Project name: 9e9eef6cb008503
Status: done
submitted: 2018-04-12 18:11:21, status changed: 2018-04-16 01:06:01
Settings
Chain sequence(s)
|
A: NYCFAGKTSSISDLKEVPRKNITLIRGLVYEGQVSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHVIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEY
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-3.437
-
Maximal score value
-
1.4748
-
Average score
-
-0.5563
-
Total score value
-
-157.4388
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
1095 |
N |
A |
-0.9066 |
|
1096 |
Y |
A |
0.0000 |
|
1097 |
C |
A |
-0.0960 |
|
1098 |
F |
A |
-0.3880 |
|
1099 |
A |
A |
-0.9788 |
|
1100 |
G |
A |
-1.1545 |
|
1101 |
K |
A |
-1.6938 |
|
1102 |
T |
A |
-1.1320 |
|
1103 |
S |
A |
0.0000 |
|
1104 |
S |
A |
-0.0840 |
|
1105 |
I |
A |
0.5502 |
|
1106 |
S |
A |
-0.4645 |
|
1107 |
D |
A |
-1.4313 |
|
1108 |
L |
A |
0.0000 |
|
1109 |
K |
A |
-2.0602 |
|
1110 |
E |
A |
-1.7147 |
|
1111 |
V |
A |
-1.1066 |
|
1112 |
P |
A |
-1.3767 |
|
1113 |
R |
A |
-1.3920 |
|
1114 |
K |
A |
-1.9828 |
|
1115 |
N |
A |
-1.2678 |
|
1116 |
I |
A |
-0.4359 |
|
1117 |
T |
A |
-0.2610 |
|
1118 |
L |
A |
0.8647 |
|
1119 |
I |
A |
0.6309 |
|
1120 |
R |
A |
-0.5939 |
|
1121 |
G |
A |
0.3177 |
|
1122 |
L |
A |
1.4748 |
|
1130 |
V |
A |
1.2232 |
|
1131 |
Y |
A |
0.8884 |
|
1132 |
E |
A |
-0.0928 |
|
1133 |
G |
A |
0.0000 |
|
1134 |
Q |
A |
-0.6386 |
|
1135 |
V |
A |
-0.5250 |
|
1136 |
S |
A |
-0.6398 |
|
1144 |
P |
A |
-0.3826 |
|
1145 |
L |
A |
-0.0917 |
|
1146 |
Q |
A |
-1.0663 |
|
1147 |
V |
A |
0.0000 |
|
1148 |
A |
A |
0.0000 |
|
1149 |
V |
A |
0.0000 |
|
1150 |
K |
A |
-0.3828 |
|
1151 |
T |
A |
-0.2953 |
|
1152 |
L |
A |
0.0000 |
|
1153 |
P |
A |
-0.6661 |
|
1154 |
E |
A |
-0.9403 |
|
1155 |
V |
A |
0.5590 |
|
1156 |
C |
A |
-0.6219 |
|
1157 |
S |
A |
-1.5867 |
|
1158 |
E |
A |
-2.5038 |
|
1159 |
Q |
A |
-2.4040 |
|
1160 |
D |
A |
-2.0910 |
|
1161 |
E |
A |
-1.9465 |
|
1162 |
L |
A |
-0.6212 |
|
1163 |
D |
A |
-1.3056 |
|
1164 |
F |
A |
0.0000 |
|
1165 |
L |
A |
0.1410 |
|
1166 |
M |
A |
0.0000 |
|
1167 |
E |
A |
-1.0055 |
|
1168 |
A |
A |
0.0000 |
|
1169 |
L |
A |
0.0000 |
|
1170 |
I |
A |
0.0000 |
|
1171 |
I |
A |
0.0000 |
|
1172 |
S |
A |
-1.0813 |
|
1173 |
K |
A |
-1.1420 |
|
1174 |
F |
A |
0.0000 |
|
1175 |
N |
A |
-1.8747 |
|
1176 |
H |
A |
-1.5028 |
|
1177 |
Q |
A |
-1.5841 |
|
1178 |
N |
A |
0.0000 |
|
1179 |
I |
A |
0.0000 |
|
1180 |
V |
A |
0.0000 |
|
1181 |
R |
A |
-1.4405 |
|
1182 |
C |
A |
-0.5827 |
|
1183 |
I |
A |
-0.0937 |
|
1184 |
G |
A |
0.0000 |
|
1185 |
V |
A |
0.0000 |
|
1186 |
S |
A |
0.0000 |
|
1187 |
L |
A |
-0.5024 |
|
1188 |
Q |
A |
-1.1163 |
|
1189 |
S |
A |
-0.2866 |
|
1190 |
L |
A |
0.5664 |
|
1191 |
P |
A |
-0.0137 |
|
1192 |
R |
A |
-0.7029 |
|
1193 |
F |
A |
0.0000 |
|
1194 |
I |
A |
0.0000 |
|
1195 |
L |
A |
0.0000 |
|
1196 |
L |
A |
-0.2737 |
|
1197 |
E |
A |
-0.5089 |
|
1198 |
L |
A |
-0.2379 |
|
1199 |
M |
A |
0.0000 |
|
1200 |
A |
A |
0.2045 |
|
1201 |
G |
A |
-0.0094 |
|
1202 |
G |
A |
-0.2708 |
|
1203 |
D |
A |
-1.1323 |
|
1204 |
L |
A |
0.0000 |
|
1205 |
K |
A |
-1.5746 |
|
1206 |
S |
A |
-1.7078 |
|
1207 |
F |
A |
0.0000 |
|
1208 |
L |
A |
0.0000 |
|
1209 |
R |
A |
-2.6145 |
|
1210 |
E |
A |
-2.8791 |
|
1211 |
T |
A |
-1.9945 |
|
1212 |
R |
A |
-1.6537 |
|
1213 |
P |
A |
0.0000 |
|
1214 |
R |
A |
-0.9182 |
|
1215 |
P |
A |
-0.6724 |
|
1216 |
S |
A |
-1.0609 |
|
1217 |
Q |
A |
-1.7173 |
|
1218 |
P |
A |
-1.0056 |
|
1219 |
S |
A |
-0.7439 |
|
1220 |
S |
A |
-0.9717 |
|
1221 |
L |
A |
0.0000 |
|
1222 |
A |
A |
-0.1746 |
|
1223 |
M |
A |
0.0000 |
|
1224 |
L |
A |
-0.1150 |
|
1225 |
D |
A |
-0.6013 |
|
1226 |
L |
A |
0.0000 |
|
1227 |
L |
A |
0.0000 |
|
1228 |
H |
A |
-1.2389 |
|
1229 |
V |
A |
0.0000 |
|
1230 |
A |
A |
0.0000 |
|
1231 |
R |
A |
-1.2590 |
|
1232 |
D |
A |
0.0000 |
|
1233 |
I |
A |
0.0000 |
|
1234 |
A |
A |
0.0000 |
|
1235 |
C |
A |
-0.2335 |
|
1236 |
G |
A |
0.0000 |
|
1237 |
C |
A |
0.0000 |
|
1238 |
Q |
A |
-0.8165 |
|
1239 |
Y |
A |
-1.1258 |
|
1240 |
L |
A |
0.0000 |
|
1241 |
E |
A |
-1.6243 |
|
1242 |
E |
A |
-2.4041 |
|
1243 |
N |
A |
-1.5460 |
|
1244 |
H |
A |
-1.5903 |
|
1245 |
V |
A |
-0.5137 |
|
1246 |
I |
A |
0.1316 |
|
1247 |
H |
A |
0.0000 |
|
1248 |
R |
A |
0.0828 |
|
1249 |
D |
A |
0.0000 |
|
1250 |
I |
A |
0.0000 |
|
1251 |
A |
A |
0.0000 |
|
1252 |
A |
A |
0.0000 |
|
1253 |
R |
A |
-2.2118 |
|
1254 |
N |
A |
0.0000 |
|
1255 |
C |
A |
0.0000 |
|
1256 |
L |
A |
-0.2822 |
|
1257 |
L |
A |
0.0000 |
|
1258 |
T |
A |
0.1865 |
|
1259 |
C |
A |
0.2571 |
|
1260 |
P |
A |
-0.2407 |
|
1261 |
G |
A |
-0.3810 |
|
1262 |
P |
A |
-0.5888 |
|
1263 |
G |
A |
-0.6911 |
|
1264 |
R |
A |
-0.3206 |
|
1265 |
V |
A |
0.0714 |
|
1266 |
A |
A |
0.0000 |
|
1267 |
K |
A |
0.0000 |
|
1268 |
I |
A |
0.0000 |
|
1269 |
G |
A |
-0.8592 |
|
1270 |
D |
A |
-1.1702 |
|
1271 |
F |
A |
0.0000 |
|
1272 |
G |
A |
-0.6979 |
|
1273 |
M |
A |
-0.0766 |
|
1274 |
A |
A |
0.1014 |
|
1275 |
R |
A |
-0.4726 |
|
1276 |
D |
A |
-0.8653 |
|
1277 |
I |
A |
1.1544 |
|
1278 |
Y |
A |
1.4274 |
|
1289 |
A |
A |
0.5674 |
|
1290 |
M |
A |
1.4109 |
|
1291 |
L |
A |
1.3619 |
|
1292 |
P |
A |
0.6117 |
|
1293 |
V |
A |
0.2743 |
|
1294 |
K |
A |
0.0000 |
|
1295 |
W |
A |
0.2504 |
|
1296 |
M |
A |
0.0000 |
|
1297 |
P |
A |
0.0000 |
|
1298 |
P |
A |
0.0000 |
|
1299 |
E |
A |
-0.3324 |
|
1300 |
A |
A |
0.0000 |
|
1301 |
F |
A |
0.4437 |
|
1302 |
M |
A |
0.2930 |
|
1303 |
E |
A |
-1.1263 |
|
1304 |
G |
A |
-0.4267 |
|
1305 |
I |
A |
0.5526 |
|
1306 |
F |
A |
0.4242 |
|
1307 |
T |
A |
0.1211 |
|
1308 |
S |
A |
-0.6543 |
|
1309 |
K |
A |
-1.2241 |
|
1310 |
T |
A |
0.0000 |
|
1311 |
D |
A |
0.0000 |
|
1312 |
T |
A |
0.0000 |
|
1313 |
W |
A |
0.0000 |
|
1314 |
S |
A |
0.0000 |
|
1315 |
F |
A |
0.0000 |
|
1316 |
G |
A |
0.0000 |
|
1317 |
V |
A |
0.0000 |
|
1318 |
L |
A |
0.0000 |
|
1319 |
L |
A |
0.0000 |
|
1320 |
W |
A |
0.0000 |
|
1321 |
E |
A |
0.0000 |
|
1322 |
I |
A |
0.0000 |
|
1323 |
F |
A |
0.0000 |
|
1324 |
S |
A |
-0.3066 |
|
1325 |
L |
A |
0.0000 |
|
1326 |
G |
A |
0.0000 |
|
1327 |
Y |
A |
1.1700 |
|
1328 |
M |
A |
1.0256 |
|
1329 |
P |
A |
0.0000 |
|
1330 |
Y |
A |
0.0000 |
|
1331 |
P |
A |
-0.0447 |
|
1332 |
S |
A |
-0.8215 |
|
1333 |
K |
A |
-1.5640 |
|
1334 |
S |
A |
-1.8659 |
|
1335 |
N |
A |
-2.2380 |
|
1336 |
Q |
A |
-2.8423 |
|
1337 |
E |
A |
-3.2419 |
|
1338 |
V |
A |
0.0000 |
|
1339 |
L |
A |
-1.6187 |
|
1340 |
E |
A |
-2.5982 |
|
1341 |
F |
A |
-1.4330 |
|
1342 |
V |
A |
0.0000 |
|
1343 |
T |
A |
-0.6204 |
|
1344 |
S |
A |
-0.8480 |
|
1345 |
G |
A |
-0.9422 |
|
1346 |
G |
A |
-0.8080 |
|
1347 |
R |
A |
-0.9345 |
|
1348 |
M |
A |
0.0000 |
|
1349 |
D |
A |
-2.1289 |
|
1350 |
P |
A |
-1.7879 |
|
1351 |
P |
A |
0.0000 |
|
1352 |
K |
A |
-2.2044 |
|
1353 |
N |
A |
-1.3945 |
|
1354 |
C |
A |
-1.2221 |
|
1355 |
P |
A |
0.0000 |
|
1356 |
G |
A |
-1.2495 |
|
1357 |
P |
A |
-1.2030 |
|
1358 |
V |
A |
0.0000 |
|
1359 |
Y |
A |
-1.2935 |
|
1360 |
R |
A |
-2.1712 |
|
1361 |
I |
A |
0.0000 |
|
1362 |
M |
A |
0.0000 |
|
1363 |
T |
A |
-1.2700 |
|
1364 |
Q |
A |
-1.4589 |
|
1365 |
C |
A |
0.0000 |
|
1366 |
W |
A |
0.0000 |
|
1367 |
Q |
A |
-1.9913 |
|
1368 |
H |
A |
-1.9424 |
|
1369 |
Q |
A |
-2.7092 |
|
1370 |
P |
A |
-2.4443 |
|
1371 |
E |
A |
-3.3143 |
|
1372 |
D |
A |
-3.4370 |
|
1373 |
R |
A |
0.0000 |
|
1374 |
P |
A |
0.0000 |
|
1375 |
N |
A |
-1.0674 |
|
1376 |
F |
A |
0.0000 |
|
1377 |
A |
A |
-0.4426 |
|
1378 |
I |
A |
-0.2772 |
|
1379 |
I |
A |
0.0000 |
|
1380 |
L |
A |
-0.9616 |
|
1381 |
E |
A |
-1.7057 |
|
1382 |
R |
A |
-1.4576 |
|
1383 |
I |
A |
0.0000 |
|
1384 |
E |
A |
-2.1865 |
|
1385 |
Y |
A |
-0.6753 |
|
1386 |
C |
A |
0.0000 |
|
1387 |
T |
A |
-1.4625 |
|
1388 |
Q |
A |
-1.6545 |
|
1389 |
D |
A |
-1.9160 |
|
1390 |
P |
A |
-1.9967 |
|
1391 |
D |
A |
-2.6275 |
|
1392 |
V |
A |
0.0000 |
|
1393 |
I |
A |
-1.0525 |
|
1394 |
N |
A |
-1.7103 |
|
1395 |
T |
A |
-0.9586 |
|
1396 |
A |
A |
-0.1798 |
|
1397 |
L |
A |
0.0000 |
|
1398 |
P |
A |
-0.1667 |
|
1399 |
I |
A |
0.5818 |
|
1400 |
E |
A |
0.0970 |
|
1401 |
Y |
A |
1.0558 |
|