Project name: 5gzo:A

Chain sequence(s)	A: IRCIGVSNRDFVEGMSGGTWVDVVLEHGGCVTVMAQDKPTVDIELVTTTVSNMAEVRSYCYEASISDMASDSRCPTQGEAYLDKQSDTQYVCKRTLVDRGWGNGCGLFGKGSLVTCAKFACSKKMTGKSIQPENLEYRIMLSVHGSENRAKVEITPNSPRAEATLGGFGSLGLDCEPRTGLDFSDLYYLTMNNKHWLVHKEWFHDIPLPWHAGADTGTPHWNNKEALVEFKDAHAKRQTVVVLGSQEGAVHTALAGALEAEMDGAKGRLSSGHLKCRLKMDKLRLKGVSYSLCTAAFTFTKIPAETLHGTVTVEVQYAGTDGPCKVPAQMAVDMQTLTPVGRLITANPVITESTENSKMMLELDPPFGDSYIVIGVGEKKITHHWHRSGS
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.3913
• Maximal score value: 1.604
• Average score: -0.8922
• Total score value: -347.95

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	I	A	0.7511
2	R	A	-0.0569
3	C	A	0.0000
4	I	A	0.1833
5	G	A	-0.0262
6	V	A	-0.3605
7	S	A	-0.5809
8	N	A	-1.5732
9	R	A	0.0000
10	D	A	-1.7095
11	F	A	-0.5251
12	V	A	-0.8345
13	E	A	-1.8611
14	G	A	-1.0587
15	M	A	0.2084
16	S	A	-0.7254
17	G	A	-1.2823
18	G	A	-0.6104
19	T	A	-1.0441
20	W	A	-0.7978
21	V	A	0.0000
22	D	A	-2.6579
23	V	A	0.0000
24	V	A	-0.6367
25	L	A	0.0000
26	E	A	-1.3777
27	H	A	-1.0544
28	G	A	-0.9097
29	G	A	0.0000
30	C	A	0.0000
31	V	A	0.0000
32	T	A	0.0000
33	V	A	0.0000
34	M	A	-0.7714
35	A	A	-1.5008
36	Q	A	-2.3819
37	D	A	-2.9205
38	K	A	-2.4709
39	P	A	0.0000
40	T	A	0.0000
41	V	A	0.0000
42	D	A	0.0000
43	I	A	0.0000
44	E	A	0.0000
45	L	A	0.0000
46	V	A	-0.0439
47	T	A	-0.5173
48	T	A	0.0000
49	T	A	-1.3891
50	V	A	0.0000
51	S	A	-2.1548
52	N	A	-2.1607
53	M	A	0.0000
54	A	A	-1.1146
55	E	A	-1.4749
56	V	A	-0.7498
57	R	A	-1.0012
58	S	A	0.0000
59	Y	A	0.0000
60	C	A	0.0000
61	Y	A	0.0000
62	E	A	-1.5261
63	A	A	-0.6502
64	S	A	-0.0305
65	I	A	-0.0559
66	S	A	-0.8474
67	D	A	-1.7080
68	M	A	-0.6441
69	A	A	-1.1078
70	S	A	-1.0557
71	D	A	-1.1726
72	S	A	-1.6839
73	R	A	-1.8380
74	C	A	-1.3447
75	P	A	0.0000
76	T	A	-1.2753
77	Q	A	-2.0087
78	G	A	-1.9642
79	E	A	-2.1768
80	A	A	0.0000
81	Y	A	-0.0601
82	L	A	-0.6638
83	D	A	-2.1553
84	K	A	-2.1952
85	Q	A	-1.7877
86	S	A	-1.4486
87	D	A	-1.7434
88	T	A	-1.2733
89	Q	A	-1.3054
90	Y	A	-1.2168
91	V	A	0.0000
92	C	A	-1.3940
93	K	A	-2.2821
94	R	A	-1.4986
95	T	A	-0.5498
96	L	A	-0.2136
97	V	A	0.0000
98	D	A	-2.0381
99	R	A	0.0000
100	G	A	0.0000
101	W	A	1.0986
102	G	A	-0.0016
103	N	A	-1.0088
104	G	A	-0.7137
105	C	A	0.0000
106	G	A	0.4459
107	L	A	1.4027
108	F	A	1.6040
109	G	A	-0.2777
110	K	A	-1.6785
111	G	A	0.0000
112	S	A	-1.4976
113	L	A	0.0000
114	V	A	0.0000
115	T	A	0.0000
116	C	A	0.0000
117	A	A	0.0000
118	K	A	-1.3363
119	F	A	0.0000
120	A	A	-0.4302
121	C	A	-0.6482
122	S	A	-1.2282
123	K	A	-2.4034
124	K	A	-1.9003
125	M	A	0.0000
126	T	A	0.0000
127	G	A	0.0000
128	K	A	-1.0903
129	S	A	-1.0392
130	I	A	0.0000
131	Q	A	-2.1967
132	P	A	-2.4760
133	E	A	-2.9888
134	N	A	-2.3228
135	L	A	0.0000
136	E	A	-1.6415
137	Y	A	0.0000
138	R	A	-1.3300
139	I	A	0.0000
140	M	A	-1.1309
141	L	A	0.0000
142	S	A	-1.2678
143	V	A	0.0000
144	H	A	0.0000
145	G	A	-0.0077
146	S	A	-0.4214
162	E	A	-2.6878
163	N	A	-2.2515
164	R	A	-3.0195
165	A	A	-2.4072
166	K	A	-2.6413
167	V	A	0.0000
168	E	A	-2.8859
169	I	A	0.0000
170	T	A	-2.1457
171	P	A	-2.1345
172	N	A	-2.1894
173	S	A	-2.0634
174	P	A	-2.2028
175	R	A	-3.2445
176	A	A	-2.3482
177	E	A	-2.7714
178	A	A	0.0000
179	T	A	-1.5439
180	L	A	0.0000
181	G	A	-1.2397
182	G	A	-0.9719
183	F	A	-1.3068
184	G	A	-1.4072
185	S	A	-1.6504
186	L	A	0.0000
187	G	A	0.0000
188	L	A	0.0000
189	D	A	-2.8714
190	C	A	0.0000
191	E	A	-2.0791
192	P	A	0.0000
193	R	A	-2.4428
194	T	A	-1.5791
195	G	A	0.0000
196	L	A	-1.0082
197	D	A	-2.2273
198	F	A	0.0000
199	S	A	-1.4820
200	D	A	-2.0244
201	L	A	0.0000
202	Y	A	0.0000
203	Y	A	0.0000
204	L	A	0.0000
205	T	A	-1.1684
206	M	A	0.0000
207	N	A	-2.4975
208	N	A	-2.3980
209	K	A	-2.2793
210	H	A	-1.9512
211	W	A	0.0000
212	L	A	0.0000
213	V	A	0.0000
214	H	A	-1.9768
215	K	A	-2.4017
216	E	A	-3.0338
217	W	A	-1.8747
218	F	A	0.0000
219	H	A	-2.5877
220	D	A	-2.6904
221	I	A	0.0000
222	P	A	-1.1953
223	L	A	0.0000
224	P	A	0.0000
225	W	A	-0.7509
226	H	A	0.0000
227	A	A	-0.8850
228	G	A	-1.2051
229	A	A	-1.4540
230	D	A	-2.1237
231	T	A	-1.2250
232	G	A	-1.0521
233	T	A	-1.0291
234	P	A	-1.2592
235	H	A	-1.6203
236	W	A	-1.1633
237	N	A	-1.6743
238	N	A	-2.2681
239	K	A	0.0000
240	E	A	-2.6837
241	A	A	-1.4289
242	L	A	0.0000
243	V	A	0.0000
244	E	A	-1.6419
245	F	A	-1.7399
246	K	A	-2.4415
247	D	A	-2.8094
248	A	A	-2.4059
249	H	A	-2.9511
250	A	A	-2.8065
251	K	A	-3.2328
252	R	A	-3.3913
253	Q	A	0.0000
254	T	A	-1.3292
255	V	A	0.0000
256	V	A	0.6683
257	V	A	0.5579
258	L	A	0.3197
259	G	A	-0.2566
260	S	A	-1.0206
261	Q	A	-1.2615
262	E	A	-1.5912
263	G	A	-0.9967
264	A	A	-0.6942
265	V	A	0.0000
266	H	A	-0.9068
267	T	A	-0.5213
268	A	A	-0.2811
269	L	A	0.0000
270	A	A	-0.4252
271	G	A	-0.6122
272	A	A	-0.5839
273	L	A	-0.4638
274	E	A	-2.2620
275	A	A	0.0000
276	E	A	-3.3388
277	M	A	-2.5042
278	D	A	-2.9390
279	G	A	-1.7657
280	A	A	-1.6310
281	K	A	-2.8106
282	G	A	0.0000
283	R	A	-2.7290
284	L	A	0.0000
285	S	A	-1.2567
286	S	A	-0.7751
287	G	A	-0.6033
288	H	A	-0.7957
289	L	A	0.0000
290	K	A	-2.0131
291	C	A	0.0000
292	R	A	-3.0649
293	L	A	0.0000
294	K	A	-2.2260
295	M	A	0.0000
296	D	A	-3.1099
297	K	A	-3.1059
298	L	A	0.0000
299	R	A	-2.8400
300	L	A	-1.2769
301	K	A	-0.7911
302	G	A	-0.2467
303	V	A	1.2585
304	S	A	0.4787
305	Y	A	0.4881
306	S	A	0.2053
307	L	A	0.5934
308	C	A	0.0000
309	T	A	-0.2421
310	A	A	-0.4710
311	A	A	-0.7385
312	F	A	0.0000
313	T	A	-0.7590
314	F	A	-0.1098
315	T	A	-0.6574
316	K	A	-0.7008
317	I	A	1.0023
318	P	A	0.0000
319	A	A	-0.4440
320	E	A	-1.3940
321	T	A	-0.2310
322	L	A	0.8283
323	H	A	-0.1570
324	G	A	-0.2538
325	T	A	0.0000
326	V	A	0.0000
327	T	A	-0.3510
328	V	A	0.0000
329	E	A	-0.6126
330	V	A	0.0000
331	Q	A	-1.7798
332	Y	A	0.0000
333	A	A	-1.4705
334	G	A	0.0000
335	T	A	-1.7280
336	D	A	-1.5215
337	G	A	-1.4732
338	P	A	-0.9239
339	C	A	0.0000
340	K	A	-0.1695
341	V	A	0.0000
342	P	A	-0.0778
343	A	A	-0.4878
344	Q	A	-0.6125
345	M	A	0.0000
346	A	A	0.0000
347	V	A	0.7681
348	D	A	-0.4330
349	M	A	-0.1515
350	Q	A	-1.0867
351	T	A	-0.5400
352	L	A	-0.0125
353	T	A	-0.0881
354	P	A	-0.4015
355	V	A	-0.2329
356	G	A	-0.9955
357	R	A	-1.8719
358	L	A	-0.8241
359	I	A	0.0000
360	T	A	0.0000
361	A	A	-0.8858
362	N	A	-1.0520
363	P	A	0.0000
364	V	A	-0.3715
365	I	A	0.0000
366	T	A	-1.0844
367	E	A	-2.5364
368	S	A	-1.9350
369	T	A	-2.0473
370	E	A	-3.1753
371	N	A	-2.8667
372	S	A	-2.4551
373	K	A	-2.3858
374	M	A	0.0000
375	M	A	-0.1348
376	L	A	0.0000
377	E	A	0.0000
378	L	A	0.0000
379	D	A	-0.8966
380	P	A	0.0000
381	P	A	0.1078
382	F	A	0.8349
383	G	A	-0.5532
384	D	A	-1.6473
385	S	A	0.0000
386	Y	A	0.0059
387	I	A	0.0000
388	V	A	0.0000
389	I	A	0.0000
390	G	A	-0.6265
391	V	A	-0.5367
392	G	A	-1.6575
393	E	A	-2.7083
394	K	A	-2.4261
395	K	A	-1.7199
396	I	A	-0.5721
397	T	A	-0.2692
398	H	A	-0.0209
399	H	A	-0.9768
400	W	A	-1.0949
401	H	A	-1.8341
402	R	A	-0.9905
403	S	A	-0.5755
404	G	A	-0.1923
405	S	A	-0.0854