 0.0000
32 A L 0.0000
33 W L 0.0000
34 Y L 0.0000
35 Q L 0.0000
36 Q L -1.4350
37 R L -1.9911
38 P L -1.4077
39 G L -1.7175
40 Q L -2.4111
41 A L -1.6823
42 P L 0.0000
43 R L -1.3966
44 L L 0.0000
45 V L 0.0000
46 I L 0.0000
47 Y L -0.4449
48 S L -0.4956
49 G L 0.0000
50 S L -1.0093
51 T L -0.7619
52 R L -1.5901
53 A L -0.9497
54 A L -0.5332
55 G L -0.8324
56 I L 0.0000
57 P L -1.4349
58 D L -2.3172
59 R L -1.6725
60 F L 0.0000
61 S L -0.9594
62 G L -0.8610
63 S L -1.2686
64 R L -2.0284
65 W L -0.4649
66 G L -0.8203
67 A L -1.4016
68 D L -1.8427
69 Y L 0.0000
70 N L -0.9415
71 L L 0.0000
72 S L 0.2249
73 I L 0.0000
74 S L -1.4882
75 N L -2.3422
76 L L 0.0000
77 E L -2.4704
78 S L -1.2333
79 G L -1.1092
80 D L 0.0000
81 F L 0.0000
82 G L 0.0000
83 V L -0.7420
84 Y L 0.0000
85 Y L 0.0000
86 C L 0.0000
87 Q L 0.0000
88 Q L 0.0000
89 Y L 0.7170
90 E L 0.3693
91 F L 1.2487
92 F L 0.0000
93 G L 0.0000
94 Q L -1.4144
95 G L 0.0000
96 T L 0.0000
97 K L -1.1428
98 V L 0.0000
99 Q L -0.6389
100 V L -0.1673
101 D L -0.4995
102 I L -0.0722
103 K L -1.3586
104 R L -1.1331
105 T L -0.2820
106 V L 0.1491
107 A L -0.1283
108 A L -0.2121
109 P L 0.0000
110 S L -0.1391
111 V L 0.0000
112 F L 0.1712
113 I L 0.1443
114 F L 0.0000
115 P L -0.7285
116 P L -0.8396
117 S L -1.8435
118 D L -3.0003
119 E L -3.0707
120 Q L 0.0000
121 L L -2.0954
122 K L -2.8867
123 S L -1.8055
124 G L -1.2692
125 T L -1.0370
126 A L 0.0000
127 S L 0.0000
128 V L 0.0000
129 V L 0.0000
130 C L 0.0000
131 L L 0.0000
132 L L 0.0000
133 N L 0.0000
134 N L -0.8925
135 F L 0.0000
136 Y L 0.0000
137 P L -1.6716
138 R L -2.9330
139 E L -3.1425
140 A L -2.3216
141 K L -2.2969
142 V L -1.0642
143 Q L -0.5562
144 W L 0.0000
145 K L -0.4703
146 V L 0.0000
147 D L -1.7491
148 N L -1.4444
149 A L -0.2164
150 L L 0.5993
151 Q L -0.2747
152 S L -0.5340
153 G L -1.1428
154 N L -1.4214
155 S L -1.5682
156 Q L -1.8219
157 E L -1.7905
158 S L -0.9194
159 V L -0.6391
160 T L 0.0000
161 E L -2.0864
162 Q L 0.0000
163 D L -1.6918
164 S L -1.5477
165 K L -2.2907
166 D L -1.6930
167 S L -1.5564
168 T L 0.0000
169 Y L 0.0000
170 S L 0.0000
171 L L 0.0000
172 S L 0.0000
173 S L 0.0000
174 T L -0.8122
175 L L 0.0000
176 T L -0.5535
177 L L -0.7561
178 S L -1.2862
179 K L -2.0630
180 A L -1.9676
181 D L -2.6632
182 Y L 0.0000
183 E L -3.7633
184 K L -3.7153
185 H L -2.9407
186 K L -3.2040
187 V L -1.2692
188 Y L 0.0000
189 A L 0.0000
190 C L 0.0000
191 E L -0.8454
192 V L 0.0000
193 T L -1.1894
194 H L -1.5625
195 Q L -1.6472
196 G L -0.5735
197 L L -0.3187
198 S L -0.4881
199 S L -0.4356
200 P L -0.5649
201 V L -0.0202
202 T L -0.4428
203 K L -0.6803
204 S L -0.4283
205 F L -0.8043
206 N L -1.8010
207 R L -2.5405
208 G L -2.0721
209 E L -2.1547
210 C L -0.7342

 

Laboratory of Theory of Biopolymers 2015