Chain sequence(s) |
H: RLSQSGGQMKKPGESMRLSCRASGYEFLNCPINWIRLAPGRRPEWMGWLKPRGGAVNYARKFQGRVTMTRDVYSDTAFLELRSLTSDDDTAVYFCTRGKYCTARDYYNWDFEHWGRGAPVTVSSASTKGPSVFPLAPSSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK L: VLTQSPATLSLSPGETAIISCRTSQSGSLAWYQQRPGQAPRLVIYSGSTRAAGIPDRFSGSRWGADYNLSISNLESGDFGVYYCQQYEFFGQGTKVQVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Distance of aggregation | 10 Å |
Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
3 | R | H | -2.5539 | |
4 | L | H | 0.0000 | |
5 | S | H | -1.7800 | |
6 | Q | H | 0.0000 | |
7 | S | H | -1.2217 | |
8 | G | H | -1.1450 | |
9 | G | H | -0.8136 | |
10 | Q | H | -0.7246 | |
11 | M | H | -0.3185 | |
12 | K | H | -1.2430 | |
13 | K | H | -2.2414 | |
14 | P | H | -1.8468 | |
15 | G | H | -1.6200 | |
16 | E | H | -1.7390 | |
17 | S | H | -1.7951 | |
18 | M | H | 0.0000 | |
19 | R | H | -2.2274 | |
20 | L | H | 0.0000 | |
21 | S | H | -1.0187 | |
22 | C | H | 0.0000 | |
23 | R | H | -2.4922 | |
24 | A | H | 0.0000 | |
25 | S | H | -1.7410 | |
26 | G | H | -1.2207 | |
27 | Y | H | -1.1743 | |
28 | E | H | -1.8377 | |
29 | F | H | 0.0000 | |
30 | L | H | -1.1111 | |
31 | N | H | -1.4976 | |
32 | C | H | 0.0000 | |
33 | P | H | 0.0000 | |
34 | I | H | 0.0000 | |
35 | N | H | 0.0000 | |
36 | W | H | 0.0000 | |
37 | I | H | 0.0000 | |
38 | R | H | 0.0000 | |
39 | L | H | 0.0000 | |
40 | A | H | -1.2262 | |
41 | P | H | -1.1332 | |
42 | G | H | -1.8435 | |
43 | R | H | -2.7226 | |
44 | R | H | -1.9681 | |
45 | P | H | 0.0000 | |
46 | E | H | -0.8067 | |
47 | W | H | -0.0933 | |
48 | M | H | 0.0000 | |
49 | G | H | 0.0000 | |
50 | W | H | -0.1132 | |
51 | L | H | 0.0000 | |
52 | K | H | -1.2625 | |
52A | P | H | 0.0000 | |
53 | R | H | -2.1621 | |
54 | G | H | -1.3734 | |
55 | G | H | -1.0602 | |
56 | A | H | -0.6447 | |
57 | V | H | -0.0019 | |
58 | N | H | -1.0172 | |
59 | Y | H | -1.2648 | |
60 | A | H | -1.8978 | |
61 | R | H | -3.1647 | |
62 | K | H | -3.0268 | |
63 | F | H | 0.0000 | |
64 | Q | H | -2.6549 | |
65 | G | H | -1.7801 | |
66 | R | H | -1.6457 | |
67 | V | H | 0.0000 | |
68 | T | H | -0.7488 | |
69 | M | H | 0.0000 | |
70 | T | H | -0.4707 | |
71 | R | H | -1.3028 | |
72 | D | H | -1.1322 | |
73 | V | H | -0.0371 | |
74 | Y | H | 0.9508 | |
75 | S | H | -0.2990 | |
76 | D | H | -1.0719 | |
77 | T | H | 0.0000 | |
78 | A | H | 0.0000 | |
79 | F | H | -0.8897 | |
80 | L | H | 0.0000 | |
81 | E | H | -1.5938 | |
82 | L | H | 0.0000 | |
82A | R | H | -1.7803 | |
82B | S | H | -1.3057 | |
82C | L | H | 0.0000 | |
83 | T | H | -1.5459 | |
84 | S | H | -1.5076 | |
85 | D | H | -1.9425 | |
86 | D | H | 0.0000 | |
87 | T | H | -0.6030 | |
88 | A | H | 0.0000 | |
89 | V | H | -0.0033 | |
90 | Y | H | 0.0000 | |
91 | F | H | 0.0000 | |
92 | C | H | 0.0000 | |
93 | T | H | 0.0000 | |
94 | R | H | -0.5090 | |
95 | G | H | 0.0000 | |
96 | K | H | -0.4134 | |
97 | Y | H | 0.2096 | |
98 | C | H | -0.4282 | |
99 | T | H | -1.0879 | |
99A | A | H | -1.5985 | |
99B | R | H | -2.6005 | |
99C | D | H | -2.0973 | |
99D | Y | H | -0.1750 | |
100 | Y | H | 1.1968 | |
101 | N | H | 0.0000 | |
102 | W | H | 0.5498 | |
103 | D | H | -0.1635 | |
104 | F | H | 0.0000 | |
105 | E | H | -1.2068 | |
106 | H | H | -1.5069 | |
107 | W | H | -1.1590 | |
108 | G | H | 0.0000 | |
109 | R | H | -2.4258 | |
110 | G | H | 0.0000 | |
111 | A | H | 0.0000 | |
112 | P | H | -0.5381 | |
113 | V | H | 0.0000 | |
114 | T | H | -0.6058 | |
115 | V | H | 0.0000 | |
116 | S | H | -1.0820 | |
117 | S | H | -0.9599 | |
118 | A | H | -0.6350 | |
119 | S | H | -0.6966 | |
120 | T | H | -0.6275 | |
121 | K | H | -1.1460 | |
122 | G | H | -1.3723 | |
123 | P | H | 0.0000 | |
124 | S | H | -0.4034 | |
125 | V | H | 0.0000 | |
126 | F | H | -0.7266 | |
127 | P | H | -1.2357 | |
128 | L | H | 0.0000 | |
129 | A | H | -0.9900 | |
130 | P | H | 0.0000 | |
131 | S | H | -0.7333 | |
132 | S | H | -0.6730 | |
137 | G | H | -0.7949 | |
138 | G | H | -0.9035 | |
139 | T | H | -0.6228 | |
140 | A | H | 0.0000 | |
141 | A | H | 0.0000 | |
142 | L | H | 0.0000 | |
143 | G | H | 0.0000 | |
144 | C | H | 0.0000 | |
145 | L | H | 0.0000 | |
146 | V | H | 0.0000 | |
147 | K | H | 0.0000 | |
148 | D | H | -0.4058 | |
149 | Y | H | 0.0000 | |
150 | F | H | 0.0000 | |
151 | P | H | -0.6935 | |
152 | E | H | -0.9403 | |
153 | P | H | -1.0889 | |
154 | V | H | -0.9300 | |
155 | T | H | -0.7668 | |
156 | V | H | -0.4208 | |
157 | S | H | -0.4395 | |
158 | W | H | 0.0000 | |
159 | N | H | -0.8470 | |
160 | S | H | -0.6615 | |
161 | G | H | -0.4239 | |
162 | A | H | -0.2014 | |
163 | L | H | 0.0158 | |
164 | T | H | -0.1401 | |
165 | S | H | -0.3701 | |
166 | G | H | -0.3744 | |
167 | V | H | 0.2179 | |
168 | H | H | 0.0000 | |
169 | T | H | 0.0479 | |
170 | F | H | 0.0000 | |
171 | P | H | -0.4366 | |
172 | A | H | 0.1414 | |
173 | V | H | 0.4400 | |
174 | L | H | 1.0517 | |
175 | Q | H | 0.2115 | |
176 | S | H | -0.0460 | |
177 | S | H | -0.2019 | |
178 | G | H | 0.0473 | |
179 | L | H | 0.0484 | |
180 | Y | H | 0.3585 | |
181 | S | H | 0.0000 | |
182 | L | H | 0.0000 | |
183 | S | H | 0.0000 | |
184 | S | H | 0.0000 | |
185 | V | H | 0.0000 | |
186 | V | H | 0.0000 | |
187 | T | H | -0.1675 | |
188 | V | H | 0.0000 | |
189 | P | H | -0.6981 | |
190 | S | H | -0.7918 | |
191 | S | H | -0.7240 | |
192 | S | H | -0.8005 | |
193 | L | H | -0.9943 | |
194 | G | H | -1.0132 | |
195 | T | H | -0.8331 | |
196 | Q | H | -1.4781 | |
197 | T | H | -1.2642 | |
198 | Y | H | 0.0000 | |
199 | I | H | -1.3612 | |
200 | C | H | 0.0000 | |
201 | N | H | -1.6184 | |
202 | V | H | 0.0000 | |
203 | N | H | -2.3175 | |
204 | H | H | 0.0000 | |
205 | K | H | -2.9362 | |
206 | P | H | -1.7373 | |
207 | S | H | -1.8572 | |
208 | N | H | -2.6643 | |
209 | T | H | -2.1576 | |
210 | K | H | -2.8730 | |
211 | V | H | -1.8897 | |
212 | D | H | -2.6841 | |
213 | K | H | -2.2750 | |
214 | R | H | -2.6832 | |
215 | V | H | 0.0000 | |
216 | E | H | -2.7423 | |
217 | P | H | -1.8383 | |
218 | K | H | -2.0808 | |
3 | V | L | 1.3762 | |
4 | L | L | 0.0000 | |
5 | T | L | -0.5585 | |
6 | Q | L | 0.0000 | |
7 | S | L | -0.4972 | |
8 | P | L | -0.1259 | |
9 | A | L | -0.3753 | |
10 | T | L | -0.4322 | |
11 | L | L | 0.0346 | |
12 | S | L | -0.2380 | |
13 | L | L | -0.1549 | |
14 | S | L | -0.7828 | |
15 | P | L | -1.4386 | |
16 | G | L | -1.7361 | |
17 | E | L | -1.7216 | |
18 | T | L | -0.6345 | |
19 | A | L | 0.0000 | |
20 | I | L | 1.3556 | |
21 | I | L | 0.0000 | |
22 | S | L | -0.7067 | |
23 | C | L | 0.0000 | |
24 | R | L | -2.2412 | |
25 | T | L | 0.0000 | |
26 | S | L | -0.9326 | |
27 | Q | L | -1.3112 | |
28 | S | L | -1.0693 | |
29 | G | L | -0.6166 | |
30 | S | L | -0.3142 | |
31 | L | L | 0.0000 | |
32 | A | L | 0.0000 | |
33 | W | L | 0.0000 | |
34 | Y | L | 0.0000 | |
35 | Q | L | 0.0000 | |
36 | Q | L | -1.4350 | |
37 | R | L | -1.9911 | |
38 | P | L | -1.4077 | |
39 | G | L | -1.7175 | |
40 | Q | L | -2.4111 | |
41 | A | L | -1.6823 | |
42 | P | L | 0.0000 | |
43 | R | L | -1.3966 | |
44 | L | L | 0.0000 | |
45 | V | L | 0.0000 | |
46 | I | L | 0.0000 | |
47 | Y | L | -0.4449 | |
48 | S | L | -0.4956 | |
49 | G | L | 0.0000 | |
50 | S | L | -1.0093 | |
51 | T | L | -0.7619 | |
52 | R | L | -1.5901 | |
53 | A | L | -0.9497 | |
54 | A | L | -0.5332 | |
55 | G | L | -0.8324 | |
56 | I | L | 0.0000 | |
57 | P | L | -1.4349 | |
58 | D | L | -2.3172 | |
59 | R | L | -1.6725 | |
60 | F | L | 0.0000 | |
61 | S | L | -0.9594 | |
62 | G | L | -0.8610 | |
63 | S | L | -1.2686 | |
64 | R | L | -2.0284 | |
65 | W | L | -0.4649 | |
66 | G | L | -0.8203 | |
67 | A | L | -1.4016 | |
68 | D | L | -1.8427 | |
69 | Y | L | 0.0000 | |
70 | N | L | -0.9415 | |
71 | L | L | 0.0000 | |
72 | S | L | 0.2249 | |
73 | I | L | 0.0000 | |
74 | S | L | -1.4882 | |
75 | N | L | -2.3422 | |
76 | L | L | 0.0000 | |
77 | E | L | -2.4704 | |
78 | S | L | -1.2333 | |
79 | G | L | -1.1092 | |
80 | D | L | 0.0000 | |
81 | F | L | 0.0000 | |
82 | G | L | 0.0000 | |
83 | V | L | -0.7420 | |
84 | Y | L | 0.0000 | |
85 | Y | L | 0.0000 | |
86 | C | L | 0.0000 | |
87 | Q | L | 0.0000 | |
88 | Q | L | 0.0000 | |
89 | Y | L | 0.7170 | |
90 | E | L | 0.3693 | |
91 | F | L | 1.2487 | |
92 | F | L | 0.0000 | |
93 | G | L | 0.0000 | |
94 | Q | L | -1.4144 | |
95 | G | L | 0.0000 | |
96 | T | L | 0.0000 | |
97 | K | L | -1.1428 | |
98 | V | L | 0.0000 | |
99 | Q | L | -0.6389 | |
100 | V | L | -0.1673 | |
101 | D | L | -0.4995 | |
102 | I | L | -0.0722 | |
103 | K | L | -1.3586 | |
104 | R | L | -1.1331 | |
105 | T | L | -0.2820 | |
106 | V | L | 0.1491 | |
107 | A | L | -0.1283 | |
108 | A | L | -0.2121 | |
109 | P | L | 0.0000 | |
110 | S | L | -0.1391 | |
111 | V | L | 0.0000 | |
112 | F | L | 0.1712 | |
113 | I | L | 0.1443 | |
114 | F | L | 0.0000 | |
115 | P | L | -0.7285 | |
116 | P | L | -0.8396 | |
117 | S | L | -1.8435 | |
118 | D | L | -3.0003 | |
119 | E | L | -3.0707 | |
120 | Q | L | 0.0000 | |
121 | L | L | -2.0954 | |
122 | K | L | -2.8867 | |
123 | S | L | -1.8055 | |
124 | G | L | -1.2692 | |
125 | T | L | -1.0370 | |
126 | A | L | 0.0000 | |
127 | S | L | 0.0000 | |
128 | V | L | 0.0000 | |
129 | V | L | 0.0000 | |
130 | C | L | 0.0000 | |
131 | L | L | 0.0000 | |
132 | L | L | 0.0000 | |
133 | N | L | 0.0000 | |
134 | N | L | -0.8925 | |
135 | F | L | 0.0000 | |
136 | Y | L | 0.0000 | |
137 | P | L | -1.6716 | |
138 | R | L | -2.9330 | |
139 | E | L | -3.1425 | |
140 | A | L | -2.3216 | |
141 | K | L | -2.2969 | |
142 | V | L | -1.0642 | |
143 | Q | L | -0.5562 | |
144 | W | L | 0.0000 | |
145 | K | L | -0.4703 | |
146 | V | L | 0.0000 | |
147 | D | L | -1.7491 | |
148 | N | L | -1.4444 | |
149 | A | L | -0.2164 | |
150 | L | L | 0.5993 | |
151 | Q | L | -0.2747 | |
152 | S | L | -0.5340 | |
153 | G | L | -1.1428 | |
154 | N | L | -1.4214 | |
155 | S | L | -1.5682 | |
156 | Q | L | -1.8219 | |
157 | E | L | -1.7905 | |
158 | S | L | -0.9194 | |
159 | V | L | -0.6391 | |
160 | T | L | 0.0000 | |
161 | E | L | -2.0864 | |
162 | Q | L | 0.0000 | |
163 | D | L | -1.6918 | |
164 | S | L | -1.5477 | |
165 | K | L | -2.2907 | |
166 | D | L | -1.6930 | |
167 | S | L | -1.5564 | |
168 | T | L | 0.0000 | |
169 | Y | L | 0.0000 | |
170 | S | L | 0.0000 | |
171 | L | L | 0.0000 | |
172 | S | L | 0.0000 | |
173 | S | L | 0.0000 | |
174 | T | L | -0.8122 | |
175 | L | L | 0.0000 | |
176 | T | L | -0.5535 | |
177 | L | L | -0.7561 | |
178 | S | L | -1.2862 | |
179 | K | L | -2.0630 | |
180 | A | L | -1.9676 | |
181 | D | L | -2.6632 | |
182 | Y | L | 0.0000 | |
183 | E | L | -3.7633 | |
184 | K | L | -3.7153 | |
185 | H | L | -2.9407 | |
186 | K | L | -3.2040 | |
187 | V | L | -1.2692 | |
188 | Y | L | 0.0000 | |
189 | A | L | 0.0000 | |
190 | C | L | 0.0000 | |
191 | E | L | -0.8454 | |
192 | V | L | 0.0000 | |
193 | T | L | -1.1894 | |
194 | H | L | -1.5625 | |
195 | Q | L | -1.6472 | |
196 | G | L | -0.5735 | |
197 | L | L | -0.3187 | |
198 | S | L | -0.4881 | |
199 | S | L | -0.4356 | |
200 | P | L | -0.5649 | |
201 | V | L | -0.0202 | |
202 | T | L | -0.4428 | |
203 | K | L | -0.6803 | |
204 | S | L | -0.4283 | |
205 | F | L | -0.8043 | |
206 | N | L | -1.8010 | |
207 | R | L | -2.5405 | |
208 | G | L | -2.0721 | |
209 | E | L | -2.1547 | |
210 | C | L | -0.7342 |